LOCUS       NM_017703               1873 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 12 (FBXL12),
            transcript variant 1, mRNA.
ACCESSION   NM_017703
VERSION     NM_017703.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Brunner,A., Li,Q., Fisicaro,S., Kourtesakis,A., Viiliainen,J.,
            Johansson,H.J., Pandey,V., Mayank,A.K., Lehtio,J.,
            Wohlschlegel,J.A., Spruck,C., Rantala,J.K., Orre,L.M. and
            Sangfelt,O.
  TITLE     FBXL12 degrades FANCD2 to regulate replication recovery and promote
            cancer cell survival under conditions of replication stress
  JOURNAL   Mol Cell 83 (20), 3720-3739 (2023)
   PUBMED   37591242
  REMARK    GeneRIF: FBXL12 degrades FANCD2 to regulate replication recovery
            and promote cancer cell survival under conditions of replication
            stress.
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Tsuruta,F., Takebe,A., Haratake,K., Kanemori,Y., Kim,J., Endo,T.,
            Kigoshi,Y., Fukuda,T., Miyahara,H., Ebina,M., Baba,T. and Chiba,T.
  TITLE     SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical
            Ubiquitin Chain Synthesis
  JOURNAL   Mol Cell Biol 36 (16), 2182-2194 (2016)
   PUBMED   27215384
  REMARK    GeneRIF: Study found that Fbl12 binds and ubiquitinates p21 which
            allows its stability. In addition, Fbl12 regulates default
            degradation under basal conditions but not under UV-stimulated
            conditions. These findings elucidate novel mechanisms that underlie
            the regulation of p21 expression level in cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Kim,M., Nakamoto,T., Nishimori,S., Tanaka,K. and Chiba,T.
  TITLE     A new ubiquitin ligase involved in p57KIP2 proteolysis regulates
            osteoblast cell differentiation
  JOURNAL   EMBO Rep 9 (9), 878-884 (2008)
   PUBMED   18660753
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB127388.1 and AK000195.1.
            
            On May 17, 2019 this sequence version replaced NM_017703.2.
            
            Summary: Members of the F-box protein family, such as FBXL12, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.139176.1,
                                           SRR3476690.723967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358, SAMEA2156099
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247977.9/ ENSP00000247977.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB127388.1         25-48
            25-1873             AK000195.1         1-1849
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1873
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /note="F-box and leucine rich repeat protein 12"
                     /db_xref="GeneID:54850"
                     /db_xref="HGNC:HGNC:13611"
                     /db_xref="MIM:609079"
     exon            1..352
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1247
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /note="isoform a is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 12; F-box protein FBL12"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 12 isoform a"
                     /protein_id="NP_060173.1"
                     /db_xref="CCDS:CCDS12218.1"
                     /db_xref="GeneID:54850"
                     /db_xref="HGNC:HGNC:13611"
                     /db_xref="MIM:609079"
                     /translation="MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLW
                     RHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCP
                     NLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDR
                     VPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADS
                     TLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILS
                     SCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM"
     exon            353..425
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /inference="alignment:Splign:2.1.0"
     exon            426..1873
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /note="hexamer: ATTAAA"
     polyA_site      1873
                     /gene="FBXL12"
                     /gene_synonym="Fbl12"
                     /note="major polyA site"
ORIGIN      
        1 ggtcttagtt cccagtcgcg gccaaatcac gcctcagcca cctcccgcaa gcctctcact
       61 gcctcagcca cgctttccag gctggtttct ggtccccatc cgcggctggt ccggccctgg
      121 gaccgaatca cttcccagcg agaggaaggt caaatttctc gaccggctac gggaaggtcg
      181 cggccgccgc cctgtcagcc gcctcggcgc ccccaggacc cctcgggtct ctttaaccgg
      241 aagcggaagt gcgtgtcggc gggatcatgg cgactttggt cgaactgccg gactcggtcc
      301 tgctcgagat cttctcttac ctcccggtac gggaccggat ccgcatctcc agggtctgtc
      361 accgctggaa gaggctggtg gacgaccggt ggctgtggcg acatgtcgac ctgacgctct
      421 acacgatgcg acctaaagtc atgtggcacc tccttcgaag gtacatggca tcccggctcc
      481 attccctgcg gatgggtggc tacctgttct ctggctccca ggccccccag ttgtcccctg
      541 ctctgttgag agccctgggc cagaagtgcc ccaacctgaa gcgcctctgc ctgcacgtgg
      601 ccgacctgag catggtgccc atcaccagcc tgcccagcac cttgaggacc ctggagctgc
      661 acagctgcga gatctccatg gcctggctcc acaagcagca ggaccccacc gtgctgcccc
      721 tgcttgaatg catcgtgctg gaccgcgtcc ccgccttccg tgacgagcac ctgcagggcc
      781 tgacgcgctt ccgggccttg cgctcgctgg tgctgggtgg tacctaccgt gtgaccgaga
      841 cagggctgga tgctggcctg caggagctca gctatctgca gaggcttgag gtgctgggct
      901 gcaccctgtc tgccgacagc accctgctgg ccatcagccg ccacctccga gatgtgcgca
      961 agatccggct gaccgtgagg ggcctctctg cccctggcct ggctgtgctg gagggaatgc
     1021 cggccctgga gagtctgtgc ctgcagggtc ccctcgtcac cccagaaatg ccctccccca
     1081 ctgaaatcct ctcctcctgc ctcactatgc ccaagctcag agtccttgag ctgcaggggc
     1141 tggggtggga gggtcaggag gcggagaaga tcctgtgtaa ggggctgccc cactgtatgg
     1201 tcatcgtcag ggcttgcccc aaagagtcta tggactggtg gatgtaacta ctccacctgc
     1261 ccttgggacc catcccagtt ttcatcattg agccccagac cctctgagca gcaccttgaa
     1321 gagggcagat aatcagactt gaggaaactg aaagccccag gttgagagaa cagaggccta
     1381 gggacctcca gaccattgga atcactgttt gccagctgtg tggccttggt catatcatca
     1441 gcctctggga agcctagttc ccacatctgg aaataaggat gatcatagct acctcacggt
     1501 tacattgcaa agccttactc taaaagctcc cagcctccag aggctctcaa tgaagagtca
     1561 ccttcatggt cgtcttcagg aacaggacgg atgaagaagg ggtggggtta agactcaggg
     1621 gcacctgagg gtctgagccc ccttatgagt acccaagaag gactgtctat gcatgcacac
     1681 ccacaagcct atacaccatt tatataccta cacgcacgca agagacgcgg agagataggc
     1741 gatgcagact cgcgattcaa tgatcgatat gctcataaaa gtgctcaatt atattttctg
     1801 tattttgtat gctgtatttt ccaagacgta tattatttta ctattaaaga aaaaaatcat
     1861 ttttttttcc cga
//
