LOCUS       NM_205849               2103 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 9 member B (FAM9B),
            mRNA.
ACCESSION   NM_205849
VERSION     NM_205849.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Zhuang,X.J., Feng,X., Tang,W.H., Zhu,J.L., Li,M., Li,J.S.,
            Zheng,X.Y., Li,R., Liu,P. and Qiao,J.
  TITLE     FAM9B serves as a novel meiosis-related protein localized in
            meiotic chromosome cores and is associated with human gametogenesis
  JOURNAL   PLoS One 16 (9), e0257248 (2021)
   PUBMED   34507348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Jin,G., Sun,J., Kim,S.T., Feng,J., Wang,Z., Tao,S., Chen,Z.,
            Purcell,L., Smith,S., Isaacs,W.B., Rittmaster,R.S., Zheng,S.L.,
            Condreay,L.D. and Xu,J.
  TITLE     Genome-wide association study identifies a new locus JMJD1C at
            10q21 that may influence serum androgen levels in men
  JOURNAL   Hum Mol Genet 21 (23), 5222-5228 (2012)
   PUBMED   22936694
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Ohlsson,C., Wallaschofski,H., Lunetta,K.L., Stolk,L., Perry,J.R.,
            Koster,A., Petersen,A.K., Eriksson,J., Lehtimaki,T.,
            Huhtaniemi,I.T., Hammond,G.L., Maggio,M., Coviello,A.D.,
            Ferrucci,L., Heier,M., Hofman,A., Holliday,K.L., Jansson,J.O.,
            Kahonen,M., Karasik,D., Karlsson,M.K., Kiel,D.P., Liu,Y.,
            Ljunggren,O., Lorentzon,M., Lyytikainen,L.P., Meitinger,T.,
            Mellstrom,D., Melzer,D., Miljkovic,I., Nauck,M., Nilsson,M.,
            Penninx,B., Pye,S.R., Vasan,R.S., Reincke,M., Rivadeneira,F.,
            Tajar,A., Teumer,A., Uitterlinden,A.G., Ulloor,J., Viikari,J.,
            Volker,U., Volzke,H., Wichmann,H.E., Wu,T.S., Zhuang,W.V., Ziv,E.,
            Wu,F.C., Raitakari,O., Eriksson,A., Bidlingmaier,M., Harris,T.B.,
            Murray,A., de Jong,F.H., Murabito,J.M., Bhasin,S., Vandenput,L. and
            Haring,R.
  CONSRTM   EMAS Study Group
  TITLE     Genetic determinants of serum testosterone concentrations in men
  JOURNAL   PLoS Genet 7 (10), e1002313 (2011)
   PUBMED   21998597
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Weerapana,E., Wang,C., Simon,G.M., Richter,F., Khare,S.,
            Dillon,M.B., Bachovchin,D.A., Mowen,K., Baker,D. and Cravatt,B.F.
  TITLE     Quantitative reactivity profiling predicts functional cysteines in
            proteomes
  JOURNAL   Nature 468 (7325), 790-795 (2010)
   PUBMED   21085121
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Martinez-Garay,I., Jablonka,S., Sutajova,M., Steuernagel,P., Gal,A.
            and Kutsche,K.
  TITLE     A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed
            exclusively in testis: implications for recombinations in this
            region
  JOURNAL   Genomics 80 (3), 259-267 (2002)
   PUBMED   12213195
  REMARK    GeneRIF: Expressed exclusively in testis; protein is located in the
            nucleus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074281.20 and AF494344.1.
            
            On Jul 3, 2014 this sequence version replaced NM_205849.2.
            
            Summary: This gene is a member of a gene family which arose through
            duplication on the X chromosome. The encoded protein may be
            localized to the nucleus as the protein contains several nuclear
            localization signals, and has similarity to a synaptonemal complex
            protein. [provided by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494344.1, SRR5189667.229383.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327220.10/ ENSP00000318716.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC074281.20        8255-8341
            88-1332             AF494344.1         87-1331
            1333-2103           AC074281.20        17380-18150
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31"
     gene            1..2103
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /note="family with sequence similarity 9 member B"
                     /db_xref="GeneID:171483"
                     /db_xref="HGNC:HGNC:18404"
                     /db_xref="MIM:300478"
     exon            1..276
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            277..393
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..926
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /note="testis expressed 39B"
                     /codon_start=1
                     /product="protein FAM9B"
                     /protein_id="NP_995321.1"
                     /db_xref="CCDS:CCDS14132.1"
                     /db_xref="GeneID:171483"
                     /db_xref="HGNC:HGNC:18404"
                     /db_xref="MIM:300478"
                     /translation="MAAWGKKHAGKDPVRDECEERNRFTETREEDVTDEHGEREPFAE
                     TDEHTGANTKKPEDTAEDLTAKRKRMKMDKTCSKTKNKSKHALRKKQLKRQKRDYIHS
                     LKLLNVLEEYITDEQKEEEEEEGEEEELIRIFQEQQKKWQQYRSVRRERLKEMKLLRD
                     QFVKALEDFEDLCDRVFSDEDSELDN"
     exon            394..514
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            515..546
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..646
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            647..758
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            759..857
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            858..957
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     exon            958..2103
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1240..1245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /note="hexamer: ATTAAA"
     polyA_site      1262
                     /gene="FAM9B"
                     /gene_synonym="TEX39B"
                     /note="major polyA site"
ORIGIN      
        1 aggaagtcct gcctgcagct ctcacgagaa ctgaggaccc gttttcttta cttttctttt
       61 tttttgtttt tttgttttgt tttttttggg acggagtctg gctcttgctg cctaggctgc
      121 agtgcagtgg tgtgatctgg gctcactgca acctccgcct cctgggttca agcaattctc
      181 ctgcctcagc ttcctgagag gacccgtttt ctaagaggtc ctagtggtgc cgctgcctgc
      241 aggttctttg agggcgccac atcaggggtc cctcaggttc ggggatcgcc tctagcttcc
      301 caggacaacc agccacggat cctgtgggca ggagggctgc caaggcccag ttggaggctc
      361 aatttatggc ggcctggggg aagaagcatg caggaaagga tccagtccgt gatgaatgtg
      421 aggaaagaaa ccgttttaca gaaacaaggg aggaagatgt aactgatgag catggggaaa
      481 gagaaccttt tgctgaaaca gatgaacaca cgggggctaa taccaagaag ccagaagata
      541 ctgcagagga tcttactgca aaaagaaaaa ggatgaaaat ggataaaact tgcagcaaaa
      601 caaagaacaa aagtaaacat gctttgagaa aaaagcaact taaaaggcag aaacgtgatt
      661 atatacattc tctgaagttg ctaaatgtcc ttgaagaata catcacagac gagcagaaag
      721 aggaagaaga agaagaggga gaagaggaag aactaattag aatatttcaa gaacaacaga
      781 agaagtggca acaatataga agtgttagga gagagaggct gaaagagatg aagctgctac
      841 gtgaccaatt cgtaaaggct cttgaggact ttgaagacct ttgtgacaga gttttttccg
      901 atgaagacag tgaacttgat aactagacat gtttttaaat aaaatcatgt cagaactctt
      961 ttggaaaagt tggcacttac ccagttgtct cttcaacctc tgttattctg atgactgaag
     1021 aaagaacttg aacctatgtt atatgataca agcacaactt gagctacagt aaactacatg
     1081 acagtgtttt gataattgtt gtataaatcg gtatagctcc tctgtcactc gtctgttaaa
     1141 tgccagacct cgtttctatg atctgttgaa tgaatcctag acacttctgt gagaaagcag
     1201 ggattgcata gttatgtaca cggtcaatta aattttaaca ttaaagataa tttagatttc
     1261 gatttggcct ctgtggattt gtatcagttc caaaaatgta gaaagcacag gcatagaaaa
     1321 gtacattttt ctctaataaa agaagacaat atctgctggg tgtggtggct cacgcctgta
     1381 atcccagcac tttgggaggc cgaggggagt ggatcacttg aggtcaggag tttgagacca
     1441 gcctggccaa catggtgaaa ccccatctct gctaaaaata ccaaaattac ccgggcgtgg
     1501 tggcacgcac gtgtagttcc agctactcag gaagctgagg caggaggatc tcttgaaccc
     1561 gggagttgga ggttgcagta agccaagatt gtgccactgc actccagcct gggcgacaga
     1621 gcaagactct ttctcagaaa acaagaagaa gaagacaaaa gctatcttat ctgtgcgttc
     1681 ttttgtattt actcattagg ataaagaggc aattccaatg aaagtaggac ttcaaaaaat
     1741 agatatactc tatggccata tcaaaattat taaaagcacc ttactgtctg tgttcttaaa
     1801 aaaaattata ctgctgtaaa tgattaaggc aactgagcaa gatatattaa tatcagtgct
     1861 gagccactgg tttgtgggta tgtcatttcc acagacatca aaatgctatt tagtttgttt
     1921 tggtccatca ttcaatgata cctcccctta gaattgaatg aaagcatttt gttaacattt
     1981 atgtatgctt acaattattt cacatctgtg gcaaggtaaa ttttgtagag tgctttgttt
     2041 atccagttta atattcgtgg attatgtgga agtttatatg gacatctaaa aacttgaatg
     2101 atg
//
