LOCUS       NM_178150               3548 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens F-box DNA helicase 1 (FBH1), transcript variant 2,
            mRNA.
ACCESSION   NM_178150
VERSION     NM_178150.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Jennings,L., Walters,H.A., McCraw,T.J., Turner,J.L. and Mason,J.M.
  TITLE     FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting
            mitotic catastrophe
  JOURNAL   DNA Repair (Amst) 133, 103611 (2024)
   PUBMED   38103522
  REMARK    GeneRIF: FBH1 deficiency sensitizes cells to WEE1 inhibition by
            promoting mitotic catastrophe.
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Liu,J., Chaves-Arquero,B., Wei,P., Tencer,A.H., Ruiz-Albor,A.,
            Zhang,G., Blanco,F.J. and Kutateladze,T.G.
  TITLE     Molecular insight into the PCNA-binding mode of FBH1
  JOURNAL   Structure 31 (5), 511-517 (2023)
   PUBMED   36990095
  REMARK    GeneRIF: Molecular insight into the PCNA-binding mode of FBH1.
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Ronson,G.E., Piberger,A.L., Higgs,M.R., Olsen,A.L., Stewart,G.S.,
            McHugh,P.J., Petermann,E. and Lakin,N.D.
  TITLE     PARP1 and PARP2 stabilise replication forks at base excision repair
            intermediates through Fbh1-dependent Rad51 regulation
  JOURNAL   Nat Commun 9 (1), 746 (2018)
   PUBMED   29467415
  REMARK    GeneRIF: Report a requirement for PARP2 in stabilizing replication
            forks that encounter base excision repair (BER) intermediates
            through Fbh1-dependent regulation of Rad51. Whereas PARP2 is
            dispensable for tolerance of cells to single stranded breaks or
            homologous recombination dysfunction, it is redundant with PARP1 in
            BER.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3548)
  AUTHORS   Hoya,S., Watanabe,Y., Hishimoto,A., Nunokawa,A., Inoue,E.,
            Igeta,H., Otsuka,I., Shibuya,M., Egawa,J., Sora,I. and Someya,T.
  TITLE     Rare FBXO18 variations and risk of schizophrenia: Whole-exome
            sequencing in two parent-affected offspring trios followed by
            resequencing and case-control studies
  JOURNAL   Psychiatry Clin Neurosci 71 (8), 562-568 (2017)
   PUBMED   28317220
  REMARK    GeneRIF: study does not provide evidence for the contribution of
            rare non-synonymous FBXO18 variations to the genetic etiol - ogy of
            schizophrenia in the Japanese population.
REFERENCE   6  (bases 1 to 3548)
  AUTHORS   Chiolo,I., Saponaro,M., Baryshnikova,A., Kim,J.H., Seo,Y.S. and
            Liberi,G.
  TITLE     The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae
            Srs2 and postreplication repair pathway roles
  JOURNAL   Mol Cell Biol 27 (21), 7439-7450 (2007)
   PUBMED   17724085
  REMARK    GeneRIF: These findings suggest that the hFBH1 helicase is a
            functional human orthologue of budding yeast Srs2 that also
            possesses self-regulation properties necessary to execute its
            recombination functions.
REFERENCE   7  (bases 1 to 3548)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3548)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 3548)
  AUTHORS   Kim,J., Kim,J.H., Lee,S.H., Kim,D.H., Kang,H.Y., Bae,S.H., Pan,Z.Q.
            and Seo,Y.S.
  TITLE     The novel human DNA helicase hFBH1 is an F-box protein
  JOURNAL   J Biol Chem 277 (27), 24530-24537 (2002)
   PUBMED   11956208
  REMARK    GeneRIF: hFBH1 exhibited DNA-dependent ATPase and DNA unwinding
            activities that displace duplex DNA in the 3' to 5' direction.
REFERENCE   10 (bases 1 to 3548)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB099150.1, BC113377.1 and
            CN478453.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_178150.2.
            
            Summary: This gene encodes a member of the F-box protein family,
            members of which are characterized by an approximately 40 amino
            acid motif, the F-box. The F-box proteins constitute one of the
            four subunits of ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into three classes:
            Fbws containing WD-40 domains, Fbls containing leucine-rich
            repeats, and Fbxs containing either different protein-protein
            interaction modules or no recognizable motifs. The protein encoded
            by this gene belongs to the Fbx class. It contains an F-box motif
            and seven conserved helicase motifs, and has both DNA-dependent
            ATPase and DNA unwinding activities. Alternatively spliced
            transcript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs at the 5' end compared
            to variant 1, resulting in translation initiation from an in-frame
            downstream AUG, and an isoform (2) with a shorter N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF456237.1, AF454502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362091.9/ ENSP00000355415.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB099150.1         41-53
            14-3267             BC113377.1         1-3254
            3268-3548           CN478453.1         18-298              c
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..3548
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /note="F-box DNA helicase 1"
                     /db_xref="GeneID:84893"
                     /db_xref="HGNC:HGNC:13620"
                     /db_xref="MIM:607222"
     exon            1..104
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3235
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /EC_number="5.6.2.4"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein, helicase, 18; F-box protein, helicase, 18;
                     DNA 3'-5' helicase 1"
                     /codon_start=1
                     /product="F-box DNA helicase 1 isoform 2"
                     /protein_id="NP_835363.1"
                     /db_xref="CCDS:CCDS7072.1"
                     /db_xref="GeneID:84893"
                     /db_xref="HGNC:HGNC:13620"
                     /db_xref="MIM:607222"
                     /translation="MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPK
                     PRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCA
                     LPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPR
                     EARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSE
                     VLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGI
                     LSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPD
                     LYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLY
                     AMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILN
                     HKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVIC
                     KTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFAS
                     ADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTH
                     DGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRG
                     AVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDA
                     KGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILLQPEEERR
                     KQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVQRIEK
                     CHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRVESFSEDE
                     WNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVRCCVGQCNNAI
                     PVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVENI
                     VLPRHEALLFLVF"
     exon            105..260
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..856
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..987
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1123
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1314
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1407
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1499
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1668
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1891
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1979
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2066
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2203
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2303
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2425
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2501
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2699
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2825
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2932
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3064
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3548
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3523..3528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3548
                     /gene="FBH1"
                     /gene_synonym="Fbx18; FBXO18; hFBH1"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggcca gaggaggagc tcgctgccgg gggacgctgg gctgagcggc cggcggcgcg
       61 ggcccggcgg cggcggcagc ggggtccggg tccggagcgc cacatgagac ggtttaagcg
      121 gaagcatctt actgccattg actgccagca tttggctcgg agtcacttgg ctgtgaccca
      181 gcccttcggt caaagatgga caaacagaga tccgaaccat ggtctctatc ctaaaccgag
      241 aacaaaaaga gggagtaggg gtcagggaag tcaaagatgc atccctgagt tcttcctagc
      301 aggcaagcag ccgtgcacca atgacatggc caaaagcaat tctgttggcc aggacagctg
      361 tcaggactct gagggtgaca tgatctttcc tgcagagagc agctgtgcac tgcctcagga
      421 aggcagtgca gggccgggct caccagggtc tgccccgccc tccaggaagc ggtcttggtc
      481 ctctgaggaa gagagtaacc aggctaccgg gaccagccgg tgggatggag tttctaagaa
      541 agctccacgg caccatttgt ctgtgccatg cacaaggcct agggaggcca ggcaagaagc
      601 agaggacagt acgtctcggc tctctgcgga gtctggtgaa accgaccaag atgctgggga
      661 cgtgggtcct gatcccattc ctgactcata ctatgggctt cttgggacct tgccctgcca
      721 ggaagcactg agccacattt gcagcctgcc tagtgaggtc ctgaggcacg tgtttgcctt
      781 cctcccggtg gaagacctct attggaacct gagcttggtg tgccacttgt ggagggagat
      841 catcagtgac ccgctgttca ttccttggaa gaagctgtac catcgatacc tgatgaatga
      901 agagcaagct gtcagcaaag tggacggcat cctgtctaac tgtggcatag aaaaggagtc
      961 agacctgtgt gtgctgaacc tcatacgata cacagccacc actaagtgct ctccgagtgt
     1021 ggatcccgag agggtgctgt ggagtctgag ggaccacccc ctcctccccg aggctgaggc
     1081 gtgtgtgcgg caacacctcc ccgacctcta cgctgctgcc gggggtgtca acatctgggc
     1141 cctggtggcg gctgtggtgc tcctctccag cagtgtgaat gacatccagc gactgctctt
     1201 ctgcctccgg agacccagct ccacggtgac catgccagat gtcaccgaga ccctgtactg
     1261 catagccgtg cttctctacg ccatgaggga gaaggggatt aacatcagca ataggattca
     1321 ctacaacatt ttctattgcc tatatcttca ggagaattcc tgcactcagg ccacaaaagt
     1381 taaagaggag ccatctgtct ggccaggcaa gaaaaccatc caacttacac atgaacaaca
     1441 gctgattctg aatcacaaga tggaacctct ccaggtggtg aaaattatgg cctttgccgg
     1501 cactgggaag acctcaacgc tggtcaagta tgcagagaag tggtctcaga gcaggtttct
     1561 gtatgtgaca ttcaacaaga gcatcgcaaa gcaggccgaa cgcgtcttcc ccagcaacgt
     1621 catctgcaaa accttccact ccatggccta cgggcacata gggcggaagt accagtcaaa
     1681 gaagaagttg aatctcttca agttaacacc cttcatggtc aactccgtcc ttgctgaagg
     1741 gaagggtgga ttcataagag ccaagcttgt gtgtaagact ctagaaaact tctttgcctc
     1801 ggctgacgaa gagctgacca ttgatcacgt gcctatttgg tgtaagaaca gccaaggaca
     1861 gagagtcatg gttgagcaga gtgaaaaact gaatggtgtc cttgaagcga gccgcctctg
     1921 ggataacatg cggaagctgg gggagtgcac agaagaggcg caccagatga ctcatgacgg
     1981 ctacttgaaa ctctggcagc tgagcaagcc ttcgctggcc tcttttgacg ccatctttgt
     2041 ggatgaggcc caggactgca caccagctat catgaacata gttctgtctc agccatgtgg
     2101 gaaaatcttt gtaggggacc cgcaccagca gatctatacc ttccggggtg cggtcaacgc
     2161 cctgttcaca gtgccccaca cccacgtctt ctatctcacg cagagttttc ggtttggtgt
     2221 ggaaatagct tatgtgggag ctactatctt ggatgtttgc aagagagtca ggaaaaagac
     2281 tttggttgga ggaaaccatc agagtggcat tagaggtgac gcaaaggggc aagtggcctt
     2341 gttgtcccgg accaacgcca acgtgtttga tgaggccgta cgggtgacgg aaggggaatt
     2401 cccttcaagg atacatttga ttggggggat taaatcattt ggattggaca gaatcattga
     2461 tatttggatc cttcttcagc cagaggaaga acggaggaaa caaaacctcg tcattaaaga
     2521 caaatttatc agaagatggg tgcacaaaga aggctttagt ggcttcaaga ggtatgtgac
     2581 cgctgccgag gacaaggagc ttgaagccaa gatcgcagtt gttgaaaagt ataacatcag
     2641 gattccagag ctggtgcaaa ggatagaaaa atgccatata gaagatttgg actttgcaga
     2701 gtacattctg ggcactgtgc acaaagccaa aggcctggag tttgacactg tgcatgtttt
     2761 ggatgatttt gtgaaagtgc cttgtgcccg gcataacctg ccccagcttc cgcacttcag
     2821 agttgagtca ttttctgagg atgaatggaa tttactgtat gttgcagtaa ctcgagccaa
     2881 gaagcgtctc atcatgacca aatcattgga aaacattttg actttggctg gggagtactt
     2941 cttgcaagca gagctgacaa gcaacgtctt aaaaacaggc gtggtgcgct gctgcgtggg
     3001 acagtgcaac aatgccatcc ctgttgacac cgtccttacc atgaagaagc tgcccatcac
     3061 ctatagcaac aggaaggaaa acaagggggg ctacctctgc cactcctgtg cggagcagcg
     3121 catcgggccc ctggcgttcc tgacagcctc cccggagcag gtgcgcgcca tggagcgcac
     3181 tgtggagaac atcgtactgc cccggcatga ggccctgctc ttcctcgtct tctgaggaca
     3241 aggcgcacgt tctccgcagt gcagagcagc ttgccgagga ccccgcgtga agaaagccag
     3301 cgaggggggc ttctgctccc tgagactctg ggttcaccca cagcactttc tgaggaagag
     3361 gacaccagcc caagctggac ctgccatttc tccactccct acagacagcc agtctccact
     3421 tgcctcccct ctggatgtat ctggtcaggg aagtggggga tgttcttttg ataaaaaaaa
     3481 aaaaaaaaat ttatgtattt aaacttttat tacaagattt caattaaaca ggcaccatag
     3541 cactggca
//
