LOCUS       NM_000135               5452 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens FA complementation group A (FANCA), transcript variant
            1, mRNA.
ACCESSION   NM_000135
VERSION     NM_000135.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5452)
  AUTHORS   Ramanagoudr-Bhojappa,R., Tryon,R., Lach,F.P., Donovan,F.X.,
            Maxwell,R., Rosenberg,A., MacMillan,M.L., Wagner,J.E.,
            Auerbach,A.D., Smogorzewska,A. and Chandrasekharappa,S.C.
  TITLE     FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice variant
            associated with delayed onset of Fanconi anemia
  JOURNAL   Blood Adv 8 (4), 899-908 (2024)
   PUBMED   38191666
  REMARK    GeneRIF: FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice
            variant associated with delayed onset of Fanconi anemia.
REFERENCE   2  (bases 1 to 5452)
  AUTHORS   Fettke,H., Dai,C., Kwan,E.M., Zheng,T., Du,P., Ng,N.,
            Bukczynska,P., Docanto,M., Kostos,L., Foroughi,S., Brown,S.,
            Graham,L.K., Mahon,K., Horvath,L.G., Jia,S., Kohli,M. and Azad,A.A.
  TITLE     BRCA-deficient metastatic prostate cancer has an adverse prognosis
            and distinct genomic phenotype
  JOURNAL   EBioMedicine 95, 104738 (2023)
   PUBMED   37549632
  REMARK    GeneRIF: BRCA-deficient metastatic prostate cancer has an adverse
            prognosis and distinct genomic phenotype.
REFERENCE   3  (bases 1 to 5452)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5452)
  AUTHORS   Bertola,N., Degan,P., Cappelli,E. and Ravera,S.
  TITLE     Mutated FANCA Gene Role in the Modulation of Energy Metabolism and
            Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma
  JOURNAL   Cells 11 (15), 2353 (2022)
   PUBMED   35954197
  REMARK    GeneRIF: Mutated FANCA Gene Role in the Modulation of Energy
            Metabolism and Mitochondrial Dynamics in Head and Neck Squamous
            Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5452)
  AUTHORS   Ianzano,L., D'Apolito,M., Centra,M., Savino,M., Levran,O.,
            Auerbach,A.D., Cleton-Jansen,A.M., Doggett,N.A., Pronk,J.C.,
            Tipping,A.J., Gibson,R.A., Mathew,C.G., Whitmore,S.A.,
            Apostolou,S., Callen,D.F., Zelante,L. and Savoia,A.
  TITLE     The genomic organization of the Fanconi anemia group A (FAA) gene
  JOURNAL   Genomics 41 (3), 309-314 (1997)
   PUBMED   9169126
REFERENCE   6  (bases 1 to 5452)
  AUTHORS   Lo Ten Foe,J.R., Rooimans,M.A., Bosnoyan-Collins,L., Alon,N.,
            Wijker,M., Parker,L., Lightfoot,J., Carreau,M., Callen,D.F.,
            Savoia,A., Cheng,N.C., van Berkel,C.G., Strunk,M.H., Gille,J.J.,
            Pals,G., Kruyt,F.A., Pronk,J.C., Arwert,F., Buchwald,M. and
            Joenje,H.
  TITLE     Expression cloning of a cDNA for the major Fanconi anaemia gene,
            FAA
  JOURNAL   Nat Genet 14 (3), 320-323 (1996)
   PUBMED   8896563
  REMARK    Erratum:[Nat Genet. 1996 Dec;14(4):488. doi: 10.1038/ng1296-488..
            PMID: 8944034]
REFERENCE   7  (bases 1 to 5452)
  AUTHORS   Gschwend,M., Levran,O., Kruglyak,L., Ranade,K., Verlander,P.C.,
            Shen,S., Faure,S., Weissenbach,J., Altay,C., Lander,E.S.,
            Auerbach,A.D. and Botstein,D.
  TITLE     A locus for Fanconi anemia on 16q determined by homozygosity
            mapping
  JOURNAL   Am J Hum Genet 59 (2), 377-384 (1996)
   PUBMED   8755924
REFERENCE   8  (bases 1 to 5452)
  AUTHORS   Pronk,J.C., Gibson,R.A., Savoia,A., Wijker,M., Morgan,N.V.,
            Melchionda,S., Ford,D., Temtamy,S., Ortega,J.J., Jansen,S. et al.
  TITLE     Localisation of the Fanconi anaemia complementation group A gene to
            chromosome 16q24.3
  JOURNAL   Nat Genet 11 (3), 338-340 (1995)
   PUBMED   7581462
REFERENCE   9  (bases 1 to 5452)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   10 (bases 1 to 5452)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC064540.1, X99226.1,
            AC005567.1 and AC005360.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000135.3.
            
            Summary: The Fanconi anemia complementation group (FANC) currently
            includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,
            FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM
            and FANCN (also called PALB2). The previously defined group FANCH
            is the same as FANCA. Fanconi anemia is a genetically heterogeneous
            recessive disorder characterized by cytogenetic instability,
            hypersensitivity to DNA crosslinking agents, increased chromosomal
            breakage, and defective DNA repair. The members of the Fanconi
            anemia complementation group do not share sequence similarity; they
            are related by their assembly into a common nuclear protein
            complex. This gene encodes the protein for complementation group A.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. Mutations in this gene are the most
            common cause of Fanconi anemia. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99226.1, SRR14038194.2399300.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389301.8/ ENSP00000373952.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BC064540.1         11-11
            2-1532              X99226.1           1-1531
            1533-1533           AC005567.1         26074-26074
            1534-2182           X99226.1           1533-2181
            2183-2183           AC005360.1         6047-6047
            2184-5058           X99226.1           2183-5057
            5059-5059           AC005360.1         39783-39783
            5060-5452           X99226.1           5058-5450
FEATURES             Location/Qualifiers
     source          1..5452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..5452
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="FA complementation group A"
                     /db_xref="GeneID:2175"
                     /db_xref="HGNC:HGNC:3582"
                     /db_xref="MIM:607139"
     exon            1..111
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..4400
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="isoform a is encoded by transcript variant 1;
                     Fanconi anemia, complementation group H; Fanconi anemia,
                     type 1; fanconi anemia group A protein; Fanconi anemia
                     complementation group A"
                     /codon_start=1
                     /product="Fanconi anemia group A protein isoform a"
                     /protein_id="NP_000126.2"
                     /db_xref="CCDS:CCDS32515.1"
                     /db_xref="GeneID:2175"
                     /db_xref="HGNC:HGNC:3582"
                     /db_xref="MIM:607139"
                     /translation="MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLK
                     ESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHSSSFIGSALQDQA
                     SRLGVPVGILSAGMVASSVGQICTAPAETSHPVLLTVEQRKKLSSLLEFAQYLLAHSM
                     FSRLSFCQELWKIQSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLC
                     EQMEASCQHADVARAMLSDFVQMFVLRGFQKNSDLRRTVEPEKMPQVTVDVLQRMLIF
                     ALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQILTHSPVL
                     KASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSF
                     VSALVVCFPEAQQLLEDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYAD
                     WFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPRYLQVHILHPPLVPGKYRSLLT
                     DYISLAKTRLADLKVSIENMGLYEDLSSAGDITEPHSQALQDVEKAIMVFEHTGNIPV
                     TVMEASIFRRPYYVSHFLPALLTPRVLPKVPDSRVAFIESLKRADKIPPSLYSTYCQA
                     CSAAEEKPEDAALGVRAEPNSAEEPLGQLTAALGELRASMTDPSQRDVISAQVAVISE
                     RLRAVLGHNEDDSSVEISKIQLSINTPRLEPREHMAVDLLLTSFCQNLMAASSVAPPE
                     RQGPWAALFVRTMCGRVLPAVLTRLCQLLRHQGPSLSAPHVLGLAALAVHLGESRSAL
                     PEVDVGPPAPGAGLPVPALFDSLLTCRTRDSLFFCLKFCTAAISYSLCKFSSQSRDTL
                     CSCLSPGLIKKFQFLMFRLFSEARQPLSEEDVASLSWRPLHLPSADWQRAALSLWTHR
                     TFREVLKEEDVHLTYQDWLHLELEIQPEADALSDTERQDFHQWAIHEHFLPESSASGG
                     CDGDLQAACTILVNALMDFHQSSRSYDHSENSDLVFGGRTGNEDIISRLQEMVADLEL
                     QQDLIVPLGHTPSQEHFLFEIFRRRLQALTSGWSVAASLQRQRELLMYKRILLRLPSS
                     VLCGSSFQAEQPITARCEQFFHLVNSEMRNFCSHGGALTQDITAHFFRGLLNACLRSR
                     DPSLMVDFILAKCQTKCPLILTSALVWWPSLEPVLLCRWRRHCQSPLPRELQKLQEGR
                     QFASDFLSPEAASPAPNPDWLSAAALHFAIQQVREENIRKQLKKLDCEREELLVFLFF
                     FSLMGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESDLRLGRLLL
                     RVAPDQHTRLLPFAFYSLLSYFHEDAAIREEAFLHVAVDMYLKLVQLFVAGDTSTVSP
                     PAGRSLELKGQGNPVELITKARLFLLQLIPRCPKKSFSHVAELLADRGDCDPEVSAAL
                     QSRQQAAPDADLSQEPHLF"
     exon            112..221
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            222..315
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            316..458
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            459..554
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            555..628
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            629..741
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            742..824
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            825..858
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            859..925
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1038
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1115
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1257
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1391
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1502
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1598
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1658
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1747
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1808
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1858
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1932
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2046
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2183
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2254
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2348
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2536
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2633
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2810
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2884
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3013
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3098
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3271
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3380
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3440
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3545
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3658
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3797
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3860
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3966
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4042
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4199
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4292
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..5452
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4447..4452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="hexamer: ATTACA"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="hexamer: ACTAAA"
     polyA_site      4484
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="major polyA site"
     polyA_site      4496
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="major polyA site"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="hexamer: AATAAA"
     polyA_site      4596
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
     regulatory      5425..5430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
                     /note="hexamer: AAGAAA"
     polyA_site      5452
                     /gene="FANCA"
                     /gene_synonym="FA; FA-H; FA1; FAA; FACA; FAH; FANCH"
ORIGIN      
        1 gagccgccgc cggggctgta ggcgccaagg ccatgtccga ctcgtgggtc ccgaactccg
       61 cctcgggcca ggacccaggg ggccgccgga gggcctgggc cgagctgctg gcgggaaggg
      121 tcaagaggga aaaatataat cctgaaaggg cacagaaatt aaaggaatca gctgtgcgcc
      181 tcctgcgaag ccatcaggac ctgaatgccc ttttgcttga ggtagaaggt ccactgtgta
      241 aaaaattgtc tctcagcaaa gtgattgact gtgacagttc tgaggcctat gctaatcatt
      301 ctagttcatt tataggctct gctttgcagg atcaagcctc aaggctgggg gttcccgtgg
      361 gtattctctc agccgggatg gttgcctcta gcgtgggaca gatctgcacg gctccagcgg
      421 agaccagtca ccctgtgctg ctgactgtgg agcagagaaa gaagctgtct tccctgttag
      481 agtttgctca gtatttattg gcacacagta tgttctcccg tctttccttc tgtcaagaat
      541 tatggaaaat acagagttct ttgttgcttg aagcggtgtg gcatcttcac gtacaaggca
      601 ttgtgagcct gcaagagctg ctggaaagcc atcccgacat gcatgctgtg ggatcgtggc
      661 tcttcaggaa tctgtgctgc ctttgtgaac agatggaagc atcctgccag catgctgacg
      721 tcgccagggc catgctttct gattttgttc aaatgtttgt tttgagggga tttcagaaaa
      781 actcagatct gagaagaact gtggagcctg aaaaaatgcc gcaggtcacg gttgatgtac
      841 tgcagagaat gctgattttt gcacttgacg ctttggctgc tggagtacag gaggagtcct
      901 ccactcacaa gatcgtgagg tgctggttcg gagtgttcag tggacacacg cttggcagtg
      961 taatttccac agatcctctg aagaggttct tcagtcatac cctgactcag atactcactc
     1021 acagccctgt gctgaaagca tctgatgctg ttcagatgca gagagagtgg agctttgcgc
     1081 ggacacaccc tctgctcacc tcactgtacc gcaggctctt tgtgatgctg agtgcagagg
     1141 agttggttgg ccatttgcaa gaagttctgg aaacgcagga ggttcactgg cagagagtgc
     1201 tctcctttgt gtctgccctg gttgtctgct ttccagaagc gcagcagctg cttgaagact
     1261 gggtggcgcg tttgatggcc caggcattcg agagctgcca gctggacagc atggtcactg
     1321 cgttcctggt tgtgcgccag gcagcactgg agggcccctc tgcgttcctg tcatatgcag
     1381 actggttcaa ggcctccttt gggagcacac gaggctacca tggctgcagc aagaaggccc
     1441 tggtcttcct gtttacgttc ttgtcagaac tcgtgccttt tgagtctccc cggtacctgc
     1501 aggtgcacat tctccaccca cccctggttc ccggcaagta ccgctccctc ctcacagact
     1561 acatctcatt ggccaagaca cggctggccg acctcaaggt ttctatagaa aacatgggac
     1621 tctacgagga tttgtcatca gctggggaca ttactgagcc ccacagccaa gctcttcagg
     1681 atgttgaaaa ggccatcatg gtgtttgagc atacggggaa catcccagtc accgtcatgg
     1741 aggccagcat attcaggagg ccttactacg tgtcccactt cctccccgcc ctgctcacac
     1801 ctcgagtgct ccccaaagtc cctgactccc gtgtggcgtt tatagagtct ctgaagagag
     1861 cagataaaat ccccccatct ctgtactcca cctactgcca ggcctgctct gctgctgaag
     1921 agaagccaga agatgcagcc ctgggagtga gggcagaacc caactctgct gaggagcccc
     1981 tgggacagct cacagctgca ctgggagagc tgagagcctc catgacagac cccagccagc
     2041 gtgatgttat atcggcacag gtggcagtga tttctgaaag actgagggct gtcctgggcc
     2101 acaatgagga tgacagcagc gttgagatat caaagattca gctcagcatc aacacgccga
     2161 gactggagcc acgggaacac atggctgtgg acctcctgct gacgtctttc tgtcagaacc
     2221 tgatggctgc ctccagtgtc gctcccccgg agaggcaggg tccctgggct gccctcttcg
     2281 tgaggaccat gtgtggacgt gtgctccctg cagtgctcac ccggctctgc cagctgctcc
     2341 gtcaccaggg cccgagcctg agtgccccac atgtgctggg gttggctgcc ctggccgtgc
     2401 acctgggtga gtccaggtct gcgctcccag aggtggatgt gggtcctcct gcacctggtg
     2461 ctggccttcc tgtccctgcg ctctttgaca gcctcctgac ctgtaggacg agggattcct
     2521 tgttcttctg cctgaaattt tgtacagcag caatttctta ctctctctgc aagttttctt
     2581 cccagtcacg agatactttg tgcagctgct tatctccagg ccttattaaa aagtttcagt
     2641 tcctcatgtt cagattgttc tcagaggccc gacagcctct ttctgaggag gacgtagcca
     2701 gcctttcctg gagacccttg caccttcctt ctgcagactg gcagagagct gccctctctc
     2761 tctggacaca cagaaccttc cgagaggtgt tgaaagagga agatgttcac ttaacttacc
     2821 aagactggtt acacctggag ctggaaattc aacctgaagc tgatgctctt tcagatactg
     2881 aacggcagga cttccaccag tgggcgatcc atgagcactt tctccctgag tcctcggctt
     2941 cagggggctg tgacggagac ctgcaggctg cgtgtaccat tcttgtcaac gcactgatgg
     3001 atttccacca aagctcaagg agttatgacc actcagaaaa ttctgatttg gtctttggtg
     3061 gccgcacagg aaatgaggat attatttcca gattgcagga gatggtagct gacctggagc
     3121 tgcagcaaga cctcatagtg cctctcggcc acaccccttc ccaggagcac ttcctctttg
     3181 agattttccg cagacggctc caggctctga caagcgggtg gagcgtggct gccagccttc
     3241 agagacagag ggagctgcta atgtacaaac ggatcctcct ccgcctgcct tcgtctgtcc
     3301 tctgcggcag cagcttccag gcagaacagc ccatcactgc cagatgcgag cagttcttcc
     3361 acttggtcaa ctctgagatg agaaacttct gctcccacgg aggtgccctg acacaggaca
     3421 tcactgccca cttcttcagg ggcctcctga acgcctgtct gcggagcaga gacccctccc
     3481 tgatggtcga cttcatactg gccaagtgcc agacgaaatg ccccttaatt ttgacctctg
     3541 ctctggtgtg gtggccgagc ctggagcctg tgctgctctg ccggtggagg agacactgcc
     3601 agagcccgct gccccgggaa ctgcagaagc tacaagaagg ccggcagttt gccagcgatt
     3661 tcctctcccc tgaggctgcc tccccagcac ccaacccgga ctggctctca gctgctgcac
     3721 tgcactttgc gattcaacaa gtcagggaag aaaacatcag gaagcagcta aagaagctgg
     3781 actgcgagag agaggagcta ttggttttcc ttttcttctt ctccttgatg ggcctgctgt
     3841 cgtcacatct gacctcaaat agcaccacag acctgccaaa ggctttccac gtttgtgcag
     3901 caatcctcga gtgtttagag aagaggaaga tatcctggct ggcactcttt cagttgacag
     3961 agagtgacct caggctgggg cggctcctcc tccgtgtggc cccggatcag cacaccaggc
     4021 tgctgccttt cgctttttac agtcttctct cctacttcca tgaagacgcg gccatcaggg
     4081 aagaggcctt cctgcatgtt gctgtggaca tgtacttgaa gctggtccag ctcttcgtgg
     4141 ctggggatac aagcacagtt tcacctccag ctggcaggag cctggagctc aagggtcagg
     4201 gcaaccccgt ggaactgata acaaaagctc gtctttttct gctgcagtta atacctcggt
     4261 gcccgaaaaa gagcttctca cacgtggcag agctgctggc tgatcgtggg gactgcgacc
     4321 cagaggtgag cgccgccctc cagagcagac agcaggctgc ccctgacgct gacctgtccc
     4381 aggagcctca tctcttctga cgggacctgc cactgcacac cagcccagct cccgtgtaaa
     4441 taatttatta caagcataac atggagctct tgttgcacta aaaagtggat tacaaatctc
     4501 ctcgactgct ttagtgggga aaggaatcaa ttatttatga actgtccggc cccgagtcac
     4561 tcagcgtttg cgggaaaata aaccactggt cccagagcag aggaaggcta cttgagccgg
     4621 acaccaagcc cgcctccagc accaagggcg ggcagcaccc tccgaccctc ccatgcgggt
     4681 gcacacgaag ggtgaggctg acacagccac tgcggagtcc aggctgctag aggtgctcat
     4741 cctcactgcc gtcctcaggt gggttcgggc ttcaccgcct ggccctctgt ggtcacagag
     4801 gggctcggtg gcccaggtgg tggttccgcc tccaggggca gggccttgtc ctgggtctgt
     4861 gtcagcgggt gcaccatgga catgtgtaca ttgaggttgt gggccttctc aaaccgccgg
     4921 ccacactggt cacaggcaaa gtccagctca gtctcagcct tgtgtttggt catgtggtac
     4981 ttgagggatg cccgctgcct gcactggaac ccacagacct cacacctggg ggacagaggc
     5041 agataagaag gtgcgagggc cacagccctg ggagggggtc ctgactcaca cttactgcaa
     5101 aggcttggct cccgaatgtc gcatttggtg gacgagaagg tgcttccgct gcttgaaggt
     5161 ttgtccacat tcgtcacaga tatagttccg cacctctgag aggggagagt ccagtgagtc
     5221 caggcccctg atgctccaac ctcccggggg gacgacgatg acaatgtgaa accatcacag
     5281 ctgggaagac atttctgcac atggttcacc atgcagtggg cccaagcaag gggcctatga
     5341 gggcctcgtt tattaagatc tttaaactgc tttatacact gtcacgtggc ttcatcagct
     5401 gtgtgcattt caggatggtt tttaaagaaa cctcagaaag ctatttcctt aa
//
