LOCUS       NM_003837               1336 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens fructose-bisphosphatase 2 (FBP2), mRNA.
ACCESSION   NM_003837
VERSION     NM_003837.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Huang,Y., Lu,H. and Li,H.
  TITLE     DNA methyltransferase 3a-induced hypermethylation of the
            fructose-1,6-bisphosphatase-2 promoter contributes to gastric
            carcinogenesis
  JOURNAL   Mol Biol Rep 51 (1), 78 (2024)
   PUBMED   38183507
  REMARK    GeneRIF: DNA methyltransferase 3a-induced hypermethylation of the
            fructose-1,6-bisphosphatase-2 promoter contributes to gastric
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Yang,X., Ma,H., Zhang,M., Wang,R. and Li,X.
  TITLE     TRIM32 promotes oral squamous cell carcinoma progression by
            enhancing FBP2 ubiquitination and degradation
  JOURNAL   Biochem Biophys Res Commun 678, 165-172 (2023)
   PUBMED   37640002
  REMARK    GeneRIF: TRIM32 promotes oral squamous cell carcinoma progression
            by enhancing FBP2 ubiquitination and degradation.
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Rakus,D., Maciaszczyk,E., Wawrzycka,D., Ulaszewski,S., Eschrich,K.
            and Dzugaj,A.
  TITLE     The origin of the high sensitivity of muscle fructose
            1,6-bisphosphatase towards AMP
  JOURNAL   FEBS Lett 579 (25), 5577-5581 (2005)
   PUBMED   16213487
  REMARK    GeneRIF: The key role in strong AMP binding to muscle isozyme play
            K20, T177 and Q179.
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Tillmann,H., Stein,S., Liehr,T. and Eschrich,K.
  TITLE     Structure and chromosomal localization of the human and mouse
            muscle fructose-1,6-bisphosphatase genes
  JOURNAL   Gene 247 (1-2), 241-253 (2000)
   PUBMED   10773464
REFERENCE   9  (bases 1 to 1336)
  AUTHORS   Tillmann,H. and Eschrich,K.
  TITLE     Isolation and characterization of an allelic cDNA for human muscle
            fructose-1,6-bisphosphatase
  JOURNAL   Gene 212 (2), 295-304 (1998)
   PUBMED   9678974
REFERENCE   10 (bases 1 to 1336)
  AUTHORS   Besancon,F., Just,J., Bourgeade,M.F., Van Weyenbergh,J.,
            Solomon,D., Guillozo,H., Wietzerbin,J. and Cayre,Y.E.
  TITLE     HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase
  JOURNAL   J Interferon Cytokine Res 17 (8), 461-467 (1997)
   PUBMED   9282826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM686555.1, CR536483.1 and
            AJ573829.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003837.3.
            
            Summary: This gene encodes a gluconeogenesis regulatory enzyme
            which catalyzes the hydrolysis of fructose 1,6-bisphosphate to
            fructose 6-phosphate and inorganic phosphate. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.13764.1,
                                           SRR5189652.149712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375337.4/ ENSP00000364486.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BM686555.1         16-83
            69-98               BM686555.1         85-114
            99-1118             CR536483.1         1-1020
            1119-1336           AJ573829.1         199-416
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..1336
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /note="fructose-bisphosphatase 2"
                     /db_xref="GeneID:8789"
                     /db_xref="HGNC:HGNC:3607"
                     /db_xref="MIM:603027"
     exon            1..268
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1118
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /EC_number="3.1.3.11"
                     /note="hexosediphosphatase; muscle FBPase; muscle
                     fructose-bisphosphatase; FBPase 2;
                     D-fructose-1,6-bisphosphate 1-phosphohydrolase 2;
                     fructose-1,6-bisphosphatase 2"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase isozyme 2"
                     /protein_id="NP_003828.2"
                     /db_xref="CCDS:CCDS6711.1"
                     /db_xref="GeneID:8789"
                     /db_xref="HGNC:HGNC:3607"
                     /db_xref="MIM:603027"
                     /translation="MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKA
                     ISSAVRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKD
                     AIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNI
                     VAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAK
                     YFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKL
                     RLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQK
                     NQAGS"
     exon            269..431
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     exon            432..524
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     exon            525..665
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     exon            666..803
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     exon            804..923
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1336
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /note="hexamer: AATAAA"
     polyA_site      1336
                     /gene="FBP2"
                     /gene_synonym="CORLK"
                     /note="major polyA site"
ORIGIN      
        1 acagatttct tatcggcttc cacactgcgg agctgcagcc ctcagaagta agcaaggttt
       61 cctgccggga gaaaaggatt tgaagcattc cagccaaaat gacggacaga agccccttcg
      121 aaaccgacat gctcaccctg acccgctacg ttatggaaaa ggggcgtcag gccaaaggga
      181 ctggggagct cacccagctg ctgaactcaa tgctgacggc catcaaagcc atctcctcgg
      241 ctgtgcgcaa ggccggtctg gcccacctgt atggaatcgc aggaagcgtt aacgtgacgg
      301 gagatgaggt gaagaaactg gatgtgctat ccaattccct ggtgatcaac atggtccaat
      361 cctcctatag tacctgcgtc ctggtctcag aagagaataa ggacgccatc atcaccgcca
      421 aggagaagcg ggggaaatac gtggtctgct ttgacccact ggatggatct tccaatattg
      481 actgcctggc ctccatcgga accatctttg ccatctatag aaagacctca gaggatgagc
      541 cttctgaaaa ggatgccctg cagtgtggcc gcaatattgt ggccgcaggt tatgcgctgt
      601 acggtagtgc aaccctggtg gctctctcca cagggcaagg cgtggacctc ttcatgcttg
      661 acccggctct tggtgaattt gtcctggtgg aaaaagatgt caagattaag aagaaaggaa
      721 agatttacag cctgaatgag ggctatgcca agtattttga tgcggccacc actgaatatg
      781 tgcagaaaaa gaaattccct gaggatggca gtgctcccta tggggccagg tatgtgggct
      841 ccatggtggc tgacgtgcac cgcaccctgg tctatggagg aatcttcctg tacccagcca
      901 accagaagag ccctaagggc aagctccggc tcctgtatga atgcaatccc gtggcctaca
      961 tcattgagca ggcaggaggc ttggcgacca cggggaccca gcctgtactg gacgtgaagc
     1021 ccgaggcaat tcaccagcga gtccccctca ttctggggtc accagaggat gtgcaggaat
     1081 atctcacctg tgtgcagaaa aatcaggcag gcagctagcg agtttgaccc cacatgccct
     1141 cttctgtttg tcttgcacct tgtctaagga ccctaaatga acgataaaca gagatggtag
     1201 ctatgagtat acaaaaggta aatccactta atcacataca gaagagcaac aacaaactgc
     1261 ttacgacagg tttggaagcc acaggcgatt ctatggtcaa tgtgaaggac tagaaataaa
     1321 aacccacatg tggaaa
//
