LOCUS       NM_000507               1473 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens fructose-bisphosphatase 1 (FBP1), transcript variant
            1, mRNA.
ACCESSION   NM_000507
VERSION     NM_000507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Li,M., Wang,Z., Tao,J., Jiang,H., Yang,H., Guo,D., Zhao,H., He,X.,
            Luo,S., Jiang,X., Yuan,L., Xiao,L., He,H., Yu,R., Fang,J.,
            Liang,T., Mao,Z., Xu,D. and Lu,Z.
  TITLE     Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT
            for tumor suppression
  JOURNAL   Nat Chem Biol 20 (11), 1505-1513 (2024)
   PUBMED   38538923
  REMARK    GeneRIF: Fructose-1,6-bisphosphatase 1 dephosphorylates and
            inhibits TERT for tumor suppression.
            Erratum:[Nat Chem Biol. 2024 Nov;20(11):1547. doi:
            10.1038/s41589-024-01623-3.. PMID: 38649455]
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Peng,X., Ma,L., Chen,X., Tang,F. and Zong,X.
  TITLE     Inhibition of FBP1 expression by KMT5A through TWIST1 methylation
            is one of the mechanisms leading to chemoresistance in breast
            cancer
  JOURNAL   Oncol Rep 52 (2) (2024)
   PUBMED   38963044
  REMARK    GeneRIF: Inhibition of FBP1 expression by KMT5A through TWIST1
            methylation is one of the mechanisms leading to chemoresistance in
            breast cancer.
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Zhang,P., Yang,J., Liu,X., Huang,C., Tao,Y., Shen,P., Bai,Z.,
            Xiao,C., Zhou,L., Li,G., Zhang,L., Zhou,W. and Gao,Y.
  TITLE     FBP1 orchestrates keratinocyte proliferation/differentiation and
            suppresses psoriasis through metabolic control of histone
            acetylation
  JOURNAL   Cell Death Dis 15 (6), 392 (2024)
   PUBMED   38834617
  REMARK    GeneRIF: FBP1 orchestrates keratinocyte
            proliferation/differentiation and suppresses psoriasis through
            metabolic control of histone acetylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   He,T., Wang,Y., Lv,W., Wang,Y., Li,X., Zhang,Q., Shen,H.M. and
            Hu,J.
  TITLE     FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1
            intracellular domain and accelerating degradation
  JOURNAL   Cell Mol Life Sci 81 (1), 87 (2024)
   PUBMED   38349431
  REMARK    GeneRIF: FBP1 inhibits NSCLC stemness by promoting ubiquitination
            of Notch1 intracellular domain and accelerating degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Wang,Z., Wang,X., Liu,L., Guo,X., Zhang,H., Yin,J., Lin,R., Shao,Y.
            and Cai,D.
  TITLE     Fructose-bisphosphatase1 (FBP1) alleviates experimental
            osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
  JOURNAL   Arthritis Res Ther 25 (1), 235 (2023)
   PUBMED   38049890
  REMARK    GeneRIF: Fructose-bisphosphatase1 (FBP1) alleviates experimental
            osteoarthritis by regulating Protein crumbs homolog 3 (CRB3).
            Erratum:[Arthritis Res Ther. 2023 Dec 28;25(1):250. doi:
            10.1186/s13075-023-03247-9.. PMID: 38155346]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   el-Maghrabi,M.R., Lange,A.J., Jiang,W., Yamagata,K., Stoffel,M.,
            Takeda,J., Fernald,A.A., Le Beau,M.M., Bell,G.I., Baker,L. et al.
  TITLE     Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron
            organization, localization to chromosome bands 9q22.2-q22.3, and
            mutation screening in subjects with fructose-1,6-bisphosphatase
            deficiency
  JOURNAL   Genomics 27 (3), 520-525 (1995)
   PUBMED   7558035
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Bijarnia-Mahay,S., Bhatia,S. and Arora,V.
  TITLE     Fructose-1,6-Bisphosphatase Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31804789
REFERENCE   8  (bases 1 to 1473)
  AUTHORS   el-Maghrabi,M.R., Lange,A.J., Kummel,L. and Pilkis,S.J.
  TITLE     The rat fructose-1,6-bisphosphatase gene. Structure and regulation
            of expression
  JOURNAL   J Biol Chem 266 (4), 2115-2120 (1991)
   PUBMED   1846613
REFERENCE   9  (bases 1 to 1473)
  AUTHORS   Ke,H.M., Zhang,Y.P. and Lipscomb,W.N.
  TITLE     Crystal structure of fructose-1,6-bisphosphatase complexed with
            fructose 6-phosphate, AMP, and magnesium
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5243-5247 (1990)
   PUBMED   2164670
REFERENCE   10 (bases 1 to 1473)
  AUTHORS   Solomon,D.H., Raynal,M.C., Tejwani,G.A. and Cayre,Y.E.
  TITLE     Activation of the fructose 1,6-bisphosphatase gene by
            1,25-dihydroxyvitamin D3 during monocytic differentiation
  JOURNAL   Proc Natl Acad Sci U S A 85 (18), 6904-6908 (1988)
   PUBMED   2842796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA962803.1 and BC012927.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000507.3.
            
            Summary: Fructose-1,6-bisphosphatase 1, a gluconeogenesis
            regulatory enzyme, catalyzes the hydrolysis of fructose
            1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.
            Fructose-1,6-diphosphatase deficiency is associated with
            hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012927.1, AK223395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375326.9/ ENSP00000364475.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA962803.1         124-134
            12-1473             BC012927.1         1-1462
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..1473
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /note="fructose-bisphosphatase 1"
                     /db_xref="GeneID:2203"
                     /db_xref="HGNC:HGNC:3606"
                     /db_xref="MIM:611570"
     exon            1..378
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1225
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /EC_number="3.1.3.11"
                     /note="FBPase 1; D-fructose-1,6-bisphosphate
                     1-phosphohydrolase 1; liver FBPase; growth-inhibiting
                     protein 17"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase 1"
                     /protein_id="NP_000498.2"
                     /db_xref="CCDS:CCDS6712.1"
                     /db_xref="GeneID:2203"
                     /db_xref="HGNC:HGNC:3606"
                     /db_xref="MIM:611570"
                     /translation="MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKA
                     ISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKH
                     AIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNL
                     VAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAR
                     DFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKL
                     RLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEK
                     HSAQ"
     exon            379..541
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     exon            542..634
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     exon            635..775
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     exon            776..913
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1033
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1473
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /note="hexamer: AATAAA"
     polyA_site      1359
                     /gene="FBP1"
                     /gene_synonym="FBP"
                     /note="major polyA site"
ORIGIN      
        1 ctggcccagt tgcaccacga gcgctgcgga cactcggggc ggcagtcggt ctgtcagtcc
       61 tcccgccagg tcccgcggcc cgcacctgcc gcccgcacct gcagctccgc acctgcggcc
      121 agtgcctact gccctctctt gccgcccgca cctgcagccc cgcacctgcc gcttgcacct
      181 gcagccccgc gctctacccg gttcaagcat ggctgaccag gcgcccttcg acacggacgt
      241 caacaccctg acccgcttcg tcatggagga gggcaggaag gcccgcggca cgggcgagtt
      301 gacccagctg ctcaactcgc tctgcacagc agtcaaagcc atctcttcgg cggtgcgcaa
      361 ggcgggcatc gcgcacctct atggcattgc tggttctacc aacgtgacag gtgatcaagt
      421 taagaagctg gacgtcctct ccaacgacct ggttatgaac atgttaaagt catcctttgc
      481 cacgtgtgtt ctcgtgtcag aagaagataa acacgccatc atagtggaac cggagaaaag
      541 gggtaaatat gtggtctgtt ttgatcccct tgatggatct tccaacatcg attgccttgt
      601 gtccgttgga accatttttg gcatctatag aaagaaatca actgatgagc cttctgagaa
      661 ggatgctctg caaccaggcc ggaacctggt ggcagccggc tacgcactgt atggcagtgc
      721 caccatgctg gtccttgcca tggactgtgg ggtcaactgc ttcatgctgg acccggccat
      781 cggggagttc attttggtgg acaaggatgt gaagataaaa aagaaaggta aaatctacag
      841 ccttaacgag ggctacgcca gggactttga ccctgccgtc actgagtaca tccagaggaa
      901 gaagttcccc ccagataatt cagctcctta tggggcccgg tatgtgggct ccatggtggc
      961 tgatgttcat cgcactctgg tctacggagg gatatttctg taccccgcta acaagaagag
     1021 ccccaatgga aagctgagac tgctgtacga atgcaacccc atggcctacg tcatggagaa
     1081 ggctggggga atggccacca ctgggaagga ggccgtgtta gacgtcattc ccacagacat
     1141 tcaccagagg gcgccggtga tcttgggatc ccccgacgac gtgctcgagt tcctgaaggt
     1201 gtatgagaag cactctgccc agtgagcacc tgccctgcct gcatccggag aattgcctct
     1261 acctggacct tttgtctcac acagcagtac cctgacctgc tgtgcacctt acattcctag
     1321 agagcagaaa taaaaagcat gactatttcc accatcaaat gctgtagaat gcttggcact
     1381 ccctaaccaa atgctgtctc cataatgcca ctggtgttaa gatatatttt gagtggatgg
     1441 aggagaaata aacttattcc tccttaaaaa aaa
//
