LOCUS       NM_020937               7131 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens FA complementation group M (FANCM), transcript variant
            1, mRNA.
ACCESSION   NM_020937 XM_048128
VERSION     NM_020937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7131)
  AUTHORS   Abbouche,L., Murphy,V.J., Gao,J., van Twest,S., Sobinoff,A.P.,
            Auweiler,K.M., Pickett,H.A., Bythell-Douglas,R. and Deans,A.J.
  TITLE     Mechanism of structure-specific DNA binding by the FANCM
            branchpoint translocase
  JOURNAL   Nucleic Acids Res 52 (18), 11029-11044 (2024)
   PUBMED   39189453
  REMARK    GeneRIF: Mechanism of structure-specific DNA binding by the FANCM
            branchpoint translocase.
REFERENCE   2  (bases 1 to 7131)
  AUTHORS   Figlioli,G., Billaud,A., Ahearn,T.U., Antonenkova,N.N., Becher,H.,
            Beckmann,M.W., Behrens,S., Benitez,J., Bermisheva,M., Blok,M.J.,
            Bogdanova,N.V., Bonanni,B., Burwinkel,B., Camp,N.J., Campbell,A.,
            Castelao,J.E., Cessna,M.H., Chanock,S.J., Czene,K., Devilee,P.,
            Dork,T., Engel,C., Eriksson,M., Fasching,P.A., Figueroa,J.D.,
            Gabrielson,M., Gago-Dominguez,M., Garcia-Closas,M.,
            Gonzalez-Neira,A., Grassmann,F., Guenel,P., Gundert,M.,
            Hadjisavvas,A., Hahnen,E., Hall,P., Hamann,U., Harrington,P.A.,
            He,W., Hillemanns,P., Hollestelle,A., Hooning,M.J., Hoppe,R.,
            Howell,A., Humphreys,K., Jager,A., Jakubowska,A.,
            Khusnutdinova,E.K., Ko,Y.D., Kristensen,V.N., Lindblom,A.,
            Lissowska,J., Lubinski,J., Mannermaa,A., Manoukian,S., Margolin,S.,
            Mavroudis,D., Newman,W.G., Obi,N., Panayiotidis,M.I., Rashid,M.U.,
            Rhenius,V., Rookus,M.A., Saloustros,E., Sawyer,E.J.,
            Schmutzler,R.K., Shah,M., Sironen,R., Southey,M.C., Suvanto,M.,
            Tollenaar,R.A.E.M., Tomlinson,I., Truong,T., van der Kolk,L.E., van
            Veen,E.M., Wappenschmidt,B., Yang,X.R., Bolla,M.K., Dennis,J.,
            Dunning,A.M., Easton,D.F., Lush,M., Michailidou,K., Pharoah,P.D.P.,
            Wang,Q., Adank,M.A., Schmidt,M.K., Andrulis,I.L., Chang-Claude,J.,
            Nevanlinna,H., Chenevix-Trench,G., Evans,D.G., Milne,R.L.,
            Radice,P. and Peterlongo,P.
  CONSRTM   NBCS Collaborators; KConFab Investigators
  TITLE     FANCM missense variants and breast cancer risk: a case-control
            association study of 75,156 European women
  JOURNAL   Eur J Hum Genet 31 (5), 578-587 (2023)
   PUBMED   36707629
  REMARK    GeneRIF: FANCM missense variants and breast cancer risk: a
            case-control association study of 75,156 European women.
REFERENCE   3  (bases 1 to 7131)
  AUTHORS   Rashid,M.U., Muhammad,N., Shehzad,U., Khan,F.A., Loya,A. and
            Hamann,U.
  TITLE     Prevalence of FANCM germline variants in BRCA1/2 negative breast
            and/or ovarian cancer patients from Pakistan
  JOURNAL   Fam Cancer 22 (1), 31-41 (2023)
   PUBMED   35802266
  REMARK    GeneRIF: Prevalence of FANCM germline variants in BRCA1/2 negative
            breast and/or ovarian cancer patients from Pakistan.
REFERENCE   4  (bases 1 to 7131)
  AUTHORS   Kim,H.R., Jin,H.S. and Eom,Y.B.
  TITLE     A Genome-Wide Association Study for Hypertensive Kidney Disease in
            Korean Men
  JOURNAL   Genes (Basel) 12 (5), 751 (2021)
   PUBMED   34067580
  REMARK    GeneRIF: A Genome-Wide Association Study for Hypertensive Kidney
            Disease in Korean Men.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7131)
  AUTHORS   Kim,J.M., Kee,Y., Gurtan,A. and D'Andrea,A.D.
  TITLE     Cell cycle-dependent chromatin loading of the Fanconi anemia core
            complex by FANCM/FAAP24
  JOURNAL   Blood 111 (10), 5215-5222 (2008)
   PUBMED   18174376
  REMARK    GeneRIF: FANCM is an anchor required for recruitment of the FA core
            complex to chromatin, and the FANCM/FAAP24 interaction is essential
            for this chromatin-loading activity
REFERENCE   6  (bases 1 to 7131)
  AUTHORS   Ciccia,A., Ling,C., Coulthard,R., Yan,Z., Xue,Y., Meetei,A.R.,
            Laghmani el,H., Joenje,H., McDonald,N., de Winter,J.P., Wang,W. and
            West,S.C.
  TITLE     Identification of FAAP24, a Fanconi anemia core complex protein
            that interacts with FANCM
  JOURNAL   Mol Cell 25 (3), 331-343 (2007)
   PUBMED   17289582
REFERENCE   7  (bases 1 to 7131)
  AUTHORS   Mosedale,G., Niedzwiedz,W., Alpi,A., Perrina,F., Pereira-Leal,J.B.,
            Johnson,M., Langevin,F., Pace,P. and Patel,K.J.
  TITLE     The vertebrate Hef ortholog is a component of the Fanconi anemia
            tumor-suppressor pathway
  JOURNAL   Nat Struct Mol Biol 12 (9), 763-771 (2005)
   PUBMED   16116434
REFERENCE   8  (bases 1 to 7131)
  AUTHORS   Meetei,A.R., Medhurst,A.L., Ling,C., Xue,Y., Singh,T.R., Bier,P.,
            Steltenpool,J., Stone,S., Dokal,I., Mathew,C.G., Hoatlin,M.,
            Joenje,H., de Winter,J.P. and Wang,W.
  TITLE     A human ortholog of archaeal DNA repair protein Hef is defective in
            Fanconi anemia complementation group M
  JOURNAL   Nat Genet 37 (9), 958-963 (2005)
   PUBMED   16116422
REFERENCE   9  (bases 1 to 7131)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   10 (bases 1 to 7131)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121809.6, BC036056.1,
            DQ140356.1 and AL833656.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020937.3.
            
            Summary: The Fanconi anemia complementation group (FANC) currently
            includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,
            FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM
            and FANCN (also called PALB2). The previously defined group FANCH
            is the same as FANCA. Fanconi anemia is a genetically heterogeneous
            recessive disorder characterized by cytogenetic instability,
            hypersensitivity to DNA crosslinking agents, increased chromosomal
            breakage, and defective DNA repair. The members of the Fanconi
            anemia complementation group do not share sequence similarity; they
            are related by their assembly into a common nuclear protein
            complex. This gene encodes the protein for complementation group M.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ140356.1, SRR1660807.189443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267430.10/ ENSP00000267430.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL121809.6         124386-124394       c
            10-2104             BC036056.1         2-2096
            2105-7128           DQ140356.1         2103-7126
            7129-7131           AL833656.1         5575-5577
FEATURES             Location/Qualifiers
     source          1..7131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.2"
     gene            1..7131
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="FA complementation group M"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
     exon            1..610
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..6249
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fanconi anemia group M protein; protein Hef ortholog;
                     ATP-dependent RNA helicase FANCM; fanconi
                     anemia-associated polypeptide of 250 kDa; Fanconi anemia
                     complementation group M"
                     /codon_start=1
                     /product="Fanconi anemia group M protein isoform 1"
                     /protein_id="NP_065988.1"
                     /db_xref="CCDS:CCDS32070.1"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
                     /translation="MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPA
                     AAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAA
                     LFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGI
                     PQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHK
                     ALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPD
                     ILTYSHERKVEKLIVPLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQI
                     ILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDG
                     TKGMTRSKNELGRNEDFMKLYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKL
                     KKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTF
                     VGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKS
                     PIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQR
                     SPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSE
                     EEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQ
                     DHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPR
                     NESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKK
                     VSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINE
                     NVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRT
                     DDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLR
                     SDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKH
                     NQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDD
                     VSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSR
                     DQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGR
                     YLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
                     LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALN
                     STFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLN
                     SPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRG
                     IKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQL
                     SQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDE
                     EESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRII
                     LPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNP
                     LAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSA
                     LEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHG
                     LQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEK
                     DREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVG
                     IHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTH
                     QKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI"
     exon            611..783
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            784..861
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1020
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1152
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1285
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1411
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1498
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1683
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1890
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2104
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2262
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2418
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..4324
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4419
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4488
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4617
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4774
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4881
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5442
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            5443..5818
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            5819..6110
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     exon            6111..7131
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6291..6296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="hexamer: ATTAAA"
     polyA_site      6312
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="major polyA site"
     regulatory      6402..6407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="hexamer: ATTAAA"
     polyA_site      6421
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
     regulatory      6585..6590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="hexamer: AGTAAA"
     polyA_site      6611
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="major polyA site"
     regulatory      7106..7111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /note="hexamer: ATTAAA"
     polyA_site      7131
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
ORIGIN      
        1 ccagagtttt gtgcgaagga aaccgatggg gatcggaacc gtagcggttg agctgctgct
       61 gctacggata tctgacagaa gccttcggtg gttgtcggcc taatgagcgg acggcaaaga
      121 acgctttttc agacgtgggg ctcaagtatc tcccgatcat ctgggactcc gggttgcagc
      181 tccggaactg agcgacctca gagccctggc agctccaagg cgcctttgcc agcagcagcg
      241 gaggctcagc tggagtcgga cgatgatgtg ttgcttgtcg cggcgtacga ggctgagcgg
      301 cagttgtgtc tagagaatgg cgggttctgc acctccgcgg gcgccctgtg gatttaccct
      361 accaattgcc cagtgcggga ctaccagctg cacatttccc gggctgctct gttttgcaat
      421 acgctggtgt gtctgcctac cggactggga aagaccttta ttgccgccgt ggtcatgtac
      481 aatttctacc gctggttccc ttcaggaaag gtggtcttca tggccccaac gaaacccttg
      541 gtgacacagc agatcgaggc ttgctaccag gtgatgggta tcccgcaatc ccacatggcc
      601 gaaatgacag ggtctacaca agcttccacc aggaaggaaa tatggtgcag taagagagtg
      661 ctttttctta cacctcaggt catggtaaat gacctttcta gaggagcttg tcccgctgct
      721 gaaataaagt gtttagttat tgatgaagct cataaagctc tcggaaacta tgcttattgc
      781 caggttgtaa gagaactagt caaatataca aatcacttta gaatcttggc tctaagtgcc
      841 acaccaggta gtgatataaa ggctgtgcaa caagttatta ctaacctgct aattgggcag
      901 atagagcttc gttctgaaga ttctccagat attttgacat attctcatga aagaaaagtt
      961 gaaaagctta ttgttccgct tggtgaagaa cttgcagcca tccaaaagac ctatatccag
     1021 attttggaat catttgctcg ttctttgatt cagaggaatg ttttgatgag aagggatatc
     1081 ccaaatctaa caaaatatca gataattctg gcaagagatc agtttaggaa aaacccatct
     1141 ccgaatattg tgggaataca acaaggcata atcgagggag agtttgctat ttgtattagt
     1201 ttatatcatg gttatgaatt attgcagcaa atgggaatga gatcattata tttcttcctt
     1261 tgtggaatta tggatggaac taaagggatg acacggtcaa aaaatgaact tggccgaaat
     1321 gaagacttca tgaaactcta taatcatcta gagtgtatgt ttgcacgtac acgtagtact
     1381 tcagcaaatg gtatttctgc tatccaacaa ggagataaaa ataaaaaatt tgtttatagt
     1441 catccaaagt taaagaaatt agaagaagtt gtaattgaac acttcaagtc atggaatgct
     1501 gaaaacacta ctgaaaagaa acgtgatgag acccgagtta tgatcttctc ttcatttcga
     1561 gatagtgttc aagaaattgc agaaatgctt tcacagcatc agccaattat tagagtaatg
     1621 acttttgtcg gccatgcctc agggaaaagc acgaagggtt ttacccagaa ggagcaactg
     1681 gaggtagtga aacagtttcg tgacggtggt tacaacacgc tggtttctac ctgtgtgggt
     1741 gaagaaggtt tggatatagg agaagttgat cttataatat gttttgattc ccagaagagc
     1801 ccaattcgtc ttgtacaacg aatgggtaga actggccgta aacgtcaagg caggatagtt
     1861 attatccttt ctgaaggacg agaggaacgt atttataatc agagtcagtc caacaaaaga
     1921 agtatatata aagctatttc aagtaacagg caggtccttc atttttacca aagaagtcca
     1981 cgaatggttc ctgatggaat caacccaaaa ttacacaaaa tgttcatcac acatggtgtc
     2041 tatgaaccag agaagccttc tcggaacttg cagcgaaagt catctatctt ttcctatagg
     2101 gatggaatga ggcaaagtag cctaaagaaa gattggttct tatcagaaga agaatttaaa
     2161 ttatggaaca gactttatag attaagggac agtgatgaaa ttaaagagat aacattgcct
     2221 caagttcagt tttcttcttt acaaaatgag gaaaacaaac cagctcaaga atcaaccact
     2281 ggaattcatc aactctctct ctctgaatgg agactgtggc aagatcatcc tttgcctaca
     2341 catcaagttg atcactcaga tcgatgccgc cattttatag gccttatgca aatgatagag
     2401 ggaatgagac acgaagaggg agaatgcagc tatgaattgg aagttgaatc ttatttacaa
     2461 atggaagatg ttacctcaac atttattgct cccaggaatg aatctaataa tcttgccagt
     2521 gacaccttta tcactcacaa gaaatcgtca tttataaaga acataaatca aggcagttca
     2581 tcctcagtga tagaatctga tgaagaatgt gctgaaattg ttaaacaaac tcatatcaaa
     2641 cctactaaaa ttgtttcttt aaagaaaaaa gtgtctaaag aaataaaaaa agatcagctt
     2701 aaaaaagaaa ataatcacgg tattatagat tctgtagata atgacagaaa ttccactgtt
     2761 gaaaatattt ttcaagaaga cctaccaaat gataaaagga catcagatac agatgaaatt
     2821 gctgccacat gtactattaa tgaaaatgtt attaaagaac cgtgtgtgtt attaacagag
     2881 tgtcagttta caaataaatc cactagttca cttgctggaa atgttttaga ttctggttat
     2941 aacagtttca atgatgaaaa atctgtttca tctaacttat ttcttccatt cgaagaagag
     3001 ctttatattg ttagaacaga tgaccaattt tataattgtc actcattgac aaaagaggta
     3061 ctagctaatg tagagagatt tttatcttat tctcctccgc ctctcagtgg actctcagac
     3121 ttggaatatg aaattgctaa gggtactgca cttgagaatt tgcttttctt accctgtgca
     3181 gagcatttac gaagtgataa atgcacctgt ttgctgtcac attcagctgt gaattctcaa
     3241 cagaatttag aattgaattc acttaaatgt ataaattatc catctgaaaa aagttgcctt
     3301 tatgatatac ctaatgataa tatttctgat gagccaagtc tctgtgactg tgatgtacat
     3361 aaacataatc aaaatgaaaa tttagtacct aacaatcgtg ttcaaataca cagaagccct
     3421 gcacagaatt tagttggaga gaacaatcat gatgttgata acagtgacct cccagtattg
     3481 tccactgatc aagatgaaag tttgctgtta tttgaagatg ttaatacaga gttcgacgat
     3541 gtgagtcttt cacccttgaa cagtaaaagc gaatctttac ctgtgtcaga caaaactgct
     3601 attagtgaaa cgcctctggt ctctcagttc ttaatttctg atgaactttt gttggacaat
     3661 aattctgaac tccaagatca aatcacccgt gatgctaata gttttaaatc tcgtgatcag
     3721 agaggtgtac aggaagaaaa agtgaagaat catgaggata tttttgattg ctctagggat
     3781 ttattttctg ttacctttga tttaggattc tgtagtccag attctgatga tgaaatattg
     3841 gaacatacat cagatagcaa tagacctcta gatgatctat atggaaggta tttggaaatt
     3901 aaggagataa gtgatgcaaa ttatgtttcg aatcaagcac taataccaag agatcatagt
     3961 aaaaatttta ctagtggaac tgttattatc ccatcaaatg aagatatgca gaatccaaat
     4021 tatgtacatt tgccactgag tgcagcaaaa aatgaagaat tgttatctcc tggttattct
     4081 cagttttctt taccagtgca aaaaaaagtt atgagtacac cactctctaa atcaaacaca
     4141 ttgaactcat tttctaagat aagaaaggaa atacttaaga caccagattc tagtaaggaa
     4201 aaagtaaacc tacaaagatt caaagaagca ttgaattcaa cttttgatta ttcagaattt
     4261 tctctagaaa agtctaaaag cagtggtcca atgtatctgc ataaatcctg tcattctgtt
     4321 gaagatggac aattattaac aagtaacgaa agtgaagatg acgagatttt ccgaagaaaa
     4381 gttaaaagag caaaaggaaa tgttttaaac tctcctgagg atcagaaaaa tagtgaagtt
     4441 gattctccac ttcatgctgt caaaaagcgc agatttccta taaacagatc agaattatca
     4501 tctagtgatg agagtgagaa ttttcccaaa ccatgttcac aattagaaga cttcaaggtt
     4561 tgtaacggga atgccagaag aggcatcaaa gtcccaaaga gacagagtca cttaaagcat
     4621 gtagctagga agtttttaga tgatgaagca gaactttctg aagaagatgc agaatatgtt
     4681 tcatcagatg aaaatgatga gtcagaaaat gaacaagatt cctcattact tgacttttta
     4741 aatgatgaaa ctcaactttc acaggctata aatgattctg aaatgagagc tatttacatg
     4801 aaatctttgc gtagtccaat gatgaacaat aagtacaaaa tgattcataa gacacataaa
     4861 aacataaaca ttttctcgca gattcctgaa caagatgaaa cctatttaga ggatagtttt
     4921 tgtgttgatg aagaggagtc ttgcaaaggc caatcaagtg aagaagaagt ttgtgttgat
     4981 tttaacttaa taactgatga ttgctttgca aatagtaaaa agtataaaac tcgacgtgca
     5041 gtaatgctaa aagaaatgat ggaacaaaat tgtgcacatt caaaaaagaa attatccaga
     5101 attattttac cagatgattc aagtgaggag gagaacaatg taaatgataa aagagaatct
     5161 aatattgcgg ttaacccaag cactgttaag aagaacaaac aacaggacca ttgtttaaat
     5221 tcagtgcctt ctggatcttc tgcgcagtcc aaggtgcgtt ctactccaag agttaatcca
     5281 ttagcaaagc agagcaaaca gacatcgctg aatttaaagg atacaatttc cgaagtctca
     5341 gacttcaaac ctcagaatca taatgaagtc cagtctacca caccaccctt cactactgtt
     5401 gattcacaga aagactgtag aaaatttcca gttccacaga aggatggtag tgctttggag
     5461 gattctagca cttcaggggc atcctgttcc aagtcaagac cacatttagc tgggacacat
     5521 acttctctta gacttccgca ggaaggaaaa ggaacctgta ttcttgtagg tggtcatgaa
     5581 atcacttctg gattagaagt aatttcttcc ctaagagcaa ttcatgggtt gcaagtagaa
     5641 gtttgtcctc ttaatggctg tgattacatc gtgagtaatc gcatggtggt ggaaaggagg
     5701 tctcaatctg agatgttaaa tagtgtcaat aagaacaagt tcattgagca gatccagcac
     5761 ctgcagagta tgtttgaaag aatatgtgtg attgtggaaa aggacagaga aaaaacagga
     5821 gacacatcaa ggatgtttag gagaacaaag agctatgaca gcctgctgac taccttaatt
     5881 ggcgctggaa tccgaattct tttcagttcc tgccaagaag aaaccgcaga tttgctaaag
     5941 gaactgtctt tagtggaaca aagaaagaat gttggtattc atgttccaac agtggtgaat
     6001 agtaataaaa gtgaggcact ccagttttat ttaagtattc ccaatataag ttatataact
     6061 gcattaaata tgtgtcacca gttttcatct gtgaaaagga tggctaacag ctcacttcaa
     6121 gaaatctcca tgtatgcaca agtaactcat cagaaggctg aggagatcta tagatatatt
     6181 cactatgtat ttgacataca aatgttacca aatgatctta accaagatag actgaaatct
     6241 gatatataat caagctgctc aagatggggt tttcaaagac ctctcacaat attaaatgca
     6301 cttcaataat cattgctgtt ttatgtttat ttgtaaataa gagaatattt tatttaaata
     6361 ttttatattg tatacatttt tatttataga ttatagaaat tattaaaaaa gaaaaatctg
     6421 atgttcagtg atcattttga ctagattata aaactaattt ttcttattaa ataaaacaag
     6481 gtttattaaa agtgttacta aggatagttt aagaaagtaa aagctaagct agagatatac
     6541 tttggaatgt ttcccaaaat taaagttgta ctgttgtgat aaatagtaaa gttgacatgt
     6601 ctatgactac agccaacttg tcgattttcc ctatgtgtag atagtatact tttaagtgta
     6661 ctgattctaa atacatgtac ttggtaaggt gtgggtgatg ggtgggttgt gagataaatg
     6721 acccagtaac taggaaagta gaaaacttaa ctgaatgttt atctgaccaa aggtgtgtcc
     6781 cagttaagta ctgtcaaatc tattaatatg aactctgata tggtttggct gtgtccccaa
     6841 ccaaaatctc atcttgactt gtaatctgaa ttataatccc aatatattgg ggagggacct
     6901 cctggaacgt gattagctca tgggggcggt tcccccatgc tgttctagtg atagttctca
     6961 gaggatctga tggttttata agcttttcct ctgttcactc tgcagttctc ttgcctactg
     7021 ccatgtggaa aaggaaacgt ttgcttcccc tccaccatga ttgtaagttc ccgaggcctc
     7081 cccagccatg caggactgtg agtcaattaa acatcttttc cttataaatt a
//
