LOCUS       NM_006712               1794 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Fas activated serine/threonine kinase (FASTK),
            transcript variant 1, mRNA.
ACCESSION   NM_006712 NM_025096
VERSION     NM_006712.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Jensen,L.R., Possfelt-Moller,E., Nielsen,A.E., Singh,U.M.,
            Svendsen,L.B. and Penninga,L.
  TITLE     Accuracy of FAST in detecting intraabdominal bleeding in major
            trauma with pelvic and/or acetabular fractures: a retrospective
            cohort study
  JOURNAL   Eur J Orthop Surg Traumatol 34 (3), 1479-1486 (2024)
   PUBMED   38253932
  REMARK    GeneRIF: Accuracy of FAST in detecting intraabdominal bleeding in
            major trauma with pelvic and/or acetabular fractures: a
            retrospective cohort study.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Magraner-Pardo,L., Gobelli,D., de la Fuente,M.A., Pons,T. and
            Simarro,M.
  TITLE     Systematic Analysis of FASTK Gene Family Alterations in Cancer
  JOURNAL   Int J Mol Sci 22 (21), 11337 (2021)
   PUBMED   34768773
  REMARK    GeneRIF: Systematic Analysis of FASTK Gene Family Alterations in
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Izquierdo,J.M. and Valcarcel,J.
  TITLE     Fas-activated serine/threonine kinase (FAST K) synergizes with
            TIA-1/TIAR proteins to regulate Fas alternative splicing
  JOURNAL   J Biol Chem 282 (3), 1539-1543 (2007)
   PUBMED   17135269
  REMARK    GeneRIF: FAST K synergizes with TIA-1/TIAR proteins to regulate Fas
            alternative splicing
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1794)
  AUTHORS   Li,W., Simarro,M., Kedersha,N. and Anderson,P.
  TITLE     FAST is a survival protein that senses mitochondrial stress and
            modulates TIA-1-regulated changes in protein expression
  JOURNAL   Mol Cell Biol 24 (24), 10718-10732 (2004)
   PUBMED   15572676
  REMARK    GeneRIF: FAST is a survival protein that senses mitochondrial
            stress and modulates TIA-1 regulated changes in protein expression.
REFERENCE   9  (bases 1 to 1794)
  AUTHORS   Li,W., Kedersha,N., Chen,S., Gilks,N., Lee,G. and Anderson,P.
  TITLE     FAST is a BCL-X(L)-associated mitochondrial protein
  JOURNAL   Biochem Biophys Res Commun 318 (1), 95-102 (2004)
   PUBMED   15110758
REFERENCE   10 (bases 1 to 1794)
  AUTHORS   Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P.
  TITLE     Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1
            during Fas-mediated apoptosis
  JOURNAL   J Exp Med 182 (3), 865-874 (1995)
   PUBMED   7544399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA253544.1, BC011770.2 and
            BU682096.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006712.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. This kinase was shown to be
            activated rapidly during Fas-mediated apoptosis in Jurkat cells. In
            response to Fas receptor ligation, it phosphorylates TIA1, an
            apoptosis-promoting nuclear RNA-binding protein. The encoded
            protein is a strong inducer of lymphocyte apoptosis. Two transcript
            variants encoding different isoforms have been found for this gene.
            Other variants exist, but their full-length natures have not yet
            been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.435169.1,
                                           SRR3476690.904973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297532.11/ ENSP00000297532.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DA253544.1         75-164
            91-1725             BC011770.2         76-1710
            1726-1792           BC011770.2         1712-1778
            1793-1794           BU682096.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1794
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /note="Fas activated serine/threonine kinase"
                     /db_xref="GeneID:10922"
                     /db_xref="HGNC:HGNC:24676"
                     /db_xref="MIM:606965"
     exon            1..125
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1693
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.8"
                     /note="isoform 1 is encoded by transcript variant 1; FAST
                     kinase; fas-activated serine/threonine kinase"
                     /codon_start=1
                     /product="fas-activated serine/threonine kinase isoform 1"
                     /protein_id="NP_006703.1"
                     /db_xref="CCDS:CCDS5918.1"
                     /db_xref="GeneID:10922"
                     /db_xref="HGNC:HGNC:24676"
                     /db_xref="MIM:606965"
                     /translation="MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQT
                     SPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWL
                     GQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHV
                     CLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRY
                     PRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKV
                     VQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALH
                     FVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLIT
                     DRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDP
                     FLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLM
                     GYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG"
     exon            126..548
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            549..728
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            729..868
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1082
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1242
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1334
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1470
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1585
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1794
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /note="hexamer: ATTAAA"
     polyA_site      1794
                     /gene="FASTK"
                     /gene_synonym="FAST"
                     /note="major polyA site"
ORIGIN      
        1 atctaggggc tgctgggaag atggcggact cggtggctag ccgatgagga ggccgcgggg
       61 ggaacccggc ccccgggccc cgagaccgac tgagggagcg acctgcgcag ggcccgggga
      121 gtcatggtct ccatcaccca actccatgct tcgagtcctg ctctctgctc agacctcccc
      181 tgctcggctg tctggcctgc tgctgatccc tccagtacag ccctgctgtt tggggcccag
      241 caaatggggg gaccggcctg ttggaggagg ccccagtgca ggtcctgtgc aaggactgca
      301 gcggcttctg gaacaggcga agagccctgg ggagctgctg cgctggctgg gccagaaccc
      361 cagcaaggtg cgcgcccacc actactcggt ggcgcttcgt cgtctgggcc agctcttggg
      421 gtctcggcca cggccccctc ctgtggagca ggtcacactg caggacttga gtcagctcat
      481 catccgaaac tgcccctcct ttgacattca caccatccac gtgtgtctgc accttgcagt
      541 cttacttggc tttccatctg atggtcccct ggtgtgtgcc ctggaacagg agcgaaggct
      601 ccgcctccct ccgaagccac ctcccccttt gcagcccctt ctccgaggtg ggcaagggtt
      661 ggaagctgct ctaagctgcc cccgttttct gcggtatcca cggcagcatc tgatcagcag
      721 cctggcagag gcaaggccag aggaactgac tccccacgtg atggtgctcc tggcccagca
      781 cctggcccgg caccggttgc gggagcccca gcttctggaa gccattgccc acttcctggt
      841 ggttcaggaa acgcaactca gcagcaaggt ggtacagaag ttggtcctgc cctttgggcg
      901 actgaactac ctgcccctgg aacagcagtt tatgccctgc cttgagagga tcctggctcg
      961 ggaagcaggg gtggcacccc tggctacagt caacatcttg atgtcactgt gccaactgcg
     1021 gtgcctgccc ttcagagccc tgcactttgt tttttcccct ggcttcatca actacatcag
     1081 tggcacccct catgctctga ttgtgcgtcg ctacctctcc ctgctggaca cggccgtgga
     1141 gctggagctc ccaggatacc ggggtccccg ccttccccga aggcagcaag tgcccatctt
     1201 tccccagcct ctcatcaccg accgtgcccg ctgcaagtac agtcacaagg acatagtagc
     1261 tgaggggttg cgccagctgc tgggggagga gaaataccgc caggacctga ctgtgcctcc
     1321 aggctactgc acagacttcc tgctgtgcgc cagcagctct ggtgctgtgc ttcccgtgag
     1381 gacccaggac cccttcctgc catacccacc aaggtcctgc ccacagggcc aggctgcctc
     1441 tagcgccact actcgagacc ctgcccagag ggtggtgctg gtgttgcggg aacgctggca
     1501 tttctgccgg gacggccggg tgctgctggg ctcgagggcc ctgagggagc ggcacctagg
     1561 cctgatgggc taccagctcc tgccgctacc cttcgaggaa ctggagtccc agagaggcct
     1621 gccccagctc aagagctacc tgaggcagaa gctccaggcc ctgggcctgc gctgggggcc
     1681 tgaagggggc tgaggggttg atgtggggtt caggatggcc cccccatggg gggtggatga
     1741 tttgcacttt ggttccctgt gttttgattt ctcattaaag ttcctttcct tccc
//
