LOCUS       NM_033085               1072 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.
ACCESSION   NM_033085
VERSION     NM_033085.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Gallegos,Z.R., Taus,P., Gibbs,Z.A., McGlynn,K., Gomez,N.C.,
            Davis,I. and Whitehurst,A.W.
  TITLE     EWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes
            Ewing Sarcoma Survival
  JOURNAL   Mol Cell Biol 39 (14), e00138-19 (2019)
   PUBMED   31036566
  REMARK    GeneRIF: Study reports that EWSR1-FLI1 directly activates the
            anomalous expression of FATE1 in Ewing sarcoma. FATE1 is essential
            for Ewing sarcoma survival through the destabilization of BNIP3L, a
            poorly characterized BH3-only protein that is toxic to Ewing
            sarcoma cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Doghman-Bouguerra,M., Granatiero,V., Sbiera,S., Sbiera,I.,
            Lacas-Gervais,S., Brau,F., Fassnacht,M., Rizzuto,R. and Lalli,E.
  TITLE     FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling
            ER and mitochondria
  JOURNAL   EMBO Rep 17 (9), 1264-1280 (2016)
   PUBMED   27402544
  REMARK    GeneRIF: In patients with ACC, FATE1 expression in their tumor is
            inversely correlated with their overall survival. the
            ER-mitochondria uncoupling activity of FATE1 is harnessed by cancer
            cells to escape apoptotic death and resist the action of
            chemotherapeutic drugs.
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Olesen,C., Silber,J., Eiberg,H., Ernst,E., Petersen,K.,
            Lindenberg,S. and Tommerup,N.
  TITLE     Mutational analysis of the human FATE gene in 144 infertile men
  JOURNAL   Hum Genet 113 (3), 195-201 (2003)
   PUBMED   12811541
  REMARK    GeneRIF: This study has shown that only 1.4% of infertile men have
            mutations in the FATE gene, and that some of these mutations do not
            singly cause infertility.
REFERENCE   7  (bases 1 to 1072)
  AUTHORS   Dong,X.Y., Su,Y.R., Qian,X.P., Yang,X.A., Pang,X.W., Wu,H.Y. and
            Chen,W.F.
  TITLE     Identification of two novel CT antigens and their capacity to
            elicit antibody response in hepatocellular carcinoma patients
  JOURNAL   Br J Cancer 89 (2), 291-297 (2003)
   PUBMED   12865919
REFERENCE   8  (bases 1 to 1072)
  AUTHORS   Olesen,C., Larsen,N.J., Byskov,A.G., Harboe,T.L. and Tommerup,N.
  TITLE     Human FATE is a novel X-linked gene expressed in fetal and adult
            testis
  JOURNAL   Mol Cell Endocrinol 184 (1-2), 25-32 (2001)
   PUBMED   11694338
REFERENCE   9  (bases 1 to 1072)
  AUTHORS   Olesen,C., Hansen,C., Bendsen,E., Byskov,A.G., Schwinger,E.,
            Lopez-Pajares,I., Jensen,P.K., Kristoffersson,U., Schubert,R., Van
            Assche,E., Wahlstroem,J., Lespinasse,J. and Tommerup,N.
  TITLE     Identification of human candidate genes for male infertility by
            digital differential display
  JOURNAL   Mol Hum Reprod 7 (1), 11-20 (2001)
   PUBMED   11134355
REFERENCE   10 (bases 1 to 1072)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF002992.2 and AY101182.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_033085.2.
            
            Summary: This gene encodes a cancer-testis antigen that is highly
            expressed in hepatocellular carcinomas and other tumors and weakly
            expressed in normal tissues except testis. The protein is strongly
            expressed in spermatogonia, primary spermatocytes, and Sertoli
            cells in seminiferous tubules. This protein may have a role in the
            control of early testicular differentiation and cell proliferation.
            [provided by RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022064.2, SRR5189652.72397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370350.7/ ENSP00000359375.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AF002992.2         9801-9801
            2-1072              AY101182.1         29-1099
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1072
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /note="fetal and adult testis expressed 1"
                     /db_xref="GeneID:89885"
                     /db_xref="HGNC:HGNC:24683"
                     /db_xref="MIM:300450"
     exon            1..191
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..637
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /note="cancer/testis antigen 43; BJ-HCC-2 antigen; tumor
                     antigen BJ-HCC-2"
                     /codon_start=1
                     /product="fetal and adult testis-expressed transcript
                     protein"
                     /protein_id="NP_149076.1"
                     /db_xref="CCDS:CCDS14700.1"
                     /db_xref="GeneID:89885"
                     /db_xref="HGNC:HGNC:24683"
                     /db_xref="MIM:300450"
                     /translation="MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRS
                     RGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYA
                     GNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRH
                     RETLIIAVLVSASIANLWLWMNQ"
     exon            192..319
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /inference="alignment:Splign:2.1.0"
     exon            320..426
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /inference="alignment:Splign:2.1.0"
     exon            427..505
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1072
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1046..1051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /note="hexamer: AATAAA"
     polyA_site      1072
                     /gene="FATE1"
                     /gene_synonym="CT43; FATE"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgatt ttctgagtgt gactcctctg ttcctggcac cctgtgcatc cttagccata
       61 gcttacaaga gaacagctgg ttgtgatggc aggaggccct cccaacacca aggcggagat
      121 ggaaatgtcc ctggcagaag aactgaatca tggacgccaa ggggaaaacc aagagcacct
      181 ggtgatagca gaaatgatgg agcttggatc tcggtcccgg ggtgcctccc agaagaagca
      241 gaagttggaa caaaaagctg ctggctctgc ttcagccaaa cgagtttgga atatgactgc
      301 cacccgaccc aagaaaatgg ggtcccagct gccaaagccc agaatgctga gagaatcagg
      361 ccatggggat gcccatctcc aggagtacgc tggcaatttc caaggcatac gtttccatta
      421 tgatcgcaac ccagggacag atgcagtggc gcagactagc ctggaagagt tcaatgtact
      481 ggagatggaa gtcatgagaa gacagctgta tgcagtcaac cggcgtctgc gcgccctgga
      541 ggaacagggc gccacctggc gccacaggga gaccctgatc atcgccgtgc tggtgtcggc
      601 cagcattgcc aacctgtggc tgtggatgaa ccagtgatcg ccccagcgcg gcctccgtat
      661 tggagccctc cctgcttccc cttctttctt tcctctttcc ccaggccgcc actgcccttg
      721 cccctttcat ctcccagcag ccctcaggag cgtcaggatc attttcaact ctggttaggc
      781 ctcctacctg gggaggccag gtcactgcac tgggaggtcc tggctgctgc gaagctggag
      841 gaggactgcg tgggctgaga tgccaccctt tgaagggtga acagcatggc ggcatctggg
      901 ccccacagta acacctagtg gcaaccttgc cttcctgacc tcagcggccc ttctgttcca
      961 tcctctgtgg gcaggggtgt ggctttgttt tcctccctcg tttgcttcca cctcgtgcac
     1021 agcgctctgc acagacaaca cgctcaataa aagttcagcc atagcagcaa aa
//
