LOCUS       NM_001436               1125 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibrillarin (FBL), mRNA.
ACCESSION   NM_001436
VERSION     NM_001436.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Liu,Y., Shi,Q., Liu,Y., Li,X., Wang,Z., Huang,S., Chen,Z. and He,X.
  TITLE     Fibrillarin reprograms glucose metabolism by driving the
            enhancer-mediated transcription of PFKFB4 in liver cancer
  JOURNAL   Cancer Lett 602, 217190 (2024)
   PUBMED   39182558
  REMARK    GeneRIF: Fibrillarin reprograms glucose metabolism by driving the
            enhancer-mediated transcription of PFKFB4 in liver cancer.
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Sun,X., Gao,C., Xu,X., Li,M., Zhao,X., Wang,Y., Wang,Y., Zhang,S.,
            Yan,Z., Liu,X. and Wu,C.
  TITLE     FBL promotes cancer cell resistance to DNA damage and BRCA1
            transcription via YBX1
  JOURNAL   EMBO Rep 24 (9), e56230 (2023)
   PUBMED   37489617
  REMARK    GeneRIF: FBL promotes cancer cell resistance to DNA damage and
            BRCA1 transcription via YBX1.
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Decle-Carrasco,S., Rodriguez-Pina,A.L., Rodriguez-Zapata,L.C. and
            Castano,E.
  TITLE     Current research on viral proteins that interact with fibrillarin
  JOURNAL   Mol Biol Rep 50 (5), 4631-4643 (2023)
   PUBMED   36928641
  REMARK    GeneRIF: Current research on viral proteins that interact with
            fibrillarin.
            Review article
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Okano,Y., Steen,V.D. and Medsger,T.A. Jr.
  TITLE     Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in
            patients with systemic sclerosis
  JOURNAL   Arthritis Rheum 35 (1), 95-100 (1992)
   PUBMED   1731817
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Baserga,S.J., Yang,X.D. and Steitz,J.A.
  TITLE     An intact Box C sequence in the U3 snRNA is required for binding of
            fibrillarin, the protein common to the major family of nucleolar
            snRNPs
  JOURNAL   EMBO J 10 (9), 2645-2651 (1991)
   PUBMED   1714385
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Jansen,R.P., Hurt,E.C., Kern,H., Lehtonen,H., Carmo-Fonseca,M.,
            Lapeyre,B. and Tollervey,D.
  TITLE     Evolutionary conservation of the human nucleolar protein
            fibrillarin and its functional expression in yeast
  JOURNAL   J Cell Biol 113 (4), 715-729 (1991)
   PUBMED   2026646
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Aris,J.P. and Blobel,G.
  TITLE     cDNA cloning and sequencing of human fibrillarin, a conserved
            nucleolar protein recognized by autoimmune antisera
  JOURNAL   Proc Natl Acad Sci U S A 88 (3), 931-935 (1991)
   PUBMED   1846968
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Lischwe,M.A., Ochs,R.L., Reddy,R., Cook,R.G., Yeoman,L.C.,
            Tan,E.M., Reichlin,M. and Busch,H.
  TITLE     Purification and partial characterization of a nucleolar
            scleroderma antigen (Mr = 34,000; pI, 8.5) rich in
            NG,NG-dimethylarginine
  JOURNAL   J Biol Chem 260 (26), 14304-14310 (1985)
   PUBMED   2414294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG831506.1 and BC019260.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001436.3.
            
            Summary: This gene product is a component of a nucleolar small
            nuclear ribonucleoprotein (snRNP) particle thought to participate
            in the first step in processing preribosomal RNA. It is associated
            with the U3, U8, and U13 small nuclear RNAs and is located in the
            dense fibrillar component (DFC) of the nucleolus. The encoded
            protein contains an N-terminal repetitive domain that is rich in
            glycine and arginine residues, like fibrillarins in other species.
            Its central region resembles an RNA-binding domain and contains an
            RNP consensus sequence. Antisera from approximately 8% of humans
            with the autoimmune disease scleroderma recognize fibrillarin.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019260.1, SRR1163658.428476.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221801.8/ ENSP00000221801.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG831506.1         36-46
            12-1125             BC019260.1         1-1114
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1125
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /note="fibrillarin"
                     /db_xref="GeneID:2091"
                     /db_xref="HGNC:HGNC:3599"
                     /db_xref="MIM:134795"
     exon            1..89
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1045
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /note="34-kD nucleolar scleroderma antigen; RNA, U3 small
                     nucleolar interacting protein 1; 34 kDa nucleolar
                     scleroderma antigen; histone-glutamine methyltransferase;
                     U6 snRNA 2'-O-methyltransferase fibrillarin"
                     /codon_start=1
                     /product="rRNA 2'-O-methyltransferase fibrillarin"
                     /protein_id="NP_001427.2"
                     /db_xref="CCDS:CCDS12545.1"
                     /db_xref="GeneID:2091"
                     /db_xref="HGNC:HGNC:3599"
                     /db_xref="MIM:134795"
                     /translation="MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRG
                     RGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGK
                     EDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPG
                     AKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDAR
                     HPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAE
                     AVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN"
     exon            90..260
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..362
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..457
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..628
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..761
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..874
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1020
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1125
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1125
                     /gene="FBL"
                     /gene_synonym="FIB; FLRN; Nop1; RNU3IP1"
                     /note="major polyA site"
ORIGIN      
        1 cttttccacg tgcgaaagcc ccggactcgt ggagttgtga acgccgcgga ctccggagcc
       61 gcacaaacca gggctcgcca tgaagccagg attcagtccc cgtgggggtg gctttggcgg
      121 ccgagggggc tttggtgacc gtggtggtcg tggaggccga gggggctttg gcgggggccg
      181 aggtcgaggc ggaggcttta gaggtcgtgg acgaggagga ggtggaggcg gcggcggcgg
      241 tggaggagga ggaagaggtg gtggaggctt ccattctggt ggcaaccggg gtcgtggtcg
      301 gggaggaaaa agaggaaacc agtcggggaa gaatgtgatg gtggagccgc atcggcatga
      361 gggtgtcttc atttgtcgag gaaaggaaga tgcactggtc accaagaacc tggtccctgg
      421 ggaatcagtt tatggagaga agagagtctc gatttcggaa ggagatgaca aaattgagta
      481 ccgagcctgg aaccccttcc gctccaagct agcagcagca atcctgggtg gtgtggacca
      541 gatccacatc aaaccggggg ctaaggttct ctacctcggg gctgcctcgg gcaccacggt
      601 ctcccatgtc tctgacatcg ttggtccgga tggtctagtc tatgcagtcg agttctccca
      661 ccgctctggc cgtgacctca ttaacttggc caagaagagg accaacatca ttcctgtgat
      721 cgaggatgct cgacacccac acaaataccg catgctcatc gcaatggtgg atgtgatctt
      781 tgctgatgtg gcccagccag accagacccg gattgtggcc ctgaatgccc acaccttcct
      841 gcgtaatgga ggacactttg tgatttccat taaggccaac tgcattgact ccacagcctc
      901 agccgaggcc gtgtttgcct ccgaagtgaa aaagatgcaa caggagaaca tgaagccgca
      961 ggagcagttg acccttgagc catatgaaag agaccatgcc gtggtcgtgg gagtgtacag
     1021 gccacccccc aaggtgaaga actgaagttc agcgctgtca ggattgcgag agatgtgtgt
     1081 tgatactgtt gcacgtgtgt ttttctatta aaagactcat ccgtc
//
