LOCUS       NM_014808               4009 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens FERM, ARH/RhoGEF and pleckstrin domain protein 2
            (FARP2), transcript variant 1, mRNA.
ACCESSION   NM_014808 XM_376193
VERSION     NM_014808.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4009)
  AUTHORS   Elbediwy,A., Zhang,Y., Cobbaut,M., Riou,P., Tan,R.S., Roberts,S.K.,
            Tynan,C., George,R., Kjaer,S., Martin-Fernandez,M.L.,
            Thompson,B.J., McDonald,N.Q. and Parker,P.J.
  TITLE     The Rho family GEF FARP2 is activated by aPKCiota to control tight
            junction formation and polarity
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30872454
  REMARK    GeneRIF: FARP2 is shown to promote GTP loading of Cdc42, which is
            consistent with it being involved in upstream regulation of the
            polarising PAR6-aPKCiota complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4009)
  AUTHORS   Sabater-Lleal,M., Huang,J., Chasman,D., Naitza,S., Dehghan,A.,
            Johnson,A.D., Teumer,A., Reiner,A.P., Folkersen,L., Basu,S.,
            Rudnicka,A.R., Trompet,S., Malarstig,A., Baumert,J., Bis,J.C.,
            Guo,X., Hottenga,J.J., Shin,S.Y., Lopez,L.M., Lahti,J., Tanaka,T.,
            Yanek,L.R., Oudot-Mellakh,T., Wilson,J.F., Navarro,P.,
            Huffman,J.E., Zemunik,T., Redline,S., Mehra,R., Pulanic,D.,
            Rudan,I., Wright,A.F., Kolcic,I., Polasek,O., Wild,S.H.,
            Campbell,H., Curb,J.D., Wallace,R., Liu,S., Eaton,C.B.,
            Becker,D.M., Becker,L.C., Bandinelli,S., Raikkonen,K., Widen,E.,
            Palotie,A., Fornage,M., Green,D., Gross,M., Davies,G., Harris,S.E.,
            Liewald,D.C., Starr,J.M., Williams,F.M., Grant,P.J., Spector,T.D.,
            Strawbridge,R.J., Silveira,A., Sennblad,B., Rivadeneira,F.,
            Uitterlinden,A.G., Franco,O.H., Hofman,A., van Dongen,J.,
            Willemsen,G., Boomsma,D.I., Yao,J., Swords Jenny,N.,
            Haritunians,T., McKnight,B., Lumley,T., Taylor,K.D., Rotter,J.I.,
            Psaty,B.M., Peters,A., Gieger,C., Illig,T., Grotevendt,A.,
            Homuth,G., Volzke,H., Kocher,T., Goel,A., Franzosi,M.G.,
            Seedorf,U., Clarke,R., Steri,M., Tarasov,K.V., Sanna,S.,
            Schlessinger,D., Stott,D.J., Sattar,N., Buckley,B.M., Rumley,A.,
            Lowe,G.D., McArdle,W.L., Chen,M.H., Tofler,G.H., Song,J.,
            Boerwinkle,E., Folsom,A.R., Rose,L.M., Franco-Cereceda,A.,
            Teichert,M., Ikram,M.A., Mosley,T.H., Bevan,S., Dichgans,M.,
            Rothwell,P.M., Sudlow,C.L., Hopewell,J.C., Chambers,J.C.,
            Saleheen,D., Kooner,J.S., Danesh,J., Nelson,C.P., Erdmann,J.,
            Reilly,M.P., Kathiresan,S., Schunkert,H., Morange,P.E.,
            Ferrucci,L., Eriksson,J.G., Jacobs,D., Deary,I.J., Soranzo,N.,
            Witteman,J.C., de Geus,E.J., Tracy,R.P., Hayward,C., Koenig,W.,
            Cucca,F., Jukema,J.W., Eriksson,P., Seshadri,S., Markus,H.S.,
            Watkins,H., Samani,N.J., Wallaschofski,H., Smith,N.L., Tregouet,D.,
            Ridker,P.M., Tang,W., Strachan,D.P., Hamsten,A. and O'Donnell,C.J.
  CONSRTM   VTE Consortium; STROKE Consortium; Wellcome Trust Case Control
            Consortium 2 (WTCCC2); C4D Consortium; CARDIoGRAM Consortium
  TITLE     Multiethnic meta-analysis of genome-wide association studies in
            >100 000 subjects identifies 23 fibrinogen-associated Loci but no
            strong evidence of a causal association between circulating
            fibrinogen and cardiovascular disease
  JOURNAL   Circulation 128 (12), 1310-1324 (2013)
   PUBMED   23969696
REFERENCE   3  (bases 1 to 4009)
  AUTHORS   Berndt,S.I., Skibola,C.F., Joseph,V., Camp,N.J., Nieters,A.,
            Wang,Z., Cozen,W., Monnereau,A., Wang,S.S., Kelly,R.S., Lan,Q.,
            Teras,L.R., Chatterjee,N., Chung,C.C., Yeager,M.,
            Brooks-Wilson,A.R., Hartge,P., Purdue,M.P., Birmann,B.M.,
            Armstrong,B.K., Cocco,P., Zhang,Y., Severi,G.,
            Zeleniuch-Jacquotte,A., Lawrence,C., Burdette,L., Yuenger,J.,
            Hutchinson,A., Jacobs,K.B., Call,T.G., Shanafelt,T.D., Novak,A.J.,
            Kay,N.E., Liebow,M., Wang,A.H., Smedby,K.E., Adami,H.O., Melbye,M.,
            Glimelius,B., Chang,E.T., Glenn,M., Curtin,K.,
            Cannon-Albright,L.A., Jones,B., Diver,W.R., Link,B.K., Weiner,G.J.,
            Conde,L., Bracci,P.M., Riby,J., Holly,E.A., Smith,M.T.,
            Jackson,R.D., Tinker,L.F., Benavente,Y., Becker,N., Boffetta,P.,
            Brennan,P., Foretova,L., Maynadie,M., McKay,J., Staines,A.,
            Rabe,K.G., Achenbach,S.J., Vachon,C.M., Goldin,L.R., Strom,S.S.,
            Lanasa,M.C., Spector,L.G., Leis,J.F., Cunningham,J.M.,
            Weinberg,J.B., Morrison,V.A., Caporaso,N.E., Norman,A.D.,
            Linet,M.S., De Roos,A.J., Morton,L.M., Severson,R.K., Riboli,E.,
            Vineis,P., Kaaks,R., Trichopoulos,D., Masala,G., Weiderpass,E.,
            Chirlaque,M.D., Vermeulen,R.C., Travis,R.C., Giles,G.G.,
            Albanes,D., Virtamo,J., Weinstein,S., Clavel,J., Zheng,T.,
            Holford,T.R., Offit,K., Zelenetz,A., Klein,R.J., Spinelli,J.J.,
            Bertrand,K.A., Laden,F., Giovannucci,E., Kraft,P., Kricker,A.,
            Turner,J., Vajdic,C.M., Ennas,M.G., Ferri,G.M., Miligi,L.,
            Liang,L., Sampson,J., Crouch,S., Park,J.H., North,K.E., Cox,A.,
            Snowden,J.A., Wright,J., Carracedo,A., Lopez-Otin,C., Bea,S.,
            Salaverria,I., Martin-Garcia,D., Campo,E., Fraumeni,J.F. Jr., de
            Sanjose,S., Hjalgrim,H., Cerhan,J.R., Chanock,S.J., Rothman,N. and
            Slager,S.L.
  TITLE     Genome-wide association study identifies multiple risk loci for
            chronic lymphocytic leukemia
  JOURNAL   Nat Genet 45 (8), 868-876 (2013)
   PUBMED   23770605
REFERENCE   4  (bases 1 to 4009)
  AUTHORS   Miyamoto,Y., Yamauchi,J. and Itoh,H.
  TITLE     Src kinase regulates the activation of a novel FGD-1-related Cdc42
            guanine nucleotide exchange factor in the signaling pathway from
            the endothelin A receptor to JNK
  JOURNAL   J Biol Chem 278 (32), 29890-29900 (2003)
   PUBMED   12771149
  REMARK    GeneRIF: FRG is a member of Cdc42-GEF and plays an important role
            in the signaling pathway downstream of G protein-coupled receptors
REFERENCE   5  (bases 1 to 4009)
  AUTHORS   Kubo,T., Yamashita,T., Yamaguchi,A., Sumimoto,H., Hosokawa,K. and
            Tohyama,M.
  TITLE     A novel FERM domain including guanine nucleotide exchange factor is
            involved in Rac signaling and regulates neurite remodeling
  JOURNAL   J Neurosci 22 (19), 8504-8513 (2002)
   PUBMED   12351724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB451463.1, AB018336.1 and HY312568.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014808.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.149866.1,
                                           SRR1660805.173894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264042.8/ ENSP00000264042.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB451463.1         37-47
            12-4008             AB018336.1         1-3997
            4009-4009           HY312568.1         31-31               c
FEATURES             Location/Qualifiers
     source          1..4009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4009
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /note="FERM, ARH/RhoGEF and pleckstrin domain protein 2"
                     /db_xref="GeneID:9855"
                     /db_xref="HGNC:HGNC:16460"
                     /db_xref="MIM:617586"
     exon            1..104
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..311
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3293
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /note="isoform a is encoded by transcript variant 1;
                     FGD1-related Cdc42-GEF; FERM, RhoGEF and pleckstrin
                     domain-containing protein 2; FERM domain including RhoGEF;
                     PH domain-containing family C member 3; pleckstrin
                     homology domain-containing family C member 3; FERM, RhoGEF
                     and pleckstrin domain protein 2; FERM, ARHGEF and
                     pleckstrin domain-containing protein 2"
                     /codon_start=1
                     /product="FERM, ARHGEF and pleckstrin domain-containing
                     protein 2 isoform a"
                     /protein_id="NP_055623.1"
                     /db_xref="CCDS:CCDS33424.1"
                     /db_xref="GeneID:9855"
                     /db_xref="HGNC:HGNC:16460"
                     /db_xref="MIM:617586"
                     /translation="MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHL
                     HLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPM
                     KPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTA
                     ALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQ
                     VLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK
                     RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVF
                     FSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPE
                     GLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVA
                     GGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPL
                     LSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVV
                     KEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILL
                     RNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPI
                     QRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQ
                     RDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIR
                     GLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKS
                     GGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWY
                     RNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLAS
                     LPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGR
                     APSIVQDGPQPSSGLEGMVRGKEE"
     exon            312..416
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..459
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..538
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            539..636
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..751
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..899
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..995
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1159
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1228
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1286
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1539
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1715
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1805
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1939
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2021
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2259
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2390
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2459
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2549
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2632
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2751
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2915
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3023
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3175
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..4009
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3987..3992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /note="hexamer: AATAAA"
     polyA_site      4009
                     /gene="FARP2"
                     /gene_synonym="FIR; FRG; PLEKHC3"
                     /note="major polyA site"
ORIGIN      
        1 agttgggagc aggcgacgcc gacgcgagtc tggcggctgc tgcttgcgac tgcggaggcc
       61 gggcgaggcc ggtgaggacg cggcgggcga gcgagaggcc gaggtgtttt cttcactcat
      121 ggtgaagaat gggggagata gaaggaacat acagagtcct gcagactgca gggatgcgct
      181 tgggtgccca gacccctgtg ggagttagca cccttgagcc tgggcagact ctcttgccca
      241 gaatgcaaga gaagcacctg cacctcagag taaagctgct ggacaacacc atggaaatat
      301 ttgacattga gcctaaatgc gatggccagg tattactgac acaagtgtgg aagcgtttaa
      361 acctggtaga atgtgactac ttcgggatgg agtttcaaaa tactcagtcc tactggattt
      421 ggcttgaacc tatgaaaccc atcattaggc aaatacgaag gccaaagaat gtggtgcttc
      481 gcctagctgt aaaatttttt ccacctgatc ctggtcagct acaagaagaa tatacaagat
      541 acttgtttgc cttgcaactt aagagagacc tgctggaaga gcgtttgacc tgtgctgaca
      601 ccacagcggc ccttctcacg tcccatctcc tgcagtcgga aataggagat tacgatgaaa
      661 cgctggaccg agagcacctc aaagtgaacg agtatttgcc tggccagcag cactgccttg
      721 agaagatact agaattccat cagaagcacg tgggccagac acctgctgag tcggatttcc
      781 aggtgctcga aattgctcga aagttggaaa tgtacggcat cagatttcac atggcttctg
      841 acagggaagg aaccaagatt caactggcag tttcccacat gggtgtactc gtgttccagg
      901 gcaccaccaa aatcaacact ttcaactggt ccaaggtccg taaactaagc ttcaagagga
      961 aaagatttct tatcaaactt catccagagg ttcatggacc ttaccaggac acattagaat
     1021 ttttgttggg tagtagagat gaatgtaaga acttctggaa gatttgtgtg gagtatcaca
     1081 ccttttttag acttttggac caacctaagc caaaagcaaa agccgtcttc ttcagccggg
     1141 gctcctcctt cagatacagt ggaagaactc agaaacaact agtagattat ttcaaagaca
     1201 gtggaatgaa gagaattcca tatgaaagaa ggcacagcaa gacccacacg tccgttcgag
     1261 ctctgactgc agacctacca aaacagagca tctcattccc cgagggattg aggactcctg
     1321 cctccccatc ttcagcgaat gccttttact cgctctctcc ctccactctg gtcccctctg
     1381 gcctgccaga gtttaaggac agcagcagct ccctcacaga tccccaggtt tcctacgtca
     1441 agagtccagc tgcagagagg cgcagtggag cagtggctgg aggccccgac acaccatcgg
     1501 cccagcccct cgggcccccc gcactccagc ctggtccagg cctttccacg aagagtcctc
     1561 agccttctcc ctccagccgg aagagccccc tgagtctgag ccctgcattt caggtgcctt
     1621 tgggcccagc tgaacagggc tcatccccac tcctgagccc tgtcctcagt gatgctggcg
     1681 gagccgggat ggactgcgag gagcccagac acaagcgcgt gcctgcagac gaggcctact
     1741 tcatagtcaa agagattctc gctacagaac gaacatacct caaggattta gaagttatta
     1801 ccgtgtggtt ccgcagcgca gtggtgaagg aggacgccat gcctgcgact ctgatgacgc
     1861 tgctcttctc caacatcgat cccatctatg agttccacag aggcttcctg cgcgaggtgg
     1921 agcagaggct ggcactctgg gaagggccct ccaaagccca cacaaaaggc agtcatcaac
     1981 gaatcgggga catcctgctc aggaacatgc gccagttaaa ggagtttacc agctacttcc
     2041 aaagacatga cgaggtccta acagaactgg aaaaggctac caaacgctgt aagaagttgg
     2101 aggcagtgta caaggagttt gagctgcaga aggtctgcta cttgcctctc aacacgttcc
     2161 tgctgaagcc catccagcgg ctgctgcact accgcctgct gctgcgccgc ctatgcggac
     2221 attacagccc cgggcaccat gactacgctg actgccatga cgccctgaaa gccatcacag
     2281 aggtgaccac cacactacag cacattctca tccggctgga gaacctgcag aagctaacgg
     2341 agctgcagcg ggacctggtg ggcatagaga acctcattgc tcctggcagg gagttcatcc
     2401 gtgagggctg ccttcacaag ctcaccaaga agggcctgca gcagaggatg ttttttctgt
     2461 tctcagatat gttgctgtac acaagcaaag gagttgcagg gaccagccac ttccggatcc
     2521 ggggcctcct tcccctccaa ggcatgctgg tggaagaaag tgataacgag tggtctgttc
     2581 cacactgttt caccatctac gcggctcaga aaacaatcgt ggtggcagcc agcactcggc
     2641 tggagaaaga gaagtggatg ctggacctga actccgcgat ccaagcagcc aagagtggcg
     2701 gtgacacggc ccctgcactg ccaggccgca ctgtgtgcac tcgtcccccc agatccccca
     2761 acgaggtatc tctggagcag gagtcagaag atgatgctcg gggtgtccgc agctccctgg
     2821 aggggcatgg ccagcaccgg gccaacacca caatgcacgt gtgctggtac cggaacacca
     2881 gcgtgtccag ggcagaccac agtgcagctg tcgagaacca gctttcagga tatctgctaa
     2941 gaaagttcaa aaacagtcat ggctggcaga agctctgggt cgtctttacc aacttctgtt
     3001 tgttcttcta caaaactcat caggatgact acccactggc cagcctcccg ctgctgggct
     3061 acagcgtgag catccccagg gaggccgatg gcatacacaa agactatgtt ttcaagctcc
     3121 agttcaaatc ccacgtctac ttcttccggg ctgagagcaa gtacacattt gaaaggtgga
     3181 tggaggtgat ccagggggcc agcagctcag ccgggagggc cccaagcatc gtgcaggatg
     3241 gcccccaacc ctcctcaggg ctggagggga tggtcagggg gaaggaggaa tgacgctcaa
     3301 cctgcccagg tttggacaca actacaaaga acagcaggac acagaggtga cctctgtcct
     3361 gaggcttctc aacagatggg aagtggctgt ggtctcactg gatccccact ggcaccagca
     3421 gtgtgggtgg gcctcatgta acatctggga ggggcttcat ccccccaccc aggacctagt
     3481 gcatgccagc agctatctgg ggccctggga aaaatgtgcg agtcttgagc gcggagccgc
     3541 tcaagccaca gctcccaggc ccctggctca aagacgcaga caaggcctga gcagtgctct
     3601 cggcatcgga ccaaagcctg ggcacaccct gcctctctcc ccagagcagg gtccctgccg
     3661 aggactggcc tagagcaagc actggaaaag aggccctgcc atacaccctg cgtacccact
     3721 gccaggaccc tctcagacaa gcgtggcaca gccatgctga ccttccatct ggtgaaccaa
     3781 gtggcagccc caggggcctg ccctgcaggt cacagctaaa caagtctggc agaagccacg
     3841 cttgttcccc atgtacctct agagaagcag aaaccaaagt ccccctgtgc cctgggaggg
     3901 tggggccgtc taatttatta ctgcccagca ttccttccaa cgggaagtag atgggcgact
     3961 gctttgttca cacacatttg attaaaaata aacaaacagc atctcccca
//
