LOCUS       NM_001999              10927 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens fibrillin 2 (FBN2), mRNA.
ACCESSION   NM_001999
VERSION     NM_001999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10927)
  AUTHORS   Ghorbani,S., Li,C., Lozinski,B.M., Moezzi,D., D'Mello,C., Dong,Y.,
            Visser,F., Li,H., Silva,C., Khakpour,M., Murray,C.J.,
            Tremblay,M.E., Xue,M. and Yong,V.W.
  TITLE     Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes
            relevant to multiple sclerosis
  JOURNAL   J Clin Invest 134 (13), e176910 (2024)
   PUBMED   38743490
  REMARK    GeneRIF: Fibulin-2 is an extracellular matrix inhibitor of
            oligodendrocytes relevant to multiple sclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10927)
  AUTHORS   Yang,S. and Li,Z.
  TITLE     FBN2 pathogenic variants in congenital contractural arachnodactyly
            with severe cardiovascular manifestations
  JOURNAL   Connect Tissue Res 65 (3), 214-225 (2024)
   PUBMED   38602424
  REMARK    GeneRIF: FBN2 pathogenic variants in congenital contractural
            arachnodactyly with severe cardiovascular manifestations.
REFERENCE   3  (bases 1 to 10927)
  AUTHORS   Hamano,S., Yamashita,D., Hasegawa,D., Sugii,H., Itoyama,T. and
            Maeda,H.
  TITLE     Effect of Fibrillin-2 on Differentiation into Periodontal Ligament
            Stem Cell-Like Cells Derived from Human-Induced Pluripotent Stem
            Cells
  JOURNAL   Stem Cells Dev 33 (9-10), 228-238 (2024)
   PUBMED   38534877
  REMARK    GeneRIF: Effect of Fibrillin-2 on Differentiation into Periodontal
            Ligament Stem Cell-Like Cells Derived from Human-Induced
            Pluripotent Stem Cells.
REFERENCE   4  (bases 1 to 10927)
  AUTHORS   Lu,Z., Lu,Z., Lai,Y., Zhou,H., Li,Z., Cai,W., Xu,Z., Luo,H.,
            Chen,Y., Li,J., Zhang,J., He,Z. and Tang,F.
  TITLE     A comprehensive analysis of FBN2 in bladder cancer: A risk factor
            and the tumour microenvironment influencer
  JOURNAL   IET Syst Biol 17 (4), 162-173 (2023)
   PUBMED   37337404
  REMARK    GeneRIF: A comprehensive analysis of FBN2 in bladder cancer: A risk
            factor and the tumour microenvironment influencer.
REFERENCE   5  (bases 1 to 10927)
  AUTHORS   Putnam,E.A., Zhang,H., Ramirez,F. and Milewicz,D.M.
  TITLE     Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder,
            congenital contractural arachnodactyly
  JOURNAL   Nat Genet 11 (4), 456-458 (1995)
   PUBMED   7493032
REFERENCE   6  (bases 1 to 10927)
  AUTHORS   Zhang,H., Hu,W. and Ramirez,F.
  TITLE     Developmental expression of fibrillin genes suggests heterogeneity
            of extracellular microfibrils
  JOURNAL   J Cell Biol 129 (4), 1165-1176 (1995)
   PUBMED   7744963
REFERENCE   7  (bases 1 to 10927)
  AUTHORS   Zhang,H., Apfelroth,S.D., Hu,W., Davis,E.C., Sanguineti,C.,
            Bonadio,J., Mecham,R.P. and Ramirez,F.
  TITLE     Structure and expression of fibrillin-2, a novel microfibrillar
            component preferentially located in elastic matrices
  JOURNAL   J Cell Biol 124 (5), 855-863 (1994)
   PUBMED   8120105
REFERENCE   8  (bases 1 to 10927)
  AUTHORS   Callewaert,B.
  TITLE     Congenital Contractural Arachnodactyly
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301560
REFERENCE   9  (bases 1 to 10927)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   10 (bases 1 to 10927)
  AUTHORS   Lee,B., Godfrey,M., Vitale,E., Hori,H., Mattei,M.G., Sarfarazi,M.,
            Tsipouras,P., Ramirez,F. and Hollister,D.W.
  TITLE     Linkage of Marfan syndrome and a phenotypically related disorder to
            two different fibrillin genes
  JOURNAL   Nature 352 (6333), 330-334 (1991)
   PUBMED   1852206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113387.2, BC040623.1,
            U03272.1, BX343658.2, BF368029.1, BG009811.1, CN300894.1,
            CN300893.1, CD243435.1, CN300888.1, CN300904.1, CN481490.1 and
            AC025169.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001999.3.
            
            Summary: The protein encoded by this gene is a component of
            connective tissue microfibrils and may be involved in elastic fiber
            assembly. Mutations in this gene cause congenital contractural
            arachnodactyly. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03272.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262464.9/ ENSP00000262464.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC113387.2         120350-120552       c
            204-896             AC113387.2         119657-120349       c
            897-1720            BC040623.1         1231-2054
            1721-2421           U03272.1           1076-1776
            2422-3202           BX343658.2         67-847
            3203-3791           U03272.1           2558-3146
            3792-3886           BF368029.1         208-302
            3887-4357           BG009811.1         53-523
            4358-5149           U03272.1           3713-4504
            5150-5543           CN300894.1         229-622
            5544-6103           CN300893.1         15-574
            6104-6775           CD243435.1         78-749
            6776-7439           U03272.1           6131-6794
            7440-7572           CN300888.1         74-206
            7573-8380           U03272.1           6928-7735
            8381-8903           CN300904.1         83-605
            8904-9302           CN481490.1         199-597
            9303-10927          AC025169.5         24311-25935         c
FEATURES             Location/Qualifiers
     source          1..10927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3"
     gene            1..10927
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /note="fibrillin 2"
                     /db_xref="GeneID:2201"
                     /db_xref="HGNC:HGNC:3604"
                     /db_xref="MIM:612570"
     exon            1..896
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..9381
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /note="fibrillin 5"
                     /codon_start=1
                     /product="fibrillin-2 precursor"
                     /protein_id="NP_001990.2"
                     /db_xref="CCDS:CCDS34222.1"
                     /db_xref="GeneID:2201"
                     /db_xref="HGNC:HGNC:3604"
                     /db_xref="MIM:612570"
                     /translation="MGRRRRLCLQLYFLWLGCVVLWAQGTAGQPQPPPPKPPRPQPPP
                     QQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWK
                     TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCA
                     DDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFT
                     QVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQD
                     VDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC
                     SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEP
                     GRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNG
                     YGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNG
                     RCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQR
                     TPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTT
                     NMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRC
                     DCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEP
                     CQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSG
                     YEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC
                     ESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGA
                     TLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCV
                     NSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVG
                     AAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK
                     CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY
                     ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINEC
                     SLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG
                     SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM
                     KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC
                     DMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCAC
                     SEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE
                     CSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPG
                     RYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSL
                     GKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCIN
                     TFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQV
                     NGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGT
                     ADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYN
                     DLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIP
                     NVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCL
                     CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCID
                     TNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTN
                     TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP
                     GEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINT
                     DGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM
                     MNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCE
                     SRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE
                     CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC
                     ELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGY
                     TTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQT
                     KQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS
                     CECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVD
                     ENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSN
                     TEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGY
                     SKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQPL
                     NNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKKKELKKL
                     EESNEDDYLLGELGEALRMRLQIQLY"
     exon            897..979
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1078
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1174
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1270
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1468
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1594
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1720
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1873
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2107
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2245
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2365
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2491
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2614
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2737
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2890
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2944
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3070
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3196
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3316
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3454
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3505
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3631
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3859
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..3985
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4114
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4240
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4366
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4489
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4615
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4741
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..4864
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..4987
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            4988..5113
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5114..5236
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5359
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5360..5521
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5522..5590
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5591..5716
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5717..5842
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5843..5995
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            5996..6064
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6065..6190
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6191..6316
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6317..6442
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6443..6559
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6560..6688
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6689..6808
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6809..6934
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            6935..7087
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7088..7153
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7154..7279
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7280..7399
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7400..7522
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7523..7654
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7655..7780
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7781..7987
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            7988..8113
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8114..8236
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8237..8353
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8354..8482
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8483..8602
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8603..8834
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            8835..9006
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     exon            9007..10927
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10907..10912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /note="hexamer: AATAAA"
     polyA_site      10927
                     /gene="FBN2"
                     /gene_synonym="CCA; DA9; EOMD"
                     /note="major polyA site"
ORIGIN      
        1 gccgcatctt ctccagcgcc cagcctcccg ccctctctct tgctggccgc acgccccggc
       61 cccgcgcacc tccgcccggc tccgcagccg ctacccgcgc ttcgttgccc tgtgggactc
      121 cgagcgagcc cggagggaac cctcctcttc ttctgggggc gacttttgtt tgcttgcctg
      181 tttctttctg gtgacttttg cagctttcca atatccgtct tcggagcgca cgggaatccg
      241 ccgagctctg cgtgcaggcc cttttttctt ttgaggttca cattttttga aattttacgc
      301 cagggctttt gtaatttcct cccccgcccg ctgacggtcc tggagtcgct cggggcttta
      361 ggccggttat gcaacgtgta ccgctcgggg ctgccggctg cacctccgcc gcgcctcgcc
      421 gctcactgcg ctagacccgg cgccccgcgt ctcgcttcgc gggcagtcag ggggccggcg
      481 ctctgtcgag gtctccagct agagcaggga gcccgagccc gagggagtcc ccggagccga
      541 cgaagggctt attagaccct gactcttttc tgaggcgcgc agattttgtc tttgatcact
      601 ccctctccgc gggtctacgg ccgcgcgctt tcggcgccgg cgatggggag aagacggagg
      661 ctgtgtctcc agctctactt cctgtggctg ggctgtgtgg tgctctgggc gcagggcacg
      721 gccggccagc ctcagcctcc tccgcccaag ccgccccggc cccagccgcc gccgcaacag
      781 gttcggtccg ctacagcagg ctctgaaggc gggtttctag cgcccgagta tcgcgaggag
      841 ggtgccgcag tggccagccg cgtccgccgg cgaggacagc aggacgtgct ccgagggccc
      901 aacgtgtgcg gctccagatt ccactcctac tgctgccctg gatggaagac gctccctgga
      961 ggaaaccagt gcattgtccc gatttgtaga aatagttgtg gagatggatt ttgttcccgt
     1021 cctaacatgt gtacttgttc cagtgggcaa atatcatcaa cctgtggatc aaaatcaatt
     1081 cagcagtgca gtgtgagatg catgaatggt gggacctgtg cagatgacca ctgccagtgc
     1141 cagaaaggat atattggaac ttattgtgga caacctgtct gtgaaaatgg atgtcagaat
     1201 ggtggacgtt gcatcggacc caaccgctgt gcttgtgttt atgggttcac tggtccacag
     1261 tgtgaaagag attacaggac aggcccgtgt ttcactcagg tcaacaacca gatgtgccaa
     1321 gggcagctga caggcattgt ctgcacgaag actctgtgct gtgccaccat tggacgggcg
     1381 tggggccatc cctgtgagat gtgtccagcc cagcctcagc cctgccgacg gggtttcatc
     1441 cccaacatcc gcactggagc ttgccaagat gttgatgaat gccaggctat cccagggata
     1501 tgccaaggag gaaactgtat caatacagtg ggctcttttg aatgcagatg ccctgctggt
     1561 cacaaacaga gtgaaactac tcagaaatgt gaagacattg atgagtgcag catcattcct
     1621 gggatatgtg aaactggtga atgttccaac accgtgggaa gctatttttg tgtttgtcca
     1681 cgtggatatg taacctcaac agatggctct cgatgcatcg atcagagaac aggcatgtgt
     1741 ttctcgggcc tggtgaatgg ccgctgtgca caagagctcc cggggagaat gacgaaaatg
     1801 cagtgctgct gtgagcctgg ccgctgctgg ggcatcggaa ccattcctga agcctgtcct
     1861 gtcagaggtt ctgaggaata tcgcagactt tgcatggatg gacttccaat gggaggaatt
     1921 ccagggagtg ctggttccag acctggaggc actgggggaa atggctttgc cccaagtggc
     1981 aatggcaatg gctatggccc aggagggaca ggcttcatcc ccatccctgg aggcaatggc
     2041 ttttctcctg gcgttggggg agccggtgtg ggggccgggg gacagggacc tatcatcact
     2101 ggactaacaa ttctgaacca gacaatagat atctgtaagc atcatgctaa cctttgttta
     2161 aatggacgct gtataccaac tgtctcaagc taccgatgtg aatgcaacat gggttataag
     2221 caggatgcaa atggagattg tatagatgtt gatgaatgca catcaaatcc ctgcactaat
     2281 ggagattgtg ttaacacacc tggttcctat tattgtaaat gtcatgctgg attccagagg
     2341 actcctacca agcaagcatg cattgatatt gatgagtgca tccagaatgg ggttctttgt
     2401 aaaaacggtc gatgcgtgaa cacagatgga agtttccagt gcatttgcaa tgccggcttt
     2461 gaattaacta cagatggaaa aaactgtgtt gatcatgatg aatgtacaac taccaacatg
     2521 tgtttgaatg gaatgtgcat caatgaagat ggcagcttca agtgcatctg caaaccagga
     2581 tttgtcttgg ctccaaatgg gcgttactgt actgatgttg atgaatgcca gaccccagga
     2641 atctgcatga atgggcactg catcaacagt gaagggtcct tccgctgtga ctgtccccca
     2701 ggcctggctg tgggcatgga tggacgtgtg tgtgttgata ctcacatgcg cagtacctgc
     2761 tatggaggaa tcaagaaagg agtgtgtgtg cgtcctttcc ccggtgcagt gaccaagtcc
     2821 gaatgctgct gtgccaatcc agactatggt tttggagaac cctgccagcc atgccctgca
     2881 aaaaattcag ctgaattcca cggcctttgt agtagtggag taggtatcac tgtggatgga
     2941 agagatatca atgaatgtgc tttggatcct gatatatgtg ccaatgggat ttgtgaaaac
     3001 ttacgtggta gttaccgttg taattgcaac agtggctatg aaccagatgc ctctggaaga
     3061 aactgtattg acattgatga atgtttagta aacagactgc tttgtgataa cggattgtgc
     3121 cgaaacacgc caggaagtta cagctgtacg tgcccaccag ggtatgtgtt caggactgag
     3181 acagagacct gtgaagatat aaatgaatgt gaaagcaacc catgtgtcaa tggggcctgc
     3241 agaaacaacc ttggatcttt caattgtgaa tgttcgcccg gcagcaaact cagctccaca
     3301 ggattgatct gtattgacag cctgaagggg acctgttggc tcaacatcca ggacagccgc
     3361 tgtgaggtga atattaatgg agccactctg aaatctgaat gctgtgccac cctcggagcc
     3421 gcctggggga gcccctgtga gcggtgtgaa ctagatacag cttgcccaag agggcttgcc
     3481 aggattaaag gtgttacgtg tgaagatgtt aatgagtgtg aggtgttccc tggcgtttgt
     3541 ccaaatggac gctgtgtcaa cagtaaggga tcttttcatt gcgagtgccc tgaaggcctt
     3601 acgttggatg ggactggccg tgtatgtttg gatattcgca tggagcagtg ttacttgaag
     3661 tgggatgaag atgaatgcat ccaccccgtt cctggaaagt tccgcatgga tgcctgctgc
     3721 tgtgctgtcg gggcggcttg gggcaccgag tgtgaggagt gccccaaacc tggcaccaag
     3781 gaatacgaga cgctgtgccc ccgcggggct ggctttgcta accgagggga tgttcttact
     3841 gggcggccat tttacaaaga catcaatgaa tgcaaagcat ttcctgggat gtgcacttat
     3901 gggaagtgca gaaatacaat cggaagcttc aaatgccgtt gcaatagtgg ctttgctcta
     3961 gacatggagg aaagaaactg cacggacatc gacgagtgca ggatttctcc tgacctctgt
     4021 ggcagtggaa tctgcgtcaa tacaccgggc agctttgagt gcgagtgctt cgaaggctat
     4081 gaaagtggct tcatgatgat gaagaactgc atggacattg acgaatgtga acgtaaccct
     4141 ctcctttgta ggggtggcac ctgtgtgaac actgagggca gctttcagtg tgactgccca
     4201 ctgggacacg agctgtcacc atcccgtgag gactgtgtgg atattaatga atgctccctg
     4261 agtgacaatc tctgcagaaa tggaaaatgt gtgaacatga ttggaaccta tcagtgctct
     4321 tgcaatcctg gatatcaggc tacgccagac cgccagggct gtacagatat tgatgaatgt
     4381 atgataatga acggaggctg tgacacccag tgcacaaatt cagagggaag ctacgaatgc
     4441 agctgcagtg agggttatgc cctgatgcca gatgggagat cgtgtgcaga cattgatgaa
     4501 tgtgaaaaca atcctgatat ctgtgatggc ggccagtgta ccaacattcc tggagagtat
     4561 cgctgcctct gctatgatgg cttcatggct tccatggaca tgaaaacatg cattgatgtc
     4621 aatgaatgtg acctaaattc aaatatctgc atgtttgggg aatgtgagaa cacaaaggga
     4681 tccttcattt gccactgtca gctgggttac tcagtgaaga aggggaccac aggatgtaca
     4741 gatgtggatg agtgtgaaat tggtgctcat aactgcgaca tgcatgcctc atgtctgaat
     4801 atcccaggaa gcttcaagtg tagctgcaga gaaggctgga ttggaaacgg catcaagtgt
     4861 attgatctgg acgaatgttc taatggaacc caccagtgta gcatcaatgc tcagtgtgta
     4921 aataccccgg gctcataccg ctgtgcctgc tccgaaggtt tcactggtga tggctttacc
     4981 tgctcagatg ttgatgagtg tgcagaaaac ataaacctct gtgagaacgg acagtgcctt
     5041 aatgtcccgg gtgcatatcg ctgcgagtgt gagatgggct tcactccagc ctcagacagc
     5101 agatcctgcc aagatattga tgaatgctcc ttccaaaaca tttgtgtctt tggaacatgt
     5161 aataacctgc ctggaatgtt tcattgcatc tgcgatgatg gttatgaatt ggacagaaca
     5221 ggagggaact gtacagatat tgatgagtgt gcagatccta taaactgtgt caatggccta
     5281 tgtgtcaaca cgcctggtcg ctatgagtgt aactgcccac ccgattttca gttgaaccca
     5341 actggtgtgg gttgtgttga caaccgtgtg ggcaactgct acctgaagtt tggacctcga
     5401 ggagatggga gtctgtcttg caacaccgag atcggggtgg gcgtcagtcg ctcttcatgc
     5461 tgctgctctc tgggaaaggc ctggggaaac ccctgtgaga catgcccccc tgtcaatagc
     5521 actgaatatt acaccctgtg tcccggaggt gaaggcttca gacctaaccc catcacaatc
     5581 attttagaag acattgacga atgccaggag ttaccaggtc tctgccaggg tggaaactgc
     5641 atcaacactt ttgggagctt ccagtgtgag tgcccacaag gctactacct cagcgaggat
     5701 acccgcatct gtgaagatat tgatgagtgt tttgcacatc ctggtgtgtg tgggcctggg
     5761 acctgctata acaccctggg aaattacacc tgcatttgcc cacctgagta catgcaggtc
     5821 aatggaggcc acaactgcat ggacatgaga aaaagctttt gctaccgaag ctataatgga
     5881 accacttgtg agaatgagtt gcctttcaat gtgacaaaaa ggatgtgctg ctgcacatat
     5941 aatgtgggca aagcctggaa caaaccttgt gaaccatgcc caactccagg aacagctgac
     6001 tttaaaacca tatgtggaaa tattcctgga ttcacctttg acattcacac aggaaaagct
     6061 gttgacattg atgaatgtaa agagattcca ggcatttgtg caaatggtgt gtgcattaac
     6121 cagattggca gtttccgctg tgaatgccct acaggattca gttacaatga cctgctgttg
     6181 gtttgtgaag atatagatga gtgcagcaat ggtgataatc tctgccagcg gaatgcagac
     6241 tgcatcaata gtcctggtag ttaccgctgt gaatgtgccg cgggtttcaa actttcaccc
     6301 aatggggcct gtgtagatcg caatgaatgt ttagaaattc ctaacgtttg cagtcatggc
     6361 ttgtgtgttg atctgcaagg aagttaccag tgcatctgcc acaatggctt taaggcttct
     6421 caggaccaga ccatgtgcat ggatgttgat gagtgcgagc ggcatccatg tggaaatgga
     6481 acttgtaaaa acaccgttgg atcctataac tgtctgtgct acccagggtt tgaactcact
     6541 cataataatg attgcctgga catagatgag tgcagttcct tttttggtca ggtgtgcaga
     6601 aatggacgtt gttttaatga aattggttct ttcaagtgtc tatgtaacga aggttatgaa
     6661 cttaccccag atggcaaaaa ctgtatagac actaatgagt gtgtcgccct tcccggctct
     6721 tgctctcctg gtacctgtca gaatttggag ggatccttca gatgcatctg tcccccaggg
     6781 tatgaagtaa aaagcgagaa ctgcattgat ataaatgaat gtgatgaaga tcccaacatt
     6841 tgtctttttg gttcctgtac taatactcca gggggcttcc agtgcctctg cccccctggc
     6901 tttgtactat ctgataatgg acggagatgc tttgatactc gccagagctt ctgcttcaca
     6961 aattttgaaa atggaaagtg ttctgtaccc aaagctttca acaccacaaa agcaaaatgc
     7021 tgctgtagta agatgccagg agagggctgg ggggacccct gtgagctgtg ccccaaagac
     7081 gatgaagttg catttcagga tttgtgtcca tatggccatg gaactgtccc tagtcttcat
     7141 gatacacgtg aagatgtcaa tgagtgtctt gagagcccag gcatttgttc aaatggtcaa
     7201 tgtatcaaca ccgacggatc ttttcgctgt gaatgtccaa tgggctacaa ccttgactac
     7261 actggagtac gctgtgtgga tactgatgag tgttcaatcg gcaatccgtg tggaaatggt
     7321 acatgcacca atgttattgg gagttttgaa tgcaattgca atgaaggctt tgagccaggg
     7381 cccatgatga attgtgaaga tatcaacgaa tgtgcccaga acccactgct gtgtgctttc
     7441 cgctgcatga acacttttgg gtcctatgaa tgcacgtgcc cgattggcta tgccctcagg
     7501 gaagatcaaa agatgtgcaa agatctggat gaatgtgctg aagggttaca cgactgtgaa
     7561 tctaggggca tgatgtgtaa gaatctaatc ggcaccttca tgtgcatctg ccctcctgga
     7621 atggcccgaa ggcccgatgg agaaggctgt gtagatgaaa atgaatgcag gaccaagcca
     7681 ggaatctgtg aaaatggacg ttgtgttaac attattggaa gctatagatg tgagtgtaat
     7741 gaaggattcc agtcaagttc ttcaggcact gaatgccttg acaatcgaca gggtctctgc
     7801 tttgcagagg tactgcagac aatatgtcaa atggcatcca gtagtcgcaa tctcgtcact
     7861 aagtcagaat gctgctgtga tggtgggcga ggctggggcc accagtgcga gctttgccca
     7921 cttcctggaa ctgcccagta caaaaagata tgtcctcatg gcccaggata tacaactgat
     7981 ggaagagata ttgatgaatg taaggtaatg ccaaacctct gcaccaatgg tcagtgcatc
     8041 aataccatgg gctcattccg atgcttctgc aaggttggct acaccacaga catcagtgga
     8101 acctcttgta tagaccttga tgaatgctcc cagtccccga aaccatgcaa ctacatctgc
     8161 aagaacactg aggggagtta tcagtgttca tgtccgaggg ggtatgtcct gcaagaggat
     8221 ggaaagacat gcaaagacct tgatgaatgt caaacaaagc agcataactg ccagttcctc
     8281 tgtgtcaaca ccctgggggg gtttacctgt aaatgtccac ctggtttcac acagcatcac
     8341 actgcttgta tcgacaacaa cgaatgtggg tctcaacctt cgctttgtgg agcaaaggga
     8401 atctgtcaaa acactccagg cagtttcagc tgtgaatgcc aaagagggtt ctctcttgat
     8461 gccaccggac tgaactgtga agatgttgat gaatgtgatg ggaaccacag gtgccaacac
     8521 ggctgccaga acatcctggg tggctacaga tgtggctgcc cccaaggcta catccagcac
     8581 taccagtgga atcagtgtgt cgatgagaat gaatgctcca atcccaatgc ctgtggctct
     8641 gcttcctgct acaacaccct ggggagttac aagtgcgcct gcccctcggg gttctccttc
     8701 gaccagttct ccagtgcctg ccacgacgtg aatgagtgct cgtcctccaa gaacccctgc
     8761 aattacggct gctctaacac ggaggggggc tacctctgtg gctgcccccc tgggtattac
     8821 agagtgggac aaggccactg tgtctcagga atgggattta acaaggggca gtacctgtca
     8881 ctggatacag aggtcgatga ggaaaatgct ctgtccccag aagcatgcta cgagtgcaaa
     8941 atcaacggct attctaagaa agacagcagg cagaagagaa gtattcatga acctgatccc
     9001 actgctgttg aacagatcag cctagagagt gtcgacatgg acagccccgt caacatgaag
     9061 ttcaacctct cccacctcgg ctctaaggag cacatcctgg aactaaggcc cgccatccag
     9121 cccctcaaca accacatccg ttatgtcatc tctcaaggga acgatgacag cgtcttccgc
     9181 atccaccaaa ggaatgggct cagctacttg cacacggcca agaagaagct catgcccggc
     9241 acatacacac tggaaatcac tagcatccct ctctacaaga agaaggagct taagaaactg
     9301 gaagagagca atgaggatga ctacctccta ggggagcttg gggaggctct cagaatgagg
     9361 ctgcagattc agctctatta acccttcaca gacttgggcc caggctcaaa tcctagcaca
     9421 gccagtctgc agaagcattt gaaaagtcaa ggactaattt taaagaggaa aaataataat
     9481 aactcttgtt tctttcctcc ctgtcttaga ctttgaatgt tgaccctcac agggagggat
     9541 aatttagact ctggtatggc caaagatttg agcacaaagg caaccgtggt tactgtattt
     9601 tttatataac ttcattttaa aatatattaa aagaaaccta aatgttcaag atatcagcat
     9661 atggcactaa atgcacaaaa ataatgtgag cttttttttt ttttcctgtt agcagtctgt
     9721 aacactttgg gtattttgct atagttgcta attaaaaaaa tatagatgtt tatttatttt
     9781 taatgcagta atatatggag aaatgaacaa actatgtaaa caaaaaggga aactcacttg
     9841 tttttcttta gatttataaa tttgagctat tttttttaga ggtgcttttt aaaaatccaa
     9901 tagatacaag agatgtttcc tttggttttc tgccagtcat ccagctgata cacacctgat
     9961 gattttaaag aaagccacac agagctgaat gggcagtgta atcaataatt taaaaaacat
    10021 gaatgtcatt agatccttta taacgtagat cgaagccaaa gcagctcatt tgtgacaaca
    10081 tttcatatca ccagacacac caggcaacag aagttgaagc acaaccactg tagcaaaata
    10141 ccttgactgc ttgtgagacc attagcattg caggccaaac cgtactgtat ttccttctca
    10201 taacctcaag gaaccatatg tgctacccac aacacctcat tcttacccag ggtgcgctgc
    10261 gtcctcatgg tactgtaggc agctgaagaa ccgccgttcc cttgaaaggg aacacctggc
    10321 attctgtggt gtttcgtgct gtcttaaata atggtgcatt tattatgttc aagttatttc
    10381 aggattgcca tatgtgcaaa caaatcatgc aatgcagcca aggaatatat gttgttgttg
    10441 ttgttttaaa cccatttttt ttttagaatt ttcattaata ctgtagttat acaccatatg
    10501 cctcatttta tcatagccta ttgtgtatga aagatgtttg tacaatgaat tgatgtttag
    10561 tttgctttag tcatttaaaa agatattgta ccaggatgtg ctattaagag cacgtatcca
    10621 ttattcttct caacccaaga acctgtttcc tggaccagtg accaaacctc atatgtgaaa
    10681 tggccaaagc acatgcaggc tcctggttgt tcctctcaaa cctgtgctga ccaaagatta
    10741 gtaaccagtt atacccagta ttttgaggtt ttattgtttt tttaataact aaaaagaaaa
    10801 aaggaacagt gtaaatttgt aatcaagagt ttgtgaggaa aaacttatgg tttttggttt
    10861 tgtttgtttt tgtaggtctg tgtatcaaat atgacacttt tcttgcaata aagcttattt
    10921 tggggta
//
