LOCUS       NM_001136193            6712 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens FAST kinase domains 2 (FASTKD2), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001136193
VERSION     NM_001136193.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6712)
  AUTHORS   Wu,T., Mao,L., Chen,C., Yin,F. and Peng,J.
  TITLE     A novel homozygous missense mutation in the FASTKD2 gene leads to
            Lennox-Gastaut syndrome
  JOURNAL   J Hum Genet 67 (10), 589-594 (2022)
   PUBMED   35729327
  REMARK    GeneRIF: A novel homozygous missense mutation in the FASTKD2 gene
            leads to Lennox-Gastaut syndrome.
REFERENCE   2  (bases 1 to 6712)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6712)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 6712)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 6712)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6712)
  AUTHORS   Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
            Adair,L.S., Lange,L.A. and Mohlke,K.L.
  TITLE     Genome-wide association study of anthropometric traits and evidence
            of interactions with age and study year in Filipino women
  JOURNAL   Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
   PUBMED   20966902
REFERENCE   7  (bases 1 to 6712)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   8  (bases 1 to 6712)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6712)
  AUTHORS   Ghezzi,D., Saada,A., D'Adamo,P., Fernandez-Vizarra,E.,
            Gasparini,P., Tiranti,V., Elpeleg,O. and Zeviani,M.
  TITLE     FASTKD2 nonsense mutation in an infantile mitochondrial
            encephalomyopathy associated with cytochrome c oxidase deficiency
  JOURNAL   Am J Hum Genet 83 (3), 415-423 (2008)
   PUBMED   18771761
  REMARK    GeneRIF: mutation in a gene segregating with a peculiar
            mitochondrial encephalomyopathy associated with COX deficiency in
            skeletal muscle. FASTKD2 is localized in the mitochondrial inner
            compartment.
REFERENCE   10 (bases 1 to 6712)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA021045.1, BC001544.1 and
            AC008269.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001136193.1.
            
            Summary: This gene encodes a protein that is localized in the
            mitochondrial inner compartment and that may play a role in
            mitochondrial apoptosis. Nonsense mutations have been reported to
            result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.187060.1,
                                           SRR1803612.163016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402774.8/ ENSP00000385990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               DA021045.1         31-592
            563-2951            BC001544.1         428-2816
            2952-6712           AC008269.4         73384-77144
FEATURES             Location/Qualifiers
     source          1..6712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..6712
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="FAST kinase domains 2"
                     /db_xref="GeneID:22868"
                     /db_xref="HGNC:HGNC:29160"
                     /db_xref="MIM:612322"
     exon            1..142
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            143..969
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2325
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 2,
                     mitochondrial"
                     /protein_id="NP_001129665.1"
                     /db_xref="CCDS:CCDS2371.1"
                     /db_xref="GeneID:22868"
                     /db_xref="HGNC:HGNC:29160"
                     /db_xref="MIM:612322"
                     /translation="MLTTLKPFGSVSVESKMNNKAGSFFWNLRQFSTLVSTSRTMRLC
                     CLGLCKPKIVHSNWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALR
                     IERLLYAKRLFFDSKQSLVPVDKSDDELKKVNLNHEVSNEDVLTKETKPNRISSRKLS
                     EECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLMFSHPAFNQLCE
                     HMMREAKIMQYKYLLFSLHAIVKLGIPQNTILVQTLLRVTQERINECDEICLSVLSTV
                     LEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLEMKAL
                     RELDRFSVLNSQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLRIMINILQSCKDL
                     QYHNLDLFKGLADYVAATFDIWKFRKVLFILILFENLGFRPVGLMDLFMKRIVEDPES
                     LNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLM
                     NYFPLAPFNQLLQKDIISELLTSDDMKNAYKLHTLDTCLKLDDTVYLRDIALSLPQLP
                     RELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMDTNRNQVLPLSDVD
                     TTSATDIQRVAVLCVSRSAYCLGSSHPRGFLAMKMRHLNAMGFHVILVNNWEMDKLEM
                     EDAVTFLKTKIYSVEALPVAAVNVQSTQ"
     exon            970..1073
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1182
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1306
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1446
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1619
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1786
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2005
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2090
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2205
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..6712
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="hexamer: ATTAAA"
     polyA_site      2471
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="major polyA site"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="hexamer: AATATA"
     polyA_site      3029
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="hexamer: ATTAAA"
     polyA_site      4135
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
     regulatory      6685..6690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="hexamer: AATAAA"
     polyA_site      6712
                     /gene="FASTKD2"
                     /gene_synonym="COXPD44; KIAA0971"
                     /note="major polyA site"
ORIGIN      
        1 gaagctgtca tggctgctcc tgtacgtagt cacggtcttg tgctctaagg tgagtggagg
       61 acgagcttgg gcttagcggc agcccgtatc acatcctaga ctttttactt cgaggagaag
      121 agtctcacga gttgtcctgg aagaaaacga cagcacgtgt tctttttcac tagtagaagt
      181 gacgttggtt tcatgttgac aactttgaag ccatttggaa gtgtttcagt ggagagcaaa
      241 atgaataaca aagcgggctc ctttttctgg aaccttagac aattcagtac attagtttca
      301 acaagcagaa ctatgaggct atgttgtttg ggactttgca aaccaaaaat agttcattca
      361 aactggaaca ttttaaataa ctttcataac agaatgcaat caactgatat cattagatat
      421 ctctttcagg atgcattcat ttttaaatca gatgttggct ttcaaacaaa gggcataagc
      481 actctaacag cccttagaat tgaaagacta ctttatgcta aaagactgtt ttttgactca
      541 aagcagtctc ttgtccctgt tgataaatct gatgatgaat tgaagaaagt aaaccttaat
      601 catgaagtct ccaatgaaga tgttcttacc aaggaaacaa aaccaaaccg tatcagcagt
      661 agaaaactgt ctgaggaatg taattccctg agtgatgtgt tagatgcatt ttcaaaagcg
      721 cccacatttc ctagtagcaa ctatttcaca gcaatgtgga caattgccaa aagactgtct
      781 gatgaccaga agcgctttga aaaacgactg atgtttagcc accctgcatt taatcagctc
      841 tgtgaacata tgatgagaga agccaagatc atgcagtata agtacctact gttcagtctt
      901 cacgccatag tgaagcttgg aatccctcag aacactattt tggtgcagac tttgctgagg
      961 gtgacccagg aacgtatcaa tgagtgtgat gagatatgcc tttcagtttt gtcaactgtt
     1021 ttagaggcaa tggaaccatg caagaatgtt catgttctac gaacgggatt cagaatacta
     1081 gttgatcagc aagtttggaa aatagaagat gtcttcacat tacaagttgt gatgaagtgt
     1141 attggaaaag atgcaccgat tgctcttaag aggaaactgg agatgaaagc cttgagggaa
     1201 ttagacagat tttctgtttt gaatagccaa cacatgtttg aagtactagc tgccatgaat
     1261 caccgatctc ttatactcct ggatgaatgc agtaaggtgg tcctagataa tatccatggg
     1321 tgtcctttaa gaataatgat caacatattg cagtcctgca aagacctcca gtaccataat
     1381 ttggatctct tcaagggact tgcagattat gtggctgcaa ctttcgacat ctggaagttc
     1441 agaaaagttc tttttatcct cattttattt gaaaaccttg gctttcgacc tgttggttta
     1501 atggacctgt ttatgaagag aatagtagag gatcctgaat ccctaaacat gaaaaacatt
     1561 ctatctattc ttcatactta ctcttctctc aatcatgtct acaaatgcca gaacaaagaa
     1621 cagttcgtgg aagttatggc tagtgctctg actggttatc ttcacactat ttcttctgaa
     1681 aacttattgg atgcagtata ttcattttgc ttgatgaatt actttcccct ggctcctttt
     1741 aatcagcttc tgcaaaaaga catcatcagt gagctgctga catcagatga catgaagaat
     1801 gcttacaagc tgcatacttt ggatacttgt ctaaaacttg atgatactgt ctatctgagg
     1861 gacatagcct tgtcactccc acagctgccg cgggagctgc catcgtcaca tacaaatgca
     1921 aaggtggcag aggtgctgag cagccttctg ggaggtgaag gacacttctc aaaggatgtg
     1981 cacttgccac acaattatca tattgatttt gaaatcagaa tggacactaa caggaatcaa
     2041 gtgctaccac tttctgatgt ggatacaact tctgctacag atattcaaag agtagctgtg
     2101 ctatgtgttt ccagatctgc ttattgtttg ggttcaagcc accccagagg attccttgct
     2161 atgaaaatgc ggcatttgaa tgcaatgggt tttcatgtga tcttggtcaa taactgggag
     2221 atggacaaac tagagatgga agatgcagtc acatttttga agactaaaat ctattcagta
     2281 gaagctcttc ctgttgctgc tgtaaatgtg caaagcacac aataaagtga aaatcaacct
     2341 tttcatatta ggagacatgc atttgtaaaa attaataaag atgacaagtc agttgtcaat
     2401 ggaattgagc tatctgctaa gacaaaaaat gttacctcag ttcactatta aaattaattt
     2461 taggagtgga agaaatgttg ttactgccat ttaaaaatat gctgagaaaa ttccagaagg
     2521 gttatttttc caaccacacc tattccctct agtgcccaga tatttgattt gtgagctgta
     2581 cgtttcacct tttcatcttt gatctactaa aaactggttt cttagttgtg aggtgtcaca
     2641 ggcaggttga tgtgggtagt agtccttgtc tttggaatct gaatatttat actcctgctc
     2701 taagctgttc taagacttgg ggttatgcct ttaaatcatt ttcaagcatt ggccaaataa
     2761 taattggaca aagttctaaa gttgtcaagt gtgtaagaat tagtgaggta gctgttgaaa
     2821 atgagtgagg atggtatttg tatttgtaat aagcactgca ggtagagata tttcatgggt
     2881 tataataaga gaaacacaga tgagatgtag atggtaagga gtcttactgt tgttggggtc
     2941 cttcctttct ctttcttttt tcccccttac ccctcccaca atttcatgaa gtcttttaaa
     3001 ttaaatatat agctgaattg tgttgtgaat cagacctgag gactattttt tcgattatgt
     3061 gtgttcattc tttgttcaaa tatttgtcca aattcaacta ttttgttcaa tatgcctgtc
     3121 tacctagtat ttggctcgct ggggatatag tgatgaatag gcatggtctc ttgtggaact
     3181 tacagcatgg gttccatgca agttggtgtt attctgcccc caagcacaca gacatgcaat
     3241 tactagacat cttagtatgt gccgggcact gctaagtatt catttgtgtg ctgccttttc
     3301 atgatctgaa ccctttgagg tgtagctgct attatgattc tctctgtgtc ttcacttcct
     3361 catctctaaa atcaggatag gtatttgccc aaggctacac agagtagggg agggctggag
     3421 tttgaatgtg agctaacata ggcttataag aaaatacaaa aactgggctg ggcacggtgg
     3481 ctcgtgcttg tcatcccagc acttgggagg ccgaggtggg ctgatcatga ggtcaggagg
     3541 tcaagacaat cctggccaac acggtgaaac cccatctcta ctaaaataca aaaaattagc
     3601 cgggcatggt ggtgcatgcc tataatccca gctactgggg aggctgaggc aggggaatcg
     3661 cttgaacccg ggaggtggag attgcagtga gccaagatgg tcctgctgca ctccagcctg
     3721 accacagagc gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaatacaaa
     3781 aactatagca atatgacaac agctgccagg ttgtatcaat ttatccagct tgcatttaga
     3841 aaaggttaga gctgaaagga aatttagtga ttatttaatt gttacttccc tcattttatg
     3901 gacgaggaag ataaggctca aagaattttc ctttcctgaa gtctcagcta tgccattggt
     3961 tccacatcat ttcatcctca cctgctcttc agcttgtgtc ccaggagatc aggcttctgg
     4021 ttccagattg gacaacctct agttttgtat acttggccaa gtgatttaac cttataagct
     4081 tcagaacaag atgcagatat tctgttatta aaggaactaa ggttttgtct ttaaatgttg
     4141 agtgtgcatc agttttgagt gtctaattat gactcctctt caaaggattt gacaaatttg
     4201 tgaatattta tgaccacctt ttagggtagt aattttcagt ttgtactagt taacctggca
     4261 gataaaaagg catccctctt ttactagcat tctagtgtta gcattcttca ttgctttgtg
     4321 tcaatgaaag aaaaatgggc aaagagctga tgaacatgaa aaaagttcag tctacttgta
     4381 aagacatgca cattgaaaca gaagagatgg ttttgccttt caaattagca gttttttttc
     4441 ttttaagaat tacagtgctg atgaaggtat aatgaggcaa gcacttgcat aagctgttgg
     4501 tagactgtaa attaatacct ttctggaatg tactttgtgg ggttttcttc tcccataatt
     4561 taaaaaatag ctttattata gtataattga catacagtaa actgcatata tttaaagtgt
     4621 accgttaggt cagttttgac gtacatacac acacacacac atctgtgaaa ccacaatcaa
     4681 gataatgaat atatctatca cctctaaaag gttcctgtct ttgctttttt ctctgtcccc
     4741 taaacaacca ctgatctatg gcacacatag aaaaaaatta ggaaatatat taaatgctca
     4801 ttttgtgtga gatatccaaa tatttttttc agaatcccta atgaaaaggt tgatcttgct
     4861 ctagatacaa gatataaaat tgtattcttg aaatagctac atgcaattct tttttattat
     4921 tttttaattt taatttttag atttttaaag atggggccct gctatgttac ccaggctagc
     4981 ttcaaactcc tgggctcaag ggatcctcct gcctcagctt ctcaagtaga taggactgat
     5041 tataggtaca ggctactgtg cccagctcaa ttcttgattg agacatttac cagctctccg
     5101 aattctcagt agttaccact gaatagaaac tttctttaca caaagctgat taaacagttt
     5161 agaactttta aaaaacattc aaaaattgaa aatttcatat atacatagcc taacaactct
     5221 tcttgtcatt gacaaaatgt gatggtattt tttttgtgat aatacacatg gacctcaaat
     5281 gcaattgaac tattcatatc aagtatttcc aaataacaat gacattccaa tttatagaat
     5341 gtcatgtgtt gtgagggtag tcaccctgca actggcttgg acatctctaa gcaaatagaa
     5401 gtttctgtaa gatagagatt tggggcatct acttggaact acctatgagg agctggcatt
     5461 cctcaaatcc caactgactg cacttttcca tgaaattacc cagcagttat gatggtcagt
     5521 ggctcactca gcagcaagcc acttaggtag ctggcgaggg acgtggcaca gccttgtctt
     5581 cacacagcac atcacagcca ggcagcaaag gacagatctc tctcatactc ttcattcaca
     5641 gggcctgaga ggtggaccat cagactccac cctgttttgc gctgacttgt agggagacct
     5701 aggtgtggag cttcctggcc aggagggcag tggctgccca gaaggcagga gatggctatc
     5761 tctttttttt tcctgagacg gagtcgtggt ctgtcgccca ggctggagtg ctgtggcgtg
     5821 atctcagctc actgcaagct ccgcctcctg ggttcaagcc attctcctgc ctcagcctcc
     5881 cgagtagctg ggactacagg tgcccacctc catgcccggc taatttttgt atttttagca
     5941 gaaacagggt ttcaccatgt tagccaggat ggtctcgatc tcctgacctt gcgatctgcc
     6001 cgcctttggc cttccaaagt gctgggatta taggcgtgag ccaccacccc cggtccaaga
     6061 tggctatctc ttaacacact tgtaacccat ttgtgcacac aggtgtgccg tgactcactg
     6121 gtggatccaa aaaaagctga agcctacatt tcccagagcc cctttcagct tgaattccaa
     6181 atgtgactta gcttcctcta tgcagatgta cctacttgaa actgggaagg ccaaatgaga
     6241 tagaggtaat gtttctgcca acaaacagcc acagagcatt ttatttttct agaagagcaa
     6301 taacagagac cccagggtgt ggtgtggcag gacgaggagc atccattttg ctggtgggga
     6361 ttgtggctaa aataatgtgg ctctggagcc agcaatgggc agcatcttca tgactttcca
     6421 gcttccaggc tgtaagcaga gatagcatct cttctggaca gccagttatg tgatagtgtt
     6481 ctgagagtca ttcctggaag tcagactaaa ggctgctcct tcagcctttc cattcatctt
     6541 gtaagcagga ggcttctgtg catggccaga aactaacaaa agcacattgt gtctaaacta
     6601 ggttgcagtg gtttctgtta tcagcaagta aatcctgatt gataaagata ctacaatata
     6661 tgcacatata tatgttatag aatcaataaa aattggatac tttgctttaa aa
//
