LOCUS       NM_000639               1805 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens Fas ligand (FASLG), transcript variant 1, mRNA.
ACCESSION   NM_000639
VERSION     NM_000639.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Schmid,A., Bello,C. and Becker,C.F.W.
  TITLE     Synthesis of N-Glycosylated Soluble Fas Ligand
  JOURNAL   Chemistry 30 (24), e202400120 (2024)
   PUBMED   38363216
  REMARK    GeneRIF: Synthesis of N-Glycosylated Soluble Fas Ligand.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Lebrault,E., Oblet,C., Kurma,K., Levoin,N., Jeannet,R., Jean,M.,
            Vacher,P. and Legembre,P.
  TITLE     CD95L concatemers highlight different stoichiometries of
            CD95-mediated apoptotic and nonapoptotic pathways
  JOURNAL   Eur J Immunol 54 (1), e2350626 (2024)
   PUBMED   37837385
  REMARK    GeneRIF: CD95L concatemers highlight different stoichiometries of
            CD95-mediated apoptotic and nonapoptotic pathways.
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Choy,J.C.
  TITLE     The complex web of FasL: cell type-specific roles in affecting and
            controlling acute graft-vs-host disease
  JOURNAL   J Leukoc Biol 114 (3), 202-204 (2023)
   PUBMED   37431614
  REMARK    GeneRIF: The complex web of FasL: cell type-specific roles in
            affecting and controlling acute graft-vs-host disease.
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Souza,I.P., Amoras,E.D.S.G., Sousa,F.D.M., Sousa,P.V.N.R.,
            Lima,S.S., Cayres-Vallinoto,I.M.V., Ishak,R., Vallinoto,A.C.R. and
            Queiroz,M.A.F.
  TITLE     Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated
            with Tuberculosis
  JOURNAL   Biomolecules 13 (1), 80 (2022)
   PUBMED   36671466
  REMARK    GeneRIF: Plasma Levels of sFas-sFasL and FASL Gene Expression Are
            Associated with Tuberculosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Asgari,R., Bidmeshkipour,A., Mansouri,K., Bakhtiari,M., Mozafari,H.
            and Abdolmaleki,A.
  TITLE     Fas cell surface death receptor/Fas ligand genetic variants in
            gastric cancer patients: A case-control study
  JOURNAL   Indian J Med Res 156 (1), 77-82 (2022)
   PUBMED   36124496
  REMARK    GeneRIF: Fas cell surface death receptor/Fas ligand genetic
            variants in gastric cancer patients: A case-control study.
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Boldin,M.P., Varfolomeev,E.E., Pancer,Z., Mett,I.L., Camonis,J.H.
            and Wallach,D.
  TITLE     A novel protein that interacts with the death domain of Fas/APO1
            contains a sequence motif related to the death domain
  JOURNAL   J Biol Chem 270 (14), 7795-7798 (1995)
   PUBMED   7536190
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Brunner,T., Mogil,R.J., LaFace,D., Yoo,N.J., Mahboubi,A.,
            Echeverri,F., Martin,S.J., Force,W.R., Lynch,D.H., Ware,C.F. et al.
  TITLE     Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates
            activation-induced apoptosis in T-cell hybridomas
  JOURNAL   Nature 373 (6513), 441-444 (1995)
   PUBMED   7530336
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Alderson,M.R., Tough,T.W., Davis-Smith,T., Braddy,S., Falk,B.,
            Schooley,K.A., Goodwin,R.G., Smith,C.A., Ramsdell,F. and Lynch,D.H.
  TITLE     Fas ligand mediates activation-induced cell death in human T
            lymphocytes
  JOURNAL   J Exp Med 181 (1), 71-77 (1995)
   PUBMED   7528780
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Suda,T., Takahashi,T., Golstein,P. and Nagata,S.
  TITLE     Molecular cloning and expression of the Fas ligand, a novel member
            of the tumor necrosis factor family
  JOURNAL   Cell 75 (6), 1169-1178 (1993)
   PUBMED   7505205
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Bleesing,J.J.H., Nagaraj,C.B. and Zhang,K.
  TITLE     Autoimmune Lymphoproliferative Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301287
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X89102.1 and Z96050.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000639.2.
            
            Summary: This gene is a member of the tumor necrosis factor
            superfamily. The primary function of the encoded transmembrane
            protein is the induction of apoptosis triggered by binding to FAS.
            The FAS/FASLG signaling pathway is essential for immune system
            regulation, including activation-induced cell death (AICD) of T
            cells and cytotoxic T lymphocyte induced cell death. It has also
            been implicated in the progression of several cancers. Defects in
            this gene may be related to some cases of systemic lupus
            erythematosus (SLE). Alternatively spliced transcript variants have
            been described. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X89102.1, BC017502.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367721.3/ ENSP00000356694.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1802              X89102.1           59-1860
            1803-1805           Z96050.1           84624-84626
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..1805
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /note="Fas ligand"
                     /db_xref="GeneID:356"
                     /db_xref="HGNC:HGNC:11936"
                     /db_xref="MIM:134638"
     exon            1..447
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..945
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /note="isoform 1 is encoded by transcript variant 1; CD95
                     ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis
                     factor ligand superfamily member 6; fas antigen ligand;
                     apoptosis antigen ligand; mutant tumor necrosis factor
                     family member 6; Fas ligand (TNF superfamily, member 6);
                     tumor necrosis factor ligand 1A"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     6 isoform 1"
                     /protein_id="NP_000630.1"
                     /db_xref="CCDS:CCDS1304.1"
                     /db_xref="GeneID:356"
                     /db_xref="HGNC:HGNC:11936"
                     /db_xref="MIM:134638"
                     /translation="MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRR
                     PPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMF
                     QLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPL
                     EWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKY
                     PQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFF
                     GLYKL"
     exon            448..493
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            494..550
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            551..1805
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="FASLG"
                     /gene_synonym="ALPS1B; APT1LG1; APTL; CD178; CD95-L;
                     CD95L; FASL; TNFSF6; TNLG1A"
                     /note="major polyA site"
ORIGIN      
        1 agcagtcagc aacagggtcc cgtccttgac acctcagcct ctacaggact gagaagaagt
       61 aaaaccgttt gctggggctg gcctgactca ccagctgcca tgcagcagcc cttcaattac
      121 ccatatcccc agatctactg ggtggacagc agtgccagct ctccctgggc ccctccaggc
      181 acagttcttc cctgtccaac ctctgtgccc agaaggcctg gtcaaaggag gccaccacca
      241 ccaccgccac cgccaccact accacctccg ccgccgccgc caccactgcc tccactaccg
      301 ctgccacccc tgaagaagag agggaaccac agcacaggcc tgtgtctcct tgtgatgttt
      361 ttcatggttc tggttgcctt ggtaggattg ggcctgggga tgtttcagct cttccaccta
      421 cagaaggagc tggcagaact ccgagagtct accagccaga tgcacacagc atcatctttg
      481 gagaagcaaa taggccaccc cagtccaccc cctgaaaaaa aggagctgag gaaagtggcc
      541 catttaacag gcaagtccaa ctcaaggtcc atgcctctgg aatgggaaga cacctatgga
      601 attgtcctgc tttctggagt gaagtataag aagggtggcc ttgtgatcaa tgaaactggg
      661 ctgtactttg tatattccaa agtatacttc cggggtcaat cttgcaacaa cctgcccctg
      721 agccacaagg tctacatgag gaactctaag tatccccagg atctggtgat gatggagggg
      781 aagatgatga gctactgcac tactgggcag atgtgggccc gcagcagcta cctgggggca
      841 gtgttcaatc ttaccagtgc tgatcattta tatgtcaacg tatctgagct ctctctggtc
      901 aattttgagg aatctcagac gtttttcggc ttatataagc tctaagagaa gcactttggg
      961 attctttcca ttatgattct ttgttacagg caccgagaat gttgtattca gtgagggtct
     1021 tcttacatgc atttgaggtc aagtaagaag acatgaacca agtggacctt gagaccacag
     1081 ggttcaaaat gtctgtagct cctcaactca cctaatgttt atgagccaga caaatggagg
     1141 aatatgacgg aagaacatag aactctgggc tgccatgtga agagggagaa gcatgaaaaa
     1201 gcagctacca ggtgttctac actcatctta gtgcctgaga gtatttaggc agattgaaaa
     1261 ggacaccttt taactcacct ctcaaggtgg gccttgctac ctcaaggggg actgtctttc
     1321 agatacatgg ttgtgacctg aggatttaag ggatggaaaa ggaagactag aggcttgcat
     1381 aataagctaa agaggctgaa agaggccaat gccccactgg cagcatcttc acttctaaat
     1441 gcatatcctg agccatcggt gaaactaaca gataagcaag agagatgttt tggggactca
     1501 tttcattcct aacacagcat gtgtatttcc agtgcaattg taggggtgtg tgtgtgtgtg
     1561 tgtgtgtgtg tgtgtgtatg actaaagaga gaatgtagat attgtgaagt acatattagg
     1621 aaaatatggg ttgcatttgg tcaagatttt gaatgcttcc tgacaatcaa ctctaatagt
     1681 gcttaaaaat cattgattgt cagctactaa tgatgttttc ctataatata ataaatattt
     1741 atgtagatgt gcatttttgt gaaatgaaaa catgtaataa aaagtatatg ttaggataca
     1801 aataa
//
