LOCUS       NM_152441               2527 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 14 (FBXL14),
            transcript variant 1, mRNA.
ACCESSION   NM_152441
VERSION     NM_152441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Cui,Y.H., Kang,J.H., Suh,Y., Zhao,Y., Yi,J.M., Bae,I.H., Lee,H.J.,
            Park,D.W., Kim,M.J. and Lee,S.J.
  TITLE     Loss of FBXL14 promotes mesenchymal shift and radioresistance of
            non-small cell lung cancer by TWIST1 stabilization
  JOURNAL   Signal Transduct Target Ther 6 (1), 272 (2021)
   PUBMED   34285182
  REMARK    GeneRIF: Loss of FBXL14 promotes mesenchymal shift and
            radioresistance of non-small cell lung cancer by TWIST1
            stabilization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2527)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2527)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2527)
  AUTHORS   Cui,Y.H., Kim,H., Lee,M., Yi,J.M., Kim,R.K., Uddin,N., Yoo,K.C.,
            Kang,J.H., Choi,M.Y., Cha,H.J., Kwon,O.S., Bae,I.H., Kim,M.J.,
            Kaushik,N. and Lee,S.J.
  TITLE     FBXL14 abolishes breast cancer progression by targeting CDCP1 for
            proteasomal degradation
  JOURNAL   Oncogene 37 (43), 5794-5809 (2018)
   PUBMED   29973690
  REMARK    GeneRIF: FBXL14 acts as an novel interaction partner of CDCP1, and
            facilitates its ubiquitination and proteasomal degradation with an
            enhanced capacity to suppress CDCP1 protein stability that
            eventually prevents CDCP1 target genes involved in breast cancer
            metastasis.
REFERENCE   5  (bases 1 to 2527)
  AUTHORS   Fung,E., Richter,C., Yang,H.B., Schaffer,I., Fischer,R.,
            Kessler,B.M., Bassermann,F. and D'Angiolella,V.
  TITLE     FBXL13 directs the proteolysis of CEP192 to regulate centrosome
            homeostasis and cell migration
  JOURNAL   EMBO Rep 19 (3) (2018)
   PUBMED   29348145
  REMARK    GeneRIF: induced FBXL13 expression downregulates centrosomal
            gamma-tubulin and disrupts centrosomal microtubule arrays. In
            addition, depletion of FBXL13 induces high levels of CEP192 and
            gamma-tubulin at the centrosomes with the consequence of defects in
            cell motility.
REFERENCE   6  (bases 1 to 2527)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   7  (bases 1 to 2527)
  AUTHORS   Zheng,H., Shen,M., Zha,Y.L., Li,W., Wei,Y., Blanco,M.A., Ren,G.,
            Zhou,T., Storz,P., Wang,H.Y. and Kang,Y.
  TITLE     PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11
            regulates epithelial-mesenchymal transition and metastasis
  JOURNAL   Cancer Cell 26 (3), 358-373 (2014)
   PUBMED   25203322
REFERENCE   8  (bases 1 to 2527)
  AUTHORS   Vinas-Castells,R., Beltran,M., Valls,G., Gomez,I., Garcia,J.M.,
            Montserrat-Sentis,B., Baulida,J., Bonilla,F., de Herreros,A.G. and
            Diaz,V.M.
  TITLE     The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for
            proteasome degradation
  JOURNAL   J Biol Chem 285 (6), 3794-3805 (2010)
   PUBMED   19955572
  REMARK    GeneRIF: Data show that Twist1 small interfering RNA prevents
            hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization.
REFERENCE   9  (bases 1 to 2527)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   10 (bases 1 to 2527)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005182.2 and AC004671.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152441.2.
            
            Summary: Members of the F-box protein family, such as FBXL14, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028132.1, SRR1660803.323268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339235.4/ ENSP00000344855.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1709              AC005182.2         11218-12926         c
            1710-2527           AC004671.1         125354-126171       c
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..2527
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /note="F-box and leucine rich repeat protein 14"
                     /db_xref="GeneID:144699"
                     /db_xref="HGNC:HGNC:28624"
                     /db_xref="MIM:609081"
     exon            1..1709
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1772
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 14"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 14 isoform 1"
                     /protein_id="NP_689654.1"
                     /db_xref="CCDS:CCDS8509.1"
                     /db_xref="GeneID:144699"
                     /db_xref="HGNC:HGNC:28624"
                     /db_xref="MIM:609081"
                     /translation="METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSV
                     WRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYN
                     LTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTG
                     LLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDL
                     SLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAM
                     GSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRT
                     LNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ
                     MTDSEKEARGDFSPLFTVRTRGSSRR"
     exon            1710..2527
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2120..2125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /note="hexamer: AATATA"
     polyA_site      2139
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /note="hexamer: AATATA"
     polyA_site      2527
                     /gene="FBXL14"
                     /gene_synonym="Fbl14"
                     /note="major polyA site"
ORIGIN      
        1 gaaaagcggg cgagagacaa aggcagcagg aagcctcctc cgcgcccgga gcccgtgcgc
       61 ccggcccccg gggccccctc gccgcccgcc ggcccgcgga gcagcggcgg cggcaggagg
      121 cggaggatgc ggcagggggc gtgggcgcgg cggcgcgggc ggagcggcgc ggcccgggcg
      181 cggcgtgggt agagccgagg cggcggcggc ggccggcctc cgggagcgag agcgaggcgc
      241 cttccccgcc cgggatgtga gcgccgtgcg gagcccgggg cgggggaggg ccgggccgga
      301 ggcgcagccg gcaggaagga aggacggacg gaccaggagg aggagcggcg gcggcggccg
      361 gagccggaag gcggggaggg gccggccgtt gggcccgagg cggcggcggc ggcggcggcg
      421 gcggctgggg agaagcgctc tcgtcgcctg cccgaggccg gagcggcggg gcccgcgcct
      481 cctcccccca gcgccgcgga ggggggagga ggaagatgga gacccacatc tcatgcctgt
      541 tcccggagct gctggccatg atcttcggct acctggacgt ccgggacaag gggcgcgcgg
      601 cgcaggtgtg caccgcctgg cgggacgccg cctaccacaa gtcggtgtgg cggggggtgg
      661 aggccaagct gcacctgcgc cgggccaacc cgtcgctgtt ccccagcctg caggcccggg
      721 gcatccgccg ggtgcagatc ctgagcctcc gccgcagcct cagctacgtg atccagggca
      781 tggccaacat cgagagcctc aacctcagcg gctgctacaa cctcaccgac aacgggctgg
      841 gccacgcgtt tgtgcaggag atcggctccc tgcgcgctct caacctgagc ctctgcaagc
      901 agatcactga cagcagcctg ggccgcatag cccagtacct caagggcctg gaggtgctgg
      961 agctgggagg ttgcagcaac atcaccaaca ctggccttct gctcatcgcc tggggtctgc
     1021 agcgcctcaa gagccttaac ctccgcagct gccgccacct ttcggatgtg ggcatcgggc
     1081 acctggccgg catgacgcgc agcgcggcgg agggctgcct gggcctggag cagctcacgc
     1141 tacaggactg ccagaagctc acagatcttt ctctaaagca catctcccga gggctgacgg
     1201 gcctgaggct cctcaacctc agcttctgtg ggggaatctc ggacgctggc ctcctgcacc
     1261 tgtcgcacat gggcagcctg cgcagcctca acctgcgctc ctgtgacaac atcagtgaca
     1321 cgggcatcat gcatctggcc atgggcagcc tgcgcctctc ggggctggat gtttcgttct
     1381 gtgacaaggt gggagaccag agtctggctt acatagccca ggggctggat ggcctcaagt
     1441 ctctctccct ctgctcctgc cacatcagtg atgatggcat caaccgcatg gtgcggcaga
     1501 tgcacgggct gcgcacgctc aacattggac agtgtgtgcg catcacggac aagggcctgg
     1561 agctgatcgc tgagcacctg agccaactca ccggcataga cctgtacggc tgcacccgaa
     1621 tcaccaagcg cggcctggag cgcatcacgc agctgccgtg cctcaaggta ctcaacctgg
     1681 gactctggca gatgacggac agtgagaagg aggcacgagg ggatttttct ccattattca
     1741 ctgtgagaac tcggggaagc tccagaaggt gagggagagg ggacaacgac atggttcccg
     1801 tggatcttta acttccagac ttgcccgctc tgcgcctccg gcactctggt gatgacagct
     1861 caggtttccc tgcctgtcac tgctcgggca gaggctgctg cccagggctt ctgctccggt
     1921 accttgtgaa gctgcattct cctgccggtt tctccagttc tggggacagt ggtttgctct
     1981 gagacctcgc ttcctttatg gatccaagga gacttgcttt ttcagtctgt tcagcttttt
     2041 acttgctagg atggaattgc aatttgcaag cttcttcgac aggaaactac aagttccaca
     2101 ctttaatttt atacatataa atatatacat gtgtacatat atctatgtac aggggtatta
     2161 tatatataca tataagatga tgatatatat aatgatgata tgtattactg agaacgtaaa
     2221 atatcattac atagtgatag ctggacacac aaggaattca caactcccca aagaaaatac
     2281 atctggatga cctgcctagc agtttcccca tgagatagag gaatgtctac gtatttcatt
     2341 ccctgttcct gccctgaaac aatttcaatc actgacaaat cattatcatt cattaataat
     2401 gtttactgag tgcccatatg tgaaagaaat ccactctaca ttccacagat gcatttcctc
     2461 tccccacggg gtttccattt taatgggaac aatgtagaat atatctgtct tccctttata
     2521 gattcca
//
