LOCUS       NM_021826               2842 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens FAST kinase domains 5 (FASTKD5), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_021826
VERSION     NM_021826.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Ohkubo,A., Van Haute,L., Rudler,D.L., Stentenbach,M., Steiner,F.A.,
            Rackham,O., Minczuk,M., Filipovska,A. and Martinou,J.C.
  TITLE     The FASTK family proteins fine-tune mitochondrial RNA processing
  JOURNAL   PLoS Genet 17 (11), e1009873 (2021)
   PUBMED   34748562
  REMARK    GeneRIF: The FASTK family proteins fine-tune mitochondrial RNA
            processing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2842)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2842)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2842)
  AUTHORS   Jourdain,A.A., Popow,J., de la Fuente,M.A., Martinou,J.C.,
            Anderson,P. and Simarro,M.
  TITLE     The FASTK family of proteins: emerging regulators of mitochondrial
            RNA biology
  JOURNAL   Nucleic Acids Res 45 (19), 10941-10947 (2017)
   PUBMED   29036396
  REMARK    GeneRIF: Despite the fact that proteins of the FASTK family
            FASTKD1-5 share the same domains, they exhibit various-sometimes
            opposing-functions in almost all steps of mitochondrial RNA
            metabolism.
            Review article
REFERENCE   7  (bases 1 to 2842)
  AUTHORS   Antonicka,H. and Shoubridge,E.A.
  TITLE     Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA
            Processing and Ribosome Biogenesis
  JOURNAL   Cell Rep 10 (6), 920-932 (2015)
   PUBMED   25683715
REFERENCE   8  (bases 1 to 2842)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 2842)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2842)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007413.2, BC011856.1 and AW182833.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021826.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023211.1, SRR1803616.39663.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380266.4/ ENSP00000369618.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BC007413.2         22-36
            16-2838             BC011856.1         1-2823
            2839-2842           AW182833.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2842
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /note="FAST kinase domains 5"
                     /db_xref="GeneID:60493"
                     /db_xref="HGNC:HGNC:25790"
                     /db_xref="MIM:614272"
     exon            1..100
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /inference="alignment:Splign:2.1.0"
     exon            101..2842
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2585
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 5,
                     mitochondrial"
                     /protein_id="NP_068598.1"
                     /db_xref="CCDS:CCDS13048.1"
                     /db_xref="GeneID:60493"
                     /db_xref="HGNC:HGNC:25790"
                     /db_xref="MIM:614272"
                     /translation="MAATLKSLKLVRYRAFCSPSAFGAVRSVSYWNVSSTQHGGQDPP
                     EHISLCHSAKKVKNICSTFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVD
                     EEDVEVFDSFENMRVFLQLRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQA
                     QVIVDYLCKLSSLPAEQHPVLLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGI
                     PHSHSMLDVYETKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDL
                     SLSQLVHLIYVIGENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGFFKSSTNLSE
                     FVMRKIGDLACANIQHLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRIPSLGVQG
                     VMHLTLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEF
                     YSSLISEIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKF
                     DLLKELYTLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLL
                     ETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKPLPFNREATPAENVAKLRLEHVGVS
                     LTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENKAAVPLGGFLCNVADKSGAMEMA
                     GLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNMKRRQLARLGYRVVELSYWEW
                     LPLLKRTRLEKLAFLHEKVFTSAL"
     regulatory      2809..2814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /note="hexamer: AATAAA"
     polyA_site      2842
                     /gene="FASTKD5"
                     /gene_synonym="dJ1187M17.5"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgaggc tcggagtcgc cggaggagcc agtatctgtg tcgccgccgc ccgcggcgtc
       61 cccggtttgg tgttgcggcg cccaccttcg ggaggatcag tatctggcac caattctgac
      121 ccagtcattt gtgatccctg gctcttgtga tatgctgaag atttccaggc agtttttgtg
      181 gaacacctcc ccgtccagct ctaatcaagc accatataaa caagaaattg cctggtcaaa
      241 tctgtgagga ctgtattctg actgccaaag agatcaatac tgacaccaga atggcagcta
      301 ctctcaagtc attaaaactt gtaagatacc gagcattttg cagtccttct gcctttggtg
      361 cagtccgaag tgtgtcatac tggaatgtga gcagcacaca gcatggggga caggaccctc
      421 cagaacacat tagcctctgc cattctgcca aaaaagttaa gaacatatgt agcaccttct
      481 cttctcggag aatcctgaca accagcagtg cccacccagg tttggaattc agcaagactt
      541 cttcctctaa ggccagtaca ttgcagctgg gctcacccag ggccacagga gttgatgaag
      601 aggacgtaga agtgtttgat tcctttgaaa acatgcgagt tttcctacag ctaagaccag
      661 aataccgtgt tcacagctat aatgcatctg agacttctca gctcctgtct gtttcagaag
      721 gtgaactaat tttgcacaaa gtcagagtta atcaaaataa tctccaggct caagtcattg
      781 ttgattattt gtgtaagctg agctctttgc ctgcagagca gcatcctgtc ttgctgggca
      841 gtaccagctt tgctctgctc tgccagctga gtgtgaagaa gatacagctc tttgataccc
      901 aagatctgat caatgttttg aaagcttttg tcattttagg aatccctcac tcccattcaa
      961 tgctagatgt gtatgagacc aagtgttgcc atcaggtatg ggagatgaat atggatcagc
     1021 tccttttggt ggctgatctc tggaggtact taggccgcaa agtacctagg tttttaaaca
     1081 ttttttctag ttatcttaat ttgcactgga aggatctatc cttgtctcag ctagttcact
     1141 taatttatgt tataggtgaa aatcgtcagg tatcccagga cctaatgcaa aaattggaat
     1201 cattgatcct taaatatata gatttgatca atttggagga ggttggtacc atctgtttgg
     1261 ggttctttaa atcaagtact aatctctctg aatttgtcat gcggaaaatt ggagacttgg
     1321 cttgtgctaa cattcagcat ctgagtagtc gctccttagt gaatattgtt aaaatgttcc
     1381 gtttcactca cgtggatcac atcaatttca tgaagcagat tggagagata gctcctcagc
     1441 gaattccttc cctgggagtt caaggtgtca tgcacctgac tctttactgc tcggccttac
     1501 gcttcctgaa tgaaggagta atgaatgcag tggctgcgtc tttgcctcct agagtggcac
     1561 actgtcgaag taaagatgtt gccaagattc tgtggtcatt tggaactctg aattataagc
     1621 cacccaatgc agaagaattt tactccagcc tgataagtga gattcacaga aagatgcctg
     1681 aattcaacca gtacccagaa cacctgccca cctgcctgct gggcctggca tttttggagt
     1741 actttccagt agagttaatt gatttcgctc tcagtccagg gtttgtcagg ttagctcagg
     1801 agagaactaa gtttgacctc cttaaggaac tatataccct cgatggtaca gttggcattg
     1861 agtgtccaga ttacagaggc aatcgtctta gtactcacct tcagcaagag gggtctgaat
     1921 tgctgtggta tttagcagag aaggatatga attcaaagcc tgaattctta gaaactgtct
     1981 ttttactgga gaccatgctg ggggggcccc agtacgtcaa gcaccatatg attttgcctc
     2041 atacccgatc ttctgactta gaggtccagc ttgatgttaa cctgaagcca ttaccattta
     2101 atagagaagc cacgccggct gaaaatgtag ccaaattaag gcttgagcat gtgggagtca
     2161 gccttacaga tgatttgatg aataagttac taaaagggaa agcaagagga catttccagg
     2221 gcaaaactga gtcagagcct gggcagcagc ccatggagtt ggagaataag gcagctgtac
     2281 ctctgggggg cttcctttgc aatgtagcag ataaatcagg ggccatggag atggctggcc
     2341 tgtgccccgc agcctgcatg cagaccccaa gaatgaagct ggctgttcag ttcacaaaca
     2401 ggaaccagta ttgctatggc tccagggatc tccttggact gcacaatatg aagaggcggc
     2461 agctggctcg gcttggctac cgtgtggtag agttatccta ctgggaatgg ctcccactac
     2521 tgaaacgaac tcgcttagaa aagttggcgt ttcttcatga gaaagtattc acctctgctc
     2581 tctgaagggc atttaggggc atttctatgg caaagctata ggtgtatact gtaccaggtg
     2641 ttgcaaaatg attataaaag ccagaatgta agtttggcga taaaatagtg tgttgaggag
     2701 acttaattgt atccaaggca ggttagagct agtgtatgtt actgtgaatt gtaatgtagt
     2761 tggattgtac aaattactgc aaatgtatac atgttactct tagtaaataa taaacatctt
     2821 aatatgtcct acggtcaagt aa
//
