LOCUS       NM_024622               4200 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FAST kinase domains 1 (FASTKD1), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024622
VERSION     NM_024622.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Jourdain,A.A., Popow,J., de la Fuente,M.A., Martinou,J.C.,
            Anderson,P. and Simarro,M.
  TITLE     The FASTK family of proteins: emerging regulators of mitochondrial
            RNA biology
  JOURNAL   Nucleic Acids Res 45 (19), 10941-10947 (2017)
   PUBMED   29036396
  REMARK    GeneRIF: Despite the fact that proteins of the FASTK family
            FASTKD1-5 share the same domains, they exhibit various-sometimes
            opposing-functions in almost all steps of mitochondrial RNA
            metabolism.
            Review article
REFERENCE   4  (bases 1 to 4200)
  AUTHORS   Boehm,E., Zaganelli,S., Maundrell,K., Jourdain,A.A., Thore,S. and
            Martinou,J.C.
  TITLE     FASTKD1 and FASTKD4 have opposite effects on expression of specific
            mitochondrial RNAs, depending upon their endonuclease-like RAP
            domain
  JOURNAL   Nucleic Acids Res 45 (10), 6135-6146 (2017)
   PUBMED   28335001
  REMARK    GeneRIF: Disruption of FASTKD1 increases ND3 mRNA level. Disrupting
            FASTKD1 and FASTKD4 decreases ND3 mRNA like depleting FASTKD4
            alone.  Each RAP domain of FASTK proteins contains a nuclease fold
            with a conserved aspartate residue at the putative active site. The
            RAP domain is essential for the function of the FASTK proteins,
            while the region upstream determines RNA targeting and protein
            localization.
REFERENCE   5  (bases 1 to 4200)
  AUTHORS   Han,S., Udeshi,N.D., Deerinck,T.J., Svinkina,T., Ellisman,M.H.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proximity Biotinylation as a Method for Mapping Proteins Associated
            with mtDNA in Living Cells
  JOURNAL   Cell Chem Biol 24 (3), 404-414 (2017)
   PUBMED   28238724
REFERENCE   6  (bases 1 to 4200)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 4200)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 4200)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA650481.1, AK055892.1, AL832058.1, AB058703.1 and CA449468.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024622.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.174551.1,
                                           SRR1660809.48958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453153.7/ ENSP00000400513.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA650481.1         57-89
            34-1493             AK055892.1         1-1460
            1494-1688           AL832058.1         1433-1627
            1689-1737           AK055892.1         1656-1704
            1738-2699           AL832058.1         1677-2638
            2700-2953           AK055892.1         2538-2791
            2954-4196           AB058703.1         2282-3524
            4197-4200           CA449468.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4200
                     /gene="FASTKD1"
                     /note="FAST kinase domains 1"
                     /db_xref="GeneID:79675"
                     /db_xref="HGNC:HGNC:26150"
                     /db_xref="MIM:617529"
     exon            1..197
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..716
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2883
                     /gene="FASTKD1"
                     /note="isoform 1 is encoded by transcript variant 1; FAST
                     kinase domain-containing protein 1, mitochondrial"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 1,
                     mitochondrial isoform 1"
                     /protein_id="NP_078898.3"
                     /db_xref="CCDS:CCDS33318.1"
                     /db_xref="GeneID:79675"
                     /db_xref="HGNC:HGNC:26150"
                     /db_xref="MIM:617529"
                     /translation="MKKTPVFLESLVTNMLRLRAICPFSWRVFQFRPISCEPLIIQMN
                     KCTDEEQMFGFIERNKAILSEKQVGCAFDMLWKLQKQKTSLLKNAEYVRDHPQFLTLH
                     NLATNKFKLMNDDTLVNVLYVTQQFAGEAHDPLVEALVTEAWRRLERFDIKLLSEFSS
                     CLADQHLYFSPLMGKIADIVHRNLETTQDLSSLSVLMVNISSLISRHFQQQLVNKTEL
                     LFDTIDSSEVNVAKSIAKFLRNVRYRYQPLLERCNNVFLSNVDHLDLDSISKILSVYK
                     FLQFNSFEFIIMAKKKLTEMIPLCNHPASFVKLFVALGPIAGPEEKKQLKSTMLLMSE
                     DLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQR
                     KEFFAKLRELLLSYLKNSFIPTEVSVLVRAISLLPSPHLDEVGISRIEAVLPQCDLNN
                     LSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDHYGRQRLQHSNSLDLLRKELKSLK
                     GNTFPESLLEEMIATLQHFMDDINYINVGEIASFISSTDYLSTLLLDRIASVAVQQIE
                     KIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLE
                     YFPEDLLKAIFNIKFLARLDSQLEILSPSRSARVQFHLMELNRSVCLECPEFQIPWFH
                     DRFCQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKK
                     PLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKS
                     AMKKRHLEILGYRVIQISQFEWNSMALSTKDARMDYLRECIFGEVKSCL"
     exon            717..785
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..911
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1310
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1421
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1553
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..2040
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2155
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2284
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2413
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2527
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2666
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2781
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..4200
                     /gene="FASTKD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD1"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="FASTKD1"
                     /note="major polyA site"
     regulatory      4180..4185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTKD1"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="FASTKD1"
ORIGIN      
        1 ctggtttggg ggcaaggtct catgggaaag gtcatgtctc tcgaagaaag gttataaacc
       61 ctgagatatg agggttgggc gagacatccg agcctgtttc gttccgtgtt gggaccagga
      121 ataaccctga cttctgagct ttcataaccc caggatcctc cagaaaattt gcggcgcgct
      181 gagggaaaac cttgctgaag ctgtacattg gaatgcgttt acagtcattg taatggaagc
      241 aaaatacatg aaggaaaaac tgttatttgt atccctgctt attgcacctg acgactagtt
      301 gcagatggtt ttgtttacct aagaaaactt gtgatataaa tgaaaaaaac acctgttttc
      361 ctagagtcat tggttacaaa tatgcttcgt ctaagagcta tttgtccatt ctcctggaga
      421 gtgtttcaat ttcgacccat cagttgtgaa ccactaatta ttcagatgaa taagtgtaca
      481 gatgaggagc aaatgtttgg ttttattgaa agaaacaaag ccatactttc agaaaagcaa
      541 gtgggatgtg catttgatat gctttggaag cttcaaaagc agaagaccag cctgttaaaa
      601 aatgctgagt atgtcagaga ccatcctcaa tttcttactc ttcataattt agctacaaat
      661 aaattcaaat taatgaatga cgataccctg gtgaatgtgt tatacgtcac acaacagttt
      721 gctggtgagg cccatgaccc gctagttgaa gcactagtta cagaagcatg gagaaggcta
      781 gaaaggtttg atattaaact gctctcagaa ttttcctctt gcctagcaga tcagcatttg
      841 tattttagtc cattaatggg aaaaatagct gatattgttc ataggaactt ggaaaccaca
      901 caggacttaa gttccttgtc tgtcttgatg gtcaacatat cttctttaat atcacgacat
      961 tttcaacaac aactggtgaa caaaacagaa cttctttttg acaccataga ttcttctgag
     1021 gtcaacgttg caaaaagcat agcaaagttt cttcgaaatg ttagatatcg ttatcaacca
     1081 ctattagaaa gatgtaataa cgtattttta agtaatgtgg accaccttga tttggattcc
     1141 atcagtaaaa tacttagtgt atacaaattt ctacaattta atagttttga atttattata
     1201 atggctaaaa agaagctaac tgaaatgatt cctctgtgta atcatcctgc tagctttgta
     1261 aaattgtttg tagcattggg acccattgca ggacctgaag aaaagaaaca acttaaatca
     1321 actatgttat tgatgtcaga ggacctaact ggcgagcaag ccctggcagt gttgggagca
     1381 atgggagata tggaaagcag aaactcatgt ctgattaaaa gagttacttc agttctgcat
     1441 aaacatttgg atggctataa accattagag ttgttgaaga taactcaaga attaactttt
     1501 ctgcatttcc aaaggaagga gttttttgcg aaacttagag aattactgct tagttatttg
     1561 aaaaatagtt tcataccaac tgaggtgtct gttctggtcc gtgctatttc cctgctccct
     1621 tctcctcact tggacgaagt ggggatatcc cgaattgaag ccgttttacc acagtgtgac
     1681 ctaaataacc tgagtagttt tgccacatct gttttaagat ggattcagca tgatcacatg
     1741 tatttggata atatgactgc gaaacaactg aaactacttc aaaaattaga tcactatggt
     1801 cgtcagagac tacaacacag caacagtttg gatctgttac ggaaggaact taaatctctc
     1861 aaaggaaaca cgtttcctga gtcacttctt gaagaaatga ttgctacttt acagcatttc
     1921 atggatgata ttaattacat aaatgttggg gagattgcat cttttatttc tagtactgat
     1981 tacctcagta ctttgctact agataggata gcctcagtgg ctgttcagca gattgaaaag
     2041 atccatcctt ttacaatccc tgctattatt cgtccattca gcgtattgaa ctatgatcca
     2101 cctcaaaggg atgaattttt gggaacttgc gtgcaacatc ttaattctta cttaggtata
     2161 ttggatcctt ttatattagt gtttcttggt ttctctttgg ccacacttga atattttcca
     2221 gaagatctgc taaaggcaat ttttaacatc aaattcttag ctagattgga ttctcaactt
     2281 gaaattttat ctccatctcg aagtgcaaga gtccagtttc atcttatgga gttaaataga
     2341 tcagtctgct tggaatgccc tgagtttcag attccatggt ttcatgaccg cttctgtcaa
     2401 caatataata aaggtattgg tggcatggat ggaacacaac agcagatttt taaaatgtta
     2461 gcagaggtac taggaggaat caattgtgta aaagcctcgg ttcttacgcc ttattaccac
     2521 aaagtagatt ttgagtgtat cttggataaa agaaaaaaac ctcttccgta tggaagccat
     2581 aatatagcat tgggacaact accagaaatg ccctgggaat caaatatcga aatagttgga
     2641 tcaaggctgc caccaggggc tgaaaggatt gctttggaat ttttggattc aaaagcactt
     2701 tgtagaaata tccctcacat gaaaggaaaa tctgctatga aaaaacgaca tttggaaatt
     2761 ctggggtatc gtgtaattca gatttcccag tttgaatgga actctatggc actgtcaaca
     2821 aaggatgctc ggatggacta cctgagagaa tgtatatttg gagaagtcaa gtcatgtttg
     2881 tagtttttat ttaaaatgaa tgttatcgtg tgttacattt ggacctattt taataaagtg
     2941 gcctgtctca attaaaaaat aggtacaaat gtcctaaggt gggaacatgc ctggcatgtt
     3001 tgagaataac aaaggatcca gtgtggctgg agcagaacaa gtggggagtg gggtgggagt
     3061 gtataagaga aaagataaga gataacagag tcaaatacaa cctcttggct actctgagcg
     3121 agatgagaag ccattggggg cttttcaagt aaggaatgat atgaattcac attttaactg
     3181 cgttactttg gctaccttgt tgagataaga aaagactacg atgaggcaaa tgtgtaagaa
     3241 agaaaactct ttacgaggtc attgcaataa tccagacaac aatggatggt ggcttggaga
     3301 gagtggtagc agtggaggta ataagaagta gtcagatttt ttggatgtat gttgaagata
     3361 aaggcaacag aatttgctca ctgattggat atgaggtatg agacaaatag gagtcaagga
     3421 taattctaag tttttgtcct aagcaactaa gaggatgtca ttagcattaa ctaagatggg
     3481 gatagtctat aggaagagca agatgggggg caggtggtgg gggttgatca caagtttgtt
     3541 ttagatatgt tgagtttgtg atgtctttta aacatctaag tggatatatc aaatagagaa
     3601 ttcagtaaat gagcttggag gtcagggaag aggtccaggc cccagatata aatgtataaa
     3661 tgtcagcagt attcaatgcc atgagagtag atgaaatcgc ttaaaatgag attagagaag
     3721 agtgtgaatg gaggagaggt ctgaggactg agttttcaag tgccccaaca ttaaaagatt
     3781 aagaggaaga ggaggaatca ggaaaggaga ctgagcaggg atggccaatg aggtaggagg
     3841 aaggaaggta agtaatactt cctagaagcc aagtggataa agcatttcaa gggggaggtg
     3901 agtagttgta tcagatgctg ctgataggtc aggaaagatg acaaatggga aatggctatt
     3961 aaatttagca acatgaaaat cattagtact ttgaaaatag tcgttttgaa gtggtgcatg
     4021 tgaaagcctg actggttcaa gagaaaatgg gaggagatac attttctcct aaatggaagc
     4081 aaagaaatgg ggtagtagct gagtggacca tcttgacctg gtgtaatcct acacattgag
     4141 ggaataatgg cttctccctg tcttacaaca catttattca ataaaatggt tactaagggc
//
