LOCUS       NM_001113378            4733 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens FA complementation group I (FANCI), transcript variant
            1, mRNA.
ACCESSION   NM_001113378
VERSION     NM_001113378.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4733)
  AUTHORS   Alcon,P., Kaczmarczyk,A.P., Ray,K.K., Liolios,T., Guilbaud,G.,
            Sijacki,T., Shen,Y., McLaughlin,S.H., Sale,J.E., Knipscheer,P.,
            Rueda,D.S. and Passmore,L.A.
  TITLE     FANCD2-FANCI surveys DNA and recognizes double- to single-stranded
            junctions
  JOURNAL   Nature 632 (8027), 1165-1173 (2024)
   PUBMED   39085614
  REMARK    GeneRIF: FANCD2-FANCI surveys DNA and recognizes double- to
            single-stranded junctions.
REFERENCE   2  (bases 1 to 4733)
  AUTHORS   Cao,L., He,X., Ren,J., Wen,C., Guo,T., Yang,F., Qin,Y., Chen,Z.J.,
            Zhao,S. and Yang,Y.
  TITLE     Novel compound heterozygous variants in FANCI cause premature
            ovarian insufficiency
  JOURNAL   Hum Genet 143 (3), 357-369 (2024)
   PUBMED   38483614
  REMARK    GeneRIF: Novel compound heterozygous variants in FANCI cause
            premature ovarian insufficiency.
REFERENCE   3  (bases 1 to 4733)
  AUTHORS   Cai,Z., Duan,Y., Li,W., Liu,Z., Gong,Z., Hong,S., He,X.,
            Xuanyuan,X., Chen,Y., Bi,X. and Wang,W.
  TITLE     FANCI serve as a prognostic biomarker correlated with immune
            infiltrates in skin cutaneous melanoma
  JOURNAL   Front Immunol 14, 1295831 (2023)
   PUBMED   38077326
  REMARK    GeneRIF: FANCI serve as a prognostic biomarker correlated with
            immune infiltrates in skin cutaneous melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4733)
  AUTHORS   Hou,Y., Li,J., Yu,A., Deng,K., Chen,J., Wang,Z., Huang,L., Ma,S.
            and Dai,X.
  TITLE     FANCI is Associated with Poor Prognosis and Immune Infiltration in
            Liver Hepatocellular Carcinoma
  JOURNAL   Int J Med Sci 20 (7), 918-932 (2023)
   PUBMED   37324186
  REMARK    GeneRIF: FANCI is Associated with Poor Prognosis and Immune
            Infiltration in Liver Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4733)
  AUTHORS   Fierheller,C.T., Alenezi,W.M., Serruya,C., Revil,T., Amuzu,S.,
            Bedard,K., Subramanian,D.N., Fewings,E., Bruce,J.P., Prokopec,S.,
            Bouchard,L., Provencher,D., Foulkes,W.D., El Haffaf,Z.,
            Mes-Masson,A.M., Tischkowitz,M., Campbell,I.G., Pugh,T.J.,
            Greenwood,C.M.T., Ragoussis,J. and Tonin,P.N.
  TITLE     Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian
            Cancer Predisposing Gene
  JOURNAL   Genes (Basel) 14 (2), 277 (2023)
   PUBMED   36833203
  REMARK    GeneRIF: Molecular Genetic Characteristics of FANCI, a Proposed New
            Ovarian Cancer Predisposing Gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4733)
  AUTHORS   Smogorzewska,A., Matsuoka,S., Vinciguerra,P., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Ballif,B.A., Gygi,S.P., Hofmann,K.,
            D'Andrea,A.D. and Elledge,S.J.
  TITLE     Identification of the FANCI protein, a monoubiquitinated FANCD2
            paralog required for DNA repair
  JOURNAL   Cell 129 (2), 289-301 (2007)
   PUBMED   17412408
  REMARK    GeneRIF: description of the Fanconi anemia protein FANCI,
            identified as an ATM/ATR kinase substrate required for resistance
            to mitomycin C; it associates with FANCD2 and, together, as the
            FANCI-FANCD2 (ID) complex, localizes to chromatin in response to
            DNA damage
REFERENCE   7  (bases 1 to 4733)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 4733)
  AUTHORS   Wang,X., Andreassen,P.R. and D'Andrea,A.D.
  TITLE     Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1
            in chromatin
  JOURNAL   Mol Cell Biol 24 (13), 5850-5862 (2004)
   PUBMED   15199141
REFERENCE   9  (bases 1 to 4733)
  AUTHORS   Levitus,M., Rooimans,M.A., Steltenpool,J., Cool,N.F., Oostra,A.B.,
            Mathew,C.G., Hoatlin,M.E., Waisfisz,Q., Arwert,F., de Winter,J.P.
            and Joenje,H.
  TITLE     Heterogeneity in Fanconi anemia: evidence for 2 new genetic
            subtypes
  JOURNAL   Blood 103 (7), 2498-2503 (2004)
   PUBMED   14630800
REFERENCE   10 (bases 1 to 4733)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU187299.1, EF567077.1 and
            AC124068.6.
            
            On Nov 25, 2019 this sequence version replaced NM_001113378.1.
            
            Summary: The Fanconi anemia complementation group (FANC) currently
            includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,
            FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM
            and FANCN (also called PALB2). The previously defined group FANCH
            is the same as FANCA. Fanconi anemia is a genetically heterogeneous
            recessive disorder characterized by cytogenetic instability,
            hypersensitivity to DNA crosslinking agents, increased chromosomal
            breakage, and defective DNA repair. The members of the Fanconi
            anemia complementation group do not share sequence similarity; they
            are related by their assembly into a common nuclear protein
            complex. This gene encodes the protein for complementation group I.
            Alternative splicing results in two transcript variants encoding
            different isoforms. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146804.1, SRR11853561.10563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310775.12/ ENSP00000310842.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BU187299.1         17-90
            75-4061             EF567077.1         1-3987
            4062-4733           AC124068.6         150039-150710
FEATURES             Location/Qualifiers
     source          1..4733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..4733
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="FA complementation group I"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
     exon            1..55
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            56..158
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..4061
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fanconi anemia group I protein; Fanconi anemia
                     complementation group I"
                     /codon_start=1
                     /product="Fanconi anemia group I protein isoform 1"
                     /protein_id="NP_001106849.1"
                     /db_xref="CCDS:CCDS45346.1"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
                     /translation="MDQKILSLAAEKTADKLQEFLQTLREGDLTNLLQNQAVKGKVAG
                     ALLRAIFKGSPCSEEAGTLRRRKIYTCCIQLVESGDLQKEIASEIIGLLMLEAHHFPG
                     PLLVELANEFISAVREGSLVNGKSLELLPIILTALATKKENLAYGKGVLSGEECKKQL
                     INTLCSGRWDQQYVIQLTSMFKDVPLTAEEVEFVVEKALSMFSKMNLQEIPPLVYQLL
                     VLSSKGSRKSVLEGIIAFFSALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIV
                     FAIKLDYELGRELVKHLKVGQQGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLKTSV
                     VKSFKDLQLLQGSKFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILMDS
                     YGPKKVLDGKTIETSPSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVT
                     RASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLLKAVQPLLK
                     VSMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVLGSLSSSQCSQSLSVSQ
                     VHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLYEGFYDVLRRNSQLANSVM
                     QTLLSQLKQFYEPKPDLLPPLKLEACILTQGDKISLQEPLDYLLCCIQHCLAWYKNTV
                     IPLQQGEEEEEEEEAFYEDLDDILESITNRMIKSELEDFELDKSADFSQSTSIGIKNN
                     ICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLFMCYKKLSDILNEKAGKAKTKMAN
                     KTSDSLLSMKFVSSLLTALFRDSIQSHQESLSVLRSSNEFMRYAVNVALQKVQQLKET
                     GHVSGPDGQNPEKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQK
                     IFSAVQQFYQPKIQQFLRALDVTDKEGEEREDADVSVTQRTAFQIRQFQRSLLNLLSS
                     QEEDFNSKEALLLVTVLTSLSKLLEPSSPQFVQMLSWTSKICKENSREDALFCKSLMN
                     LLFSLHVSYKSPVILLRDLSQDIHGHLGDIDQDVEVEKTNHFAIVNLRTAAPTVCLLV
                     LSQAEKVLEEVDWLITKLKGQVSQETLSEEASSQATLPNQPVEKAIIMQLGTLLTFFH
                     ELVQTALPSGSCVDTLLKDLCKMYTTLTALVRYYLQVCQSSGGIPKNMEKLVKLSGSH
                     LTPLCYSFISYVQNKSKSLNYTGEKKEKPAAVATAMARVLRETKPIPNLIFAIEQYEK
                     FLIHLSKKSKVNLMQHMKLSTSRDFKIKGNILDMVLREDGEDENEEGTASEHGGQNKE
                     PAKKKRKK"
     exon            159..231
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            232..362
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            363..519
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            520..577
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            578..619
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            620..743
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            744..829
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            830..956
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1049
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1186
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1367
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1455
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1586
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1657
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1772
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1895
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1964
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2066
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2243
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2365
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2530
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2710
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2877
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2963
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3080
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3132
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3260
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3329
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3423
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3611
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3665
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3725
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3794
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3890
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..3998
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4733
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4061..4066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="hexamer: AATGAA"
     polyA_site      4085
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="major polyA site"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="hexamer: AATAAA"
     polyA_site      4733
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /note="major polyA site"
ORIGIN      
        1 aacggaagtg tggcggcgtt gggttgagcg ggctttttgg aagtttgtgg cggagttctg
       61 tgatatgagc aacaatggac cagaagattt tatctctagc agcagaaaaa acagcagaca
      121 aactgcaaga atttcttcaa accctgagag aaggtgattt gactaatctc cttcagaatc
      181 aagcagtgaa aggaaaagtt gctggagcac tcctgagagc catcttcaaa ggttccccct
      241 gctctgagga agctggaaca cttaggagac gtaagatata cacttgttgt atccagttgg
      301 tggaatcggg ggatttgcag aaagaaatag cgtctgagat cataggatta ctgatgctgg
      361 aggctcacca ttttccagga ccattattgg ttgaattagc caatgagttt attagtgctg
      421 tcagagaagg cagcctagtg aatggaaaat ctttggagtt actacctatc attctcactg
      481 ccctggctac gaaaaaggaa aatctggctt atggaaaagg tgtactgagt ggggaagaat
      541 gtaagaaaca gttgattaac accctgtgtt ctggcaggtg ggatcagcaa tatgtaatcc
      601 aactcacctc catgttcaag gatgtccctc tgactgcaga agaggtggaa tttgtggtgg
      661 aaaaagcatt gagcatgttc tccaagatga atcttcaaga aataccacct ttggtctatc
      721 agcttctggt tctctcctcc aagggaagca gaaagagtgt tttggaagga atcatagcct
      781 tcttcagtgc actagataag cagcacaatg aggaacagag tggtgacgag ctattggatg
      841 ttgtcactgt gccatcaggt gaacttcgtc atgtggaagg caccattatt ctacacattg
      901 tgtttgccat caaattggac tatgaactag gcagagaact cgtgaaacac ttaaaggtag
      961 gacagcaagg agattccaat aataacttaa gtcccttcag cattgctctt cttctgtctg
     1021 taacaagaat acaaagattt caggaccagg tgcttgatct tttaaagact tcggttgtaa
     1081 agagctttaa ggatcttcaa ctcctccaag gctcaaaatt tcttcagaat ctagttcctc
     1141 atagatctta tgtttcaacc atgatcttgg aagtagtgaa gaatagcgtt catagctggg
     1201 accatgttac tcagggcctc gtagaacttg gtttcatttt gatggattca tatgggccaa
     1261 agaaggttct tgatggaaaa actattgaaa ccagcccaag tctttctaga atgccaaacc
     1321 agcatgcatg taagctcgga gctaatatcc tgttggaaac ttttaagatc catgagatga
     1381 tcagacaaga aattttggag caggtcctca acagggttgt taccagagca tcttctccca
     1441 tcagtcattt cttagacctg ctttcaaata tcgtcatgta tgcaccctta gttcttcaaa
     1501 gttgttcttc taaagtcaca gaagcttttg actatttgtc ctttctgccc cttcagactg
     1561 tacaaaggct gcttaaggca gtgcagcccc ttctcaaagt cagcatgtca atgagagact
     1621 gcttgatact tgtccttcgg aaagctatgt ttgccaacca gcttgatgcc cgaaaatctg
     1681 cagttgctgg gtttttgctg ctcctgaaga actttaaagt tttaggcagc ctgtcatcct
     1741 ctcagtgcag tcagtctctc agtgtcagtc aggttcatgt ggatgttcac agccattaca
     1801 attctgtcgc caatgaaact ttttgccttg agatcatgga tagtttgagg agatgcttaa
     1861 gccagcaagc tgatgttcga ctcatgcttt atgaggggtt ttatgatgtt cttcgaagga
     1921 actctcagct ggctaattca gtcatgcaaa ctctgctctc acagttaaaa cagttctatg
     1981 agccaaaacc tgatctgctg cctcctctga aattagaagc ttgtattctg acccaaggag
     2041 ataagatctc tctacaagaa ccactggatt atctgctgtg ttgtattcag cattgtttgg
     2101 cctggtataa gaatacagtc atacccttac agcagggaga ggaggaagag gaggaggaag
     2161 aggcattcta cgaagaccta gatgatatat tggagtccat tactaataga atgattaaga
     2221 gtgagctgga agactttgaa ctggataaat cagcagattt ttctcagagc accagtattg
     2281 gcataaaaaa taatatctgt gcttttcttg tgatgggagt ttgtgaggtt ttaatagaat
     2341 acaatttctc cataagtagt ttcagtaaga ataggtttga ggacattctg agcttattta
     2401 tgtgttacaa aaaactctct gacattctta atgaaaaagc gggtaaagcc aaaactaaaa
     2461 tggccaacaa gacaagtgat agtcttttgt ccatgaaatt tgtgtccagt cttctcactg
     2521 ctcttttcag ggatagtatc caaagccacc aagaaagcct ttctgttctc aggtccagca
     2581 atgagtttat gcgctatgca gtgaatgtag ctctgcagaa agtacagcag ctaaaggaaa
     2641 cagggcatgt gagtggccct gatggccaaa acccagaaaa gatctttcag aacctctgtg
     2701 acataactcg agtcttgcta tggagataca cttcaattcc tacttcagtg gaagagtcgg
     2761 gaaagaaaga gaaaggaaag agcatctcac tgctgtgctt ggagggttta cagaaaatat
     2821 tcagtgctgt gcaacagttc tatcagccca agattcagca gtttctcaga gctctggatg
     2881 tcacagataa ggaaggagaa gagagagaag atgcagatgt cagtgtcact cagagaacag
     2941 cattccagat ccggcaattt cagaggtcct tgttgaattt acttagcagt caagaggaag
     3001 attttaatag caaagaagcc ctcctgctag tcacggttct taccagtttg tccaagttac
     3061 tggagccctc ctctcctcag tttgtgcaga tgttatcctg gacatcaaag atttgcaagg
     3121 aaaacagccg ggaggatgcc ttgttttgca agagcttgat gaacttgctc ttcagcctgc
     3181 atgtttcgta taagagtcct gtcattctgc tgcgtgactt gtcccaggat atccacgggc
     3241 atctgggaga tatagaccag gatgtagagg tggagaaaac aaaccacttt gcaatagtga
     3301 atttgagaac ggctgccccc actgtctgtt tacttgttct gagtcaggcc gagaaggttc
     3361 tagaagaagt ggactggcta atcaccaagc ttaagggaca agtgagccaa gaaaccttat
     3421 cagaagaggc ctcttctcag gcaaccctac caaatcagcc tgttgagaaa gctatcatca
     3481 tgcaactggg aactctgctt acatttttcc acgagctggt gcagacagct ctgccatcag
     3541 gcagctgtgt ggacaccttg ttaaaggact tgtgcaaaat gtacaccaca cttacagccc
     3601 ttgtcagata ttatctccag gtgtgtcaga gctccggagg aattccaaaa aatatggaaa
     3661 agctggtgaa gctgtctggt tctcatctga cccccctgtg ttattctttc atttcttacg
     3721 tacagaataa gagtaagagc ctgaactata cgggagagaa aaaggagaaa cctgctgccg
     3781 ttgccacagc catggccaga gttcttcggg aaaccaagcc aatccctaac ctcatctttg
     3841 ccatagaaca gtatgaaaaa tttctcatcc acctttctaa gaagtccaag gtgaacctga
     3901 tgcagcacat gaagctcagc acctcacgag acttcaagat caaaggaaac atcctagaca
     3961 tggttcttcg agaggatggt gaagatgaaa atgaagaggg cactgcatca gagcatgggg
     4021 gacagaacaa agaaccagcc aagaagaaaa ggaaaaaata aatgaaatgc ctgagttaat
     4081 gtgaactttg gggcttctgc ttcattttta cccaacaagc aacaatgccc cttgtcctgt
     4141 agtccacacc gatgttggca tcttggttct gaacccactg aattcaactg caccttcagt
     4201 tagaaggaat cttcttggca ggtcctgcta ctgaaaaatg gctggcctta ggcaagccct
     4261 tttgcaaaaa gcacagctga aagcctgagt ttgggagcct gcaccacccc gatgaagctc
     4321 cacgggagca aatacagagc ctccaggcag tgctatggtc caggctggct tcgtttttcc
     4381 aaggagcctt tggtgagttc aattatctgg taaatatcca gcgcttcacc tgaaagatag
     4441 tgcaaattgg ttaggatgcc acctcaagaa ctgtaactga gagctcagaa gtgagcaaag
     4501 gagcttaatg ctaaggtcaa aaggagagtg aaaggttgag aacaattgcc acgaacggta
     4561 atgttacatg ttaggagggt ctgttttctt tttatataag tgtgtcttag atatatttta
     4621 aatagaaaat aagctttctg atttacttgt ttggtattta aagcacagtt tgtttttctg
     4681 tcacctatag agtgcaagaa tgcactctat agaataaatt atctttaaac att
//
