LOCUS       NM_001018115            5096 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens FA complementation group D2 (FANCD2), transcript
            variant 2, mRNA.
ACCESSION   NM_001018115
VERSION     NM_001018115.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5096)
  AUTHORS   Blaize,J.L., Garzon,J.L.N. and Howlett,N.G.
  TITLE     FANCD2 genome binding is nonrandom and is enriched at large
            transcriptionally active neural genes prone to copy number
            variation
  JOURNAL   Funct Integr Genomics 24 (5), 180 (2024)
   PUBMED   39365306
  REMARK    GeneRIF: FANCD2 genome binding is nonrandom and is enriched at
            large transcriptionally active neural genes prone to copy number
            variation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5096)
  AUTHORS   Alcon,P., Kaczmarczyk,A.P., Ray,K.K., Liolios,T., Guilbaud,G.,
            Sijacki,T., Shen,Y., McLaughlin,S.H., Sale,J.E., Knipscheer,P.,
            Rueda,D.S. and Passmore,L.A.
  TITLE     FANCD2-FANCI surveys DNA and recognizes double- to single-stranded
            junctions
  JOURNAL   Nature 632 (8027), 1165-1173 (2024)
   PUBMED   39085614
  REMARK    GeneRIF: FANCD2-FANCI surveys DNA and recognizes double- to
            single-stranded junctions.
REFERENCE   3  (bases 1 to 5096)
  AUTHORS   Morita,S., Fujikane,R., Uechi,Y., Matsuura,T. and Hidaka,M.
  TITLE     FANCD2 counteracts O6-methylguanine-induced mismatch
            repair-dependent apoptosis
  JOURNAL   Mol Biol Rep 51 (1), 745 (2024)
   PUBMED   38874758
  REMARK    GeneRIF: FANCD2 counteracts O[6]-methylguanine-induced mismatch
            repair-dependent apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5096)
  AUTHORS   Zhao,Z., Wang,R., Wang,R., Song,J., Ma,F., Pan,H., Gao,C., Wang,D.,
            Chen,X. and Fan,X.
  TITLE     Pancancer analysis of the prognostic and immunological role of
            FANCD2: a potential target for carcinogenesis and survival
  JOURNAL   BMC Med Genomics 17 (1), 69 (2024)
   PUBMED   38443946
  REMARK    GeneRIF: Pancancer analysis of the prognostic and immunological
            role of FANCD2: a potential target for carcinogenesis and survival.
            Erratum:[BMC Med Genomics. 2024 May 14;17(1):129. doi:
            10.1186/s12920-024-01896-6. PMID: 38745241]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5096)
  AUTHORS   Garcia-Higuera,I., Taniguchi,T., Ganesan,S., Meyn,M.S., Timmers,C.,
            Hejna,J., Grompe,M. and D'Andrea,A.D.
  TITLE     Interaction of the Fanconi anemia proteins and BRCA1 in a common
            pathway
  JOURNAL   Mol Cell 7 (2), 249-262 (2001)
   PUBMED   11239454
REFERENCE   6  (bases 1 to 5096)
  AUTHORS   Timmers,C., Taniguchi,T., Hejna,J., Reifsteck,C., Lucas,L.,
            Bruun,D., Thayer,M., Cox,B., Olson,S., D'Andrea,A.D., Moses,R. and
            Grompe,M.
  TITLE     Positional cloning of a novel Fanconi anemia gene, FANCD2
  JOURNAL   Mol Cell 7 (2), 241-248 (2001)
   PUBMED   11239453
REFERENCE   7  (bases 1 to 5096)
  AUTHORS   Hejna,J.A., Timmers,C.D., Reifsteck,C., Bruun,D.A., Lucas,L.W.,
            Jakobs,P.M., Toth-Fejel,S., Unsworth,N., Clemens,S.L., Garcia,D.K.,
            Naylor,S.L., Thayer,M.J., Olson,S.B., Grompe,M. and Moses,R.E.
  TITLE     Localization of the Fanconi anemia complementation group D gene to
            a 200-kb region on chromosome 3p25.3
  JOURNAL   Am J Hum Genet 66 (5), 1540-1551 (2000)
   PUBMED   10762542
REFERENCE   8  (bases 1 to 5096)
  AUTHORS   Whitney,M., Thayer,M., Reifsteck,C., Olson,S., Smith,L.,
            Jakobs,P.M., Leach,R., Naylor,S., Joenje,H. and Grompe,M.
  TITLE     Microcell mediated chromosome transfer maps the Fanconi anaemia
            group D gene to chromosome 3p
  JOURNAL   Nat Genet 11 (3), 341-343 (1995)
   PUBMED   7581463
REFERENCE   9  (bases 1 to 5096)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   10 (bases 1 to 5096)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034193.5.
            
            On Sep 16, 2019 this sequence version replaced NM_001018115.2.
            
            Summary: The Fanconi anemia complementation group (FANC) currently
            includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,
            FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM
            and FANCN (also called PALB2). The previously defined group FANCH
            is the same as FANCA. Fanconi anemia is a genetically heterogeneous
            recessive disorder characterized by cytogenetic instability,
            hypersensitivity to DNA crosslinking agents, increased chromosomal
            breakage, and defective DNA repair. The members of the Fanconi
            anemia complementation group do not share sequence similarity; they
            are related by their assembly into a common nuclear protein
            complex. This gene encodes the protein for complementation group
            D2. This protein is monoubiquinated in response to DNA damage,
            resulting in its localization to nuclear foci with other proteins
            (BRCA1 AND BRCA2) involved in homology-directed DNA repair.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1. It encodes isoform
            b which has a shorter and distinct C-terminus, compared to isoform
            a. Variants 2 and 3 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF340183.1, SRR14038196.2278805.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675286.1/ ENSP00000502379.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC034193.5         137641-137677       c
            38-134              AC034193.5         135393-135489       c
            135-275             AC034193.5         131142-131282       c
            276-343             AC034193.5         129578-129645       c
            344-447             AC034193.5         129316-129419       c
            448-508             AC034193.5         128881-128941       c
            509-561             AC034193.5         127775-127827       c
            562-640             AC034193.5         124757-124835       c
            641-765             AC034193.5         124269-124393       c
            766-853             AC034193.5         122404-122491       c
            854-958             AC034193.5         121451-121555       c
            959-1059            AC034193.5         120964-121064       c
            1060-1168           AC034193.5         120522-120630       c
            1169-1204           AC034193.5         120250-120285       c
            1205-1348           AC034193.5         117391-117534       c
            1349-1483           AC034193.5         116063-116197       c
            1484-1615           AC034193.5         114609-114740       c
            1616-1726           AC034193.5         111617-111727       c
            1727-1836           AC034193.5         103711-103820       c
            1837-1897           AC034193.5         101903-101963       c
            1898-2017           AC034193.5         100203-100322       c
            2018-2091           AC034193.5         99685-99758         c
            2092-2238           AC034193.5         99239-99385         c
            2239-2339           AC034193.5         98620-98720         c
            2340-2455           AC034193.5         98135-98250         c
            2456-2564           AC034193.5         96797-96905         c
            2565-2675           AC034193.5         91133-91243         c
            2676-2785           AC034193.5         90752-90861         c
            2786-2929           AC034193.5         89441-89584         c
            2930-3046           AC034193.5         85917-86033         c
            3047-3175           AC034193.5         82886-83014         c
            3176-3294           AC034193.5         82650-82768         c
            3295-3405           AC034193.5         78192-78302         c
            3406-3536           AC034193.5         76850-76980         c
            3537-3630           AC034193.5         75572-75665         c
            3631-3753           AC034193.5         75164-75286         c
            3754-3847           AC034193.5         73729-73822         c
            3848-3919           AC034193.5         71862-71933         c
            3920-3958           AC034193.5         70791-70829         c
            3959-4033           AC034193.5         69751-69825         c
            4034-4108           AC034193.5         68840-68914         c
            4109-4255           AC034193.5         67642-67788         c
            4256-4351           AC034193.5         65299-65394         c
            4352-5096           AC034193.5         62182-62926         c
FEATURES             Location/Qualifiers
     source          1..5096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..5096
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /note="FA complementation group D2"
                     /db_xref="GeneID:2177"
                     /db_xref="HGNC:HGNC:3585"
                     /db_xref="MIM:613984"
     exon            1..37
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            38..134
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            135..275
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            276..343
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            344..447
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            448..508
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            509..561
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            562..640
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            641..765
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            766..853
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            854..958
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1059
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1168
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1204
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1348
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1483
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1615
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1726
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1836
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1897
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2017
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2091
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2238
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2339
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2455
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2564
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2675
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2785
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2929
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3046
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3175
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3294
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3405
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3536
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3630
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3753
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3847
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3919
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..3958
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4033
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4108
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4255
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4351
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..5096
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5074..5079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /note="hexamer: AATAAA"
     polyA_site      5096
                     /gene="FANCD2"
                     /gene_synonym="FA-D2; FA4; FACD; FAD; FAD2; FANCD"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagtcg aaaactacgg gcggcgacgg cttctcggaa gtaatttaag tgcacaagac
       61 attggtcaaa atggtttcca aaagaagact gtcaaaatct gaggataaag agagcctgac
      121 agaagatgcc tccaaaacca ggaagcaacc actttccaaa aagacaaaga aatctcatat
      181 tgctaatgaa gttgaagaaa atgacagcat ctttgtaaag cttcttaaga tatcaggaat
      241 tattcttaaa acgggagaga gtcagaatca actagctgtg gatcaaatag ctttccaaaa
      301 gaagctcttt cagaccctga ggagacaccc ttcctatccc aaaataatag aagaatttgt
      361 tagtggcctg gagtcttaca ttgaggatga agacagtttc aggaactgcc ttttgtcttg
      421 tgagcgtctg caggatgagg aagccagtat gggtgcatct tattctaaga gtctcatcaa
      481 actgcttctg gggattgaca tactgcagcc tgccattatc aaaaccttat ttgagaagtt
      541 gccagaatat ttttttgaaa acaagaacag tgatgaaatc aacatacctc gactcattgt
      601 cagtcaacta aaatggcttg acagagttgt ggatggcaag gacctcacca ccaagatcat
      661 gcagctgatc agtattgctc cagagaacct gcagcatgac atcatcacca gcctacctga
      721 gatcctaggg gattcccagc acgctgatgt ggggaaagaa ctcagtgacc tactgataga
      781 gaatacttca ctcactgtcc caatcctgga tgtcctttca agcctccgac ttgacccaaa
      841 cttcctattg aaggttcgcc agttggtgat ggataagttg tcgtctatta gattggagga
      901 tttacctgtg ataataaagt tcattcttca ttccgtaaca gccatggata cacttgaggt
      961 aatttctgag cttcgggaga agttggatct gcagcattgt gttttgccat cacggttaca
     1021 ggcttcccaa gtaaagttga aaagtaaagg acgagcaagt tcctcaggaa atcaagaaag
     1081 cagcggtcag agctgtatta ttctcctctt tgatgtaata aagtcagcta ttagatatga
     1141 gaaaaccatt tcagaagcct ggattaaggc aattgaaaac actgcctcag tatctgaaca
     1201 caaggtgttt gacctggtga tgcttttcat catctatagc accaatactc agacaaagaa
     1261 gtacattgac agggtgctaa gaaataagat tcgatcaggc tgcattcaag aacagctgct
     1321 ccagagtaca ttctctgttc attacttagt tcttaaggat atgtgttcat ccattctgtc
     1381 gctggctcag agtttgcttc actctctaga ccagagtata atttcatttg gcagtctcct
     1441 atacaaatat gcatttaagt tttttgacac gtactgccag caggaagtgg ttggtgcctt
     1501 agtgacccat atctgcagtg ggaatgaagc tgaagttgat actgccttag atgtccttct
     1561 agagttggta gtgttaaacc catctgctat gatgatgaat gctgtctttg taaagggcat
     1621 tttagattat ctggataaca tatcccctca gcaaatacga aaactcttct atgttctcag
     1681 cacactggca tttagcaaac agaatgaagc cagcagccac atccaggatg acatgcactt
     1741 ggtgataaga aagcagctct ctagcaccgt attcaagtac aagctcattg ggattattgg
     1801 tgctgtgacc atggctggca tcatggcggc agacagaagt gaatcaccta gtttgaccca
     1861 agagagagcc aacctgagcg atgagcagtg cacacaggtg acctccttgt tgcagttggt
     1921 tcattcctgc agtgagcagt ctcctcaggc ctctgcactt tactatgatg aatttgccaa
     1981 cctgatccaa catgaaaagc tggatccaaa agccctggaa tgggttgggc ataccatctg
     2041 taatgatttc caggatgcct tcgtagtgga ctcctgtgtt gttccggaag gtgactttcc
     2101 atttcctgtg aaagcactgt acggactgga agaatacgac actcaggatg ggattgccat
     2161 aaacctcctg ccgctgctgt tttctcagga ctttgcaaaa gatgggggtc cggtgacctc
     2221 acaggaatca ggccaaaaat tggtgtctcc gctgtgcctg gctccgtatt tccggttact
     2281 gagactttgt gtggagagac agcataacgg aaacttggag gagattgatg gtctactaga
     2341 ttgtcctata ttcctaactg acctggagcc tggagagaag ttggagtcca tgtctgctaa
     2401 agagcgttca ttcatgtgtt ctctcatatt tcttactctc aactggttcc gagagattgt
     2461 aaatgccttc tgccaggaaa catcacctga gatgaagggg aaggtgctca ctcggttaaa
     2521 gcacattgta gaattgcaaa taatcctgga aaagtacttg gcagtcaccc cagactatgt
     2581 ccctcctctt ggaaactttg atgtggaaac tttagatata acacctcata ctgttactgc
     2641 tatttcagca aaaatcagaa agaaaggaaa aatagaaagg aaacaaaaaa cagatggcag
     2701 caagacatcc tcctctgaca cactttcaga agagaaaaat tcagaatgtg accctacgcc
     2761 atctcataga ggccagctaa acaaggagtt cacagggaag gaagaaaaga catcattgtt
     2821 actacataat tcccatgctt ttttccgaga gctggacatt gaggtcttct ctattctaca
     2881 ttgtggactt gtgacgaagt tcatcttaga tactgaaatg cacactgaag ctacagaagt
     2941 tgtgcaactt gggccccctg agctgctttt cttgctggaa gatctctccc agaagctgga
     3001 gagtatgctg acacctccta ttgccaggag agtccccttt ctcaagaaca aaggaagccg
     3061 gaatattgga ttctcacatc tccaacagag atctgcccaa gaaattgttc attgtgtttt
     3121 tcaactgctg accccaatgt gtaaccacct ggagaacatt cacaactatt ttcagtgttt
     3181 agctgctgag aatcacggtg tagttgatgg accaggagtg aaagttcagg agtaccacat
     3241 aatgtcttcc tgctatcaga ggctgctgca gatttttcat gggctttttg cttggagtgg
     3301 attttctcaa cctgaaaatc agaatttact gtattcagcc ctccatgtcc ttagtagccg
     3361 actgaaacag ggagaacaca gccagccttt ggaggaacta ctcagccaga gcgtccatta
     3421 cttgcagaat ttccatcaaa gcattcccag tttccagtgt gctctttatc tcatcagact
     3481 tttgatggtt attttggaga aatcaacagc ttctgctcag aacaaagaaa aaattgcttc
     3541 ccttgccaga caattcctct gtcgggtgtg gccaagtggg gataaagaga agagcaacat
     3601 ctctaatgac cagctccatg ctctgctctg tatctacctg gagcacacag agagcattct
     3661 gaaggccata gaggagattg ctggtgttgg tgtcccagaa ctgatcaact ctcctaaaga
     3721 tgcatcttcc tccacattcc ctacactgac caggcatact tttgttgttt tcttccgtgt
     3781 gatgatggct gaactagaga agacggtgaa aaaaattgag cctggcacag cagcagactc
     3841 gcagcagatt catgaagaga aactcctcta ctggaacatg gctgttcgag acttcagtat
     3901 cctcatcaac ttgataaagg tatttgatag tcatcctgtt ctgcatgtat gtttgaagta
     3961 tgggcgtctc tttgtggaag catttctgaa gcaatgtatg ccgctcctag acttcagttt
     4021 tagaaaacac cgggaagatg ttctgagctt actggaaacc ttccagttgg acacaaggct
     4081 gcttcatcac ctgtgtgggc attccaagat tcaccaggac acgagactca cccaacatgt
     4141 gcctctgctc aaaaagaccc tggaactttt agtttgcaga gtcaaagcta tgctcactct
     4201 caacaattgt agagaggctt tctggctggg caatctaaaa aaccgggact tgcagggtga
     4261 agagattaag tcccaaaatt cccaggagag cacagcagat gagagtgagg atgacatgtc
     4321 atcccaggcc tccaagagca aagccactga ggatggtgaa gaagacgaag taagtgctgg
     4381 agaaaaggag caagatagtg atgagagtta tgatgactct gattagaccc cagataaatt
     4441 gttgcctgct tctgtgtctc tgccagcctg tgatcatttt gtgttagagt ttgaaatccg
     4501 ctgtttgcct ttcttactgg taggatcctt ttttgttcct cttttttttt tttttttttt
     4561 ttttttaaag acggggactc gctgtgtttc ccaggctgga gtgcagtgct gcaatcttgg
     4621 ctcactgcaa cctccatctc ctaggttcaa gcgattctcc tgcctcagcc tcctgagtag
     4681 ctgggacgac aggcacatgc caccatgccc agctaatttt tgtattttta gtagatacgg
     4741 ggttttacca tgtcggccag atggtctcaa tctcctgaac tcatgatcca cctgcctcag
     4801 cctcccaaag tgctgggatt acaggcatga gccaccgctc ccagccatat tttgttctta
     4861 aagtggggtc tttattaact tgtggacatc atggattgtc taacaccatc acagtccctg
     4921 gctcaggatt ctaatgtagc attatttatt ggtttggata aacccagctg tgctacactg
     4981 cagagtaaaa tctctgagtc atgattctgg actttgggag ctagttttga aactctgatt
     5041 tattgtagaa cttaggcttg taccaatttt acaaataaat tctgttctaa gttctg
//
