LOCUS       NM_032447               9108 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens fibrillin 3 (FBN3), transcript variant 1, mRNA.
ACCESSION   NM_032447
VERSION     NM_032447.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9108)
  AUTHORS   Toparcean,A.M., Acatrinei,A., Rusu,I., Festila,D., Campian,R.S.,
            Kelemen,B. and Ghergie,M.C.D.
  TITLE     Genetic Insights into Skeletal Malocclusion: The Role of the FBN3
            rs7351083 SNP in the Romanian Population
  JOURNAL   Medicina (Kaunas) 60 (7), 1061 (2024)
   PUBMED   39064490
  REMARK    GeneRIF: Genetic Insights into Skeletal Malocclusion: The Role of
            the FBN3 rs7351083 SNP in the Romanian Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9108)
  AUTHORS   Karakaya,C., Cil,A.P., Bilguvar,K., Cakir,T., Karalok,M.H.,
            Karabacak,R.O. and Caglayan,A.O.
  TITLE     Further delineation of familial polycystic ovary syndrome (PCOS)
            via whole-exome sequencing: PCOS-related rare FBN3 and FN1 gene
            variants are identified
  JOURNAL   J Obstet Gynaecol Res 48 (5), 1202-1211 (2022)
   PUBMED   35141985
  REMARK    GeneRIF: Further delineation of familial polycystic ovary syndrome
            (PCOS) via whole-exome sequencing: PCOS-related rare FBN3 and FN1
            gene variants are identified.
REFERENCE   3  (bases 1 to 9108)
  AUTHORS   Sabatier,L., Djokic,J., Hubmacher,D., Dzafik,D., Nelea,V. and
            Reinhardt,D.P.
  TITLE     Heparin/heparan sulfate controls fibrillin-1, -2 and -3
            self-interactions in microfibril assembly
  JOURNAL   FEBS Lett 588 (17), 2890-2897 (2014)
   PUBMED   25034023
REFERENCE   4  (bases 1 to 9108)
  AUTHORS   Xie,G.B., Xu,P., Che,Y.N., Xia,Y.J., Cao,Y.X., Wang,W.J., Qiao,D.,
            Wu,X.K., Yi,L., Gao,Q. and Wang,Y.
  TITLE     Microsatellite polymorphism in the fibrillin 3 gene and
            susceptibility to PCOS: a case-control study and meta-analysis
  JOURNAL   Reprod Biomed Online 26 (2), 168-174 (2013)
   PUBMED   23265956
  REMARK    GeneRIF: an association study showed a potential association of the
            D19S884 marker with PCOS in Chinese Han women and the meta-analysis
            identified that the A8 allele may increase susceptibility to PCOS
REFERENCE   5  (bases 1 to 9108)
  AUTHORS   Yalamanchi,S.K., Sam,S., Cardenas,M.O., Holaday,L.W., Urbanek,M.
            and Dunaif,A.
  TITLE     Association of fibrillin-3 and transcription factor-7-like 2 gene
            variants with metabolic phenotypes in PCOS
  JOURNAL   Obesity (Silver Spring) 20 (6), 1273-1278 (2012)
   PUBMED   22301903
  REMARK    GeneRIF: The FBN3 risk allele may be associated with changes in
            basal glucose homeostasis in PCOS.
REFERENCE   6  (bases 1 to 9108)
  AUTHORS   Urbanek,M., Sam,S., Legro,R.S. and Dunaif,A.
  TITLE     Identification of a polycystic ovary syndrome susceptibility
            variant in fibrillin-3 and association with a metabolic phenotype
  JOURNAL   J Clin Endocrinol Metab 92 (11), 4191-4198 (2007)
   PUBMED   17785364
  REMARK    GeneRIF: fibrillin-3 gene showed the strongest evidence for
            association with Polycystic ovary syndrome
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9108)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 9108)
  AUTHORS   Corson,G.M., Charbonneau,N.L., Keene,D.R. and Sakai,L.Y.
  TITLE     Differential expression of fibrillin-3 adds to microfibril variety
            in human and avian, but not rodent, connective tissues
  JOURNAL   Genomics 83 (3), 461-472 (2004)
   PUBMED   14962672
REFERENCE   9  (bases 1 to 9108)
  AUTHORS   Uyeda,T., Takahashi,T., Eto,S., Sato,T., Xu,G., Kanezaki,R.,
            Toki,T., Yonesaka,S. and Ito,E.
  TITLE     Three novel mutations of the fibrillin-1 gene and ten single
            nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome
            patients
  JOURNAL   J Hum Genet 49 (8), 404-407 (2004)
   PUBMED   15221638
REFERENCE   10 (bases 1 to 9108)
  AUTHORS   Faivre,L., Megarbane,A., Alswaid,A., Zylberberg,L., Aldohayan,N.,
            Campos-Xavier,B., Bacq,D., Legeai-Mallet,L., Bonaventure,J.,
            Munnich,A. and Cormier-Daire,V.
  TITLE     Homozygosity mapping of a Weill-Marchesani syndrome locus to
            chromosome 19p13.3-p13.2
  JOURNAL   Hum Genet 110 (4), 366-370 (2002)
   PUBMED   11941487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY165863.1, AC022146.8,
            AC008946.7 and BC153882.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032447.4.
            
            Summary: This gene encodes a memebr of the fibrillin protein
            family. Fibrillins are extracellular matrix molecules that assemble
            into microfibrils in many connective tissues. This gene is most
            highly expressed in fetal tissues and its protein product is
            localized to extracellular microfibrils of developing skeletal
            elements, skin, lung, kidney, and skeletal muscle. This gene is
            potentially involved in Weill-Marchesani syndrome. [provided by
            RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY165863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600128.6/ ENSP00000470498.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2144              AY165863.1         255-2398
            2145-2145           AC022146.8         73338-73338         c
            2146-4063           AY165863.1         2400-4317
            4064-4064           AC022146.8         53813-53813         c
            4065-5000           AY165863.1         4319-5254
            5001-5001           AC008946.7         108407-108407       c
            5002-6337           AY165863.1         5256-6591
            6338-6338           AC008946.7         94852-94852         c
            6339-6763           AY165863.1         6593-7017
            6764-6764           AC008946.7         92587-92587         c
            6765-7579           AY165863.1         7019-7833
            7580-7580           AC008946.7         85783-85783         c
            7581-7990           AY165863.1         7835-8244
            7991-7991           AC008946.7         77916-77916         c
            7992-9107           AY165863.1         8246-9361
            9108-9108           BC153882.1         8968-8968
FEATURES             Location/Qualifiers
     source          1..9108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..9108
                     /gene="FBN3"
                     /note="fibrillin 3"
                     /db_xref="GeneID:84467"
                     /db_xref="HGNC:HGNC:18794"
                     /db_xref="MIM:608529"
     exon            1..144
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..328
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..8591
                     /gene="FBN3"
                     /codon_start=1
                     /product="fibrillin-3 precursor"
                     /protein_id="NP_115823.3"
                     /db_xref="CCDS:CCDS12196.1"
                     /db_xref="GeneID:84467"
                     /db_xref="HGNC:HGNC:18794"
                     /db_xref="MIM:608529"
                     /translation="MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGR
                     VRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCT
                     CADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGR
                     CIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAW
                     GLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPV
                     GHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELC
                     PPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS
                     LGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDV
                     DECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNT
                     EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPG
                     GHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAI
                     EKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD
                     INECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC
                     QNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD
                     PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACA
                     RGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL
                     EPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGF
                     ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDID
                     ECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT
                     NTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS
                     TPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP
                     RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFV
                     CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
                     DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQC
                     LNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL
                     DRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFL
                     ETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF
                     QPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECS
                     THSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN
                     VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG
                     EIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIP
                     GSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQ
                     TLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRF
                     GHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPP
                     GFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSF
                     CFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGA
                     VPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSV
                     GHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLC
                     TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGE
                     GCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQ
                     TMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDV
                     DECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKN
                     TKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH
                     QACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC
                     QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCP
                     SGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGF
                     SPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGL
                     NLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGP
                     GTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL"
     exon            329..411
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            412..510
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..606
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..702
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..900
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1026
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1179
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1362
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1506
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1626
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1752
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1875
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2151
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2205
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2331
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2457
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2577
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2715
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2766
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2892
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3117
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3243
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3372
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3498
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3624
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3747
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3873
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3999
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4122
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..4245
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4371
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4372..4494
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4617
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4779
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..4848
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..4974
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5100
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5101..5250
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5322
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5323..5448
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5449..5574
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5575..5700
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5701..5817
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5818..5946
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5947..6066
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6067..6192
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6193..6345
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6346..6411
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6537
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6538..6657
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6658..6780
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6781..6915
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6916..7041
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7042..7248
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7249..7374
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7375..7497
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7498..7614
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7615..7743
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7744..7863
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7864..8098
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            8099..8249
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            8250..9108
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9088..9093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN3"
                     /note="hexamer: AATAAA"
     polyA_site      9108
                     /gene="FBN3"
                     /note="major polyA site"
ORIGIN      
        1 agctctgggc tgggaacgcg gcggggtcgg cctctcggct ttgcgttccc gccccgggtc
       61 cccggcgccg caggagcccg ccctgcagcg ctgagtcccg cgcgtccgcc tgccgtgccc
      121 gcctccacgc gcgccgcctc gcagcctcca ggggacacgc catgactctg gagggtctgt
      181 atttggcaag gggccccctg gcccggctcc tgctggcctg gtcggccctg ttgtgcatgg
      241 caggtggcca aggccgctgg gacggggcct tggaggctgc aggtcctgga cgtgtgcgga
      301 ggcggggcag cccaggcatc ttgcaggggc cgaatgtgtg cggctcccgg ttccatgcct
      361 actgctgtcc aggctggagg acattccctg gcaggagcca gtgtgtcgta cccatctgta
      421 ggcgcgcctg cggtgaaggc ttctgctccc agcccaacct gtgcacctgt gcggatggga
      481 cgctggctcc cagctgcggg gtgagccgag ggtcagggtg cagtgtgagc tgtatgaatg
      541 ggggcacctg ccggggggcg tcctgtctgt gtcagaaggg ctacacaggc accgtgtgtg
      601 ggcagcccat ctgtgaccgc ggctgccaca atgggggtcg ctgcattggg cccaaccgct
      661 gcgcctgtgt gtatggcttc atgggacctc aatgtgagag agattaccgg acgggaccct
      721 gctttggcca agtaggcccc gaggggtgcc agcatcagct gacgggcctc gtgtgcacca
      781 aggcactttg ctgtgccact gtgggccgtg cctggggcct tccatgtgaa ctttgccctg
      841 cacagccaca cccctgccgc cgcggcttca tccccaatat ccacacgggg gcctgccaag
      901 atgtggatga gtgccaggct gtgccaggcc tgtgccaggg aggcagctgc gtcaacatgg
      961 tgggctcctt ccattgccgc tgtccagttg gacaccggct cagtgacagc agcgccgcat
     1021 gtgaagacta ccgggccggc gcctgcttct cagtgctttt cgggggccgc tgtgctggag
     1081 acctcgccgg ccactacact cgcaggcagt gctgctgtga caggggcagg tgctgggcag
     1141 ctggcccggt ccctgagctg tgtcctcctc ggggctccaa tgaattccag caactgtgcg
     1201 cccagcggct gccgctgcta cccggccacc ctggcctctt ccctggcctc ctgggcttcg
     1261 gatccaatgg catgggtccc cctcttgggc cagcgcgact caacccccat ggctctgatg
     1321 cgcgtgggat ccccagcctg ggccctggca actctaatat tggcactgct accctgaacc
     1381 agaccattga catctgccga cacttcacca acctgtgtct gaatggccgc tgcctgccca
     1441 cgccttccag ctaccgctgc gagtgtaacg tgggctacac ccaggacgtg cgcggcgagt
     1501 gcattgatgt agacgaatgc accagcagcc cctgccacca cggtgactgc gtcaacatcc
     1561 ccggcaccta ccactgccgg tgctacccgg gcttccaggc cacgcccacc aggcaggcat
     1621 gcgtggatgt ggacgagtgc attgtcagtg gtggcctttg tcacctgggc cgctgtgtca
     1681 acacagaggg cagcttccag tgtgtctgca atgcaggctt cgagctcagc cctgacggca
     1741 agaactgtgt ggaccacaac gagtgtgcca ccagcaccat gtgcgtcaac ggcgtgtgtc
     1801 tcaacgagga tggcagcttc tcctgcctct gcaaacccgg cttcctgctg gcgcctggcg
     1861 gccactactg catggacatt gacgagtgcc agacgcccgg catctgcgtg aacggccact
     1921 gtaccaacac cgagggctcc ttccgctgcc agtgcctggg ggggctggcg gtaggcacgg
     1981 atggccgcgt gtgcgtggac acccacgtgc gcagcacctg ctatggggcc atcgagaagg
     2041 gctcctgtgc ccgccccttc cctggcactg tcaccaagtc cgagtgctgc tgtgccaatc
     2101 cggaccacgg ttttggggag ccctgccagc tttgtcctgc caaagactcc gctgagttcc
     2161 aggcactgtg cagcagtggg cttggcatta ccacggatgg tcgagacatc aacgagtgtg
     2221 ctctggatcc tgaggtttgt gccaatggcg tgtgcgagaa ccttcggggc agctaccgct
     2281 gtgtctgcaa cctgggttat gaggcaggtg cctcaggcaa ggactgcaca gacgtggatg
     2341 agtgtgccct caacagcctc ctgtgtgaca acgggtggtg ccagaatagc cctggcagct
     2401 acagctgctc ctgccccccc ggcttccact tctggcagga cacggagatc tgcaaagatg
     2461 tcgacgaatg cctgtccagc ccgtgtgtga gtggcgtctg tcggaacctg gccggctcct
     2521 acacctgcaa atgtggccct ggcagccggc tggacccctc tggtaccttc tgtctagaca
     2581 gcaccaaggg cacctgctgg ctgaagatcc aggagagccg ctgtgaggtg aaccttcagg
     2641 gagccagcct gcggtctgag tgctgcgcca ccctcggggc agcctggggg agcccctgcg
     2701 aacgctgcga gatcgaccct gcctgtgccc ggggctttgc ccggatgacg ggtgtcacct
     2761 gcgatgatgt gaacgagtgt gagtccttcc cgggagtctg tcccaacggg cgttgcgtca
     2821 acactgctgg gtctttccgc tgtgagtgtc cagagggcct gatgctggac gcctcaggcc
     2881 ggctgtgcgt ggatgtgaga ttggaaccat gtttcctgcg atgggatgag gatgagtgtg
     2941 gggtcaccct gcctggcaag taccggatgg acgtctgctg ctgctccatc ggggccgtgt
     3001 ggggagtcga gtgcgaggcc tgcccggatc ccgagtctct ggagttcgcc agcctgtgcc
     3061 cgcgggggct gggcttcgcc agccgggact tcctgtctgg ccgaccattc tataaagatg
     3121 tgaatgaatg caaggtgttc cctggcctct gcacgcacgg tacctgcaga aacacggtgg
     3181 gcagcttcca ctgcgcctgt gcggggggct tcgccctgga tgcccaggaa cggaactgca
     3241 cagatatcga cgagtgtcgc atctctcctg acctctgcgg ccagggcacc tgtgtcaaca
     3301 cgccgggcag ctttgagtgc gagtgttttc ccggctacga gagtggcttc atgctgatga
     3361 agaactgcat ggacgtggac gagtgtgcaa gggacccgct gctctgccgg ggaggcactt
     3421 gcaccaacac ggatgggagc tacaagtgcc agtgtccccc tgggcatgag ctgacggcca
     3481 agggcactgc ctgtgaggac atcgatgagt gctccctgag tgatggcctg tgtccccatg
     3541 gccagtgtgt caatgtcatc ggtgccttcc agtgctcctg ccatgccggc ttccagagca
     3601 cacctgaccg ccagggctgc gtggacatca acgaatgccg ggtccagaat ggtgggtgtg
     3661 acgtgcactg tattaacact gagggcagct accggtgcag ctgtgggcag ggctactcgc
     3721 tgatgcccga cggaagggca tgtgcagacg tggacgagtg tgaagagaac ccccgcgttt
     3781 gtgaccaagg ccactgcacc aacatgccag ggggtcaccg ctgcctgtgc tatgatggct
     3841 tcatggccac gccagacatg aggacatgtg ttgatgtgga tgagtgtgac ctgaaccctc
     3901 acatctgcct ccatggggac tgcgagaaca cgaagggttc ctttgtctgc cactgtcagc
     3961 tgggctacat ggtcaggaag ggggccacag gctgctctga tgtggatgaa tgcgaggttg
     4021 gaggacacaa ctgtgacagt cacgcctcct gtctcaacat cccggggagt ttcagctgta
     4081 ggtgcctgcc aggctgggtg ggggatggct tcgaatgtca cgacctggat gaatgcgtct
     4141 cccaggagca ccggtgcagc ccaagaggtg actgtctcaa tgtccctggc tcctaccgct
     4201 gcacctgccg ccagggcttt gccggggatg gcttcttctg cgaagacagg gatgaatgtg
     4261 ccgagaacgt ggacctctgt gacaacgggc agtgcctcaa tgcgcccggc gggtaccgct
     4321 gtgaatgtga gatgggcttt gaccccaccg aggaccaccg ggcctgccag gatgtggacg
     4381 agtgtgcgca agggaacctc tgtgcatttg ggagctgtga gaacctgcct ggaatgttcc
     4441 gctgcatctg caatggtggc tacgaactgg accgaggggg tggcaactgc acagacatca
     4501 acgagtgtgc agacccagta aactgcatca acggcgtgtg cattaacacc cccggcagct
     4561 acctctgcag ctgcccccag gattttgagc tgaaccccag cggagtgggc tgcgtggaca
     4621 ctcgggccgg gaactgtttc ctggagacgc atgaccgagg ggacagtggc atttcctgca
     4681 gtgccgagat cggagttggt gtcacccgag cttcctgctg ttgctccctg ggccgggctt
     4741 ggggcaatcc ctgtgagctg tgccctatgg ccaacaccac tgagtacaga accctgtgcc
     4801 cgggtggtga gggcttccag cctaaccgca tcactgtcat tctggaagac atcgacgagt
     4861 gccaagagct gccagggctg tgtcaggggg gtgactgcgt caacacgttt ggcagtttcc
     4921 agtgtgagtg cccacctggc taccacctca gtgagcacac ccgcatctgt gaggatattg
     4981 acgaatgctc cacacactcc ggcatctgtg gccctggcac ctgctacaac accctgggga
     5041 actacacctg tgtctgccct gcagagtacc tccaagtcaa tggtggcaac aactgcatgg
     5101 atatgaggaa gagtgtctgc ttccggcact ataacggcac atgtcaaaat gagctggcct
     5161 tcaacgtgac ccggaaaatg tgttgctgct cctacaacat tggccaggcc tggaatagac
     5221 cctgtgaggc ctgccccact cccatcagtc ctgactacca gatcctgtgt ggaaatcagg
     5281 ccccgggatt cctcactgac atccacacgg ggaagcccct tgacattgat gagtgtgggg
     5341 agatccccgc catctgtgcc aatggcatct gcataaacca gatcgggagt ttccgctgcg
     5401 agtgccccgc aggcttcaac tacaacagca tcctgctggc ttgtgaagat gtcgatgagt
     5461 gtggcagcag ggagagtccc tgccagcaga atgctgactg catcaacatc cccggtagct
     5521 accgctgcaa gtgcacccga gggtacaaac tgtcgccagg cggggcttgt gtgggacgga
     5581 atgagtgtcg ggagatcccg aatgtctgta gccatggtga ctgcatggac acagaaggca
     5641 gctacatgtg tctgtgtcac cgtggattcc aggcctctgc agaccagacc ctgtgcatgg
     5701 acattgacga gtgtgaccgg cagccttgtg gaaatgggac ctgcaagaac atcattggct
     5761 cctacaactg cctctgcttc cctggctttg tggtgacaca caatggggat tgtgtggatt
     5821 ttgatgagtg tactaccctg gtggggcagg tgtgccgatt tggccattgc ctcaacacag
     5881 ctggttcctt ccactgcctc tgccaggatg gctttgagct cacagctgat gggaagaact
     5941 gtgtggacac caatgagtgc ctcagccttg caggaacctg cctacccggc acttgccaga
     6001 acctcgaggg ctccttccgc tgcatctgtc cccctggctt ccaggtgcag agtgaccact
     6061 gcattgatat cgacgagtgc tcagaggagc ccaacctctg cctctttggc acctgtacca
     6121 acagccctgg gagcttccag tgcctctgcc cacctggctt tgtcctctct gacaatgggc
     6181 accgttgctt tgacacacgg cagagtttct gcttcacccg ttttgaggct gggaagtgct
     6241 cggtgcccaa agctttcaac accaccaaga cccgctgctg ctgcagtaag aggcctgggg
     6301 agggctgggg agacccctgc gaactgtgtc cccaggaggg cagcgctgcc tttcaggagc
     6361 tctgcccctt tggccacggg gcagtcccag gcccggatga ctcccgagaa gacgtgaatg
     6421 agtgtgcaga gaaccctggc gtctgcacta acggcgtctg tgtcaacacc gatggatcct
     6481 tccgctgtga gtgtcccttt ggctacagcc tggacttcac tggcatcaac tgtgtggaca
     6541 cagacgagtg ctctgtcggc cacccctgtg ggcaagggac atgcaccaat gtcatcggag
     6601 gcttcgaatg tgcctgtgct gacggctttg agcctggcct catgatgacc tgcgaggaca
     6661 tcgacgaatg ctccctgaac ccgctgctct gtgccttccg ctgccacaat accgagggct
     6721 cctacctgtg cacctgtcca gccggctaca ccctgcggga ggatggggcc atgtgtcgag
     6781 atgtggacga gtgtgcagat ggtcagcagg actgccacgc ccggggcatg gagtgcaaga
     6841 acctcatcgg taccttcgcg tgcgtctgtc ccccaggcat gcggcccctg cctggctctg
     6901 gggagggctg cacagatgac aatgaatgcc acgctcagcc tgacctctgt gtcaacggcc
     6961 gctgtgtcaa caccgcgggc agcttccggt gcgactgtga tgagggattc cagcccagcc
     7021 ccacccttac cgagtgccac gacatccggc aggggccctg ctttgccgag gtgctgcaga
     7081 ccatgtgccg gtctctgtcc agcagcagtg aggctgtcac cagggccgag tgctgctgtg
     7141 ggggtggccg gggctggggg ccccgctgcg agctctgtcc cctgcccggc acctctgcct
     7201 acaggaagct gtgcccccat ggctcaggct acactgctga gggccgagat gtagatgaat
     7261 gccgtatgct tgctcacctg tgtgctcatg gggagtgcat caacagcctt ggctccttcc
     7321 gctgccactg tcaggccggg tacacaccgg atgctactgc tactacctgc ctggatatgg
     7381 atgagtgcag ccaggtcccc aagccatgta ccttcctctg caaaaacacg aagggcagtt
     7441 tcctgtgcag ctgtccccga ggctacctgc tggaggagga tggcaggacc tgcaaagacc
     7501 tggacgaatg cacctcccgg cagcacaact gtcagttcct ctgtgtcaac actgtgggcg
     7561 ccttcacctg ccgctgtccg cccggcttca cccagcacca ccaggcctgc ttcgacaatg
     7621 atgagtgctc agcccagcct ggcccatgtg gtgcccacgg gcactgccac aacaccccgg
     7681 gcagcttccg ctgtgaatgc caccaaggct tcaccctggt cagctcaggc catggctgtg
     7741 aagatgtgaa tgaatgtgat gggccccacc gctgccagca tggctgtcag aaccagctag
     7801 ggggctaccg ctgcagctgc ccccagggtt tcacccagca ctcccagtgg gcccagtgtg
     7861 tggatgagaa tgagtgtgcc ctgtcgcccc ccacctgcgg gagcgcctcc tgtcgcaaca
     7921 ctcttggtgg cttccgctgc gtctgcccct ctggctttga ctttgatcag gccctcgggg
     7981 gctgccagga ggtggatgag tgcgccggac ggcgtggccc ctgtagctac agctgtgcca
     8041 acacgcctgg tggcttcctg tgcggctgtc ctcaaggcta cttccgggct gggcaagggc
     8101 actgtgtctc cggcctgggc ttcagccccg gaccccagga caccccggac aaagaggagc
     8161 tgctctcgtc tgaagcctgc tacgaatgca agatcaatgg cctctcccct cgggaccggc
     8221 cacgacgcag tgcccacagg gaccaccagg tgaacctggc cacccttgac tccgaggccc
     8281 tgctgacctt gggcctgaac ctctcacacc tgggccgggc cgagcgcatc ctggagctcc
     8341 ggccggccct ggagggtcta gagggccgga tccgctacgt catcgtccgc ggaaacgagc
     8401 aaggtttctt tcgcatgcat cacctccgtg gcgtcagctc cctgcagctg gggcggaggc
     8461 ggccggggcc tggaacctac cggctggagg tggtgagcca catggcagga ccctggggtg
     8521 tccagccaga ggggcagcca gggccatggg gccaggcctt gaggctgaag gtgcagctgc
     8581 agttgcttta gttgggagga gcctcagtgg gccccagctg tccagagaag ggggattctg
     8641 gaactgggaa ggactgatcc ccagaagcga tggctgacca gattgaaccc cgaaactcag
     8701 gaagagtgaa atgctacacg acaacctcag gcaagcccgg cctctgcctg ggcctctgtg
     8761 ccagccccgg gggcccccca gttactcagt ctttcctgga gacagcaaga agctgcaatg
     8821 tgcaatcccc ctgcccccac agccaaggtc aggaagaggc cctgtggtca ccgtgtctgg
     8881 ccaatctcag gctttcactt ctgtactgca ctgtggcttg ccctggcggg gggcaggggg
     8941 ttggcaggac atggcaatgg gcaactgggg tgggcacagg gcttattcct cggagtagaa
     9001 gggtgtacag ggggcccaga ctccacagtg acttgccaca tttgcccccc atttggagaa
     9061 tgcttttata tcaaaagtgg agacgataat aaagttattt tgggttaa
//
