LOCUS       NM_001997                506 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens FAU ubiquitin like and ribosomal protein S30 fusion
            (FAU), mRNA.
ACCESSION   NM_001997
VERSION     NM_001997.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Zhen,X.X., Yang,L., Gu,Y., Yang,Q., Gu,W.W., He,Y.P., Wang,Y.L. and
            Wang,J.
  TITLE     MNSFbeta Regulates TNFalpha Production by Interacting with RC3H1 in
            Human Macrophages, and Dysfunction of MNSFbeta in Decidual
            Macrophages Is Associated With Recurrent Pregnancy Loss
  JOURNAL   Front Immunol 12, 691908 (2021)
   PUBMED   34589082
  REMARK    GeneRIF: MNSFbeta Regulates TNFalpha Production by Interacting with
            RC3H1 in Human Macrophages, and Dysfunction of MNSFbeta in Decidual
            Macrophages Is Associated With Recurrent Pregnancy Loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 506)
  AUTHORS   van den Heuvel,J., Ashiono,C., Gillet,L.C., Dorner,K., Wyler,E.,
            Zemp,I. and Kutay,U.
  TITLE     Processing of the ribosomal ubiquitin-like fusion protein
            FUBI-eS30/FAU is required for 40S maturation and depends on USP36
  JOURNAL   Elife 10, e70560 (2021)
   PUBMED   34318747
  REMARK    GeneRIF: Processing of the ribosomal ubiquitin-like fusion protein
            FUBI-eS30/FAU is required for 40S maturation and depends on USP36.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 506)
  AUTHORS   Wang,N., Yang,Q., Gu,Y., Zhen,X., Shi,Y., Gu,W., Wang,J., He,Y. and
            Wang,J.
  TITLE     MNSFbeta Promotes the Proliferation and Migration of Human
            Extravillous Trophoblast Cells and the Villus Expression Level of
            MNSFbeta Is Decreased in Recurrent Miscarriage Patients
  JOURNAL   Gynecol Obstet Invest 86 (1-2), 27-39 (2021)
   PUBMED   33326956
  REMARK    GeneRIF: MNSFbeta Promotes the Proliferation and Migration of Human
            Extravillous Trophoblast Cells and the Villus Expression Level of
            MNSFbeta Is Decreased in Recurrent Miscarriage Patients.
REFERENCE   4  (bases 1 to 506)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 506)
  AUTHORS   Tollin,M., Bergman,P., Svenberg,T., Jornvall,H., Gudmundsson,G.H.
            and Agerberth,B.
  TITLE     Antimicrobial peptides in the first line defence of human colon
            mucosa
  JOURNAL   Peptides 24 (4), 523-530 (2003)
   PUBMED   12860195
  REMARK    GeneRIF: The C-terminal portion of the encoded protein displays
            antimicrobial activity against B. megaterium.
REFERENCE   6  (bases 1 to 506)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 506)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 506)
  AUTHORS   Michiels,L., Van der Rauwelaert,E., Van Hasselt,F., Kas,K. and
            Merregaert,J.
  TITLE     fau cDNA encodes a ubiquitin-like-S30 fusion protein and is
            expressed as an antisense sequence in the Finkel-Biskis-Reilly
            murine sarcoma virus
  JOURNAL   Oncogene 8 (9), 2537-2546 (1993)
   PUBMED   8395683
REFERENCE   9  (bases 1 to 506)
  AUTHORS   Kas,K., Schoenmakers,E., van de Ven,W., Weber,G., Nordenskjold,M.,
            Michiels,L., Merregaert,J. and Larsson,C.
  TITLE     Assignment of the human FAU gene to a subregion of chromosome 11q13
  JOURNAL   Genomics 17 (2), 387-392 (1993)
   PUBMED   8406491
REFERENCE   10 (bases 1 to 506)
  AUTHORS   Kas,K., Michiels,L. and Merregaert,J.
  TITLE     Genomic structure and expression of the human fau gene: encoding
            the ribosomal protein S30 fused to a ubiquitin-like protein
  JOURNAL   Biochem Biophys Res Commun 187 (2), 927-933 (1992)
   PUBMED   1326960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU602831.1, BC033877.1 and AA449261.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001997.4.
            
            Summary: This gene is the cellular homolog of the fox sequence in
            the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It
            encodes a fusion protein consisting of the ubiquitin-like protein
            fubi at the N terminus and ribosomal protein S30 at the C terminus.
            It has been proposed that the fusion protein is
            post-translationally processed to generate free fubi and free
            ribosomal protein S30. Fubi is a member of the ubiquitin family,
            and ribosomal protein S30 belongs to the S30E family of ribosomal
            proteins. Whereas the function of fubi is currently unknown,
            ribosomal protein S30 is a component of the 40S subunit of the
            cytoplasmic ribosome and displays antimicrobial activity.
            Pseudogenes derived from this gene are present in the genome.
            Similar to ribosomal protein S30, ribosomal proteins S27a and L40
            are synthesized as fusion proteins with ubiquitin. [provided by
            RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV762842.1, BP196602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000529639.6/
                                                  ENSP00000435370.1
            Protein has antimicrobial activity :: PMID: 12860195
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BU602831.1         70-145
            77-502              BC033877.1         61-486
            503-506             AA449261.1         8-11                c
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..506
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /note="FAU ubiquitin like and ribosomal protein S30
                     fusion"
                     /db_xref="GeneID:2197"
                     /db_xref="HGNC:HGNC:3597"
                     /db_xref="MIM:134690"
     exon            1..45
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /inference="alignment:Splign:2.1.0"
     exon            46..128
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..455
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /note="Finkel-Biskis-Reilly murine sarcoma virus
                     (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal
                     protein S30; monoclonal nonspecific suppressor factor
                     beta; ubiquitin-like-S30 fusion protein; 40S ribosomal
                     protein S30; FBR-MuSV-associated ubiquitously expressed;
                     FAU-encoded ubiquitin-like protein; small ribosomal
                     subunit protein eS30; ubiquitin-like protein fubi and
                     ribosomal protein S30; FAU ubiquitin-like and ribosomal
                     protein S30; ubiquitin-like FUBI-ribosomal protein eS30
                     fusion protein"
                     /codon_start=1
                     /product="ubiquitin-like FUBI-ribosomal protein eS30
                     fusion protein precursor"
                     /protein_id="NP_001988.1"
                     /db_xref="CCDS:CCDS8095.1"
                     /db_xref="GeneID:2197"
                     /db_xref="HGNC:HGNC:3597"
                     /db_xref="MIM:134690"
                     /translation="MQLFVRAQELHTFEVTGQETVAQIKAHVASLEGIAPEDQVVLLA
                     GAPLEDEATLGQCGVEALTTLEVAGRMLGGKVHGSLARAGKVRGQTPKVAKQEKKKKK
                     TGRAKRRMQYNRRFVNVVPTFGKKKGPNANS"
     exon            129..273
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /inference="alignment:Splign:2.1.0"
     exon            274..329
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /inference="alignment:Splign:2.1.0"
     exon            330..506
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      481..486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /note="hexamer: AATAAA"
     polyA_site      506
                     /gene="FAU"
                     /gene_synonym="asr1; eS30; FAU1; Fub1; Fubi; MNSFbeta;
                     RPS30; S30"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctcg actccatctt cgcggtagct gggaccgccg ttcagtcgcc aatatgcagc
       61 tctttgtccg cgcccaggag ctacacacct tcgaggtgac cggccaggaa acggtcgccc
      121 agatcaaggc tcatgtagcc tcactggagg gcattgcccc ggaagatcaa gtcgtgctcc
      181 tggcaggcgc gcccctggag gatgaggcca ctctgggcca gtgcggggtg gaggccctga
      241 ctaccctgga agtagcaggc cgcatgcttg gaggtaaagt ccatggttcc ctggcccgtg
      301 ctggaaaagt gagaggtcag actcctaagg tggccaaaca ggagaagaag aagaagaaga
      361 caggtcgggc taagcggcgg atgcagtaca accggcgctt tgtcaacgtt gtgcccacct
      421 ttggcaagaa gaagggcccc aatgccaact cttaagtctt ttgtaattct ggctttctct
      481 aataaaaaag ccacttagtt cagtca
//
