LOCUS       NM_001394494            4657 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 13 (FBXL13),
            transcript variant 5, mRNA.
ACCESSION   NM_001394494 XM_005250205
VERSION     NM_001394494.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   He,J., Kelly,T.N., Zhao,Q., Li,H., Huang,J., Wang,L., Jaquish,C.E.,
            Sung,Y.J., Shimmin,L.C., Lu,F., Mu,J., Hu,D., Ji,X., Shen,C.,
            Guo,D., Ma,J., Wang,R., Shen,J., Li,S., Chen,J., Mei,H., Chen,C.S.,
            Chen,S., Chen,J., Li,J., Cao,J., Lu,X., Wu,X., Rice,T.K., Gu,C.C.,
            Schwander,K., Hamm,L.L., Liu,D., Rao,D.C., Hixson,J.E. and Gu,D.
  TITLE     Genome-wide association study identifies 8 novel loci associated
            with blood pressure responses to interventions in Han Chinese
  JOURNAL   Circ Cardiovasc Genet 6 (6), 598-607 (2013)
   PUBMED   24165912
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Curtiss,N.P., Bonifas,J.M., Lauchle,J.O., Balkman,J.D., Kratz,C.P.,
            Emerling,B.M., Green,E.D., Le Beau,M.M. and Shannon,K.M.
  TITLE     Isolation and analysis of candidate myeloid tumor suppressor genes
            from a commonly deleted segment of 7q22
  JOURNAL   Genomics 85 (5), 600-607 (2005)
   PUBMED   15820312
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073127.11, AC005250.1 and AC006477.4.
            
            On Jan 25, 2022 this sequence version replaced NM_001394494.1.
            
            Summary: Members of the F-box protein family, such as FBXL13, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440067.4/ ENSP00000390126.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC073127.11        150696-150796       c
            102-205             AC073127.11        131644-131747       c
            206-296             AC073127.11        131088-131178       c
            297-364             AC073127.11        105351-105418       c
            365-513             AC073127.11        104600-104748       c
            514-623             AC073127.11        103449-103558       c
            624-791             AC073127.11        101063-101230       c
            792-887             AC073127.11        44022-44117         c
            888-1020            AC073127.11        39533-39665         c
            1021-1073           AC073127.11        7881-7933           c
            1074-1174           AC073127.11        2274-2374           c
            1175-1304           AC005250.1         81422-81551         c
            1305-1403           AC005250.1         52550-52648         c
            1404-1521           AC005250.1         51904-52021         c
            1522-1684           AC005250.1         51641-51803         c
            1685-1804           AC005250.1         46667-46786         c
            1805-1931           AC005250.1         45803-45929         c
            1932-2015           AC005250.1         23113-23196         c
            2016-2150           AC005250.1         1176-1310           c
            2151-2314           AC006477.4         111696-111859       c
            2315-4657           AC006477.4         100845-103187       c
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4657
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="F-box and leucine rich repeat protein 13"
                     /db_xref="GeneID:222235"
                     /db_xref="HGNC:HGNC:21658"
                     /db_xref="MIM:609080"
     exon            1..101
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2504
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="isoform 4 is encoded by transcript variant 5;
                     F-box/LRR-repeat protein 13; dynein regulatory complex
                     subunit 6; cilia and flagella associated protein 169"
                     /codon_start=1
                     /product="F-box and leucine-rich repeat protein 13 isoform
                     4"
                     /protein_id="NP_001381423.1"
                     /db_xref="CCDS:CCDS94164.1"
                     /db_xref="GeneID:222235"
                     /db_xref="HGNC:HGNC:21658"
                     /db_xref="MIM:609080"
                     /translation="MASLRNANPRLKNYFKENYIPQVCEALLCGILVTCPEDPLRYLE
                     GMIMVIIKSGLQNLLWDMCITPSMKPNIRRLSETYLEQLFELDDQLMTPELMIKACSF
                     YTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHWHSYMEDQKEK
                     LKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKWKNRLILKR
                     AAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWM
                     LMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHC
                     RNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLS
                     LAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM
                     PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASF
                     KFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGP
                     ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVS
                     IDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQ
                     LSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQIL
                     EDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTE
                     LDNITSSKGALELTVKKSTYSSEDQAA"
     exon            102..205
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            206..296
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            297..364
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            365..513
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            514..623
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            624..791
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1020
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1073
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1174
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1304
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1403
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1521
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1684
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1804
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1931
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2015
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2150
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2314
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..4657
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="hexamer: AACAAG"
     polyA_site      2616
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="major polyA site"
     regulatory      3253..3258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="hexamer: AATACA"
     polyA_site      3285
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
     regulatory      3823..3828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="hexamer: ATTAAA"
     polyA_site      3841
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
     regulatory      4629..4634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
                     /note="hexamer: AATATA"
     polyA_site      4657
                     /gene="FBXL13"
                     /gene_synonym="CFAP169; DRC6; Fbl13"
ORIGIN      
        1 gcagcttctc cgtcaggcct tgggccatgg cctcgctacg caatgccaac ccgaggctga
       61 agaactactt caaggagaac tacattcctc aggtctgcga ggcactgtta tgtggtatac
      121 ttgttacatg tcctgaggat ccgctgaggt atttagaggg aatgatcatg gttataatca
      181 aaagtggtct tcagaatctt ctttgggata tgtgcattac tccatcaatg aaaccaaaca
      241 ttcgaagatt gtctgaaact tacctggaac aactttttga attggatgat cagctgatga
      301 ctccggaatt gatgataaaa gcctgtagct tttatactgg acatttagta aagactcatt
      361 tttgcacttg gagagacata gctcgtacaa atgaaaatgt cgtcctggct gaaaaaatga
      421 acagagcagt gacatgctac aatttcagac ttcaaaaatc tgtatttcat cactggcact
      481 cttatatgga agaccagaaa gaaaaactta aaaatattct attgcggata caacagatca
      541 tctattgtca caagctaacc attatcctaa caaaatggcg gaatacagca agacataaga
      601 gtaaaaagaa agaagatgag ctgatattaa aacatgaact tcaattgaaa aaatggaaaa
      661 ataggttaat actcaaaaga gctgctgcag aagaatccaa ttttcctgaa cgaagttctt
      721 ctgaagtctt tcttgtagat gagactctaa aatgtgacat ttcactgtta cctgaaagag
      781 caatattaca gattttcttc tacctcagtt taaaagatgt gataatatgt ggtcaagtta
      841 atcatgcctg gatgttgatg acacaactaa actcactgtg gaatgctatt gatttttcct
      901 cagtgaaaaa tgtgattcca gataaatata tagtgtctac tttgcaaagg tggcgtttaa
      961 atgtgctgcg tttgaatttt cgtggttgtc ttctccgacc caaaactttc agatctgtca
     1021 gccactgtag gaacttgcaa gagttgaatg tctctgactg cccaacattc acagatgaat
     1081 caatgagaca catttctgag ggctgcccgg gggtcctgtg tctcaatctg tctaacacaa
     1141 ctatcaccaa caggacgatg cgactcctgc cgaggcactt ccacaactta cagaatctta
     1201 gtttggctta ttgcagacgg ttcacagaca aaggcttaca gtacctgaac ttggggaatg
     1261 gatgccacaa gctcatctat ctggacctct ctggctgcac ccagatttca gtccaaggct
     1321 tcaggtacat tgcaaacagc tgcactggaa ttatgcatct taccattaat gacatgccaa
     1381 ctctgacgga caactgtgta aaagctttag ttgaaaaatg ctctcgtatt acatcgctgg
     1441 ttttcactgg tgcaccgcat atctccgatt gtactttcag agctctttct gcttgtaaac
     1501 tcagaaagat ccgatttgaa ggaaataaaa gggttactga tgcatccttc aaatttatag
     1561 acaagaatta tccaaatctc agtcacattt atatggctga ctgcaaggga ataacagaca
     1621 gcagcctcag atccctttca cctttgaagc aactgactgt gttgaatttg gcaaattgtg
     1681 taagaattgg tgatatggga ctaaagcaat ttcttgatgg tcctgcaagc atgaggataa
     1741 gagagctaaa tttaagcaac tgtgtgcggc taagtgatgc ctctgttatg aaactatctg
     1801 agcgctgccc taatttaaac tacttgagtt tacgaaattg tgaacatttg actgcccaag
     1861 gaattggata tattgtaaac atcttttcct tggtatcaat agatctctct ggaacagaca
     1921 tctctaatga gggtttgaat gtgctttcca gacataaaaa attgaaggaa ctttctgtat
     1981 ctgaatgtta tagaatcact gatgatggaa ttcaggcatt ctgcaaaagc tcactgatct
     2041 tggaacattt ggatgtctct tattgctccc agctgtcaga tatgattatc aaagcactgg
     2101 ccatttactg cattaacctc acatctctca gcattgctgg ctgtccaaag attactgact
     2161 cagcaatgga gatgttatcg gcaaaatgcc attacctgca cattttggat atctctggtt
     2221 gtgtcttgct tactgaccaa atccttgagg accttcagat aggctgcaaa caactccgga
     2281 tccttaagat gcaatactgc acaaatattt ccaagaaggc agctcaaaga atgtcatcta
     2341 aagttcagca gcaggaatac aacactaatg accctccacg ttggtttggc tatgataggg
     2401 aaggaaaccc tgttacagag cttgacaaca taacatcatc taaaggagcc ttagaattaa
     2461 cagtgaaaaa gtcaacatac agcagtgaag accaagcagc gtgaccttca gcctcaagca
     2521 ggaagaacaa aaaatcaaga acttggcaag ttttctccat ttgttgcaag tatgtttact
     2581 agctgaatct caataacaat gtaaacaagc aacaaaccat cttctgattc ttattccaac
     2641 tacaaatatt tccaaacaca tcagtagttc ttctgtctaa ataatcatga tttaaaaaag
     2701 aagccaggcc aggagcggtg gctcacacct gtaatcctag cactttggta ggccaaggcg
     2761 ggtggaccat aagtcaggag ttcaagacca gcctggccaa catggtgaaa ccccatcttt
     2821 actaaaaata caaaaattag ccgggtgtgg tggtgggcgc ctgtaatccc agctactcag
     2881 gaggctgagg caggggactt gcttgaacct gagaggcgga ggttgcagtg agcctagatc
     2941 acgtcactgc attccagcct cggcgacaga gcaagactcc gtctcaaaaa aaaaaaaaaa
     3001 aaaaagaagc caaatcaagt actgactaca caaaatttct gcctaaattt aatcaaacca
     3061 atagttttga tgagattata aaatctacag ttatatgaaa caaccctgag agatgagact
     3121 tttttgacaa gaaattaaga aatttttctt tagaaaggaa aaagaaagca gagatggcca
     3181 tatgtcaaac taagagtttg agccagggga ataactttaa ggatctgtaa cgctttttaa
     3241 ggctttataa agaatacaga catatattaa tattttcaaa ggaaatgtgg cttttctgtg
     3301 gtttccagac atttaacaac aaaagagaac taaatgccgc caattaactc tgtacttatc
     3361 tcaacatttg acttagtcag gggcaaatta aatagaaaca agaactatct gaatagaaag
     3421 aatgtccctg caatgtctca gaaagacatc tctttaatca aatttgcaca acggaggaat
     3481 tcttaaacta tgctatgcca aaaaagatgc tccctcaatt ttatgctagg aagtatgggt
     3541 tattaattgc atatctacat attagttttt aataagcttt aatccgtagg ttttagtata
     3601 tgtgctgccg aagtgagcac atctgtgggt ttttaccatt atttgatatt atgtaacact
     3661 gatgttgaca cagtccaaga gaaaacacaa ctctgttctg actgccgcaa acaagccttg
     3721 tcagcaatat cagatcagcc ttttaacctt tctatttcct caattactta tctctcacgt
     3781 ggagttaatt ctctttttgt atcccacaag tttcaaataa ggattaaaaa cttaagataa
     3841 agcatcgtta ttttgaaaag ttttaaaaag attgtacaaa gtattattat aggctacctt
     3901 gtattagcta aatgctttta gtaattctcc cccactgagg ttgacttgca aagtttttga
     3961 aataaggtaa tattacttag ctgtggaaag gttcctagga gtgggcacac aggcaacaga
     4021 atcatttgag tgggaagttt tagaccatag ccaagagaca taagatgaca taagagtatg
     4081 attttaacct aaatttggaa atttctggca gctgcattaa agatgttttc aaaaatctga
     4141 tccctaagtg cttcatgcac acaactggtg gaacttataa aagaggcaat tgctttctaa
     4201 aggaatgaca cctgcactgg ttagaccccg gtaagaaaca caccctgtta tgttctccag
     4261 aaacctagca ggttgcttta cattcagagc ttgctccaaa gctctttgag taacatcctt
     4321 tcttaaacaa gaacagaaga cacattcatt cattctgggg agacaaattt tacagctaca
     4381 taaatgaaga aaaggagtag aaaaagtgag ctatgaaagg agaccaagaa tagggataca
     4441 ggtagagaaa tcttttaagt tttcgatgca aactactcaa aatatcaaag atattagtta
     4501 ggtctttagc ccttacgtat ttcatattca taggtctgtg tccaagagag taaattatgg
     4561 cagctttttc tttttgtctg ggacttaaca atgtgatcca aatatgtaca attccattag
     4621 tagctttaaa tatagttgac tgctgttatg cttatga
//
