LOCUS       NM_001321431            9087 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens fibrillin 3 (FBN3), transcript variant 2, mRNA.
ACCESSION   NM_001321431 XM_011528373
VERSION     NM_001321431.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9087)
  AUTHORS   Toparcean,A.M., Acatrinei,A., Rusu,I., Festila,D., Campian,R.S.,
            Kelemen,B. and Ghergie,M.C.D.
  TITLE     Genetic Insights into Skeletal Malocclusion: The Role of the FBN3
            rs7351083 SNP in the Romanian Population
  JOURNAL   Medicina (Kaunas) 60 (7), 1061 (2024)
   PUBMED   39064490
  REMARK    GeneRIF: Genetic Insights into Skeletal Malocclusion: The Role of
            the FBN3 rs7351083 SNP in the Romanian Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9087)
  AUTHORS   Karakaya,C., Cil,A.P., Bilguvar,K., Cakir,T., Karalok,M.H.,
            Karabacak,R.O. and Caglayan,A.O.
  TITLE     Further delineation of familial polycystic ovary syndrome (PCOS)
            via whole-exome sequencing: PCOS-related rare FBN3 and FN1 gene
            variants are identified
  JOURNAL   J Obstet Gynaecol Res 48 (5), 1202-1211 (2022)
   PUBMED   35141985
  REMARK    GeneRIF: Further delineation of familial polycystic ovary syndrome
            (PCOS) via whole-exome sequencing: PCOS-related rare FBN3 and FN1
            gene variants are identified.
REFERENCE   3  (bases 1 to 9087)
  AUTHORS   Sabatier,L., Djokic,J., Hubmacher,D., Dzafik,D., Nelea,V. and
            Reinhardt,D.P.
  TITLE     Heparin/heparan sulfate controls fibrillin-1, -2 and -3
            self-interactions in microfibril assembly
  JOURNAL   FEBS Lett 588 (17), 2890-2897 (2014)
   PUBMED   25034023
REFERENCE   4  (bases 1 to 9087)
  AUTHORS   Xie,G.B., Xu,P., Che,Y.N., Xia,Y.J., Cao,Y.X., Wang,W.J., Qiao,D.,
            Wu,X.K., Yi,L., Gao,Q. and Wang,Y.
  TITLE     Microsatellite polymorphism in the fibrillin 3 gene and
            susceptibility to PCOS: a case-control study and meta-analysis
  JOURNAL   Reprod Biomed Online 26 (2), 168-174 (2013)
   PUBMED   23265956
  REMARK    GeneRIF: an association study showed a potential association of the
            D19S884 marker with PCOS in Chinese Han women and the meta-analysis
            identified that the A8 allele may increase susceptibility to PCOS
REFERENCE   5  (bases 1 to 9087)
  AUTHORS   Yalamanchi,S.K., Sam,S., Cardenas,M.O., Holaday,L.W., Urbanek,M.
            and Dunaif,A.
  TITLE     Association of fibrillin-3 and transcription factor-7-like 2 gene
            variants with metabolic phenotypes in PCOS
  JOURNAL   Obesity (Silver Spring) 20 (6), 1273-1278 (2012)
   PUBMED   22301903
  REMARK    GeneRIF: The FBN3 risk allele may be associated with changes in
            basal glucose homeostasis in PCOS.
REFERENCE   6  (bases 1 to 9087)
  AUTHORS   Urbanek,M., Sam,S., Legro,R.S. and Dunaif,A.
  TITLE     Identification of a polycystic ovary syndrome susceptibility
            variant in fibrillin-3 and association with a metabolic phenotype
  JOURNAL   J Clin Endocrinol Metab 92 (11), 4191-4198 (2007)
   PUBMED   17785364
  REMARK    GeneRIF: fibrillin-3 gene showed the strongest evidence for
            association with Polycystic ovary syndrome
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9087)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 9087)
  AUTHORS   Corson,G.M., Charbonneau,N.L., Keene,D.R. and Sakai,L.Y.
  TITLE     Differential expression of fibrillin-3 adds to microfibril variety
            in human and avian, but not rodent, connective tissues
  JOURNAL   Genomics 83 (3), 461-472 (2004)
   PUBMED   14962672
REFERENCE   9  (bases 1 to 9087)
  AUTHORS   Uyeda,T., Takahashi,T., Eto,S., Sato,T., Xu,G., Kanezaki,R.,
            Toki,T., Yonesaka,S. and Ito,E.
  TITLE     Three novel mutations of the fibrillin-1 gene and ten single
            nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome
            patients
  JOURNAL   J Hum Genet 49 (8), 404-407 (2004)
   PUBMED   15221638
REFERENCE   10 (bases 1 to 9087)
  AUTHORS   Faivre,L., Megarbane,A., Alswaid,A., Zylberberg,L., Aldohayan,N.,
            Campos-Xavier,B., Bacq,D., Legeai-Mallet,L., Bonaventure,J.,
            Munnich,A. and Cormier-Daire,V.
  TITLE     Homozygosity mapping of a Weill-Marchesani syndrome locus to
            chromosome 19p13.3-p13.2
  JOURNAL   Hum Genet 110 (4), 366-370 (2002)
   PUBMED   11941487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY165864.1, AC022146.8,
            AC008946.7 and BC153882.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001321431.1.
            
            Summary: This gene encodes a memebr of the fibrillin protein
            family. Fibrillins are extracellular matrix molecules that assemble
            into microfibrils in many connective tissues. This gene is most
            highly expressed in fetal tissues and its protein product is
            localized to extracellular microfibrils of developing skeletal
            elements, skin, lung, kidney, and skeletal muscle. This gene is
            potentially involved in Weill-Marchesani syndrome. [provided by
            RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY165864.1, SRR18074969.504692.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AY165864.1         1-88
            89-89               AC022146.8         90559-90559         c
            90-2123             AY165864.1         90-2123
            2124-2124           AC022146.8         73338-73338         c
            2125-4042           AY165864.1         2125-4042
            4043-4043           AC022146.8         53813-53813         c
            4044-4979           AY165864.1         4044-4979
            4980-4980           AC008946.7         108407-108407       c
            4981-6316           AY165864.1         4981-6316
            6317-6317           AC008946.7         94852-94852         c
            6318-6742           AY165864.1         6318-6742
            6743-6743           AC008946.7         92587-92587         c
            6744-7558           AY165864.1         6744-7558
            7559-7559           AC008946.7         85783-85783         c
            7560-7969           AY165864.1         7560-7969
            7970-7970           AC008946.7         77916-77916         c
            7971-9086           AY165864.1         7971-9086
            9087-9087           BC153882.1         8968-8968
FEATURES             Location/Qualifiers
     source          1..9087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..9087
                     /gene="FBN3"
                     /note="fibrillin 3"
                     /db_xref="GeneID:84467"
                     /db_xref="HGNC:HGNC:18794"
                     /db_xref="MIM:608529"
     exon            1..123
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            124..307
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..8570
                     /gene="FBN3"
                     /codon_start=1
                     /product="fibrillin-3 precursor"
                     /protein_id="NP_001308360.1"
                     /db_xref="CCDS:CCDS12196.1"
                     /db_xref="GeneID:84467"
                     /db_xref="HGNC:HGNC:18794"
                     /db_xref="MIM:608529"
                     /translation="MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGR
                     VRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCT
                     CADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGR
                     CIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAW
                     GLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPV
                     GHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELC
                     PPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS
                     LGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDV
                     DECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNT
                     EGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPG
                     GHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAI
                     EKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD
                     INECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC
                     QNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD
                     PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACA
                     RGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL
                     EPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGF
                     ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDID
                     ECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT
                     NTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS
                     TPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP
                     RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFV
                     CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
                     DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQC
                     LNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL
                     DRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFL
                     ETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF
                     QPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECS
                     THSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN
                     VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG
                     EIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIP
                     GSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQ
                     TLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRF
                     GHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPP
                     GFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSF
                     CFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGA
                     VPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSV
                     GHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLC
                     TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGE
                     GCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQ
                     TMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDV
                     DECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKN
                     TKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH
                     QACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC
                     QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCP
                     SGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGF
                     SPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGL
                     NLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGP
                     GTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL"
     exon            308..390
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..489
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..585
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..681
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..879
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1005
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1158
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1341
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1485
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1605
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1731
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1854
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2130
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2184
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2310
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2436
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2556
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2694
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2745
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2871
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3096
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3222
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3351
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3477
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3603
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3726
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3852
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..3978
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4101
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4224
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4350
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4473
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4596
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4758
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4827
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..4953
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5079
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5080..5229
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5230..5301
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5302..5427
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5553
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5554..5679
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5680..5796
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5925
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6045
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6046..6171
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6172..6324
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6325..6390
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6516
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6517..6636
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6637..6759
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6760..6894
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            6895..7020
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7021..7227
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7228..7353
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7354..7476
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7477..7593
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7594..7722
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7723..7842
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            7843..8077
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            8078..8228
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     exon            8229..9087
                     /gene="FBN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9067..9072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN3"
                     /note="hexamer: AATAAA"
     polyA_site      9087
                     /gene="FBN3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctcag agtgcggact gacccggaca actgagaaga aaaagagggc gcccctctcc
       61 agccagccaa ccctccaacg ttgacagggg tctctccctt ctccggggcc tttggacaac
      121 cagcctccag gggacacgcc atgactctgg agggtctgta tttggcaagg ggccccctgg
      181 cccggctcct gctggcctgg tcggccctgt tgtgcatggc aggtggccaa ggccgctggg
      241 acggggcctt ggaggctgca ggtcctggac gtgtgcggag gcggggcagc ccaggcatct
      301 tgcaggggcc gaatgtgtgc ggctcccggt tccatgccta ctgctgtcca ggctggagga
      361 cattccctgg caggagccag tgtgtcgtac ccatctgtag gcgcgcctgc ggtgaaggct
      421 tctgctccca gcccaacctg tgcacctgtg cggatgggac gctggctccc agctgcgggg
      481 tgagccgagg gtcagggtgc agtgtgagct gtatgaatgg gggcacctgc cggggggcgt
      541 cctgtctgtg tcagaagggc tacacaggca ccgtgtgtgg gcagcccatc tgtgaccgcg
      601 gctgccacaa tgggggtcgc tgcattgggc ccaaccgctg cgcctgtgtg tatggcttca
      661 tgggacctca atgtgagaga gattaccgga cgggaccctg ctttggccaa gtaggccccg
      721 aggggtgcca gcatcagctg acgggcctcg tgtgcaccaa ggcactttgc tgtgccactg
      781 tgggccgtgc ctggggcctt ccatgtgaac tttgccctgc acagccacac ccctgccgcc
      841 gcggcttcat ccccaatatc cacacggggg cctgccaaga tgtggatgag tgccaggctg
      901 tgccaggcct gtgccaggga ggcagctgcg tcaacatggt gggctccttc cattgccgct
      961 gtccagttgg acaccggctc agtgacagca gcgccgcatg tgaagactac cgggccggcg
     1021 cctgcttctc agtgcttttc gggggccgct gtgctggaga cctcgccggc cactacactc
     1081 gcaggcagtg ctgctgtgac aggggcaggt gctgggcagc tggcccggtc cctgagctgt
     1141 gtcctcctcg gggctccaat gaattccagc aactgtgcgc ccagcggctg ccgctgctac
     1201 ccggccaccc tggcctcttc cctggcctcc tgggcttcgg atccaatggc atgggtcccc
     1261 ctcttgggcc agcgcgactc aacccccatg gctctgatgc gcgtgggatc cccagcctgg
     1321 gccctggcaa ctctaatatt ggcactgcta ccctgaacca gaccattgac atctgccgac
     1381 acttcaccaa cctgtgtctg aatggccgct gcctgcccac gccttccagc taccgctgcg
     1441 agtgtaacgt gggctacacc caggacgtgc gcggcgagtg cattgatgta gacgaatgca
     1501 ccagcagccc ctgccaccac ggtgactgcg tcaacatccc cggcacctac cactgccggt
     1561 gctacccggg cttccaggcc acgcccacca ggcaggcatg cgtggatgtg gacgagtgca
     1621 ttgtcagtgg tggcctttgt cacctgggcc gctgtgtcaa cacagagggc agcttccagt
     1681 gtgtctgcaa tgcaggcttc gagctcagcc ctgacggcaa gaactgtgtg gaccacaacg
     1741 agtgtgccac cagcaccatg tgcgtcaacg gcgtgtgtct caacgaggat ggcagcttct
     1801 cctgcctctg caaacccggc ttcctgctgg cgcctggcgg ccactactgc atggacattg
     1861 acgagtgcca gacgcccggc atctgcgtga acggccactg taccaacacc gagggctcct
     1921 tccgctgcca gtgcctgggg gggctggcgg taggcacgga tggccgcgtg tgcgtggaca
     1981 cccacgtgcg cagcacctgc tatggggcca tcgagaaggg ctcctgtgcc cgccccttcc
     2041 ctggcactgt caccaagtcc gagtgctgct gtgccaatcc ggaccacggt tttggggagc
     2101 cctgccagct ttgtcctgcc aaagactccg ctgagttcca ggcactgtgc agcagtgggc
     2161 ttggcattac cacggatggt cgagacatca acgagtgtgc tctggatcct gaggtttgtg
     2221 ccaatggcgt gtgcgagaac cttcggggca gctaccgctg tgtctgcaac ctgggttatg
     2281 aggcaggtgc ctcaggcaag gactgcacag acgtggatga gtgtgccctc aacagcctcc
     2341 tgtgtgacaa cgggtggtgc cagaatagcc ctggcagcta cagctgctcc tgcccccccg
     2401 gcttccactt ctggcaggac acggagatct gcaaagatgt cgacgaatgc ctgtccagcc
     2461 cgtgtgtgag tggcgtctgt cggaacctgg ccggctccta cacctgcaaa tgtggccctg
     2521 gcagccggct ggacccctct ggtaccttct gtctagacag caccaagggc acctgctggc
     2581 tgaagatcca ggagagccgc tgtgaggtga accttcaggg agccagcctg cggtctgagt
     2641 gctgcgccac cctcggggca gcctggggga gcccctgcga acgctgcgag atcgaccctg
     2701 cctgtgcccg gggctttgcc cggatgacgg gtgtcacctg cgatgatgtg aacgagtgtg
     2761 agtccttccc gggagtctgt cccaacgggc gttgcgtcaa cactgctggg tctttccgct
     2821 gtgagtgtcc agagggcctg atgctggacg cctcaggccg gctgtgcgtg gatgtgagat
     2881 tggaaccatg tttcctgcga tgggatgagg atgagtgtgg ggtcaccctg cctggcaagt
     2941 accggatgga cgtctgctgc tgctccatcg gggccgtgtg gggagtcgag tgcgaggcct
     3001 gcccggatcc cgagtctctg gagttcgcca gcctgtgccc gcgggggctg ggcttcgcca
     3061 gccgggactt cctgtctggc cgaccattct ataaagatgt gaatgaatgc aaggtgttcc
     3121 ctggcctctg cacgcacggt acctgcagaa acacggtggg cagcttccac tgcgcctgtg
     3181 cggggggctt cgccctggat gcccaggaac ggaactgcac agatatcgac gagtgtcgca
     3241 tctctcctga cctctgcggc cagggcacct gtgtcaacac gccgggcagc tttgagtgcg
     3301 agtgttttcc cggctacgag agtggcttca tgctgatgaa gaactgcatg gacgtggacg
     3361 agtgtgcaag ggacccgctg ctctgccggg gaggcacttg caccaacacg gatgggagct
     3421 acaagtgcca gtgtccccct gggcatgagc tgacggccaa gggcactgcc tgtgaggaca
     3481 tcgatgagtg ctccctgagt gatggcctgt gtccccatgg ccagtgtgtc aatgtcatcg
     3541 gtgccttcca gtgctcctgc catgccggct tccagagcac acctgaccgc cagggctgcg
     3601 tggacatcaa cgaatgccgg gtccagaatg gtgggtgtga cgtgcactgt attaacactg
     3661 agggcagcta ccggtgcagc tgtgggcagg gctactcgct gatgcccgac ggaagggcat
     3721 gtgcagacgt ggacgagtgt gaagagaacc cccgcgtttg tgaccaaggc cactgcacca
     3781 acatgccagg gggtcaccgc tgcctgtgct atgatggctt catggccacg ccagacatga
     3841 ggacatgtgt tgatgtggat gagtgtgacc tgaaccctca catctgcctc catggggact
     3901 gcgagaacac gaagggttcc tttgtctgcc actgtcagct gggctacatg gtcaggaagg
     3961 gggccacagg ctgctctgat gtggatgaat gcgaggttgg aggacacaac tgtgacagtc
     4021 acgcctcctg tctcaacatc ccggggagtt tcagctgtag gtgcctgcca ggctgggtgg
     4081 gggatggctt cgaatgtcac gacctggatg aatgcgtctc ccaggagcac cggtgcagcc
     4141 caagaggtga ctgtctcaat gtccctggct cctaccgctg cacctgccgc cagggctttg
     4201 ccggggatgg cttcttctgc gaagacaggg atgaatgtgc cgagaacgtg gacctctgtg
     4261 acaacgggca gtgcctcaat gcgcccggcg ggtaccgctg tgaatgtgag atgggctttg
     4321 accccaccga ggaccaccgg gcctgccagg atgtggacga gtgtgcgcaa gggaacctct
     4381 gtgcatttgg gagctgtgag aacctgcctg gaatgttccg ctgcatctgc aatggtggct
     4441 acgaactgga ccgagggggt ggcaactgca cagacatcaa cgagtgtgca gacccagtaa
     4501 actgcatcaa cggcgtgtgc attaacaccc ccggcagcta cctctgcagc tgcccccagg
     4561 attttgagct gaaccccagc ggagtgggct gcgtggacac tcgggccggg aactgtttcc
     4621 tggagacgca tgaccgaggg gacagtggca tttcctgcag tgccgagatc ggagttggtg
     4681 tcacccgagc ttcctgctgt tgctccctgg gccgggcttg gggcaatccc tgtgagctgt
     4741 gccctatggc caacaccact gagtacagaa ccctgtgccc gggtggtgag ggcttccagc
     4801 ctaaccgcat cactgtcatt ctggaagaca tcgacgagtg ccaagagctg ccagggctgt
     4861 gtcagggggg tgactgcgtc aacacgtttg gcagtttcca gtgtgagtgc ccacctggct
     4921 accacctcag tgagcacacc cgcatctgtg aggatattga cgaatgctcc acacactccg
     4981 gcatctgtgg ccctggcacc tgctacaaca ccctggggaa ctacacctgt gtctgccctg
     5041 cagagtacct ccaagtcaat ggtggcaaca actgcatgga tatgaggaag agtgtctgct
     5101 tccggcacta taacggcaca tgtcaaaatg agctggcctt caacgtgacc cggaaaatgt
     5161 gttgctgctc ctacaacatt ggccaggcct ggaatagacc ctgtgaggcc tgccccactc
     5221 ccatcagtcc tgactaccag atcctgtgtg gaaatcaggc cccgggattc ctcactgaca
     5281 tccacacggg gaagcccctt gacattgatg agtgtgggga gatccccgcc atctgtgcca
     5341 atggcatctg cataaaccag atcgggagtt tccgctgcga gtgccccgca ggcttcaact
     5401 acaacagcat cctgctggct tgtgaagatg tcgatgagtg tggcagcagg gagagtccct
     5461 gccagcagaa tgctgactgc atcaacatcc ccggtagcta ccgctgcaag tgcacccgag
     5521 ggtacaaact gtcgccaggc ggggcttgtg tgggacggaa tgagtgtcgg gagatcccga
     5581 atgtctgtag ccatggtgac tgcatggaca cagaaggcag ctacatgtgt ctgtgtcacc
     5641 gtggattcca ggcctctgca gaccagaccc tgtgcatgga cattgacgag tgtgaccggc
     5701 agccttgtgg aaatgggacc tgcaagaaca tcattggctc ctacaactgc ctctgcttcc
     5761 ctggctttgt ggtgacacac aatggggatt gtgtggattt tgatgagtgt actaccctgg
     5821 tggggcaggt gtgccgattt ggccattgcc tcaacacagc tggttccttc cactgcctct
     5881 gccaggatgg ctttgagctc acagctgatg ggaagaactg tgtggacacc aatgagtgcc
     5941 tcagccttgc aggaacctgc ctacccggca cttgccagaa cctcgagggc tccttccgct
     6001 gcatctgtcc ccctggcttc caggtgcaga gtgaccactg cattgatatc gacgagtgct
     6061 cagaggagcc caacctctgc ctctttggca cctgtaccaa cagccctggg agcttccagt
     6121 gcctctgccc acctggcttt gtcctctctg acaatgggca ccgttgcttt gacacacggc
     6181 agagtttctg cttcacccgt tttgaggctg ggaagtgctc ggtgcccaaa gctttcaaca
     6241 ccaccaagac ccgctgctgc tgcagtaaga ggcctgggga gggctgggga gacccctgcg
     6301 aactgtgtcc ccaggagggc agcgctgcct ttcaggagct ctgccccttt ggccacgggg
     6361 cagtcccagg cccggatgac tcccgagaag acgtgaatga gtgtgcagag aaccctggcg
     6421 tctgcactaa cggcgtctgt gtcaacaccg atggatcctt ccgctgtgag tgtccctttg
     6481 gctacagcct ggacttcact ggcatcaact gtgtggacac agacgagtgc tctgtcggcc
     6541 acccctgtgg gcaagggaca tgcaccaatg tcatcggagg cttcgaatgt gcctgtgctg
     6601 acggctttga gcctggcctc atgatgacct gcgaggacat cgacgaatgc tccctgaacc
     6661 cgctgctctg tgccttccgc tgccacaata ccgagggctc ctacctgtgc acctgtccag
     6721 ccggctacac cctgcgggag gatggggcca tgtgtcgaga tgtggacgag tgtgcagatg
     6781 gtcagcagga ctgccacgcc cggggcatgg agtgcaagaa cctcatcggt accttcgcgt
     6841 gcgtctgtcc cccaggcatg cggcccctgc ctggctctgg ggagggctgc acagatgaca
     6901 atgaatgcca cgctcagcct gacctctgtg tcaacggccg ctgtgtcaac accgcgggca
     6961 gcttccggtg cgactgtgat gagggattcc agcccagccc cacccttacc gagtgccacg
     7021 acatccggca ggggccctgc tttgccgagg tgctgcagac catgtgccgg tctctgtcca
     7081 gcagcagtga ggctgtcacc agggccgagt gctgctgtgg gggtggccgg ggctgggggc
     7141 cccgctgcga gctctgtccc ctgcccggca cctctgccta caggaagctg tgcccccatg
     7201 gctcaggcta cactgctgag ggccgagatg tagatgaatg ccgtatgctt gctcacctgt
     7261 gtgctcatgg ggagtgcatc aacagccttg gctccttccg ctgccactgt caggccgggt
     7321 acacaccgga tgctactgct actacctgcc tggatatgga tgagtgcagc caggtcccca
     7381 agccatgtac cttcctctgc aaaaacacga agggcagttt cctgtgcagc tgtccccgag
     7441 gctacctgct ggaggaggat ggcaggacct gcaaagacct ggacgaatgc acctcccggc
     7501 agcacaactg tcagttcctc tgtgtcaaca ctgtgggcgc cttcacctgc cgctgtccgc
     7561 ccggcttcac ccagcaccac caggcctgct tcgacaatga tgagtgctca gcccagcctg
     7621 gcccatgtgg tgcccacggg cactgccaca acaccccggg cagcttccgc tgtgaatgcc
     7681 accaaggctt caccctggtc agctcaggcc atggctgtga agatgtgaat gaatgtgatg
     7741 ggccccaccg ctgccagcat ggctgtcaga accagctagg gggctaccgc tgcagctgcc
     7801 cccagggttt cacccagcac tcccagtggg cccagtgtgt ggatgagaat gagtgtgccc
     7861 tgtcgccccc cacctgcggg agcgcctcct gtcgcaacac tcttggtggc ttccgctgcg
     7921 tctgcccctc tggctttgac tttgatcagg ccctcggggg ctgccaggag gtggatgagt
     7981 gcgccggacg gcgtggcccc tgtagctaca gctgtgccaa cacgcctggt ggcttcctgt
     8041 gcggctgtcc tcaaggctac ttccgggctg ggcaagggca ctgtgtctcc ggcctgggct
     8101 tcagccccgg accccaggac accccggaca aagaggagct gctctcgtct gaagcctgct
     8161 acgaatgcaa gatcaatggc ctctcccctc gggaccggcc acgacgcagt gcccacaggg
     8221 accaccaggt gaacctggcc acccttgact ccgaggccct gctgaccttg ggcctgaacc
     8281 tctcacacct gggccgggcc gagcgcatcc tggagctccg gccggccctg gagggtctag
     8341 agggccggat ccgctacgtc atcgtccgcg gaaacgagca aggtttcttt cgcatgcatc
     8401 acctccgtgg cgtcagctcc ctgcagctgg ggcggaggcg gccggggcct ggaacctacc
     8461 ggctggaggt ggtgagccac atggcaggac cctggggtgt ccagccagag gggcagccag
     8521 ggccatgggg ccaggccttg aggctgaagg tgcagctgca gttgctttag ttgggaggag
     8581 cctcagtggg ccccagctgt ccagagaagg gggattctgg aactgggaag gactgatccc
     8641 cagaagcgat ggctgaccag attgaacccc gaaactcagg aagagtgaaa tgctacacga
     8701 caacctcagg caagcccggc ctctgcctgg gcctctgtgc cagccccggg ggccccccag
     8761 ttactcagtc tttcctggag acagcaagaa gctgcaatgt gcaatccccc tgcccccaca
     8821 gccaaggtca ggaagaggcc ctgtggtcac cgtgtctggc caatctcagg ctttcacttc
     8881 tgtactgcac tgtggcttgc cctggcgggg ggcagggggt tggcaggaca tggcaatggg
     8941 caactggggt gggcacaggg cttattcctc ggagtagaag ggtgtacagg gggcccagac
     9001 tccacagtga cttgccacat ttgcccccca tttggagaat gcttttatat caaaagtgga
     9061 gacgataata aagttatttt gggttaa
//
