LOCUS       XM_011510797            2570 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens fibroblast activation protein alpha (FAP),
            transcript variant X2, mRNA.
ACCESSION   XM_011510797
VERSION     XM_011510797.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011510797.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2570
                     /gene="FAP"
                     /gene_synonym="DPPIV; FAPA; FAPalpha; SIMP"
                     /note="fibroblast activation protein alpha; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 80 ESTs, 53 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     18 samples with support for all annotated introns"
                     /db_xref="GeneID:2191"
                     /db_xref="HGNC:HGNC:3590"
                     /db_xref="MIM:600403"
     CDS             119..1594
                     /gene="FAP"
                     /gene_synonym="DPPIV; FAPA; FAPalpha; SIMP"
                     /codon_start=1
                     /product="prolyl endopeptidase FAP isoform X2"
                     /protein_id="XP_011509099.1"
                     /db_xref="GeneID:2191"
                     /db_xref="HGNC:HGNC:3590"
                     /db_xref="MIM:600403"
                     /translation="MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTL
                     KDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASN
                     YGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGS
                     KLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNG
                     KFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVG
                     PQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPK
                     TQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITS
                     GKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQY
                     YTASFSDYAKYYALVCYGPGIPISTLHDGRTDQATSHCCHV"
     polyA_site      2570
                     /gene="FAP"
                     /gene_synonym="DPPIV; FAPA; FAPalpha; SIMP"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtcctggctt cagcttccaa ctacaaagac agacttggtc cttttcaacg gttttcacag
       61 atccagtgac ccacgctctg aagacagaat tagctaactt tcaaaaacat ctggaaaaat
      121 gaagacttgg gtaaaaatcg tatttggagt tgccacctct gctgtgcttg ccttattggt
      181 gatgtgcatt gtcttacgcc cttcaagagt tcataactct gaagaaaata caatgagagc
      241 actcacactg aaggatattt taaatggaac attttcttat aaaacatttt ttccaaactg
      301 gatttcagga caagaatatc ttcatcaatc tgcagataac aatatagtac tttataatat
      361 tgaaacagga caatcatata ccattttgag taatagaacc atgaaaagtg tgaatgcttc
      421 aaattacggc ttatcacctg atcggcaatt tgtatatcta gaaagtgatt attcaaagct
      481 ttggagatac tcttacacag caacatatta catctatgac cttagcaatg gagaatttgt
      541 aagaggaaat gagcttcctc gtccaattca gtatttatgc tggtcgcctg ttgggagtaa
      601 attagcatat gtctatcaaa acaatatcta tttgaaacaa agaccaggag atccaccttt
      661 tcaaataaca tttaatggaa gagaaaataa aatatttaat ggaatcccag actgggttta
      721 tgaagaggaa atgcttgcta caaaatatgc tctctggtgg tctcctaatg gaaaattttt
      781 ggcatatgcg gaatttaatg atacggatat accagttatt gcctattcct attatggcga
      841 tgaacaatat cctagaacaa taaatattcc atacccaaag gctggagcta agaatcccgt
      901 tgttcggata tttattatcg ataccactta ccctgcgtat gtaggtcccc aggaagtgcc
      961 tgttccagca atgatagcct caagtgatta ttatttcagt tggctcacgt gggttactga
     1021 tgaacgagta tgtttgcagt ggctaaaaag agtccagaat gtttcggtcc tgtctatatg
     1081 tgacttcagg gaagactggc agacatggga ttgtccaaag acccaggagc atatagaaga
     1141 aagcagaact ggatgggctg gtggattctt tgtttcaaca ccagttttca gctatgatgc
     1201 catttcgtac tacaaaatat ttagtgacaa ggatggctac aaacatattc actatatcaa
     1261 agacactgtg gaaaatgcta ttcaaattac aagtggcaag tgggaggcca taaatatatt
     1321 cagagtaaca caggattcac tgttttattc tagcaatgaa tttgaagaat accctggaag
     1381 aagaaacatc tacagaatta gcattggaag ctatcctcca agcaagaagt gtgttacttg
     1441 ccatctaagg aaagaaaggt gccaatatta cacagcaagt ttcagcgact acgccaagta
     1501 ctatgcactt gtctgctacg gcccaggcat ccccatttcc acccttcatg atggacgcac
     1561 tgatcaagct acatcacatt gttgccacgt atgaacgccc tgaaatttgg aggctctttc
     1621 cattttcaac tgctatcaag acagtcctcc tctatcctgt atttgtgata ttggttcaaa
     1681 atagttcaca tctcaaagac gaccagtttt gctcgcagca gagttgtcca agtatctaat
     1741 tgctctgata ctcttcctgc tggctctcca ttatcttttg atttactatt aaacaacatt
     1801 atagggttgg agttgttgga ggccagggac aatgaggcag atgccacttt cttcagcact
     1861 catgcctgcg attgtccctg gacagctttg gtgacaagtc aggagactgc cttgggatta
     1921 ctttggctgt cagctcaatg gctcaagtgt aggtgaaaat aacaagaaaa aaaaacaaaa
     1981 acagaatcaa tttgggaact ctggacagga caggcattgt gataatggga ctgtgaattt
     2041 agtttcattt taaggttttt tttgaaacct tgtgtctaat aaggaaatac ttttaagaat
     2101 aacagattat atttcttaat ttgaccatct cagtcagtga gattgatttc aagtcgacaa
     2161 ggttttgttt taatagaaat cactattagc atataattct catcttttca agactgcaaa
     2221 ataatagcca gcctttcttt ttccatagca tgaatttcta ctttcttgag atccttgtta
     2281 gattcctggc agatctgtgt actgattttg aagctctatt acttcactca ctatttacaa
     2341 aataggtacg ccctcagata tgtcagatgt aattaaataa gtaccaacag aaaaaatcaa
     2401 attctttcag agcacagttc cacaacttac ctaatgtgaa attattctcc tatgttcatt
     2461 ataaatacgg attcccagga cttccccaaa gattttaatg tggtacgtct taagttatgc
     2521 ttggaaattt gtatttttaa tagtaaatgt tcagctgctg ttttggagca
//
