LOCUS       NM_001271783            3538 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fatty acyl-CoA reductase 2 (FAR2), transcript variant
            1, mRNA.
ACCESSION   NM_001271783
VERSION     NM_001271783.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3538)
  AUTHORS   Backer,G., Eddy,S., Sheehan,S.M., Takemon,Y., Reznichenko,A.,
            Savage,H.S., Kretzler,M. and Korstanje,R.
  TITLE     FAR2 is associated with kidney disease in mice and humans
  JOURNAL   Physiol Genomics 50 (8), 543-552 (2018)
   PUBMED   29652635
  REMARK    GeneRIF: Results indicate fatty acyl CoA reductase 2 FAR2's role in
            the development of mesangial matrix expansion and chronic kidney
            disease.
REFERENCE   2  (bases 1 to 3538)
  AUTHORS   Honsho,M., Asaoku,S., Fukumoto,K. and Fujiki,Y.
  TITLE     Topogenesis and homeostasis of fatty acyl-CoA reductase 1
  JOURNAL   J Biol Chem 288 (48), 34588-34598 (2013)
   PUBMED   24108123
REFERENCE   3  (bases 1 to 3538)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   4  (bases 1 to 3538)
  AUTHORS   Wanders,R.J. and Waterham,H.R.
  TITLE     Biochemistry of mammalian peroxisomes revisited
  JOURNAL   Annu Rev Biochem 75, 295-332 (2006)
   PUBMED   16756494
  REMARK    Review article
REFERENCE   5  (bases 1 to 3538)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   6  (bases 1 to 3538)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136843.1, AK314670.1,
            AK001927.1, AC009318.11 and CB217408.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001271783.1.
            
            Summary: This gene belongs to the short chain
            dehydrogenase/reductase superfamily. It encodes a reductase enzyme
            involved in the first step of wax biosynthesis wherein fatty acids
            are converted to fatty alcohols. The encoded peroxisomal protein
            utilizes saturated fatty acids of 16 or 18 carbons as preferred
            substrates. Alternatively spliced transcript variants have been
            observed for this gene. Related pseudogenes have been identified on
            chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.169819.1,
                                           SRR1803612.115474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536681.8/ ENSP00000443291.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AL136843.1         79-396
            319-688             AK314670.1         298-667
            689-1733            AK001927.1         642-1686
            1734-3294           AC009318.11        111394-112954
            3295-3538           CB217408.1         46-289              c
FEATURES             Location/Qualifiers
     source          1..3538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..3538
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /note="fatty acyl-CoA reductase 2"
                     /db_xref="GeneID:55711"
                     /db_xref="HGNC:HGNC:25531"
                     /db_xref="MIM:616156"
     exon            1..130
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..357
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1716
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /EC_number="1.2.1.84"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     chain dehydrogenase/reductase family 10E, member 2; male
                     sterility domain-containing protein 1; epididymis
                     secretory protein Li 81"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 2 isoform 1"
                     /protein_id="NP_001258712.1"
                     /db_xref="CCDS:CCDS8717.1"
                     /db_xref="GeneID:55711"
                     /db_xref="HGNC:HGNC:25531"
                     /db_xref="MIM:616156"
                     /translation="MSTIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILV
                     RPKAGQTLQQRVFQILDSKLFEKVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQELL
                     SCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNL
                     KHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIRDWPNIYTYTKALGEMVVQQE
                     SRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVI
                     PVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLATFEKIPFERP
                     FRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLE
                     YFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDM
                     AGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFCYKFLSYFR
                     ASSTLKV"
     exon            358..533
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..713
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..891
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..936
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1055
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1123
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1295
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1425
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1553
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..3538
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /note="hexamer: ATTAAA"
     polyA_site      1995
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /note="major polyA site"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
                     /note="hexamer: AATAAA"
     polyA_site      3538
                     /gene="FAR2"
                     /gene_synonym="HEL-S-81; MLSTD1; SDR10E2"
ORIGIN      
        1 agagtgtcac gtttgggagc cgaaagactg gagccgtttc cttgtggctg gagcgcttcc
       61 cgtagcctcg gggaaggagc aggatttaga ggaccactag ttggacccca tcctcgtgct
      121 ggaggaacag gaacctcttt caggagctat aaaagaaagg gaggaatcat gtccacaatt
      181 gcagctttct atggcggcaa gtccattctc atcacggggg ccacaggctt tctgggcaaa
      241 gtgctgatgg agaagctgtt tcgcaccagc ccagacctga aagtcattta catccttgtg
      301 aggcccaagg ctggccagac actgcagcag agggttttcc agatcctaga cagtaagcta
      361 tttgagaaag tcaaagaagt ttgtccaaat gtgcatgaga agatcagagc tatttatgca
      421 gatctcaatc agaatgactt tgccatcagc aaagaggaca tgcaggagct tctctcctgt
      481 acaaacataa tatttcactg tgcagccact gtacgctttg acgacactct cagacatgct
      541 gtgcaactta acgtcactgc cacccggcag ctcttgctta tggctagtca gatgccaaag
      601 ctggaagcct ttatacatat ctctactgcc tattcaaatt gtaacctgaa gcacatcgat
      661 gaagttatct atccgtgccc tgtggagcca aaaaaaatca ttgattccct tgagtggtta
      721 gacgatgcta ttattgacga gattacaccc aagctgatca gagattggcc caatatttat
      781 acctacacca aggccttggg agaaatggtg gtgcagcaag agagcaggaa cctgaacatt
      841 gccatcataa ggccctccat tgtgggagca acttggcagg agcctttccc aggttgggtt
      901 gataatataa atggacctaa tggaatcatt attgcgactg ggaaagggtt tcttcgggcc
      961 ataaaagcta ctccaatggc tgtggcagac gtaattccag ttgatacagt cgtcaatctc
     1021 atgctagctg taggatggta tactgcagtt cacagaccta agtcaacatt agtctaccac
     1081 attacatctg gtaacatgaa tccctgcaat tggcacaaaa tgggagtcca agtcttggca
     1141 acctttgaaa aaatcccatt tgagagacct ttcaggaggc caaatgctaa ttttaccagc
     1201 aacagcttca catcacagta ctggaatgcg gtcagccacc gggcccctgc cattatctat
     1261 gactgctatc tgcggctcac tggaaggaag cccaggatga caaagctcat gaatcggctt
     1321 ttaagaactg tttccatgtt ggagtatttc atcaaccgga gttgggaatg gagcacgtac
     1381 aatacagaaa tgctgatgtc tgagctgagt cctgaagacc agagagtatt caactttgac
     1441 gtgcgccagt tgaactggtt ggaatacatt gaaaattatg ttttgggagt taaaaaatac
     1501 ttattgaaag aggatatggc tgggatccca aaagcaaagc aacgcttaaa aaggctccga
     1561 aatattcact acctctttaa tactgccctc ttccttatcg cctggcgcct tctcattgca
     1621 agatctcaga tggctcggaa tgtctggttc ttcattgtaa gcttctgtta taaattcctc
     1681 tcctacttta gagcatccag cacgctcaaa gtttaagagc atttagccat cgctttttat
     1741 ctggaacctc tcagatacct ctaaaacagc aaactgtgat tctcaagatt agaaagtaac
     1801 aaggaatatg cccaaactgt caaatgtcac ctgttatgta ttcgtcccta ttccttaact
     1861 atgtattttt atttcagtga gagaaggaaa gttgtaaact agcccatagt cacctatatt
     1921 ttagggaaaa aaatccaaat tgtttcctaa cattctattt tatgcccttg cgtattaaac
     1981 gtgaaagtac tcccactttt ctatatttag tttttctttt ctctctgaga tgattcattt
     2041 aaactcagta aatatggaaa gatgcatggc agaagctgaa atgagctcaa gcagtactaa
     2101 ccttggaacc attctgggta cccaaaagaa aaatttaaaa tcaagatgag taaaaggaga
     2161 atggtctcaa tatcctcaaa aatgcagtaa gagaagtaat tccccactga aaatgtctct
     2221 ctttctttct atgttatacc ctggagtcct ggttgagggg tgggggaatc agaaaagtag
     2281 gtttacattt aacatttttc ttaactacat tcacttctta aaaaggaaca agaagtgtaa
     2341 ataagtatgt atagagtgag ggattaagca tatttgcatt ggggactcgt gtattatgct
     2401 tttaagtcaa aattaatatt ctcaaattcg aatttgatag ctattatttc taaatctttt
     2461 taatcctcaa ttttcctggt aaccttcttt caagagtctc cttcttctaa aagttgccaa
     2521 accctttata tttaagcttt ttccactcag gactcaatta gagtggtcaa cagggagagg
     2581 gatggtccca tttgatcttt gccactgagc aaaacaaaac ttcaaatgaa cttttaaact
     2641 gtagctttag tcttctggta taaagtgggg aagattacac ttatgtgatc accaaaggat
     2701 ttactagtat cttggtcatt ccaattgcac aatgttaact gtacaacaca cagcagaaaa
     2761 gtgaatagac ttcactaagg gattctaagt ttagaaaata ggttttgttt tcttaaaaaa
     2821 ttttgtgtat aatacaaact aatgaaaact atacatattc tccaattcct atagtaataa
     2881 taatgtaact gttacaccaa ctttcctcat atttgagaga tgagtacatg ttggattgca
     2941 gcatttcttc atgttaaaaa catggaatat tattcaaata tagtacttgg ggcctaaaca
     3001 actaaaatta gtcaccgcat aactagttga aaatggcata ggcataaaat gttaataaag
     3061 aatggcagtt atatttatgc tcacttcctg gagtaattgg gtaatattca gaaaggcaca
     3121 tcgtggtagt ttaagtgtac aaggccttag ggcagtatct agcccagtat tattccagat
     3181 tctcctgagc tctatataaa gggcattttg gaggaactct tctgggcaat atctttccca
     3241 atctcatcta aattctggga aatattttcc atagcagaca acccagctct gaaactaagc
     3301 acctggtgat ctttagtttg agatgtctat atggtacttt tgagttatat caattaagat
     3361 acaagctata gacatgataa aaatatgaaa tcaagatata gctcagtggg attggattaa
     3421 gacataataa tagttctaag aattcacttt tgattgtatg ttttaccaat tcaataattc
     3481 cactaatcaa gtattcacat tttgactttt gattaaataa aaatttgaat taaaatta
//
