LOCUS       NM_174951               1519 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 9 member A (FAM9A),
            transcript variant 2, mRNA.
ACCESSION   NM_174951
VERSION     NM_174951.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   6  (bases 1 to 1519)
  AUTHORS   Martinez-Garay,I., Jablonka,S., Sutajova,M., Steuernagel,P., Gal,A.
            and Kutsche,K.
  TITLE     A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed
            exclusively in testis: implications for recombinations in this
            region
  JOURNAL   Genomics 80 (3), 259-267 (2002)
   PUBMED   12213195
  REMARK    GeneRIF: Expressed exclusively in testis; protein is located in the
            nucleus, and localizes to the nucleolus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF494343.1 and AC003685.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 16, 2010 this sequence version replaced NM_174951.2.
            
            Summary: This gene is a member of a gene family which arose through
            duplication on the X chromosome. The encoded protein may be a
            nuclear protein that is localized to the nucleolus, and has some
            similarity to a synaptonemal complex protein. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494343.1, BC112022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381003.7/ ENSP00000370391.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1187              AF494343.1         1-1187
            1188-1190           AC003685.1         66128-66130         c
            1191-1519           AF494343.1         1191-1519
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31"
     gene            1..1519
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /note="family with sequence similarity 9 member A"
                     /db_xref="GeneID:171482"
                     /db_xref="HGNC:HGNC:18403"
                     /db_xref="MIM:300477"
     exon            1..73
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            74..202
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1110
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /note="testis expressed 39A"
                     /codon_start=1
                     /product="protein FAM9A"
                     /protein_id="NP_777611.1"
                     /db_xref="CCDS:CCDS14131.1"
                     /db_xref="GeneID:171482"
                     /db_xref="HGNC:HGNC:18403"
                     /db_xref="MIM:300477"
                     /translation="MEPVGRKRSRKAAKAQLEAQVTAAQGATKEGSGIASNFPGQPTM
                     EPVGRKRSRKAAKAQLEAQVRAAPAKKHTGKDPVRDECEERNPFTETREEDVTDEHGE
                     REPFAEKDEHTGIHTMKLEHIAADIKKGLAAKREMIKIDKAAYRKTKNTIERALKKKQ
                     LKRQKRDYRHTRKLLNVLKEYIAEKQKDDEAEEAEAAAAAAEAAAAAEAAAAAAEVIV
                     VEDEEEEEKEEEEEKEEEEEEGEEEGGGEEGEEGGGGGEGEETEEEEEEEEEEEEEEQ
                     IKAFQEKQKRWQQPTGVRSWRLREMKPLLEQLLKAAKDTKDNYCIISSSEESELDN"
     exon            203..331
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            332..452
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            453..484
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            485..599
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            600..942
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1041
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1141
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1519
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /note="hexamer: ATTAAA"
     polyA_site      1446
                     /gene="FAM9A"
                     /gene_synonym="TEX39A"
                     /note="major polyA site"
ORIGIN      
        1 catttttcta agagagcgtc gtggtgccag tgcctgcagg ttctgtgagg aagcggcatc
       61 aggggtccct caggttcagg gatcgcctct aacttcccag gacagccaac catggagccc
      121 gtgggcagga agcgcagcag gaaggctgcc aaagctcagt tggaagctca agttacggcc
      181 gcccaggggg ccacgaaaga aggttcaggg atcgcctcta acttcccagg acagccaacc
      241 atggagcccg tgggcaggaa gcgcagcagg aaggctgcca aagctcagtt ggaagctcaa
      301 gttagggccg ccccggcgaa gaagcacaca ggaaaggatc cagtccgtga tgaatgtgag
      361 gaaagaaacc cttttacaga aacaagggag gaagatgtaa ctgatgagca tggggaaaga
      421 gaaccttttg ctgaaaaaga tgaacacacg gggattcata ccatgaagct agaacatatt
      481 gcagctgaca ttaaaaaggg ccttgctgca aaaagagaaa tgataaaaat agataaagca
      541 gcttacagga aaaccaagaa cacaattgaa cgtgctttga aaaaaaaaca actaaaaagg
      601 cagaaacgtg attatagaca tactcggaag ttgctgaatg tccttaaaga atacatcgca
      661 gagaagcaga aagatgatga agcagaagaa gcagaagccg cagcagcagc agcagaagcc
      721 gcagcagcag cagaagccgc agcagcagca gcagaagtaa tagtagtaga agacgaagag
      781 gaggaagaga aggaggagga ggaggagaaa gaagaggagg aagaagaagg agaagaagaa
      841 ggaggaggag aagaaggaga agaaggagga ggaggaggag aaggagaaga aacagaagaa
      901 gaggaagagg aagaagaaga agaggaagag gaagaacaaa ttaaagcatt tcaagaaaaa
      961 cagaagaggt ggcaacaacc tacaggtgtt aggagctgga ggctgagaga gatgaagccg
     1021 ctacttgagc aattactaaa ggctgccaag gacactaaag acaattattg catcatttct
     1081 tccagtgaag aaagtgaact tgataactag ccgtgttttt aaaaagaatc gtgtcagaac
     1141 tcttttggaa gagttggcac ttcattgtct cttcaacctc tgttattctg atgactgaag
     1201 aaagaacttg aacctatgtt atatgatacg agcacaactt gagctacagt aaactacatg
     1261 acagtgtttt gataattgtt gtataaatcg gtatagctcc tctgtcactt gtctgttaaa
     1321 tgccagacct cgtttctatg atctgttgaa tgaatcctag acacttctgt gagaaggcag
     1381 ggattgcaca gttatgtaca tggtcaatta aattttaaca ttaaagataa tttagatttc
     1441 agttcacctc tgtggatctg tatcagtttc aaaaacgtag aaagcacggg catagaaaag
     1501 tacatttttc tctaataaa
//
