LOCUS       NM_001164839            1087 bp    mRNA    linear   PRI 30-JAN-2025
DEFINITION  Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant
            2, mRNA.
ACCESSION   NM_001164839
VERSION     NM_001164839.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1087)
  AUTHORS   Perez-Palma,E., Bustos,B.I., Villaman,C.F., Alarcon,M.A.,
            Avila,M.E., Ugarte,G.D., Reyes,A.E., Opazo,C. and De Ferrari,G.V.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; NIA-LOAD/NCRAD Family
            Study Group
  TITLE     Overrepresentation of glutamate signaling in Alzheimer's disease:
            network-based pathway enrichment using meta-analysis of genome-wide
            association studies
  JOURNAL   PLoS One 9 (4), e95413 (2014)
   PUBMED   24755620
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034193.5, AF230334.1 and AW074860.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001164839.1.
            
            Summary: This gene encodes a conserved protein of unknown function.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.315129.1, AF230334.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450660.3/ ENSP00000429608.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC034193.5         55859-55890
            33-880              AF230334.1         1-848
            881-889             AW074860.1         5-13                c
            890-1087            AC034193.5         59980-60177
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..1087
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /note="FANCD2 opposite strand"
                     /db_xref="GeneID:115795"
                     /db_xref="HGNC:HGNC:28623"
                     /db_xref="MIM:621082"
     exon            1..241
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            242..1087
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..783
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /note="Fanconi anemia group D2 protein opposite strand
                     transcript protein"
                     /codon_start=1
                     /product="FANCD2 opposite strand protein"
                     /protein_id="NP_001158311.1"
                     /db_xref="CCDS:CCDS2596.1"
                     /db_xref="GeneID:115795"
                     /db_xref="HGNC:HGNC:28623"
                     /db_xref="MIM:621082"
                     /translation="MAGYQLWSPWTPLDESFQWLRHTTPTPSSKHPFKASPCFPHTPS
                     DLEVQLCFQEVTLVLDSPFLESGVSPKLPCHTSELRTMNNKGLVRKPQPIRLSGVDSV
                     FGRVITAQPPKWTGTFRVSDKSAFCKIISREHQWPIGLKEPQIQMTVTMCKQMLRSIL
                     LLYATYKKCTFALQHSK"
     regulatory      863..868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /note="hexamer: AATGAA"
     polyA_site      889
                     /gene="FANCD2OS"
                     /gene_synonym="C3orf24"
                     /note="major polyA site"
ORIGIN      
        1 agagttcagc aggtgagccc cgggcccgga tggtgggact gggcccaggt tcccaccgca
       61 tcgtccgcct cagccagaac cttctggtcc ccgcccccgg atagggaccc aggaggccca
      121 agccccttct tccggcgggg agtgggagcc tctcgcactc tcggcagctc cagaccctcg
      181 ggatctccgt ttacagttca ggacctcagc tgcactttgg cgctaacgcc ctgtttccca
      241 ggactgtcaa tggcaggata ccagctctgg tcaccatgga ccccactgga tgagagtttc
      301 caatggctgc ggcacacgac acctacacct tcctccaagc acccattcaa ggcctccccc
      361 tgcttcccac acacaccgtc cgaccttgaa gtgcagctgt gctttcaaga ggtcactcta
      421 gtcctagaca gcccattcct ggaatctgga gtgagtccca agttaccctg ccacacatca
      481 gagttgcgca cgatgaacaa caaaggactg gtcaggaagc cccagcccat ccgcctcagt
      541 ggagtagatt ctgtctttgg cagggttatc acagctcagc caccaaagtg gaccgggact
      601 ttcagagttt cagacaagtc agccttttgc aaaatcatta gcagggagca ccagtggccc
      661 attggactga aggagcctca gattcagatg acagtcacta tgtgcaaaca gatgctgcgc
      721 tctatcctct tgctgtatgc aacttacaaa aagtgcacct ttgccttgca gcactccaag
      781 taaagggtcc tcatttgatc cccatttact cacaccatgc cctttggtat gtacctaaag
      841 cttacagaaa cctgtccatg taaatgaaac tgtgacattg tcccagccat cttgcttttg
      901 tttcaagcag tgatgattca ggagcccctt tcatcccttc ccctccaaaa aaggaccaat
      961 gatagagaac aaggaagaac attcccattg taaggttgaa ccatttagag tcaaactagc
     1021 attgacatgt ccatgtgata accgttaaac aaatgatata aaccaatgag cctagtgtga
     1081 actcaca
//
