LOCUS       NM_005687               6761 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phenylalanyl-tRNA synthetase subunit beta (FARSB),
            transcript variant 1, mRNA.
ACCESSION   NM_005687
VERSION     NM_005687.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6761)
  AUTHORS   Wang,Y., Wang,G., Hu,S., Yin,C., Zhao,P., Zhou,X., Shao,S., Liu,R.,
            Hu,W., Liu,G.L., Ke,W. and Song,Z.
  TITLE     FARSB Facilitates Hepatocellular Carcinoma Progression by
            Activating the mTORC1 Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (23), 16709 (2023)
   PUBMED   38069034
  REMARK    GeneRIF: FARSB Facilitates Hepatocellular Carcinoma Progression by
            Activating the mTORC1 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6761)
  AUTHORS   Gao,X., Guo,R., Li,Y., Kang,G., Wu,Y., Cheng,J., Jia,J., Wang,W.,
            Li,Z., Wang,A., Xu,H., Jia,Y., Li,Y., Qi,X., Wei,Z. and Wei,C.
  TITLE     Contribution of upregulated aminoacyl-tRNA biosynthesis to
            metabolic dysregulation in gastric cancer
  JOURNAL   J Gastroenterol Hepatol 36 (11), 3113-3126 (2021)
   PUBMED   34159625
  REMARK    GeneRIF: Contribution of upregulated aminoacyl-tRNA biosynthesis to
            metabolic dysregulation in gastric cancer.
REFERENCE   3  (bases 1 to 6761)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6761)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6761)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6761)
  AUTHORS   Moor,N., Linshiz,G. and Safro,M.
  TITLE     Cloning and expression of human phenylalanyl-tRNA synthetase in
            Escherichia coli: comparative study of purified recombinant enzymes
  JOURNAL   Protein Expr Purif 24 (2), 260-267 (2002)
   PUBMED   11858721
REFERENCE   7  (bases 1 to 6761)
  AUTHORS   Rodova,M., Ankilova,V. and Safro,M.G.
  TITLE     Human phenylalanyl-tRNA synthetase: cloning, characterization of
            the deduced amino acid sequences in terms of the structural domains
            and coordinately regulated expression of the alpha and beta
            subunits in chronic myeloid leukemia cells
  JOURNAL   Biochem Biophys Res Commun 255 (3), 765-773 (1999)
   PUBMED   10049785
REFERENCE   8  (bases 1 to 6761)
  AUTHORS   Sen,S., Zhou,H., Ripmaster,T., Hittelman,W.N., Schimmel,P. and
            White,R.A.
  TITLE     Expression of a gene encoding a tRNA synthetase-like protein is
            enhanced in tumorigenic human myeloid leukemia cells and is cell
            cycle stage- and differentiation-dependent
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6164-6169 (1997)
   PUBMED   9177188
REFERENCE   9  (bases 1 to 6761)
  AUTHORS   Nazarenko,I.A., Peterson,E.T., Zakharova,O.D., Lavrik,O.I. and
            Uhlenbeck,O.C.
  TITLE     Recognition nucleotides for human phenylalanyl-tRNA synthetase
  JOURNAL   Nucleic Acids Res 20 (3), 475-478 (1992)
   PUBMED   1741281
REFERENCE   10 (bases 1 to 6761)
  AUTHORS   Archambault de Vencay,J., Thomes,J.C. and Julien,R.
  TITLE     Phenylalanyl-tRNA synthetase of the human placenta. Evidence for
            different enzymatic forms in equilibrium
  JOURNAL   FEBS Lett 89 (1), 98-102 (1978)
   PUBMED   658405
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG721840.1, AF042346.1 and
            AC097461.3.
            
            On May 17, 2019 this sequence version replaced NM_005687.4.
            
            Summary: This gene encodes a highly conserved enzyme that belongs
            to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme
            comprises the regulatory beta subunits that form a tetramer with
            two catalytic alpha subunits. In the presence of ATP, this tetramer
            is responsible for attaching L-phenylalanine to the terminal
            adenosine of the appropriate tRNA. A pseudogene located on
            chromosome 10 has been identified. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.157152.1,
                                           SRR1660803.72872.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281828.8/ ENSP00000281828.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BG721840.1         266-284
            20-1771             AF042346.1         1-1752
            1772-6761           AC097461.3         118702-123691       c
FEATURES             Location/Qualifiers
     source          1..6761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..6761
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /note="phenylalanyl-tRNA synthetase subunit beta"
                     /db_xref="GeneID:10056"
                     /db_xref="HGNC:HGNC:17800"
                     /db_xref="MIM:609690"
     exon            1..77
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1789
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /EC_number="6.1.1.20"
                     /note="phenylalanine-tRNA synthetase-like, beta subunit;
                     phenylalanyl-tRNA synthetase-like, beta subunit;
                     phenylalanine tRNA ligase 1, beta, cytoplasmic;
                     phenylalanine-tRNA ligase beta chain; phenylalanyl-tRNA
                     synthetase beta chain; phenylalanyl-tRNA synthetase beta
                     subunit"
                     /codon_start=1
                     /product="phenylalanine--tRNA ligase beta subunit"
                     /protein_id="NP_005678.3"
                     /db_xref="CCDS:CCDS2454.1"
                     /db_xref="GeneID:10056"
                     /db_xref="HGNC:HGNC:17800"
                     /db_xref="MIM:609690"
                     /translation="MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEI
                     ISKEQGNVKAAGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKAPVYKRVMPD
                     GKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIG
                     THDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDNHLKHYLHIIENKP
                     LYPVIYDSNGVVLSMPPIINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSE
                     YCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRM
                     YLKSEVIGDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFP
                     LNKLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVA
                     RTTLLPGLLKTIAANRKMPLPLKLFEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGF
                     EIIHGLLDRIMQLLDVPPGEDKGGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHP
                     DVITKFELTMPCSSLEINVGPFL"
     exon            78..133
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            134..288
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            289..358
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            359..474
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            475..625
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            626..734
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            735..805
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            806..867
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            868..919
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            920..981
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1189
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1270
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1363
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1481
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1637
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..6761
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /note="hexamer: AATAAA"
     polyA_site      1915
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /note="major polyA site"
     polyA_site      1976
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /note="hexamer: AACAAG"
     polyA_site      2176
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
     regulatory      6738..6743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
                     /note="hexamer: AATAAA"
     polyA_site      6761
                     /gene="FARSB"
                     /gene_synonym="FARSLB; FRSB; HSPC173; NEDBLLA; PheHB;
                     PheRS; RILDBC; RILDBC1; RJBS"
ORIGIN      
        1 gcagtgagtt cgacacacca tgccgactgt cagcgtgaag cgtgatctgc tcttccaagc
       61 cctgggccgc acctacactg acgaagaatt tgatgaacta tgttttgaat ttggtctgga
      121 gcttgatgaa attacatctg agaaggaaat aataagtaaa gaacaaggta atgtaaaggc
      181 agcaggagcc tctgatgttg ttctttacaa aattgacgtc cctgccaata gatatgatct
      241 cctgtgtctg gaaggattgg ttcgaggact tcaggtcttc aaagaaagga taaaggctcc
      301 agtgtataaa cgggtaatgc ctgatggaaa aatccagaaa ttgattatca cagaagagac
      361 agctaagata cgtccttttg cggtagcagc agttctccgt aatataaagt ttactaaaga
      421 tcgatatgac agcttcattg aacttcagga gaaattacat cagaatattt gcaggaaaag
      481 agcactggtt gccattggta cccatgattt ggacactttg tcgggcccat ttacttatac
      541 tgcaaagcgt ccttcagata tcaaattcaa gcctctaaat aagaccaagg agtatacagc
      601 ctgtgaactg atgaacatat acaagactga caatcacctg aaacattatt tacatatcat
      661 tgaaaacaaa cccctgtatc cagttatcta tgatagcaat ggtgtcgtcc tttcaatgcc
      721 tcccatcatc aatggggatc attccagaat aacagtaaat actagaaata tttttattga
      781 atgcacggga actgacttta ctaaggcaaa aatagttctt gatattattg tcaccatgtt
      841 cagtgaatat tgtgagaatc aatttacggt cgaagctgct gaagtggttt ttcctaatgg
      901 aaaatcacat acctttccag aattagctta ccgaaaggag atggtgagag ctgacctaat
      961 taacaaaaaa gttggaatca gagaaactcc agaaaatctt gccaaacttc tgaccaggat
     1021 gtatttaaaa tcagaagtca taggtgatgg gaatcagatt gagattgaaa tccctccaac
     1081 cagagctgac attatccatg catgtgatat tgtagaagat gcagctattg cttatggata
     1141 taacaacatt cagatgactc tcccgaaaac ttacaccata gctaatcaat ttcctcttaa
     1201 taagctcact gaacttctcc gacatgacat ggcagccgct ggcttcactg aagcacttac
     1261 ctttgccctg tgctcccaag aagatattgc tgataaacta ggtgtggata tctctgcaac
     1321 aaaggcagtc cacataagta atcctaaaac agctgaattt caggtggcac gcactaccct
     1381 tcttcctggc ctcctgaaga ccatagcagc aaatcgtaag atgccccttc cactgaaact
     1441 gtttgaaatc tctgacattg taataaaaga ttctaataca gatgtaggtg caaaaaacta
     1501 cagacatctc tgtgctgttt attacaacaa gaatcctggg tttgagatca ttcatgggct
     1561 gctggacaga attatgcagt tgctcgatgt gcctcctggt gaagacaagg ggggatatgt
     1621 gatcaaagca tcagaagggc ctgctttctt ccccgggcga tgtgcagaga tctttgccag
     1681 gggtcaaagc gtcgggaagc ttggggtcct tcatcctgac gttatcacca aatttgagct
     1741 gaccatgccc tgctcctccc tagaaatcaa tgttggaccc tttttgtgaa gattggtctc
     1801 tgtggtgtga ttctcttccc aggtgtccct ttctcctccc ctagtgtcct taagtcctcc
     1861 tccacaggga acatctattt gggctttgat gtttaataaa gtagaaagca ctgtctggct
     1921 gtgtgggtag agaccatcct ttccctgcat attaggccag cttgtgccat ataccagtgt
     1981 ggtgtctgtg tgtgaagctg cattgttggg taaaagcccc gtggagtgct ggagaaatgc
     2041 actagcagag tgcaggatct gttctgaaag gcagacgtgc tcctcagaca tcagaacatc
     2101 acattggaac ggattactcc tgcataacaa gatcccattt ctttccttat tgataaaaca
     2161 agataatcga tgagaattca tgttgcatga gttcgagata actgaggggt ttagctttga
     2221 ttttctacat ttgacatgta ttcatcattg agaaacacta aaataacaat atttttagaa
     2281 aacgtttaag aatcaattat ggtccaacaa ttatagcttc tgaggtcagt ttaaagtgaa
     2341 agaaaaatct gtaatacaag gattcaaaat atgtgagggt gcataggtat tttttactct
     2401 atctgtgata ctctaagata gagtacatgc aacaaagatc tgttctgctg taagagttaa
     2461 aatggacaag tattgatatc aatgcagtat gaacattagg aaacaatgag aagcttattt
     2521 ttgccatagg ccatacatgt tactgtaatc agtcagttat aaaatcatgg ttttaaatac
     2581 ttaattgagc tactagtttc tctattgtcc cagggagata ttagacctct ctttttctga
     2641 agctaagctt cagccaatcc tccttgtttt atatcctaat ttcctttctt acttcaatct
     2701 agaattctcc agtaggtacc atctctggaa aaaagctggg tctcatgttt gagacaagtt
     2761 cccaggtact attgaagtaa taagaaatat gataaaatat aatactttaa agtcccagta
     2821 gaaatagcta acaaaggctg ggtgcgctgt ggctcatgcc tgtaatccta gcactttggg
     2881 aggctgaggt gggcagatca cttgaggcca atagttcgag atcagcctga ccaacatggt
     2941 gaaatgccat ctccactaaa aatataaaaa ttagccaggc atggtggtgt gggcctgcag
     3001 tcccagctac ctgggaggct gagtcaggaa aatctcttga accaggaggt ggacgttgca
     3061 gtgatcccag attgtgccac tgccctccag cctgggtgac agagtgagat tctgtctaca
     3121 aaaaaaaaaa agaagaagta gctaacaaag atagtgaaat aagaattatg tttatggatc
     3181 ttttgctgag tctactacta ggagaaaacc tgaccatatt acaaccttga attggggcag
     3241 cagtgtctaa ctctgtaaga tttgtgaaca cacacacttc cagctgaccc ttcacagctc
     3301 tgttataagc agatccttac aacattttaa aaatgaaata tgccctctaa aaataatgca
     3361 tgccaaaagg acttgtatcc agcatgcata aagatttctt aaaacttaat aataaaactt
     3421 aatagtaaaa ataaaacaac tgttttttaa aaatgtgcaa gagttgagca aacatttccc
     3481 aaaagatgac atatgaatga gcacttgaaa agatcctcaa catcgttagt catcagggaa
     3541 atgcaactaa aattcacaat gacaaactgc atacccatta aaatggctaa aatttaagat
     3601 tcataaatca aatactgctg agactggagc aagtggaact ttcatgcact gctggtgagt
     3661 cacaatgtaa aatgttacat tgtgacttta gaaaacagct tggcagtctc ttgaaacata
     3721 cacctaccat ctagccattc tattcctagg tttacccata tggccaaaga tttttatgca
     3781 agtgttcaca gtgttactta tagtagttac aaattgcagt atatccatac tatgaaatac
     3841 ttctcagcaa taagaaggaa tgaactactg atcctcaaaa caacatgaat gaatttcaaa
     3901 acagtatgct aagtgaaagc aagagacaca aaagactcta tttaattcta tttacctgag
     3961 agtctaaaaa agtcaaaagc aggtggtcgg caggacctca ggaaagagaa ctgactgcag
     4021 tgggttaaga gaaaactttt tggggtgatg gaaattttat cttaattgag gtggtaggtg
     4081 tacttcaggt gtaggttata cctttgtaaa gctgggagaa aaagaatgta atgtaacatg
     4141 tagtatttta ctgattttaa ctacataaca ccagttgata aatgcctaga gaaatagcct
     4201 gaactgtaga attggcagtt gtgctcaagg tggctcactg gtccacagct attaatgata
     4261 tattctccct tagtttcagg ttcgctctag ttaaaatcat ggcttatgga tcatcatatg
     4321 atagcccttg ttgaagtagg tggaaccatt tgttctgtca gcagctaccc acctggatat
     4381 ttttgggggt ggccaaaatt acttgtaatg aaaaacccac taatgcctaa ttgtatatcc
     4441 cagcatgaaa ggggaaagat caactccatg catcatgtag atgtttctgc cctcggaagc
     4501 aggaaatggt aggcagaaaa acagtgtcgg ctgcattgga agaagcgaat ccagctcatg
     4561 agtcgaggct ctgcagccag atcatcttac acttgtccct ggtgaagcat ttgaactgga
     4621 gccagggcag tctgtgagta ctgccaaaag cctttattac agaagatgca caccttctta
     4681 gtaaaaactg ggagctctag tattaaagtg aaaattaaat ggaattgatt tttgttctag
     4741 cttagaaaaa acttaaattc taccactaca gcctcacagt cctgcagtgc tcttctagtt
     4801 ttgtttgttt tttgtttttt tagacggagt ctcgctctgt cacccaggct ggagtgcaat
     4861 ggcacaatct tggctcactg caacctccac ctcctgggtt caagcaattc tcctgcctca
     4921 gcttcccgag tagctgggac tacaggtgtg tgccaccatg cctggataat ttttgtattt
     4981 ttagtagaga cggggtttca ccacgttagc taggctggtc tcgaacttct gacctcaggc
     5041 gatctgtcca cctctgcctc ccaaagtgct gggattacag gcgcccagcc tgctcttctg
     5101 tttttaaatt atttttgaat tgatcttttt tcacatttta atttttttgg tttaataacg
     5161 gtatgagagt aggaattctc cctgatgtgt agggtgaaaa cagttgagtt tcagagagat
     5221 caataactta ctcagaagtc acatagccaa taaatgagtt tgagacacta taaaagagtg
     5281 acttggagtc cacagaccac tcactgattt gcattattta cttatttatg cgaaagtaaa
     5341 taatgggact ttctacactt tttaaaaata taaaaataat gggagacaaa aagttaaaaa
     5401 ttgttaagtc caatacttta aaaaaactct gcaaactgtg gccttactga gttaatctac
     5461 ctttcttcct cctgattccc tgaagtaact aactgctgtt aacaatttag cctgtattgt
     5521 tccttagttt ggacattttc cttgatttgt acagtcagcc acacacacct gctcacattt
     5581 ttgggggtca tgctctactt actggtttgc aacaagtttt gttttttatt ttacatatat
     5641 ctcatgacat ttcacttaat atgccccatt ttttcaggtc agtgcctata gacctatctc
     5701 attcttttaa atgaggtaat attctattgt acagatgtcc gtaattgttc aattattccc
     5761 ttgttggtgg acattcagtt gtttccaact gtttgcaatt ataaacactg ctccaatgaa
     5821 ccccctatcc tgctaaatag cactggctta ggaccccaag gaaaaccagt cctaatgggt
     5881 gcaagactgt ataaatatcc acatttgaca gacacattca gagatgcata gagttcatta
     5941 gatatttctt tgatgtgacg tttgtacttg aactatatat tattccagta ccttacatct
     6001 tagatgtaga agtcgctagg tcaaaggatg tgttttgaat ttaaaacatg ttgaatgact
     6061 gttctcacat tttaaacagg agtaatctac tacaaaccag ccagcctaac cactgcccct
     6121 gctctcagca atgatgggct catcagcttg gtaagagaga acattactca caatcttgct
     6181 tctcaatctt aatctatttg tgcttggtgt tttatataac atcactaacc ctaatacttg
     6241 agtatttact ttggcccttc tgtccatttt atccaaaagc aaacagatag ccttcaaggg
     6301 acaccattgc cttaagcaga atatgcctcc taagcattga aagcctttga cccatctgat
     6361 atccaagttc tggcttatta tgttattagg gccttgaata actttatgta tattattatg
     6421 gactgaatgt atccccacaa attcatgttg accctctgac ctccagtgtg atggtctttg
     6481 gagatgaggc ctttggcagg tgattagagc tagatgaggt catgagaggg aggccctcat
     6541 gaaaggctca gtggcctgat aagaagaaac accagagagc ttgctctgtt tctctgccta
     6601 cctggcgcac acatacagaa gaggtgatat gaccacacag caacatggtg gccaccagca
     6661 agctaggaga gggatcagaa tgaaacctat tttgctggca ccttgatctt gaaattctag
     6721 cctccagaac tgtgagaaat aaaattcttt tattgaagcc a
//
