LOCUS       NP_001306122            1148 aa            linear   PRI 01-MAY-2025
DEFINITION  fas-binding factor 1 [Homo sapiens].
ACCESSION   NP_001306122
VERSION     NP_001306122.1
DBSOURCE    REFSEQ: accession NM_001319193.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1148)
  AUTHORS   Zhang,Y., Hao,J., Tarrago,M.G., Warner,G.M., Giorgadze,N., Wei,Q.,
            Huang,Y., He,K., Chen,C., Peclat,T.R., White,T.A., Ling,K.,
            Tchkonia,T., Kirkland,J.L., Chini,E.N. and Hu,J.
  TITLE     FBF1 deficiency promotes beiging and healthy expansion of white
            adipose tissue
  JOURNAL   Cell Rep 36 (5), 109481 (2021)
   PUBMED   34348145
  REMARK    GeneRIF: FBF1 deficiency promotes beiging and healthy expansion of
            white adipose tissue.
REFERENCE   2  (residues 1 to 1148)
  AUTHORS   Inoko,A., Yano,T., Miyamoto,T., Matsuura,S., Kiyono,T., Goshima,N.,
            Inagaki,M. and Hayashi,Y.
  TITLE     Albatross/FBF1 contributes to both centriole duplication and
            centrosome separation
  JOURNAL   Genes Cells 23 (12), 1023-1042 (2018)
   PUBMED   30318703
  REMARK    GeneRIF: Albatross is a novel protein that spatiotemporally
            integrates different aspects of centrosome function, namely
            ciliogenesis, centriole duplication, and centrosome separation.
REFERENCE   3  (residues 1 to 1148)
  AUTHORS   Huang,W.Q., Ye,H.M., Li,F.F., Yi,K.H., Zhang,Y., Cai,L.L.,
            Lin,H.N., Lin,Q. and Tzeng,C.M.
  TITLE     Analysis of genetic polymorphisms associated with leukoaraiosis in
            the southern Chinese population: A case-control study
  JOURNAL   Medicine (Baltimore) 95 (35), e3857 (2016)
   PUBMED   27583843
  REMARK    GeneRIF: These results suggest that rs1135889 in FBF1 is not
            associated with leukoaraiosis (LA) risk in the Chinese population.
            However, the association of rs1135889 (FBF1) with LA before
            Bonferroni correction and Sidak correction is worth highlighting.
REFERENCE   4  (residues 1 to 1148)
  AUTHORS   Tanos,B.E., Yang,H.J., Soni,R., Wang,W.J., Macaluso,F.P.,
            Asara,J.M. and Tsou,M.F.
  TITLE     Centriole distal appendages promote membrane docking, leading to
            cilia initiation
  JOURNAL   Genes Dev 27 (2), 163-168 (2013)
   PUBMED   23348840
REFERENCE   5  (residues 1 to 1148)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (residues 1 to 1148)
  AUTHORS   Sugimoto,M., Inoko,A., Shiromizu,T., Nakayama,M., Zou,P.,
            Yonemura,S., Hayashi,Y., Izawa,I., Sasoh,M., Uji,Y., Kaibuchi,K.,
            Kiyono,T. and Inagaki,M.
  TITLE     The keratin-binding protein Albatross regulates polarization of
            epithelial cells
  JOURNAL   J Cell Biol 183 (1), 19-28 (2008)
   PUBMED   18838552
  REMARK    GeneRIF: Keratins and the keratin-binding protein Albatross are
            important for epithelial cell polarization.
REFERENCE   7  (residues 1 to 1148)
  AUTHORS   Schmidt,T., Karsunky,H., Frass,B., Baum,W., Denzel,A. and Moroy,T.
  TITLE     A novel protein (Fbf-1) that binds to CD95/APO-1/FAS and shows
            sequence similarity to trichohyalin and plectin
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 249-254 (2000)
   PUBMED   10978533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087289.9.
            
            CCDS Note: The coding region has been updated to represent an
            alternative splicing pattern that is more supported by the
            available transcript data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1642665.1,
                                           SRR14038195.2543215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636174.2/ ENSP00000490726.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     Protein         1..1148
                     /product="fas-binding factor 1"
                     /note="Fas binding protein 1; albatross; protein
                     albatross; Fas (TNFRSF6) binding factor 1"
                     /calculated_mol_wt=126910
     Region          103..212
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TES7.2)"
     Region          <116..579
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            156
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8TES7.2)"
     Region          225..558
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TES7.2)"
     Region          <574..>1062
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          1077..1100
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TES7.2)"
     CDS             1..1148
                     /gene="FBF1"
                     /gene_synonym="Alb; FBF-1"
                     /coded_by="NM_001319193.2:279..3725"
                     /db_xref="CCDS:CCDS45779.2"
                     /db_xref="GeneID:85302"
                     /db_xref="HGNC:HGNC:24674"
                     /db_xref="MIM:616807"
ORIGIN      
        1 mapktkkgck gsiddflgdl lgddmtlpek pvklashtrd ttgvsqmfps skartksllg
       61 ddvfstmagl eeadaevsgi seadpqallq amkdldgmda dilglkksns apskkaakdp
      121 gkgelpnhpk paggaiptkk slpspsssgh qnrrfssedl edplrgllsy deggitkqpp
      181 vtqsktasdk spstvrdqgp sipltpgdtp irkkeellfd dgddimatlg fgdspkaekr
      241 qigdqegprp arstldellg rgmatkllar pgtgehrefk ldkkyqrpqd sedmwgdedf
      301 tfgayqptvv ssegrqsrrq svsrffadsg adpkgepgsk qsppmasspi qprkggadwl
      361 glkdedldlf pasptreahr essvpvtpsv pppasqhstp aglppsrakp ptegagspak
      421 asqasklras keekedwlsh alsrkksqgl areqhagtse glhlagtagh ppsgsqplts
      481 tqglehaaag gssgttarer pcvrpgvsgs pvtqnhaasa lptgspkrgt apgdlsatep
      541 atcfpstqkp tepsvpvqpl lpeslarsll psteyqkqll aaqvqlqcsp aelqaellhs
      601 qarlaeleaq vrkleleraq helllgslqq qhqadlelie sahrsrikvl etsyqqreer
      661 lrreneelsa rylsqcqeae qaraeltaqh qrrlaaiaqe kdqemerlre lqrasildmr
      721 rdheeqlqrl kllkdrevda atsatshtrs lnsiihqmek fssslhelss rveashltts
      781 qerelgirqr deqlralqer lgqqqrdmee ersrqqevig kmearlneqs rlleqerwrv
      841 taeqskaesm qraleeqrkv taqqmamera eleraksall eeqksvmlkc geerrrlaae
      901 waefsaqqkl skeraereae ralqvdtqre gtlislakeq aelkirasel raeekqlaae
      961 raaleqerqe lrlekerina talrvklrae evesmskvas ekyeegeral reaqqvqaeq
     1021 qarlqavqqq qerlrkqeqh mhqehlslaq qrlqldrarq dlpsslvglf praqgpaass
     1081 qsalmppapt trwcsqpptg ldpsplhlha rlallrhmae qdrdfleneq ffletlkkgs
     1141 ynltshsa
//
