LOCUS       NM_014967               4849 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens FANCD2 and FANCI associated nuclease 1 (FAN1),
            transcript variant 1, mRNA.
ACCESSION   NM_014967 XM_375181
VERSION     NM_014967.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4849)
  AUTHORS   Csaszar,I., Kalmar,T., Maroti,Z., Aved,J., Szederkenyi,E.,
            Zombori,J., Pankotai-Bodo,G., Turkevi-Nagy,S. and Ivanyi,B.
  TITLE     Phenotypic and Genotypic Features of the FAN1 Mutation-Related
            Disease in a Large Hungarian Family
  JOURNAL   Int J Mol Sci 25 (11), 5907 (2024)
   PUBMED   38892095
  REMARK    GeneRIF: Phenotypic and Genotypic Features of the FAN1
            Mutation-Related Disease in a Large Hungarian Family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4849)
  AUTHORS   Kim,K.H., Hong,E.P., Lee,Y., McLean,Z.L., Elezi,E., Lee,R.,
            Kwak,S., McAllister,B., Massey,T.H., Lobanov,S., Holmans,P.,
            Orth,M., Ciosi,M., Monckton,D.G., Long,J.D., Lucente,D.,
            Wheeler,V.C., MacDonald,M.E., Gusella,J.F. and Lee,J.M.
  TITLE     Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512
            underlies onset-delaying genetic modification in Huntington's
            disease
  JOURNAL   Proc Natl Acad Sci U S A 121 (16), e2322924121 (2024)
   PUBMED   38607933
  REMARK    GeneRIF: Posttranscriptional regulation of FAN1 by miR-124-3p at
            rs3512 underlies onset-delaying genetic modification in
            Huntington's disease.
REFERENCE   3  (bases 1 to 4849)
  AUTHORS   Phadte,A.S., Bhatia,M., Ebert,H., Abdullah,H., Elrazaq,E.A.,
            Komolov,K.E. and Pluciennik,A.
  TITLE     FAN1 removes triplet repeat extrusions via a PCNA- and
            RFC-dependent mechanism
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2302103120 (2023)
   PUBMED   37549289
  REMARK    GeneRIF: FAN1 removes triplet repeat extrusions via a PCNA- and
            RFC-dependent mechanism.
REFERENCE   4  (bases 1 to 4849)
  AUTHORS   Airik,M., Phua,Y.L., Huynh,A.B., McCourt,B.T., Rush,B.M., Tan,R.J.,
            Vockley,J., Murray,S.L., Dorman,A., Conlon,P.J. and Airik,R.
  TITLE     Persistent DNA damage underlies tubular cell polyploidization and
            progression to chronic kidney disease in kidneys deficient in the
            DNA repair protein FAN1
  JOURNAL   Kidney Int 102 (5), 1042-1056 (2022)
   PUBMED   35931300
  REMARK    GeneRIF: Persistent DNA damage underlies tubular cell
            polyploidization and progression to chronic kidney disease in
            kidneys deficient in the DNA repair protein FAN1.
REFERENCE   5  (bases 1 to 4849)
  AUTHORS   Liu,T., Ghosal,G., Yuan,J., Chen,J. and Huang,J.
  TITLE     FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link
            repair
  JOURNAL   Science 329 (5992), 693-696 (2010)
   PUBMED   20671156
  REMARK    GeneRIF: study characterizes FANI which promotes DNA interstrand
            cross-linking repair in a manner strictly dependent on its ability
            to accumulate at or near sites of DNA damage and that relies on
            mono-ubiquitylation of the FANCI-FANCD2 complex
REFERENCE   6  (bases 1 to 4849)
  AUTHORS   Smogorzewska,A., Desetty,R., Saito,T.T., Schlabach,M., Lach,F.P.,
            Sowa,M.E., Clark,A.B., Kunkel,T.A., Harper,J.W., Colaiacovo,M.P.
            and Elledge,S.J.
  TITLE     A genetic screen identifies FAN1, a Fanconi anemia-associated
            nuclease necessary for DNA interstrand crosslink repair
  JOURNAL   Mol Cell 39 (1), 36-47 (2010)
   PUBMED   20603073
  REMARK    GeneRIF: FAN1 colocalizes at sites of DNA damage with the ID
            complex in a manner dependent on FAN1's ubiquitin-binding domain
            (UBZ), the FANCI-FAND2 (ID) complex, and monoubiquitination of
            FANCD2.
REFERENCE   7  (bases 1 to 4849)
  AUTHORS   Kratz,K., Schopf,B., Kaden,S., Sendoel,A., Eberhard,R.,
            Lademann,C., Cannavo,E., Sartori,A.A., Hengartner,M.O. and
            Jiricny,J.
  TITLE     Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes
            cells to interstrand crosslinking agents
  JOURNAL   Cell 142 (1), 77-88 (2010)
   PUBMED   20603016
  REMARK    GeneRIF: KIAA1018 is a 5'-->3' exonuclease and a structure-specific
            endonuclease that preferentially incises 5' flaps; like cells from
            FA patients, human cells depleted of KIAA1018 are sensitized to
            ICL-inducing agents and display chromosomal instability.
REFERENCE   8  (bases 1 to 4849)
  AUTHORS   MacKay,C., Declais,A.C., Lundin,C., Agostinho,A., Deans,A.J.,
            MacArtney,T.J., Hofmann,K., Gartner,A., West,S.C., Helleday,T.,
            Lilley,D.M. and Rouse,J.
  TITLE     Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to
            DNA damage by monoubiquitinated FANCD2
  JOURNAL   Cell 142 (1), 65-76 (2010)
   PUBMED   20603015
  REMARK    GeneRIF: Study describes how a highly conserved protein,
            KIAA1018/MTMR15/FAN1, that interacts with, and is recruited to
            sites of DNA damage by, the monoubiquitinated form of FANCD2.
REFERENCE   9  (bases 1 to 4849)
  AUTHORS   Alonso,A., Sasin,J., Bottini,N., Friedberg,I., Friedberg,I.,
            Osterman,A., Godzik,A., Hunter,T., Dixon,J. and Mustelin,T.
  TITLE     Protein tyrosine phosphatases in the human genome
  JOURNAL   Cell 117 (6), 699-711 (2004)
   PUBMED   15186772
  REMARK    Review article
REFERENCE   10 (bases 1 to 4849)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA841207.1, AB023235.2,
            BC044890.1, CR936727.1 and CR936734.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014967.4.
            
            Summary: This gene plays a role in DNA interstrand cross-link
            repair and encodes a protein with 5' flap endonuclease and 5'-3'
            exonuclease activity. Mutations in this gene cause karyomegalic
            interstitial nephritis. Alternatively spliced transcript variants
            encoding distinct isoforms have been described. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936734.1, SRR1660809.91497.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362065.9/ ENSP00000354497.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA841207.1         43-53
            12-1708             AB023235.2         1-1697
            1709-1709           BC044890.1         1608-1608
            1710-4116           AB023235.2         1699-4105
            4117-4543           CR936727.1         4273-4699
            4544-4849           CR936734.1         4556-4861
FEATURES             Location/Qualifiers
     source          1..4849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..4849
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /note="FANCD2 and FANCI associated nuclease 1"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
     exon            1..97
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1483
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3303
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /EC_number="3.1.4.1"
                     /note="isoform a is encoded by transcript variant 1;
                     fanconi anemia associated nuclease 1; coiled-coil
                     domain-containing protein MTMR15; myotubularin-related
                     protein 15; FANCD2/FANCI-associated nuclease 1"
                     /codon_start=1
                     /product="fanconi-associated nuclease 1 isoform a"
                     /protein_id="NP_055782.3"
                     /db_xref="CCDS:CCDS32186.1"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
                     /translation="MMSEGKPPDKKRPRRSLSISKNKKKASNSIISCFNNAPPAKLAC
                     PVCSKMVPRYDLNRHLDEMCANNDFVQVDPGQVGLINSNVSMVDLTSVTLEDVTPKKS
                     PPPKTNLTPGQSDSAKREVKQKISPYFKSNDVVCKNQDELRNRSVKVICLGSLASKLS
                     RKYVKAKKSIDKDEEFAGSSPQSSKSTVVKSLIDNSSEIEDEDQILENSSQKENVFKC
                     DSLKEECIPEHMVRGSKIMEAESQKATRECEKSALTPGFSDNAIMLFSPDFTLRNTLK
                     STSEDSLVKQECIKEVVEKREACHCEEVKMTVASEAKIQLSDSEAKSHSSADDASAWS
                     NIQEAPLQDDSCLNNDIPHSIPLEQGSSCNGPGQTTGHPYYLRSFLVVLKTVLENEDD
                     MLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEEL
                     TNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQRS
                     VCTWGKNKPGIGAVILKRAKALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACG
                     GQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNW
                     EEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHM
                     YEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRT
                     GHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITGRLCPQRGMCKSVFV
                     MEAGEAADPTTVLCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIP
                     DVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVA
                     SLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFK
                     LVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAVGAKSQSLS"
     exon            1484..1624
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1826
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2060
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2192
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2301
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2421
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2586
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2737
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2841
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3036
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3165
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3306
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..4849
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4828..4833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /note="hexamer: AATAAA"
     polyA_site      4849
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /note="major polyA site"
ORIGIN      
        1 gatcttgggt gacagggcac cgagggaagg aggacgcgag ggcagccagg ccctagggag
       61 cagggagagt ggctcgggct cagtcgcgtg gccccaggaa gaagaaattg tcgagacgaa
      121 taacatgagg tcatatagaa tcccactttt ggtgatttca agtcaagaaa gtaaaagtaa
      181 accattgcta tctttcacct taaatatcct gtgttttatt gctcagaaca tccagttttt
      241 ctaatactca tgatgtcaga agggaaacct cctgacaaaa aaaggcctcg tagaagctta
      301 tcaatcagca agaataagaa aaaagcatct aattctatta tttcgtgttt taacaatgca
      361 ccacctgcta aacttgcctg ccccgtttgc agtaaaatgg tgcctagata tgacttaaac
      421 cggcaccttg atgaaatgtg tgctaacaat gacttcgttc aagtggatcc agggcaggtt
      481 ggcttaataa attcaaatgt gtctatggta gatttaacca gtgttacctt agaagatgta
      541 acacctaaga agtcaccacc accaaagaca aatttaaccc ctggccaaag tgattcagca
      601 aaaagggaag taaagcagaa gatcagtccc tactttaaaa gtaatgatgt ggtgtgcaaa
      661 aatcaagatg agctgagaaa tcgtagtgtg aaagtcattt gtttgggaag cctagcatct
      721 aaattgtcca gaaaatacgt aaaggctaaa aaatcaatag ataaggatga agaatttgcc
      781 ggttctagtc cacagagttc caaatccaca gttgttaaga gcctgattga taactcttca
      841 gaaattgagg acgaggatca aattttggag aacagttctc aaaaagaaaa cgtgtttaaa
      901 tgtgattctc taaaggaaga gtgcattcct gaacatatgg taagaggaag taaaataatg
      961 gaagccgaaa gccaaaaggc tacccgggaa tgtgagaaat cagccctcac ccctggattc
     1021 tcagataatg cgatcatgtt attctcacca gatttcactc ttaggaatac attaaagtct
     1081 acttcagaag acagtcttgt aaagcaagag tgtatcaaag aagtggttga aaaacgtgag
     1141 gcatgtcatt gtgaagaagt aaaaatgact gttgcttcag aagctaaaat acagctgtca
     1201 gattcagagg caaaatctca tagttctgca gatgatgctt ctgcatggag taacatccaa
     1261 gaggctcctc tgcaggatga cagttgctta aacaatgata tccctcacag cattcctttg
     1321 gagcaggggt caagctgcaa tggtcctggt caaacaaccg gtcatcctta ctaccttcgg
     1381 agtttccttg tggtgctgaa aaccgtactt gagaatgaag atgatatgtt gctctttgat
     1441 gagcaggaga agggaattgt aactaaattt tatcagttat cagctactgg tcagaagtta
     1501 tatgtaaggc tctttcaacg taaattaagc tggattaaga tgaccaaatt agagtatgaa
     1561 gagattgcct tagacttaac acctgtgatt gaagaattga cgaatgcagg ctttctacag
     1621 acagaatctg agttgcaaga actctctgaa gtgcttgaac tcctttctgc tcctgaacta
     1681 aaatccctag ccaagacctt ccacttggtg aatcccaatg gacagaaaca gcagctggtg
     1741 gacgcctttc tcaaattggc caaacagcgt tcagtctgca cttggggcaa gaataagcct
     1801 ggaattggtg cagtgatttt aaaaagagcc aaagccttgg ctggacagtc agtacgaatc
     1861 tgtaaaggcc ccagggctgt gttttcccgc atcttgctac tgttttcgtt gaccgactca
     1921 atggaagatg aagacgccgc ttgtggaggt cagggacagc tttcaacagt cctgttggtc
     1981 aacctcggcc gaatggagtt tcctagttac accatcaatc ggaaaaccca catcttccaa
     2041 gacagagatg atcttatcag atatgcagca gccacgcaca tgctgagtga catttcttcc
     2101 gcaatggcca atgggaactg ggaagaagct aaggagctcg ctcagtgtgc aaaaagggat
     2161 tggaacagac tgaaaaacca cccttctctg agatgccacg aagatttacc actcttcctg
     2221 cggtgtttca ctgttgggtg gatttataca aggattttgt ctcggtttgt ggaaatactg
     2281 cagagacttc acatgtatga ggaagccgtc agagaacttg aaagcctttt gtctcagaga
     2341 atttattgtc ctgacagcag aggccgatgg tgggatcgac tggcccttaa tttacaccag
     2401 cacttgaagc gcctggaacc gactatcaag tgcatcacag aggggctggc ggatccggaa
     2461 gtcagaacgg gacaccgcct ttcactgtat cagcgagccg tgcgcctgcg agagtctccg
     2521 agctgtaaaa agttcaagca cctcttccag cagctcccag aaatggctgt gcaagatgtg
     2581 aaacacgtga ccatcacagg caggctgtgc ccacagcgtg ggatgtgcaa gtctgtgttt
     2641 gtgatggagg ccggggaggc cgctgacccc accacggtcc tgtgctctgt ggaggagctg
     2701 gcactggccc attacagacg cagcggtttt gaccagggga ttcatggcga agggtccacc
     2761 ttcagcaccc tgtatggcct cctcctgtgg gacatcatct tcatggatgg gattccggat
     2821 gtcttcagaa acgcctgtca ggcattcccc ctggacttgt gcacagacag cttcttcaca
     2881 agcagacgcc cagcccttga ggccaggctg cagctgattc atgatgcccc cgaggagagc
     2941 ctgcgggcct gggtggcagc cacgtggcat gagcaggaag gcagagtggc ttcccttgtc
     3001 agctgggatc gcttcacgtc tcttcagcaa gctcaggatc ttgtctcctg cctggggggc
     3061 cctgtgctca gtggtgtgtg caggcacctg gctgctgact ttcgacactg tcgagggggc
     3121 ctccccgacc tggtggtgtg gaactcccag agccgtcact ttaagctggt ggaagttaaa
     3181 ggccccaatg atcgtctttc acataagcag atgatctggc tggctgaact gcagaagctg
     3241 ggggctgaag tagaagtctg ccatgtggtt gcagttggag ctaagagcca aagccttagc
     3301 taaaagattc cctacaggag aaaatggaaa tgaggaggag agaaactccg gtgtccccga
     3361 ggtgtcggtg tggtgagggc cgctggcgtt gaagtacatc ctgctctggc ccagctcccc
     3421 atagcaggcc tccagggggc cactgcgctg ttgccgcagc atcctgctca gtacgtcgac
     3481 ttcatcagcc aggagggaga gcttgtgaaa ggctgtgatg gagccaccca ggctgatctg
     3541 ggcctcggga acccagcgga agtagcacag tttccacagt tttatgtgtg ttccagagac
     3601 acgtggcaga ataacaccgt gcaggttggc gggtttggaa aaccattctc taaaatactg
     3661 ctccgtatca ctgttctggc tgtcggtttg ctgagctgga tctggctttg gttttaatat
     3721 caatgaattt ctccttggaa gtaattcttg gtcactgatg attccattct ttaaggcaga
     3781 cggcattcct cttagtgtgg agctgtagct tttctataca gaagagattt tattatgttc
     3841 cggggattcc ctttttagaa agattgaagg atgcaatggc aaatataaac tcaatactat
     3901 gaaaaattaa tggaatttca gcctcaaaga acattttcct cccttccttt gtgtccttat
     3961 tctaatcctc ctcccctgga attacacttt tttatgtgtt gactctacct aggctgttac
     4021 tatcagcctg aatgggggcg ggatgagagt acctcctatc cactaatttg cttaaggata
     4081 agttctaaga cgggctagaa aaaacactag acctggccga ttctatcaag aacaatggca
     4141 aactgaacag aggcagtcag gaggccaaat gtctgattct ttgttctgta cctttcagta
     4201 gtctgcaaat tttctaccaa aaaaaatccc aagaatttat ttgggaatta ttaaaaaggc
     4261 aaacaatgaa tgttattagg acaagaatat agcagtcagg aggccatgac tacatcacag
     4321 ccaggcggca ttccctgcca cagtggcggc ttgaatcatc aagaaatgga taaatggggc
     4381 tttagtaaat caggcttgca ggctcaaagc tgcaatctgc ccactctcag gtactgagac
     4441 tttgtgggcc tcagacacca ggaagaaagc tgggatacag tcatttgagt taaaaaggga
     4501 atgacccctc agaaacccgc attagcagtg ttactcttgg aagtgccttt acttttaacg
     4561 ctctctgttc tgaaaaagag gtgtttggtt acgtgtgagc caacatcacg ttttgttagc
     4621 tgtgatttac ctttgtccgt ttaaaagact tcacggagcc attctgtata caaggtgtgc
     4681 tctttccaat gtagaagggg ttatggaaaa gggtgcgatc ctttgctgta aactggagag
     4741 accagtccca aacagagggg aattttaagc ccttctcatc acccaattgg atgtttttgc
     4801 ttatagcaaa ttcctgcaaa ataaataaat aaatatttgc aaaactaaa
//
