LOCUS       NM_000138              11609 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens fibrillin 1 (FBN1), transcript variant 1, mRNA.
ACCESSION   NM_000138
VERSION     NM_000138.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11609)
  AUTHORS   Dougarem,D., Chen,Y.X., Sun,Y.N., Huang,H.F. and Luo,Q.
  TITLE     A Novel Heterozygous Intronic FBN1 Variant Contributes to Aberrant
            RNA Splicing in Marfan Syndrome
  JOURNAL   Mol Genet Genomic Med 12 (9), e70004 (2024)
   PUBMED   39219382
  REMARK    GeneRIF: A Novel Heterozygous Intronic FBN1 Variant Contributes to
            Aberrant RNA Splicing in Marfan Syndrome.
REFERENCE   2  (bases 1 to 11609)
  AUTHORS   Romere,C., Duerrschmid,C., Bournat,J., Constable,P., Jain,M.,
            Xia,F., Saha,P.K., Del Solar,M., Zhu,B., York,B., Sarkar,P.,
            Rendon,D.A., Gaber,M.W., LeMaire,S.A., Coselli,J.S., Milewicz,D.M.,
            Sutton,V.R., Butte,N.F., Moore,D.D. and Chopra,A.R.
  TITLE     Asprosin, a Fasting-Induced Glucogenic Protein Hormone
  JOURNAL   Cell 165 (3), 566-579 (2016)
   PUBMED   27087445
  REMARK    GeneRIF: Authors discovered a protein hormone that regulates
            glucose homeostasis. It is the C-terminal cleavage product of
            profibrillin (encoded by FBN1). Its absence in humans results in a
            unique pattern of metabolic dysregulation that includes partial
            lipodystrophy, accompanied by reduced plasma insulin, while
            maintaining euglycemia.
REFERENCE   3  (bases 1 to 11609)
  AUTHORS   Ramachandra,C.J., Mehta,A., Guo,K.W., Wong,P., Tan,J.L. and Shim,W.
  TITLE     Molecular pathogenesis of Marfan syndrome
  JOURNAL   Int J Cardiol 187, 585-591 (2015)
   PUBMED   25863307
  REMARK    GeneRIF: Progressive pathological aortic root enlargement as the
            result of degeneration of microfibril architecture and
            consequential loss of extracellular matrix integrity due to
            fibrillin-1 (FBN1) mutations are commonly diagnosed clinical
            manifestations of MFS.
            Review article
REFERENCE   4  (bases 1 to 11609)
  AUTHORS   Marzin,P. and Cormier-Daire,V.
  TITLE     Geleophysic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301776
REFERENCE   5  (bases 1 to 11609)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   6  (bases 1 to 11609)
  AUTHORS   Dietz,H.
  TITLE     FBN1-Related Marfan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301510
REFERENCE   7  (bases 1 to 11609)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   8  (bases 1 to 11609)
  AUTHORS   Marzin,P., Cormier-Daire,V. and Tsilou,E.
  TITLE     Weill-Marchesani Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301293
REFERENCE   9  (bases 1 to 11609)
  AUTHORS   Magenis,R.E., Maslen,C.L., Smith,L., Allen,L. and Sakai,L.Y.
  TITLE     Localization of the fibrillin (FBN) gene to chromosome 15, band
            q21.1
  JOURNAL   Genomics 11 (2), 346-351 (1991)
   PUBMED   1769651
REFERENCE   10 (bases 1 to 11609)
  AUTHORS   Maslen,C.L., Corson,G.M., Maddox,B.K., Glanville,R.W. and
            Sakai,L.Y.
  TITLE     Partial sequence of a candidate gene for the Marfan syndrome
  JOURNAL   Nature 352 (6333), 334-337 (1991)
   PUBMED   1852207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084757.2, BC146854.1 and
            AC084758.3.
            
            On Sep 26, 2019 this sequence version replaced NM_000138.4.
            
            Summary: This gene encodes a member of the fibrillin family of
            proteins. The encoded preproprotein is proteolytically processed to
            generate two proteins including the extracellular matrix component
            fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an
            extracellular matrix glycoprotein that serves as a structural
            component of calcium-binding microfibrils. These microfibrils
            provide force-bearing structural support in elastic and nonelastic
            connective tissue throughout the body. Asprosin, secreted by white
            adipose tissue, has been shown to regulate glucose homeostasis.
            Mutations in this gene are associated with Marfan syndrome and the
            related MASS phenotype, as well as ectopia lentis syndrome,
            Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and
            neonatal progeroid syndrome. [provided by RefSeq, Apr 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63556.1, BC146854.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316623.10/ ENSP00000325527.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC084757.2         45417-45471         c
            56-9245             BC146854.1         1-9190
            9246-11609          AC084758.3         137809-140172       c
FEATURES             Location/Qualifiers
     source          1..11609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..11609
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="fibrillin 1"
                     /db_xref="GeneID:2200"
                     /db_xref="HGNC:HGNC:3603"
                     /db_xref="MIM:134797"
     exon            1..135
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..480
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..8932
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 1; fibrillin 15; fibrillin-1 preproprotein;
                     asprosin; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="fibrillin-1 isoform a preproprotein"
                     /protein_id="NP_000129.3"
                     /db_xref="CCDS:CCDS32232.1"
                     /db_xref="GeneID:2200"
                     /db_xref="HGNC:HGNC:3603"
                     /db_xref="MIM:134797"
                     /translation="MRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKR
                     RGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTC
                     PSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRC
                     VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWG
                     HPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAG
                     HKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPG
                     YCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVP
                     MVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVT
                     DYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQ
                     GSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRD
                     GKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICM
                     NGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSE
                     CCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICE
                     NLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIY
                     KPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQT
                     VIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDEC
                     EVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIA
                     GRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDIN
                     ECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVN
                     TPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQL
                     SPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIM
                     NGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYR
                     CLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGC
                     TDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHA
                     DCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFV
                     PSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDP
                     TTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNE
                     IGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDEC
                     QELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVG
                     NYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIG
                     RAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCIN
                     MVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFT
                     STGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDAC
                     GNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQC
                     NEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDE
                     CVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPK
                     SRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECK
                     EPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFEC
                     TCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDE
                     DECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR
                     CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC
                     CDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDR
                     GSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDG
                     RSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSK
                     GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGY
                     LQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGS
                     AQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSP
                     EACYECKINGYPKRGRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISH
                     VSNKVRILELLPALTTLTNHNRYLIESGNEDGFFKINQKEGISYLHFTKKKPVAGTYS
                     LQISSTPLYKKKELNQLEDKYDKDYLSGELGDNLKMKIQVLLH"
     exon            481..563
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..662
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..758
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..854
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1052
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1178
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1304
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1463
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1643
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1784
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1904
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2030
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2153
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2276
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2429
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2483
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2609
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2735
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2855
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2993
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3044
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3170
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3398
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3524
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3653
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3779
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3905
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4028
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4154
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4280
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4403
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4526
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4652
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4653..4775
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4898
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..5063
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5064..5132
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5258
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5381
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5382..5540
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5541..5612
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5613..5738
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..5861
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5862..5987
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5988..6104
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6105..6233
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6234..6353
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6354..6479
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6480..6629
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6630..6695
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6696..6812
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6813..6932
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6933..7055
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7056..7187
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7188..7313
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7314..7520
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7521..7646
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7647..7769
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7770..7886
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7887..8015
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8016..8135
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8136..8367
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8368..8542
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8543..11609
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9819..9824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="hexamer: AATAAA"
     polyA_site      9849
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="major polyA site"
     regulatory      9908..9913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="hexamer: AATAAA"
     polyA_site      9932
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
     regulatory      11589..11594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
                     /note="hexamer: AATAAA"
     polyA_site      11609
                     /gene="FBN1"
                     /gene_synonym="ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS;
                     MFS1; OCTD; SGS; SSKS; WMS; WMS2"
ORIGIN      
        1 agagactgtg ggtgccacaa gcggacagga gccacagctg ggacagctgc gagcggagcc
       61 gagcagtggc tgtagcggcc acgactggga gcagccgccg ccgcctcctc gggagtcgga
      121 gccgccgctt ctccactggc aggggccgcc tgaagtggga gcagcgcctg gagaaggcgg
      181 gaggagcccg gcccggggga cgggcggcgg gatagcggga ccccggcggc gcggtgcgct
      241 tcagggcgca gcggcggccg cagaccgagc cccgggcgcg gcaagaggcg gcgggagccg
      301 gtggcggctc ggcatcatgc gtcgagggcg tctgctggag atcgccctgg gatttaccgt
      361 gcttttagcg tcctacacga gccatggggc ggacgccaat ttggaggctg ggaacgtgaa
      421 ggaaaccaga gccagtcggg ccaagagaag aggcggtgga ggacacgacg cgcttaaagg
      481 acccaatgtc tgtggatcac gttataatgc ttactgttgc cctggatgga aaaccttacc
      541 tggcggaaat cagtgtattg tccccatttg ccggcattcc tgtggggatg gattttgttc
      601 gaggccaaat atgtgcactt gcccatctgg tcagatagct ccttcctgtg gctccagatc
      661 catacaacac tgcaatattc gctgtatgaa tggaggtagc tgcagtgacg atcactgtct
      721 atgccagaaa ggatacatag ggactcactg tggacaacct gtttgtgaaa gtggctgtct
      781 caatggagga aggtgtgtgg ccccaaatcg atgtgcatgc acttacggat ttactggacc
      841 ccagtgtgaa agagattaca ggacaggccc atgttttact gtgatcagca accagatgtg
      901 ccagggacaa ctcagcggga ttgtctgcac aaaaacgctc tgctgtgcca cagtcggccg
      961 agcctggggc cacccctgtg agatgtgtcc tgcccagcct cacccctgcc gccgtggctt
     1021 cattccaaat atccgcacgg gagcttgtca agatgtggat gaatgccagg ccatccccgg
     1081 gctctgtcag ggaggaaatt gcattaatac tgttgggtct tttgagtgca aatgccctgc
     1141 tggacacaaa cttaatgaag tgtcacaaaa atgtgaagat attgatgaat gcagcaccat
     1201 tcctggaatc tgtgaagggg gtgaatgtac aaacacagtc agcagttact tttgcaaatg
     1261 tccccctggt ttttacacct ctccagatgg taccagatgc atagatgttc gcccaggata
     1321 ctgttacaca gctctgacaa acgggcgctg ctctaaccag ctgccacagt ccataaccaa
     1381 aatgcagtgc tgctgtgatg ccggccgatg ctggtctcca ggggtcactg tcgcccctga
     1441 gatgtgtccc atcagagcaa ccgaggattt caacaagctg tgctctgttc ctatggtaat
     1501 tcctgggaga ccagaatatc ctcccccacc ccttggcccc attcctccag ttctccctgt
     1561 tcctcctggc tttcctcctg gacctcaaat tccggtccct cgaccaccag tggaatatct
     1621 gtatccatct cgggagccac caagggtgct gccagtaaac gttactgatt actgccagtt
     1681 ggtccgctat ctctgtcaaa atggacgctg cattccaact cctgggagtt accggtgtga
     1741 gtgcaacaaa gggttccagc tggacctccg tggggagtgt attgatgttg atgaatgtga
     1801 gaaaaacccc tgtgctggtg gtgagtgtat taacaaccag ggttcgtaca cctgtcagtg
     1861 ccgagctgga tatcagagca cactcacgcg gacagaatgc cgagacattg atgagtgttt
     1921 acagaatggc cggatctgca ataatggacg ctgcatcaac acagatggca gttttcattg
     1981 cgtgtgtaat gcgggctttc atgttacacg agatgggaag aactgtgaag atatggatga
     2041 atgcagcata aggaacatgt gccttaatgg aatgtgtatc aatgaagatg gcagttttaa
     2101 atgtatttgc aaacctggat tccagctggc atcagatgga cgttattgca aagacattaa
     2161 cgagtgtgaa acccctggga tctgcatgaa tgggcgttgc gtcaacactg atggctccta
     2221 cagatgtgaa tgcttccctg gactggctgt gggtctggat ggccgtgtgt gtgttgacac
     2281 acacatgcgg agcacatgct atggtggata caagagaggc cagtgtatca aacctttgtt
     2341 tggtgctgtc actaaatctg aatgctgttg cgccagcact gagtatgcat ttggggaacc
     2401 ttgccagccg tgtcctgcac agaattcagc ggaatatcag gcactctgca gcagtgggcc
     2461 aggaatgacg tcagcaggca gtgatataaa tgaatgtgca ctagatcctg atatttgccc
     2521 aaatggaatc tgtgaaaacc ttcgtgggac ctataaatgt atatgcaatt caggatatga
     2581 agtggattca actgggaaaa actgcgttga tattaatgaa tgtgtactga acagtctcct
     2641 ttgtgacaat ggacaatgta gaaatactcc tggaagtttt gtctgtacct gccccaaggg
     2701 atttatctac aaacctgatc taaaaacatg tgaagacatt gatgaatgcg aatcaagtcc
     2761 ttgcattaat ggagtctgca agaacagccc aggctctttt atttgtgaat gttcttctga
     2821 aagtactttg gatccaacaa aaaccatctg catagaaacc atcaagggca cttgctggca
     2881 gactgtcatt gatgggcgat gtgagatcaa catcaatgga gccaccttaa agtcccagtg
     2941 ctgctcctcc ctcggtgctg cgtggggaag cccgtgcacc ctatgccaag ttgatcccat
     3001 atgtggtaaa gggtactcaa gaattaaagg aacacaatgt gaagatatag atgaatgtga
     3061 agtgttccca ggagtgtgta aaaatggcct gtgtgttaac actagggggt cattcaagtg
     3121 tcagtgtccc agtggaatga ctttggatgc cacaggaagg atctgtcttg atatccgcct
     3181 ggaaacctgc ttcctgaggt acgaggacga ggagtgcacc ctgcctattg ctggccgcca
     3241 ccgcatggac gcctgctgct gctccgtcgg ggcagcctgg ggtactgagg aatgcgagga
     3301 gtgtcccatg agaaatactc ctgagtacga ggagctgtgt ccgagaggac ccggatttgc
     3361 cacaaaagaa attacaaatg gaaagccttt cttcaaagat atcaatgagt gcaagatgat
     3421 acccagcctc tgcacccacg gcaagtgcag aaacaccatt ggcagcttta agtgcaggtg
     3481 tgacagcggc tttgctcttg attctgaaga aaggaactgc acagacattg acgaatgccg
     3541 catatctcct gacctctgtg gcagaggcca gtgtgtgaac acccctgggg actttgaatg
     3601 caagtgtgac gaaggctatg aaagtggatt catgatgatg aagaactgca tggatattga
     3661 tgagtgtcag agagatcctc tcctatgccg aggtggtgtt tgccataaca cagagggaag
     3721 ttaccgctgt gaatgcccgc ctggccatca gctgtccccc aacatctccg cgtgtatcga
     3781 catcaatgaa tgtgagctga gtgcacacct gtgccccaat ggccgttgcg tgaacctcat
     3841 agggaagtat cagtgtgcct gcaaccctgg ctaccattca actcccgata ggctattttg
     3901 tgttgacatt gatgaatgca gcataatgaa tggtggttgt gaaaccttct gcacaaactc
     3961 tgaaggcagc tatgaatgta gctgtcagcc gggatttgca ctaatgcctg accagagatc
     4021 atgcaccgac atcgatgagt gtgaagataa tcccaatatc tgtgatggtg gtcagtgcac
     4081 aaatatccct ggagagtaca ggtgcttgtg ttatgatgga ttcatggcat ctgaagacat
     4141 gaagacttgt gtagatgtca atgagtgtga cctgaatcca aatatctgcc taagtgggac
     4201 ctgtgaaaac acgaaaggct catttatctg ccactgtgat atgggctact ccggcaaaaa
     4261 aggaaaaact ggctgtacag acatcaatga atgtgaaatt ggagcacaca actgtggcaa
     4321 acatgctgta tgtaccaata cagcaggaag cttcaaatgt agctgcagtc ccgggtggat
     4381 tggagatggc attaagtgca ctgatctgga cgaatgttcc aatggaaccc atatgtgcag
     4441 ccagcatgca gactgcaaga ataccatggg atcttaccgc tgtctgtgca aggaaggata
     4501 cacaggtgat ggcttcactt gtacagacct tgatgagtgc tctgagaacc tgaatctctg
     4561 tggcaatggc cagtgcctca atgcaccagg aggataccgc tgtgaatgcg acatgggctt
     4621 cgtgcccagt gctgacggga aagcctgtga agatattgat gagtgctccc ttccgaacat
     4681 ctgtgtcttt ggaacttgcc acaacctccc tggcctgttc cgctgtgagt gtgagatagg
     4741 ctacgaactg gacagaagcg gcgggaactg cacagatgtg aatgaatgcc tggatccaac
     4801 cacgtgcatc agtgggaact gtgtcaacac tccaggcagc tatatctgtg actgcccacc
     4861 tgattttgaa ctgaacccaa ctcgagttgg ctgtgttgat acccgctctg gaaattgcta
     4921 tttggatatt cgacctcgag gagacaatgg agatacagcc tgcagcaatg aaattggagt
     4981 tggtgtttcc aaagcttcct gctgctgttc tctgggtaaa gcctggggta ctccttgtga
     5041 gatgtgtcct gctgtgaaca catccgagta caaaattctt tgtcctggag gggaaggttt
     5101 ccgaccaaat cctatcaccg ttatattgga agatattgat gagtgccagg agctaccagg
     5161 gctgtgccaa ggaggaaaat gtatcaacac ctttgggagt ttccagtgcc gctgtccaac
     5221 cggctactac ctgaatgaag atacacgagt gtgtgatgat gtgaatgaat gtgagactcc
     5281 tggaatctgt ggtccaggga catgttacaa caccgttggc aactacacct gtatctgtcc
     5341 tccagactac atgcaagtga atgggggaaa taattgcatg gatatgagaa gaagtttgtg
     5401 ctacagaaac tactatgctg acaaccagac ctgtgatgga gaattgttat tcaacatgac
     5461 caagaagatg tgctgctgtt cctacaacat tggccgggcg tggaacaagc cctgtgaaca
     5521 gtgtcccatc ccaagtacag atgagtttgc tacactctgt ggaagtcaaa ggccaggctt
     5581 tgtcatcgac atttataccg gtttacccgt tgatattgat gagtgccggg agatcccagg
     5641 ggtctgtgaa aatggagtgt gtatcaacat ggttggcagc ttccgatgtg aatgtccagt
     5701 gggattcttc tataatgaca agttgttggt ttgtgaagat attgacgagt gtcagaacgg
     5761 cccagtgtgc cagcgcaacg ccgaatgcat caacactgca ggcagctacc gctgtgactg
     5821 taagcccggc taccgcttca cctccacagg acagtgcaat gatcgtaatg aatgtcaaga
     5881 aatccccaat atatgcagtc atgggcagtg cattgacaca gttggaagct tttattgcct
     5941 ttgccacact ggttttaaaa caaatgatga ccaaaccatg tgcttggaca taaatgaatg
     6001 tgaaagagat gcctgtggga atggaacttg ccggaacaca attggttcct tcaactgccg
     6061 ctgcaatcat ggtttcatcc tttctcacaa caatgactgt atagatgttg atgaatgtgc
     6121 aagtggaaat gggaatcttt gcagaaatgg ccaatgcatt aatacagtgg ggtctttcca
     6181 gtgccagtgc aatgaaggct atgaggtggc tccagatggg aggacctgtg tggatatcaa
     6241 tgaatgtctt ctagaaccca gaaaatgtgc accaggtacc tgtcaaaact tggatgggtc
     6301 ctacagatgc atttgcccac ctggatacag tcttcaaaat gagaagtgtg aagatattga
     6361 tgagtgtgtc gaagagccag aaatttgtgc cctgggcaca tgcagtaaca ctgaaggcag
     6421 cttcaaatgt ctgtgtccag aagggttttc cttgtcctcc agtggaagaa ggtgccaaga
     6481 tttgcgaatg agctactgtt atgcgaagtt tgaaggagga aagtgttcat cacccaaatc
     6541 cagaaatcac tccaagcagg aatgctgctg tgccttgaag ggagaaggct ggggagaccc
     6601 ctgcgagctc tgccccacgg aacctgatga ggccttccgc cagatatgtc cttatggaag
     6661 tgggatcatc gtgggacctg atgattcagc agttgatatg gacgaatgca aagaacccga
     6721 tgtctgtaaa catggacagt gcatcaatac agatggttcc tatcgctgcg agtgtccctt
     6781 tggttatatt ctagcaggga atgaatgtgt agatactgat gaatgttctg ttggcaatcc
     6841 ttgtggaaat ggaacctgca agaatgtgat tggaggtttt gaatgcacct gcgaggaggg
     6901 atttgagccc ggtccaatga tgacatgtga agatataaat gaatgtgccc agaatcctct
     6961 gctctgtgcc ttccgatgtg tgaacactta tgggtcatat gaatgcaaat gtcccgtggg
     7021 atatgtgctc agagaagacc gtaggatgtg caaagatgag gatgagtgtg aagagggaaa
     7081 acatgactgt actgaaaaac aaatggaatg caagaacctc attggcacat atatgtgcat
     7141 ctgtggaccc gggtatcagc ggagacctga tggagaaggc tgtgtagatg agaatgaatg
     7201 tcagacgaag ccagggatct gtgagaatgg gcgctgcctc aacacccgtg ggagctacac
     7261 ctgtgagtgt aatgatgggt ttaccgccag ccccaaccag gacgagtgcc ttgacaatcg
     7321 ggaagggtac tgcttcacag aggtgctaca aaacatgtgt cagatcggct ccagcaacag
     7381 gaaccccgtc accaaatcgg aatgctgctg tgacggaggg agaggctggg gtccccactg
     7441 tgagatctgc cctttccagg ggactgtggc tttcaagaaa ctctgtcccc atggccgagg
     7501 attcatgacc aatggagcag atatcgatga atgcaaggtt attcacgatg tttgccgaaa
     7561 tggggaatgt gtcaatgaca gaggatcata tcattgcatt tgtaaaactg ggtacactcc
     7621 agatataact gggacttcct gtgtagatct gaacgagtgc aaccaggctc ccaaaccctg
     7681 caattttatc tgcaaaaaca cagaagggag ttaccagtgt tcatgcccga aaggctacat
     7741 tctgcaagag gatggaagga gctgcaaaga tcttgatgag tgtgcaacca agcaacacaa
     7801 ctgccagttc ctatgtgtta acaccattgg cggcttcaca tgcaaatgtc ctcccggatt
     7861 tacccaacac catacgtcct gcattgataa caatgaatgc acctctgaca tcaatctgtg
     7921 cgggtctaag ggcatttgcc agaacactcc tggaagcttc acctgtgaat gccagcgggg
     7981 attctcactt gatcagaccg gctccagctg tgaagacgtg gacgagtgtg agggtaacca
     8041 ccgctgccag catggctgcc agaacatcat tgggggctac aggtgcagct gcccccaggg
     8101 ctacctccag cactaccagt ggaaccagtg tgttgatgaa aacgaatgcc tcagcgctca
     8161 catctgcgga ggagcctcct gtcacaacac cctggggagc tacaagtgca tgtgtcccgc
     8221 cggcttccag tatgaacagt tcagtggagg atgccaagac atcaatgaat gtggctctgc
     8281 gcaggccccc tgcagctatg gctgttccaa taccgagggc ggttacctgt gtggctgtcc
     8341 acctggttac ttccgcatag gccaagggca ctgtgtttct ggaatgggca tgggccgagg
     8401 aaacccagag ccacctgtca gtggtgaaat ggatgacaat tcactctccc cagaggcttg
     8461 ttacgagtgt aagatcaatg gctaccccaa acggggcagg aaacggagaa gcacaaacga
     8521 aactgatgcc tccaatatcg aggatcagtc tgagacagaa gccaatgtga gtcttgcaag
     8581 ttgggatgtt gagaagacag ccatctttgc tttcaatatt tcccacgtca gtaacaaggt
     8641 tcgaatccta gaactccttc cagctcttac aactctgacg aatcacaaca gatacttgat
     8701 cgaatctgga aatgaagatg gcttctttaa aatcaaccaa aaggaaggga tcagctacct
     8761 ccacttcaca aagaagaagc cagtggctgg aacctattca ttacaaatca gtagtactcc
     8821 actttataaa aagaaagaac ttaaccaact agaagacaaa tatgacaaag actacctcag
     8881 tggtgaactg ggtgataatc tgaagatgaa aatccaggtt ttgcttcatt aattcaccat
     8941 ccagagacca aataattaaa agaaaaacaa atatagatag gtagaactat attttccccc
     9001 aatcagaatc atcatatcat aggtacaatc tttcaccaag taaatttgta taaataagca
     9061 ctattctttg tattaccaaa gcaaggtaca ggtgactacc ctagttcaaa acaaccactt
     9121 tctcaggctt ctcatgtgtg tagctaagct accttgtcat atgtgttgat tcttgaaaac
     9181 tgggacgtgt atttccattg ggggttggcc atttatgctg acatgccatc cttccagcaa
     9241 acgtacggga atgtgctttc aattgatgga ctactctatt ttttgcaaat ttgtaaactt
     9301 tgcttctcca aatacaagta ctaggttgtc catttatggt acctatttgg tgctagtaaa
     9361 ttttcaaact agatttataa atgcactgta atatgtacac aacttagaaa ccaaattaca
     9421 agtattcagt tccaatactt cattaatttc aatcaaccaa agttagttca gtagcttatc
     9481 tcagttatga gtataataca ttacatgtaa attaagtgtg tgtatactgt aatcgtgcta
     9541 ttttttatca ttgaaacatt tataaactag aataataatg cccttaatgt gagggtttgt
     9601 aatggtgctt attaagacca aagacttgtt aaatgtatac accaagtggt aatgaaattt
     9661 cggtgactgg cccacacgtg catagaggtc tgggaggacc aggaaacagc ctcagtggcc
     9721 agaggatcac cagtgcatcc ttcatcacag catgtgcaat atgccaagat taccctcggt
     9781 cattcctgtc aacaaggggt caatgtcata aatgtcacaa taaaacaatc tcttcttttt
     9841 tttagtttac cccttggctt tgtgttcttg catggatttg gggttggagg ggccattccg
     9901 gaggctaaat aaagtctcct ggatttaaat tatcctgggt ctcttactta tggcttatga
     9961 aagtaccaaa tgtataacca ctagaagaaa atttaacata tgagtcgatc ccttgtttta
    10021 tccattgaaa gtagcagagt ctggtgtcat taacctgact tgcttgtgag aaatttagat
    10081 tgtagagtca tttctgaaac atgacctaat tcatcttgtg acttttaaat agtcttaaat
    10141 accaagttca gtcattgtct tagagcacat gaatttcatt ataatagatt tatcatgccc
    10201 ccctctcaaa tatacacagt tttggcaagc cttaggtgtt ctgttccatt tttttttccc
    10261 ctaaacatct ttcgttagtc aatgctcatc taattacaaa gggataatcc cagactgtat
    10321 ccaattgctg taacttttgg tttcttaatg tcataatttt taaagtctgt tttattttaa
    10381 gtgcaatatt gagtatttag ctgttaggct caatccgtcg atatgaaata attttttaaa
    10441 tccctaaggg caggaaagca tttcgtggta gtgaaaataa gaggaaataa gatggcatga
    10501 aggtggtggg cggagaaact aggtaggaca caggaaagtg ctctcaaaaa tctttgaaga
    10561 gctcagctga aaaaaatgga gtagatttgg ctcatactat tccggaaggc aaaaccaggg
    10621 tcagctgatg tcagccccag tttaatacac acggtcccaa ttatagagct actcactgaa
    10681 agaatgggtt tccttgcatt gtggtgagct ccctgtcaca agatagaaga gtttcagtct
    10741 aggcttaatg gcaaccattg gacaaagatg ctttcttcca cctaacaggc cattaacatc
    10801 ttaaaggtat ttttgtatct ctaattttgt ttataatagg tgctcaacag aatgagctga
    10861 atggctgtta caaagggggt ttgtaccttg ggtaagagat taaaatataa ctcaaaattt
    10921 ccttctaacg ctgcacctat ggaaccatgt gatagaggtg tattaaaatt gttatcgaag
    10981 aatatatagc atatggtaaa caacagtttg catatggaaa atgtctttga taatttaacc
    11041 agaactgcat tatattcaat aacggatttt ctttataaca aacaacaggg gaaaatggag
    11101 ttggcacaca gtggatcact ttgatatttt taatagtcca agtctggatt ttatttattc
    11161 ctgagccaac aattttgaac agcatatttt ccatgtttct gactgtaaca aaacattttc
    11221 ctcattgttc cattgtaaat attcctcttg ttggaactct ttttaatcct gagatttaaa
    11281 cctgtacctt tcaattgtct gtgacctttc aatttcactt tcaatagttg aagaacttgg
    11341 ctttgtaaat ctctcagaag cttgaaaata tcttgtctct accccctcag cccatttcat
    11401 ttgccaataa ttattttgta agtagggttg aaatgaactc agctggcctt gtgaaatgtt
    11461 taaacttgca caaacaacta catttttgtt caacaaatag cagtttactc agccaaaatc
    11521 actttggata ttgccattac aaatactgtt aaacttcaga aatcatgtct gtaaattaga
    11581 tgagccaaaa taaaggacaa ttgggttga
//
