LOCUS       NM_174901               1077 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 9 member C (FAM9C),
            mRNA.
ACCESSION   NM_174901 XM_001129351 XM_005274461
VERSION     NM_174901.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Zhou,J.D., Shen,F., Ji,J.S., Zheng,K., Huang,M. and Wu,J.C.
  TITLE     FAM9C plays an anti-apoptotic role through activation of the
            PI3K/Akt pathway in human hepatocellular carcinoma
  JOURNAL   Oncol Rep 30 (3), 1275-1284 (2013)
   PUBMED   23836295
  REMARK    GeneRIF: FAM9C overexpression increased the phosphorylation levels
            of Akt and anti-apoptotic ability in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Martinez-Garay,I., Jablonka,S., Sutajova,M., Steuernagel,P., Gal,A.
            and Kutsche,K.
  TITLE     A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed
            exclusively in testis: implications for recombinations in this
            region
  JOURNAL   Genomics 80 (3), 259-267 (2002)
   PUBMED   12213195
  REMARK    GeneRIF: Expressed exclusively in testis; protein is located in the
            nucleus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF494345.1 and AC139705.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_174901.5.
            
            Summary: This gene is a member of a gene family which arose through
            duplication on the X chromosome. The encoded protein may be
            localized to the nucleus as the protein contains several nuclear
            localization signals, and has similarity to a synaptonemal complex
            protein. [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494345.1, SRR11853559.33520.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380625.8/ ENSP00000369999.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1061              AF494345.1         62-1122
            1062-1077           AC139705.4         114519-114534       c
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..1077
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /note="family with sequence similarity 9 member C"
                     /db_xref="GeneID:171484"
                     /db_xref="HGNC:HGNC:18405"
                     /db_xref="MIM:300479"
     exon            1..81
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            82..210
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..650
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /note="testis expressed 39C"
                     /codon_start=1
                     /product="protein FAM9C"
                     /protein_id="NP_777561.1"
                     /db_xref="CCDS:CCDS35203.1"
                     /db_xref="GeneID:171484"
                     /db_xref="HGNC:HGNC:18405"
                     /db_xref="MIM:300479"
                     /translation="MAAKDQLEVQVMAAQEMELAGKDPVSHEHEERKPVTETKEGDVT
                     DEHGERGSFAETDEHTGVDTKELEDIAADIKEHLAAKRKRIEKIAKACSEIKNRIKNV
                     LRTTQLKRQKRDYRISLKLPNVLEEFITDEQKDEEGDGEKEEQIKIFQEQQKRWQQDG
                     KGTERD"
     exon            211..331
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            332..363
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            364..478
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            479..587
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            588..675
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1077
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /note="hexamer: ATTAAA"
     polyA_site      982
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="FAM9C"
                     /gene_synonym="TEX39C"
                     /note="major polyA site"
ORIGIN      
        1 agaggaccca ggccctcgga ggagcttcgc ggtgccagcc tctgcaggtc ctctgaggga
       61 gcaacatcag ggctccctca ggttcagagg tcgcctctag cttcccaggc cagtcagcca
      121 cggagcccgt gggcaggaag ggcagcagga tggctgccaa ggaccagttg gaggttcaag
      181 ttatggccgc ccaggaaatg gagcttgcag gaaaggatcc agtaagtcat gagcatgagg
      241 aaagaaaacc tgttacagag acaaaggagg gagatgtaac tgatgagcat ggggaaagag
      301 gatcttttgc tgaaacagat gaacacacgg gggttgatac caaggagcta gaagatattg
      361 cagctgacat taaagagcat cttgctgcaa agagaaaaag gattgaaaag attgcaaaag
      421 cttgcagcga aataaagaac agaattaaaa atgttttgag aacaacacaa ctaaaaaggc
      481 agaaacgtga ttatagaatt tctctgaagt tgccgaatgt ccttgaagag ttcatcacag
      541 atgagcagaa agatgaggaa ggagatggag aaaaggaaga acaaattaaa atatttcaag
      601 agcaacaaaa gaggtggcaa caagatggga aaggaactga aagagattga gccaccacac
      661 gagcaattca caaagctgca gcaagagttg gcacttattc agatgtatct tcaacctctg
      721 ttattctggt gactgacaaa agaacttgaa cctatgttat atgatacatg cataacttga
      781 gctacactaa accacatgac agtgtttagt taattcttgt ataaattagt atatctcttc
      841 tattattagt ctgtttgtta aatgccagac cacgtttcta tgatctgttg aatgaaccct
      901 agacagttct gtgagaaagc agcaattgca cagttacata cacagtcaat taaattttaa
      961 cattaaagat aatttagttt taggtttggc ctctgtggat ctgtatcagt tccaaaatgt
     1021 ggaaagcacg ggcatggaaa agtacatttt tctctaataa aagaagacaa accctta
//
