LOCUS       NM_001105079            5196 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fibrosin (FBRS), mRNA.
ACCESSION   NM_001105079 XM_011545915
VERSION     NM_001105079.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5196)
  AUTHORS   Prakash,S., Paul,W.E. and Robbins,P.W.
  TITLE     Fibrosin, a novel fibrogenic cytokine, modulates expression of
            myofibroblasts
  JOURNAL   Exp Mol Pathol 82 (1), 42-48 (2007)
   PUBMED   17083929
  REMARK    GeneRIF: In a mouse model, fibrosin upregulates the appearance of
            myofibroblasts during wound healing and may be important in the
            process of scarring.
REFERENCE   2  (bases 1 to 5196)
  AUTHORS   Prakash,S. and Robbins,P.W.
  TITLE     Fibrosin: a novel lymphokine in wound healing
  JOURNAL   Exp Mol Pathol 71 (3), 247-255 (2001)
   PUBMED   11733950
  REMARK    GeneRIF: Fibrosin stimulates epithelialization of wounds in mouse
            and reduces wound healing time by approximately 30-40%.
REFERENCE   3  (bases 1 to 5196)
  AUTHORS   Prakash,S., Nanji,A.A. and Robbins,P.W.
  TITLE     Fibrosin: A novel lymphokine in alcohol-induced fibrosis
  JOURNAL   Exp Mol Pathol 67 (1), 40-49 (1999)
   PUBMED   10493891
  REMARK    GeneRIF: In a rat model, ethanol can directly stimulate fibroblast
            proliferation and production of fibrogenic cytokines, particularly
            fibrosin, which appears to contribute to alcohol-induced hepatic
            fibrosis in vivo.
REFERENCE   4  (bases 1 to 5196)
  AUTHORS   Prakash,S. and Robbins,P.W.
  TITLE     Cloning and analysis of the cDNA for human fibrosin, a novel
            fibrogenic lymphokine
  JOURNAL   DNA Cell Biol 17 (10), 879-884 (1998)
   PUBMED   9809749
REFERENCE   5  (bases 1 to 5196)
  AUTHORS   Prakash,S., Robbins,P.W. and Wyler,D.J.
  TITLE     Cloning and analysis of murine cDNA that encodes a fibrogenic
            lymphokine, fibrosin
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2154-2158 (1995)
   PUBMED   7892239
  REMARK    GeneRIF: Characterization of mouse fibrosin and demonstration of
            growth-stimulating effects in fibroblasts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093249.4.
            
            On Jan 3, 2019 this sequence version replaced NM_001105079.2.
            
            Summary: Fibrosin is a lymphokine secreted by activated lymphocytes
            that induces fibroblast proliferation (Prakash and Robbins, 1998
            [PubMed 9809749]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356166.11/ ENSP00000348489.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1547              AC093249.4         47142-48688         c
            1548-1727           AC093249.4         46677-46856         c
            1728-1763           AC093249.4         45904-45939         c
            1764-1793           AC093249.4         45786-45815         c
            1794-1842           AC093249.4         44651-44699         c
            1843-2143           AC093249.4         44260-44560         c
            2144-2445           AC093249.4         42603-42904         c
            2446-2651           AC093249.4         42199-42404         c
            2652-2696           AC093249.4         42040-42084         c
            2697-2792           AC093249.4         41718-41813         c
            2793-2861           AC093249.4         41413-41481         c
            2862-2891           AC093249.4         40578-40607         c
            2892-2963           AC093249.4         40129-40200         c
            2964-3081           AC093249.4         39682-39799         c
            3082-3162           AC093249.4         39497-39577         c
            3163-3246           AC093249.4         38476-38559         c
            3247-3454           AC093249.4         38140-38347         c
            3455-5196           AC093249.4         36309-38050         c
FEATURES             Location/Qualifiers
     source          1..5196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5196
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /note="fibrosin"
                     /db_xref="GeneID:64319"
                     /db_xref="HGNC:HGNC:20442"
                     /db_xref="MIM:608601"
     exon            1..1547
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1089..4031
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /note="fibrosin 1; probable fibrosin-1 long transcript
                     protein; fibrogenic lymphokine"
                     /codon_start=1
                     /product="probable fibrosin-1"
                     /protein_id="NP_001098549.2"
                     /db_xref="CCDS:CCDS45462.2"
                     /db_xref="GeneID:64319"
                     /db_xref="HGNC:HGNC:20442"
                     /db_xref="MIM:608601"
                     /translation="METAAAAAPGPGWAAEGERRRRRCSRRDRDREQRRRRGPGGDAP
                     RALLAAPRGSSSSSSPPPPARPWSSASSGERPGGPRRRRPRPRPRPPRPRARKRPAGS
                     GSRGEEEEEEEEEGGADDGEAEEEPEEEEEEEEDLIDGFAIASFATLEALQKDASLQP
                     PERLEHRLKHSGKRKRGGSSGATGEPGDSSDREPGRPPGDRARKWPNKRRRKEASSRH
                     SLEAGYICDAESDLDERVSDDDLDPSFTVSTSKASGPHGAFNGNCEAKLSVVPKVSGL
                     ERSQEQPPGPDPLLVPFPPKEPPPPPVPRPPVSPPAPLPATPSLPPPPQPQLQLRVSP
                     FGLRTSPYGSSLDLSTGSSSRPPPKAPAPPVAQPPPSSSSSSSSSSSASSSSAQLTHR
                     PPTPSLPLPLSTHSFPPPGLRPPPPPHHPSLFSPGPTLPPPPPLLQVPGHPGASAANA
                     LSEQDLIGQDLNSRYLNAQGGPEVVGAGGSARPLAFQFHQHNHQHQHTHQHTHQHFTP
                     YPPGLLPPHGPHMFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQ
                     PKSTNPELPPRLGPVPSGLSQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKM
                     KGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAAPGAHG
                     PFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPAFASP
                     PDPWGRLHRSPLTFPAWVRPPEAARTPGSDKERPVERREPSITKEEKDRDLPFSRPQL
                     RVSPATPKARAGEEGPRPTKESVRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLH
                     LLFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPRLARPPRFYEAGEELTGPGAVAAAR
                     LYGLEPAHPLLYSRLAPPPPPAAAPGTPHLLSKTPPGALLGAPPPLVPAPRPSSPPRG
                     PGPARADR"
     exon            1548..1727
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1763
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1793
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1842
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2143
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2445
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2651
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2696
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2792
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2861
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2891
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2963
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3081
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3162
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3246
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3454
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..5196
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5172..5177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /note="hexamer: TATAAA"
     polyA_site      5196
                     /gene="FBRS"
                     /gene_synonym="FBS; FBS1"
                     /note="major polyA site"
ORIGIN      
        1 gagagaggaa ggaggcgtag gctgaggagg aagagggagg aggggtaggg aagtcctggc
       61 ggagaagcgc cctaagactc caaaggagac aacaggagtt tgtgctggag ctcccccgct
      121 gcccatcggc cgttccggat cccctaaggc ccaagtcgga cagagacgga ggaaaggagg
      181 aagagacttt tatgtcggcg gacaggggag ctgtacccgt caccgttgcc tcacatccgg
      241 ggctttggag ggctggcctc gctgccccgc cccgcctcgc gcctttcatg gcgaccggag
      301 gcggaggctg gaggagctgg gcccggagga ggccccttta aatctcctta aaggggtggc
      361 cactgaactc ggcggactgc aacgccagcc ttaaagggga agccgccgag cagacgctga
      421 caaattgaga actgtgccgt tgggagaact ggggcgagtg gggtttttct ttacgtcctc
      481 ctcccccaca cacaagaagt cttttaaatt caacttaaag gggaagtggc cgcttgtgga
      541 ggactagaaa ctaactccga gcccttaaag ggacggcctg ctgttagaag gaccctggac
      601 tccttaaagg ggtggcctct ttgagccgga ggacttgaga cacttttaaa ggggaggtct
      661 gcgtttcggg gcgagctttc ggcccctttt aaaggggtgg cccttcctct tcctcgggga
      721 gacttgcatc gacccctggc agggggtggc caccgcacta ggccgccgga cactgtcggg
      781 tcgtcttaaa ggggccggga gctggacaac ttggggcctc gccttaaagg gacggccgcc
      841 ccgttttcgc cgtcgcggcc ccgccgagcc cgcagggggg gccctcgggc ttgtcgcccc
      901 gggggcggcg ccggctcccc gggccgtggc cttggggcaa gctcggggcc agcagatccg
      961 gctttaaagg agaagccgtg gccctctcgt cactgtgcag ccgccagcgc cgcgcctgcg
     1021 accccgggcc tgcggacagg ccgcttcggg ccccgccgcc tccggatgcg gcgctgaggg
     1081 cggtcgccat ggagacggca gcggccgcgg ccccgggtcc gggctgggca gcagaggggg
     1141 agcgccgacg gcggcgctgc tcgcgccgag accgagaccg ggagcagcgg cgccgccgag
     1201 gtccaggcgg cgacgcgccc cgggccctgt tggccgcccc gcgcggctcc tcgtcctcgt
     1261 cgtcgccgcc gccgcccgcc aggccttggt cgtcagcttc gtctggagag cggcctgggg
     1321 gcccgagacg ccggcggccc cgtccgagac ctcgaccccc gcgaccccga gctcggaagc
     1381 ggcctgccgg ctcgggcagc cgcggggagg aagaggagga ggaggaggag gaggggggcg
     1441 cagacgacgg cgaagccgag gaggagcctg aggaggagga agaggaggag gaggacttga
     1501 tcgatggctt cgccatcgcc agcttcgcca ccctcgaggc cttgcagaag gatgcatctc
     1561 ttcagccccc agagcgactg gaacatcggc tgaagcattc tgggaagcgg aaaagggggg
     1621 gctccagtgg ggccaccggg gagccagggg acagctctga tcgagagcct ggccggcccc
     1681 ctggggatcg ggcccgaaaa tggcccaata agcggagaag aaaagaggcg tcctcccgtc
     1741 actctctgga agctggatac atatgtgacg cggaaagtga tctggacgag agggtctccg
     1801 atgatgacct cgacccatcc tttactgtct caaccagcaa agcctcgggc ccccacggcg
     1861 ccttcaatgg gaactgtgaa gcaaaactct ccgtggtccc taaagtgtcg ggcctggagc
     1921 ggagccaaga acagcccccg gggcccgacc cgctgctagt gcctttcccc ccaaaggaac
     1981 caccgcctcc accggtccct cggcctcctg tctcaccccc tgcacccctg ccggccactc
     2041 ccagtctgcc acccccaccc cagccccagc tgcagcttcg ggtctcaccc ttcggcctcc
     2101 gcacttctcc atatggcagc agcctggacc tcagcactgg cagctcttca cggccgcccc
     2161 ccaaggcccc ggcccctccc gtggctcagc ctcccccctc atcatcctct tcgtcctcct
     2221 cctcctcatc tgcctcctcc tcgtccgcgc agctcaccca ccggcccccg acgccctcac
     2281 tgcccctgcc tttgtccacc cacagctttc cccctcccgg gctgcggccc cccccaccac
     2341 cccaccaccc ctccttgttc tcccctggcc ccaccctgcc cccaccccca cccctgctgc
     2401 aggtgccagg gcaccctggg gcctcagccg ctaacgccct ttctgagcag gacctgatcg
     2461 gccaggacct gaactctcgc tacctgaatg cccagggtgg ccctgaggtg gtgggggcag
     2521 ggggctcggc ccggcccctg gccttccagt tccaccagca caaccaccag caccagcaca
     2581 cccaccagca cacccaccag cacttcaccc cttatccccc gggcctgctg ccaccccacg
     2641 gcccccacat gtttgagaaa tatccaggaa agatggaagg ccttttccga cataatccgt
     2701 acacggcctt ccctcccgca gtgcccgggc tgcctccggg cctcccgccg gccgtctcct
     2761 ttggctccct gcagggggcc ttccagccca agagcacgaa ccctgagctg ccaccacgac
     2821 tggggccggt gccgagcggg ctctcccaga aggggacaca gatccccgac catttccggc
     2881 cacctttgag gaaaccaggg aagtggtgtg ccatgcacgt gcgtgtggct tacatgatcc
     2941 tgagacacca ggagaaaatg aagggtgact cccacaagct tgactttcgg aatgacctcc
     3001 tgccctgcct tccggggccc tatggggccc tgccccctgg gcaggagctc tcccacccgg
     3061 cctccctctt cactgcgact ggtgccgtcc acgctgcagc caaccctttc acggcagctc
     3121 ccggggccca cggacccttc ctgagcccca gcacccacat tgatcccttt gggcgtccca
     3181 caagcttcgc ctctttggct gccctctcca acggggcctt tggaggcctg ggcagcccca
     3241 cattcaactc cggcgccgtc tttgcccaga aagaaagccc aggggcccca ccagccttcg
     3301 cctccccacc ggacccatgg ggccgcctgc accgcagtcc tctgaccttt cctgcctggg
     3361 tccggccccc tgaggccgcc cggactccag gctcagacaa ggagcggcct gtggagcgga
     3421 gggagccctc catcaccaag gaggagaagg acagggacct ccccttctca cggccccagc
     3481 tccgagtttc tcctgctact cccaaggccc gggctggtga ggaggggcct cggccaacca
     3541 aggaatctgt gcgggtaaag gaagagcgga aggaggaggc tgccgccgcc gctgccgctg
     3601 ctgctgccgc cgccgctgcc gccgccgcag cagccactgg gccccagggc cttcacctgc
     3661 tgtttgagag gccccggccg cccccgtttc tgggccctag cccaccagat cgctgtgctg
     3721 gcttcctgga gccaacctgg ttggcagcac ccccacgcct ggcaaggcca ccccgcttct
     3781 atgaggcggg tgaggagcta actggacccg gggccgtggc cgctgcccgc ctctacggtc
     3841 tggaacctgc tcaccccttg ctctacagcc gcttggctcc tccaccacca cctgctgcgg
     3901 ccccgggaac ccctcacctt ctcagcaaga ccccaccggg agcccttttg ggggcaccac
     3961 ctccgcttgt gcccgccccc cggcccagtt ccccacctag gggccctggc ccagctcggg
     4021 ctgacaggtg aggggaacgg gggggggtcg gggcaaagct ccatctcccc ttcctttaac
     4081 caggtcctag ggctgaggtt ttaagccagg gctggagggc aaaggtcata acctcaccag
     4141 ccacctctga ggtcatggaa cctgggaaca gaagcctcaa cccccacaag accaagcatc
     4201 acatggagtg tagggtcact gggagagcag aggtcacagc ctctagagaa gggagagggg
     4261 cgtgtgcatg ggagtgtggc tcatctcggg ggccatgggg cctcctgagg tacacctttg
     4321 cccctgtaag ggcctctagg ccctgggcct gcctccccaa gggctcacta agccagaggc
     4381 caaagtgccc cctcccgttc acctaccacc caagtcctca tgccctccga gggctggggg
     4441 aggaggggct caaggaaggg gggttccatg tacatattta tcaccccttt cacatagccc
     4501 caagaccttt tgtacatttt tacaggggtg cccctcccaa cagttccctt cctggttaat
     4561 taaaccctca gactggtgct gtgttcctag cctctggcct ctctgtgggg aaaggggact
     4621 gcagggggaa gagccgggaa gggacagtca ggcttctccc tgggaaggtg gggccagcag
     4681 gagatgacca acagggggca ggacctgggg acctgggctg gagggaaggg cagaagcttc
     4741 ctacttggct gacagccccg gttcccccaa catgttcccg ttcactctgc ccccaccccc
     4801 aaaggctcag cctctaaatc tcagactcca ccacctctta atggctcagt ccccttcacc
     4861 ccatttccaa gtgcccccag gactcctggg ccctgcttcc ctgaaccctg ttctccaaaa
     4921 ccctgcccca ggctaagggt ggccagagaa ggtcaccatg taccacacac caaagaaggg
     4981 ggtcggccca ggggtgggcg acacaggcag cttcttcggc agcctcacgg cagcaacccc
     5041 agccttccca aagcagcagg cgcctccagg ctggggccca acctagaagg caggggtcaa
     5101 tctaacaaaa ccctaacgtt gacttttttc cctggtgggg cttcttctgt aacatgactt
     5161 gcgaatattt atataaaaac gagtgttaca atgaga
//
