LOCUS       NM_005766              10419 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FERM, ARH/RhoGEF and pleckstrin domain protein 1
            (FARP1), transcript variant 1, mRNA.
ACCESSION   NM_005766
VERSION     NM_005766.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10419)
  AUTHORS   Hu,C., Xia,R., Zhang,X., Li,T., Ye,Y., Li,G., He,R., Li,Z., Lin,Q.,
            Zheng,S. and Chen,R.
  TITLE     circFARP1 enables cancer-associated fibroblasts to promote
            gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
  JOURNAL   Mol Cancer 21 (1), 24 (2022)
   PUBMED   35045883
  REMARK    GeneRIF: circFARP1 enables cancer-associated fibroblasts to promote
            gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10419)
  AUTHORS   Cooke,M., Kreider-Letterman,G., Baker,M.J., Zhang,S.,
            Sullivan,N.T., Eruslanov,E., Abba,M.C., Goicoechea,S.M.,
            Garcia-Mata,R. and Kazanietz,M.G.
  TITLE     FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase
            effectors for Rac1-dependent cell motility in human lung
            adenocarcinoma
  JOURNAL   Cell Rep 37 (5), 109905 (2021)
   PUBMED   34731623
  REMARK    GeneRIF: FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine
            kinase effectors for Rac1-dependent cell motility in human lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 10419)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 10419)
  AUTHORS   Chen,Z.H. and Wang,L.H.
  TITLE     FARP1 Facilitates Cell Proliferation Through Modulating MAPK
            Signaling Pathway in Cutaneous Melanoma
  JOURNAL   Am J Dermatopathol 41 (12), 908-913 (2019)
   PUBMED   31021836
  REMARK    GeneRIF: FARP1 facilitates malignant melanoma cell proliferation
            and migration by modulating the MAPK signaling pathway.
REFERENCE   5  (bases 1 to 10419)
  AUTHORS   Croise,P., Houy,S., Gand,M., Lanoix,J., Calco,V., Toth,P.,
            Brunaud,L., Lomazzi,S., Paramithiotis,E., Chelsky,D., Ory,S. and
            Gasman,S.
  TITLE     Cdc42 and Rac1 activity is reduced in human pheochromocytoma and
            correlates with FARP1 and ARHGEF1 expression
  JOURNAL   Endocr Relat Cancer 23 (4), 281-293 (2016)
   PUBMED   26911374
  REMARK    GeneRIF: We have reported here for the first time a reduced
            activity of both Rac1 and Cdc42 in human pheochromocytoma resection
            as well as tumor-associated expression changes of FARP1, ARHGEF1,
            and ARHGAP36
REFERENCE   6  (bases 1 to 10419)
  AUTHORS   He,X., Kuo,Y.C., Rosche,T.J. and Zhang,X.
  TITLE     Structural basis for autoinhibition of the guanine nucleotide
            exchange factor FARP2
  JOURNAL   Structure 21 (3), 355-364 (2013)
   PUBMED   23375260
REFERENCE   7  (bases 1 to 10419)
  AUTHORS   Cheadle,L. and Biederer,T.
  TITLE     The novel synaptogenic protein Farp1 links postsynaptic
            cytoskeletal dynamics and transsynaptic organization
  JOURNAL   J Cell Biol 199 (6), 985-1001 (2012)
   PUBMED   23209303
REFERENCE   8  (bases 1 to 10419)
  AUTHORS   Zhuang,B., Su,Y.S. and Sockanathan,S.
  TITLE     FARP1 promotes the dendritic growth of spinal motor neuron subtypes
            through transmembrane Semaphorin6A and PlexinA4 signaling
  JOURNAL   Neuron 61 (3), 359-372 (2009)
   PUBMED   19217374
REFERENCE   9  (bases 1 to 10419)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 10419)
  AUTHORS   Koyano,Y., Kawamoto,T., Shen,M., Yan,W., Noshiro,M., Fujii,K. and
            Kato,Y.
  TITLE     Molecular cloning and characterization of CDEP, a novel human
            protein containing the ezrin-like domain of the band 4.1
            superfamily and the Dbl homology domain of Rho guanine nucleotide
            exchange factors
  JOURNAL   Biochem Biophys Res Commun 241 (2), 369-375 (1997)
   PUBMED   9425278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136300.22, DB498534.1,
            CF994038.1, AB008430.1, BC071592.1, BC053593.1, AW514534.1 and
            AL137249.29.
            
            On May 17, 2019 this sequence version replaced NM_005766.3.
            
            Summary: This gene encodes a protein containing a FERM (4.2, exrin,
            radixin, moesin) domain, a Dbl homology domain, and two pleckstrin
            homology domains. These domains are found in guanine nucleotide
            exchange factors and proteins that link the cytoskeleton to the
            cell membrane. The encoded protein functions in neurons to promote
            dendritic growth. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB008430.1, SRR1803615.250729.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319562.11/ ENSP00000322926.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL136300.22        99580-99583
            5-373               DB498534.1         1-369
            374-494             CF994038.1         385-505
            495-3535            AB008430.1         121-3161
            3536-4007           BC071592.1         3446-3917
            4008-5012           BC053593.1         44-1048
            5013-5016           AW514534.1         11-14               c
            5017-10419          AL137249.29        56032-61434
FEATURES             Location/Qualifiers
     source          1..10419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.2"
     gene            1..10419
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="FERM, ARH/RhoGEF and pleckstrin domain protein 1"
                     /db_xref="GeneID:10160"
                     /db_xref="HGNC:HGNC:3591"
                     /db_xref="MIM:602654"
     exon            1..399
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            400..593
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..3560
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chondrocyte-derived ezrin-like protein; FERM, RhoGEF and
                     pleckstrin domain-containing protein 1; PH
                     domain-containing family C member 2; pleckstrin homology
                     domain-containing family C member 2; protein phosphatase
                     1, regulatory subunit 75; FERM, RhoGEF (ARHGEF) and
                     pleckstrin domain protein 1 (chondrocyte-derived); FERM,
                     ARHGEF and pleckstrin domain-containing protein 1;
                     glycolysis-associated lncRNA of colorectal cancer"
                     /codon_start=1
                     /product="FERM, ARHGEF and pleckstrin domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_005757.1"
                     /db_xref="CCDS:CCDS9487.1"
                     /db_xref="GeneID:10160"
                     /db_xref="HGNC:HGNC:3591"
                     /db_xref="MIM:602654"
                     /translation="MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKI
                     QMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV
                     KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLI
                     SHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEI
                     ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF
                     LIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRG
                     SSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQS
                     TSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEE
                     EEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQ
                     ASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWF
                     QSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIG
                     DVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFL
                     LRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKL
                     HELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQ
                     FKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAID
                     LAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHV
                     CWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHP
                     LASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSS
                     ASRPHVLSHKESLVY"
     exon            594..698
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            699..741
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            742..820
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            821..918
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1033
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1181
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1277
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1441
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1510
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1586
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1836
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2024
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2114
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2248
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2327
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2565
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2696
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2765
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2855
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2938
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3051
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3218
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3326
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3478
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..10419
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5012
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="major polyA site"
     regulatory      7411..7416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="hexamer: TATAAA"
     polyA_site      7456
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
     regulatory      7840..7845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="hexamer: AATAAA"
     polyA_site      7864
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
     regulatory      8176..8181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
                     /note="hexamer: AATAAA"
     polyA_site      8193
                     /gene="FARP1"
                     /gene_synonym="CDEP; FARP1-IT1; GLCC1; PLEKHC2; PPP1R75"
ORIGIN      
        1 gcacttcccg ctcgccggcc tcagaggcgg cgggtccggc gcgggcgcag cggtgcgggc
       61 gctcggctgg ggcgcggggc ggggacgcgg ccgctgcccg ctttgcgccg ctcctccctg
      121 cgcgagtagc gctggccccg gcgtcgaggc ggccatggcg acccggagcc cgctccccac
      181 ccaccccgcc tgctccgccc tcccctccgc cccgcgccac ctttgatggc tcggacctca
      241 gccggccacc gccagccctg ctcgcgcgcc cgcgccgccg ccgcccgcgg gtattaatag
      301 ccggcgccgc cgcgccctcg gccgccgggg gcttgggagc cgccgatccc ggagcccgag
      361 ccgggagagg gagccgccgc agccgccggc gctgtggaga tattctctaa gccgctttca
      421 tcatgggaga aatagagcag aggccgaccc caggatcacg actgggggcc ccggaaaatt
      481 cggggatcag taccttggaa cgtggacaga agccgccccc aacaccttca ggaaaactcg
      541 tgtccatcaa aatccagatg ctggatgaca cccaggaggc atttgaagtt ccacaaagag
      601 ctcctgggaa ggtgctgctg gatgcagttt gcaaccacct caacctcgtg gaaggtgact
      661 attttggcct cgagtttcct gatcacaaaa agatcacggt gtggctggat ctcctaaaac
      721 ccattgtgaa acagattaga aggccaaagc acgttgttgt taagtttgtg gtgaaattct
      781 ttccgcctga ccacacacaa ctccaagaag aactcacaag gtacctgttc gcgctgcagg
      841 tgaagcagga cttggctcaa ggcaggttga cgtgtaatga caccagcgca gctctcttga
      901 tttcacacat tgtgcaatct gagattgggg attttgatga agccttggac agagagcact
      961 tagcaaaaaa taaatacata cctcagcaag acgcactaga ggacaaaatc gtggaatttc
     1021 accataacca cattggacaa acaccagcag aatcagattt ccagctccta gagattgccc
     1081 gtcggctaga gatgtatgga atccggttgc acccggccaa ggacagggaa ggcacgaaga
     1141 tcaatctggc cgttgccaac acgggaattc tagtgtttca gggtttcact aagatcaatg
     1201 ccttcaactg ggccaaggtg cggaagctga gcttcaagag gaagcgcttt ctcatcaagc
     1261 tccggccaga tgccaatagt gcgtaccagg ataccttgga attcctgatg gccagtcggg
     1321 atttctgcaa gtccttctgg aaaatctgtg ttgaacatca tgccttcttt agactttttg
     1381 aagagcccaa accaaagccc aagcccgtcc tctttagccg ggggtcatca tttcggttca
     1441 gtggtcggac tcagaagcag gttctcgact atgttaaaga aggaggacat aagaaggtgc
     1501 agtttgaaag gaagcacagc aagattcatt ctatccggag ccttgcttca cagcctacag
     1561 aactgaattc ggaagtgctg gagcagtctc agcagagcac cagccttaca tttggagaag
     1621 gtgccgaatc tccagggggc cagagctgcc ggcgaggaaa ggaaccgaag gtttccgccg
     1681 gggagccggg gtcgcacccg agccctgcgc cgaggagaag ccccgcgggt aacaagcagg
     1741 cggacggagc cgcctcggcg cccacggagg aagaggagga ggtcgttaag gataggaccc
     1801 agcagagtaa acctcagccc ccgcagccaa gcacaggctc cctgactggc agtcctcacc
     1861 tttccgagct gtctgtgaac tcgcaggggg gagtggcccc tgccaacgtg accttgtctc
     1921 ccaacctgag ccccgacacc aagcaggcct ctcccttgat cagcccgctg ctgaatgacc
     1981 aggcctgccc ccggacggac gatgaggatg agggccggag gaagagattc ccaactgata
     2041 aagcgtactt catagctaag gaagtgtcta ccaccgagcg aacatatctg aaggatctcg
     2101 aagttatcac ttcgtggttt cagagcacag tgagcaaaga ggacgccatg ccggaagcac
     2161 tgaaaagtct catattcccg aattttgaac ctttgcacaa atttcatact aattttctca
     2221 aggaaattga gcaacgactt gccctgtggg aaggccgctc aaatgcccaa atcagagatt
     2281 accaaagaat cggcgatgtc atgctgaaga acattcaggg catgaagcac ctggcggctc
     2341 acctgtggaa gcacagcgag gccttggagg ccctggagaa tggaatcaag agctcccggc
     2401 ggctggagaa cttctgcaga gactttgagc tgcagaaggt gtgttaccta ccgctcaaca
     2461 ccttcctcct gcggccactg caccggctca tgcactacaa gcaggtcctg gagcggctgt
     2521 gcaaacacca cccgccgagc cacgccgact tcagggactg ccgagccgct ttggcagaga
     2581 tcacggagat ggtggcacag ctccacggta cgatgatcaa gatggagaat ttccagaagc
     2641 tgcacgaact caagaaagat ttgattggca ttgacaatct tgtggttccg ggaagggagt
     2701 tcatccgtct gggcagcctc agcaagctct cggggaaggg gctccagcag cgcatgttct
     2761 tcctgttcaa cgacgtcctg ctatacacga gccgggggct gacggcctcc aatcagttta
     2821 aagtccacgg gcagctcccg ctctatggca tgacgattga ggagagcgaa gacgagtggg
     2881 gggtgcccca ctgcctgacc ctccggggcc agcggcagtc catcatcgtg gccgccagtt
     2941 ctcggtccga gatggagaag tgggttgagg acatccagat ggccattgac ctggcggaga
     3001 agagcagcag ccccgcccct gagttcctgg ccagcagccc ccctgacaac aagtcccctg
     3061 atgaagccac cgcggctgac caggagtcag aggatgacct gagcgcctcg cgcacatcgc
     3121 tggagcgcca ggccccgcac cgcggcaaca caatggtgca cgtgtgctgg caccgcaaca
     3181 ccagcgtctc catggtggac ttcagcatcg cagtggagaa tcagttgtct ggaaacctgc
     3241 tgaggaaatt caaaaacagc aacgggtggc agaagctgtg ggtggtgttc acaaacttct
     3301 gcctgttctt ctacaaatca caccaggaca atcatcccct tgccagcctg cctctgctcg
     3361 gctactcgct caccatcccc tctgagtccg agaacatcca gaaagactac gtgttcaagc
     3421 tgcacttcaa gtcccacgtc tactacttca gggcggaaag cgagtacacg ttcgaaaggt
     3481 ggatggaagt gatccgcagt gccaccagct ctgcctcgcg accccacgtg ttgagtcaca
     3541 aagagtctct tgtgtattga tggccggaca cactcgtttc cgcagtggct gctttcctgg
     3601 aagacgtttc ctttcttctg tattaatgaa gcctggtaaa attaacacct gtctgaaaat
     3661 caaaaacatg gcttcccagc agctctcctg tctccacagc cgcgtttttt aaccccgacc
     3721 tctcagcgtc tgaatgaaca gcgctcccac ctccagtcct ggcatccgct gggggcgctg
     3781 ttctttagct agtgccagta ttaaaacatt gtcattacga gagtgccaaa tgacatcttc
     3841 cctccaccct gcccctgaaa aacagtacac acacatccgt tcaacacaag acagggcaag
     3901 tgtttttctt cctaaaaaaa gttctttctt ttattatttt cacctattgg ctgctgcatt
     3961 ttacgaagtg gacttcccgg tgtttgtttg tttgtttgca atacactcag tgcagcctta
     4021 agcaaatgag atcattttca gatttcattt tttttttcag tctttctact tttgtaataa
     4081 taggaagtta gtaggactca cttctctgat taataagcaa tttgcagcac acagcgttcc
     4141 actgcggggt ttcacgctca cctgaaaaca cctgttccca acctacttct tggtgcaagt
     4201 tgaccaaatc gttttaagtg gtaactcttt ccaaccgtag cagggttgtt ttctgttaag
     4261 caaagccgag atccagtgca atacctggac tgtcaccgtc ctgtgagtgg tgtacacaat
     4321 gggaagataa taagccgtgg tgttttgctg tctgtctgtg tcacaagcat gaaaacccgt
     4381 gtgtcattga tcagcaccat ttgtggtatg ttccgtgatg agcgtttagt gagcctgctg
     4441 gctgcagagc actatgaaat catggtacgt agtccccggc acctgtcgtt attcctatat
     4501 cctcctgcaa ctgtggtttg aaactgcgca ttctctagta gtatatatcg tgcctgtctt
     4561 caaaaacatt tcccttttta tactcattcc ccccaggcat ggggtagtgt cagtcggact
     4621 gcacagggaa cacggtttcc agtggctttg gcccctactc gggaaacgtc tgcctgttct
     4681 cgatggtgat ggggtggctg ccattccctt ggttttccta agccctttct aacgagagtc
     4741 tcaaacaagc ggaggcgagg gccaattcaa ccccattctt tccagcgccc cgcaccatag
     4801 cacctgccca cctgagaacc aggaacgcac cctctctgtg gagctctgac tggtgtagct
     4861 ggaaacaaac agcaacttgc aaacggacga agagcctgcc gtgtgttaat catttgcctt
     4921 acaagatgta ccagacggtt tccagtacta acaaagggaa taaaaatacc tcacgccaca
     4981 atccagcata ttgatgtttt aaggcaaaac aaccaacttt gtctgtagtc ttcattttct
     5041 gtgtgggggg ggagggggga aggggacact ccagcaaggg tttctaaagc cccagtgttc
     5101 agagtgacac agggagggcc tgccccccac tgttccctat gctcccccca cctccaggca
     5161 ggggcagagc aaacaaacag ctccgggcca cacagcagca tcaggctccc tccagaagtc
     5221 accactcact cattcctgga gacttgggga caaggcagtc tcctcagcta tttatttctg
     5281 aatgattgat tgattccaaa ctacttgctg gacactggtg gttctgacct gtgaccagca
     5341 cctctgcttc ctgtgtgccc tcaagaaaat actagtgtgg gtaacagtcc atctgagtgg
     5401 agtttgagac acactacaca tgagacacac aatgatgcag atactcgttt tcttgagctt
     5461 tattggcccc tgcatgatac agtccctgtg cttaagaaca tgccctatta ggtcactctg
     5521 cctttgctga cacattttat agcagaaata cacaagctgt ttttaaagga gggaaatata
     5581 aaaaatgttt ataaactgac agtgttttgc cagaggaaag gtacaaaatg ctacatacag
     5641 aaccaaacca gccacttcac aagagcaatg cagggataaa actattggat aaggaaggca
     5701 gatgcacttc caagaaaatc agaacccagc aagaagtggc cagtgcaccc caaaccacac
     5761 tggtgtccac ctcattggca gcagccagcc aggacacagc tcaaaaacgc aggagctacc
     5821 agccacccag tccacggccc tcgtctccca gaggctgagt acctccccag gctgcaggct
     5881 ctgggcagct gagccaggag cagctcaggg ctggcactga gaggctactg gtgacagtaa
     5941 acccgtctca aaggctgggc ctggctacag accagcagca gttgacgctg aggcaggttc
     6001 cagtggtagc cctggtgcct gggctctctc ttaatgcagg cctggaagtg gcgacacaaa
     6061 agccagcttc cttggctaag atgcccttaa aaacattggg gctgattttg tgcgtctaca
     6121 gaaagtaaca gcccaggaga gaatgtacac agaggcgagc tttctaactc catcaaaccc
     6181 cacctccccc gacaggaaat gctgccagtc aactctaaaa gaaccacttg ttgctctacg
     6241 ggggaagggg ctgagtatga tttgtctggc gactgcagag actccccgtt cataccagta
     6301 ttcattagaa cccagtccct cgagcggctc acccactgtt actagcatga gactggcttc
     6361 agtgctaaaa actgtgatgt cattgtccat ttgtaaatct gaagaactct gtaaatcaga
     6421 aaagctgctg tccgccctgg ctcacttaaa aatcaggtaa cggcacaccc tggggaacac
     6481 agactcaatc tgtgtgattc gcaaggacaa aactcatctt tgacttatgc cgccggcctc
     6541 acgtaaggaa acagttcccc acacagaata ctccctggaa acacaaaatg aaatcttctc
     6601 caattttatt attcaacata acattcttgt atggagtaat gagtacaata agaattagca
     6661 actcagttct atttccccaa ccaaaatata tcccttatac aaattaagag ttcaacccaa
     6721 atccacttct aataaaatac ctcaatttta gagcttaaaa accagactgc actagcaaac
     6781 cgacacaata acccactcaa gcatctgtag ctcagggctc tgtcccctcc ctatagctta
     6841 gaggccacta gaccagcaga tagctgagct acatccccaa gctcacccac taacttcctt
     6901 gcttccaaaa atcctgtctt aactccacaa gaactggcac acccacggga gatgtcaatc
     6961 atcagcttca acaaacataa aagaatgctt catgtaccag tcaacagctg ctgcacgaac
     7021 cctcccactc cagaaaccca gagattttcc ccctcgccaa gcaaggtccc acagcaaacc
     7081 aagaaaaaca gacacactgg ctgcctgcct agcaagcata ggccccttcc agagaagcaa
     7141 aataactctt aaggtccccg gcaaccgcta cagcaatcgc acagatcagc aacctccaac
     7201 tgcatcatct cggtgagcaa gtgcgcaagc agtccagggc gctgacctgg gcactcggca
     7261 gctccaggcc tggggacttc tccctggagt cttccaaagt gtctcatcac acacacacag
     7321 ccacgagtac acacgcacgg ccacacatac acagcaggtg ccctgtcctc tgaagagtca
     7381 catttcaagg agtatgcaaa ataagcgtgt tataaaattt atttgtgtaa gcattcagac
     7441 atttttaggt gggaaagatg atatgcagaa tccactacaa ggtgcaacag aaaatcgtat
     7501 tggaaaggac ggtacatctg gcgcagacca gcagtggcac gattccaaac aaatgtcaga
     7561 cgagagcgct tcatggggag aaactgaaaa ttataattta aagcttcatg aggcaagata
     7621 tgttccaatt taaaacacta agaaatagta ccatcgatga aaaaggaaat caacctctag
     7681 gtgtaccaaa aggggcgtag ggcaaacggg gaaaatttgc atttgttgag gtacaaatag
     7741 gagtgttctg taagagaggg gcattaatta ttaatgacaa accctgcaaa tacaaaataa
     7801 aacccaaatc actggtcaca gaattcaaaa tgtacatgta ataaaggcaa ggcaatagac
     7861 tcaagttatg gcctgtcgaa tatttactcc actgacgtta tctacagaag cacttggcca
     7921 gtttgtacac agtgattcct tatgcacgcc gaaagggttt ccgtaaaaat gacattatat
     7981 acaaatctgt acacccatcc accagagcga ttctccagct cccagaggga gttatcaact
     8041 taaagcagga tacctgaggt ttcatgtctt tagttgcctt atcataatcc caaatataca
     8101 tttcagggtt tgtttttgtt tttaaagaca ctttcctgga atatgtgcac tatggttaaa
     8161 attaaaaaca aaagtaataa aataaaataa aatgatcgct ggaaggagct gaccctcccc
     8221 acccatctga gagacttcat ctggctgcag cacagtgaag actgtgtgtg tccctggacg
     8281 ggcgcctggc gctggggtgg ctcccagtgg cgcacctctt cggtggagtc agcgaaggct
     8341 ctcgttgact tttaaaaaag gaggaggatg aagaaggaaa aaaggaaaaa caaaacccca
     8401 aatgccaaag gaatttcagt gggatgaagt tcctccacca cttagagagt atctagggaa
     8461 aaagagagag agagaagtca acacatgtca tttctcatcc ctgtgcaaaa attcatatag
     8521 taaccaaaat cttagttttc ataagaaatt ccaagtcata caaaaataag tggagcaaat
     8581 atcaatgtgt aagtctaatt ttaaaagaat gcatataaag actgagaaga tcatgattct
     8641 tacacaaaaa ctccagagca tgtcaccaaa aaccaagaat gggttcagcc tccctggaga
     8701 gatgtgaata aaacgggaaa tcatatccct tttacttacg atcaattgtc aaaaagtgaa
     8761 cattgatcca tacatgatga cacagtaaga ttccagggat gcatatgcat tcccgatgtg
     8821 agggcaggaa acccattttg gccataaaaa tagtgatgca gtccaagaat ctatttccta
     8881 gaactgcttc cgaaatatgg tccaaagcag gaacaacgtg tctgcacaaa gatgtctctc
     8941 gggattttcg taattacact aatttggaaa caactctgat gcccaacagt acagaatcag
     9001 ttaagtaaat tatacaaact gaaataacag actaaaaatg gtaattatct gtatttacat
     9061 atatatatta aagcaatatt aaaaatatgt acaagtttaa aagtacatac aaaattacag
     9121 attgggcatc ccttatctga aatgcttctg gctttggatc tgggaatatc cgcattatac
     9181 ttaccagtgt gcagccccaa atccgaaatc tgacatgccc cagagagcag ttcctttgag
     9241 ccccatgctg gcgctcaaaa gtttcagatt ggggatttgg gatattcagc ctgtatatgt
     9301 gcactatata agtatattta catgaacaac ttctgtatcc taaattaagt actatagaaa
     9361 ttctaaaaaa tcttctttgc actataaggt agataagaga attcagtaag tttatgacct
     9421 ggtatgacaa cagaaggcaa tgcacccaaa gatgctgatg agatttgggc tacagtggtg
     9481 ggatcatggg taatttctgt gtcttccaaa aattctacaa gattgtcttc agaagacaac
     9541 aaagggtgag aacggggtcc cctcatgacc acaattccct caaccatttt acaacagact
     9601 ccaaatcaca ggtccaggag agatggctga ggatgtcttt gaccaggctt atctcaaacg
     9661 ttccaatcta gagctcctct tttcaggcat ttgaaatact tggcatctct cccagagaac
     9721 aaatggttac ataaggtcct cccaaaagca cacattagcc acggagccta agactcaact
     9781 atcaagaaat acaaatgact aaatcacggg atgagttgat gtcacacaaa agaatccaaa
     9841 cattaattcc agctgagaca gaaaggctct gaaaatgctt cagaggagag gcggctctca
     9901 tttttcctac agccatccac tgaaacaaca tgtttggagc aaaactggca ggaagtctaa
     9961 gccatggcca ccgtggtttt ggcagccatc ggggtgaacg ctcagtggga gcttcaggag
    10021 cagggaagga agaagtgggt accacagcca agcctgcaga gagatgataa gcacctcaag
    10081 aggcagctca tctgaggaca gaggaggaaa gagggcactc ctcatcacag acaaaggaaa
    10141 gagagcacca acttggcttc ccccatgcat cactgcaaag taaagtttta aacacaacac
    10201 agacatcagg tagctacaga cccgcccgag ggtaaatagg gtcaacccca gccacgatgc
    10261 ccagtgagca cgtaaaatgt gctgcgtctg aatggagatg tgctaagtgt aaaacacaca
    10321 ccaactccaa agacggtccc tccaaaaatg taaaatacct tattgatgat tgttgttatt
    10381 aatgttgaaa taatactttg gatctggcag gttaaaaaa
//
