LOCUS       NM_174905               1313 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 98 member C (FAM98C),
            transcript variant 1, mRNA.
ACCESSION   NM_174905
VERSION     NM_174905.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1313)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1313)
  AUTHORS   Shaheen,R., Szymanska,K., Basu,B., Patel,N., Ewida,N., Faqeih,E.,
            Al Hashem,A., Derar,N., Alsharif,H., Aldahmesh,M.A., Alazami,A.M.,
            Hashem,M., Ibrahim,N., Abdulwahab,F.M., Sonbul,R., Alkuraya,H.,
            Alnemer,M., Al Tala,S., Al-Husain,M., Morsy,H., Seidahmed,M.Z.,
            Meriki,N., Al-Owain,M., AlShahwan,S., Tabarki,B., Salih,M.A.,
            Faquih,T., El-Kalioby,M., Ueffing,M., Boldt,K., Logan,C.V.,
            Parry,D.A., Al Tassan,N., Monies,D., Megarbane,A., Abouelhoda,M.,
            Halees,A., Johnson,C.A. and Alkuraya,F.S.
  CONSRTM   Ciliopathy WorkingGroup
  TITLE     Characterizing the morbid genome of ciliopathies
  JOURNAL   Genome Biol 17 (1), 242 (2016)
   PUBMED   27894351
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005789.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2021 this sequence version replaced NM_174905.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100033.1, SRR18074967.3639049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252530.10/ ENSP00000252530.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC005789.1         37584-37709
            127-275             AC005789.1         37829-37977
            276-410             AC005789.1         38051-38185
            411-616             AC005789.1         39399-39604
            617-694             AC005789.1         39835-39912
            695-811             AC005789.1         40010-40126
            812-979             AC005789.1         41401-41568
            980-1313            AC005789.1         43242-43575
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1313
                     /gene="FAM98C"
                     /note="family with sequence similarity 98 member C"
                     /db_xref="GeneID:147965"
                     /db_xref="HGNC:HGNC:27119"
     exon            1..126
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1111
                     /gene="FAM98C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM98C"
                     /codon_start=1
                     /product="protein FAM98C isoform 1"
                     /protein_id="NP_777565.3"
                     /db_xref="CCDS:CCDS42562.1"
                     /db_xref="GeneID:147965"
                     /db_xref="HGNC:HGNC:27119"
                     /translation="MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCV
                     RLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLRELHCPDRALCGGDG
                     AAALREPGAGLRLLRFLCSELQATRLLCLRSLLDPSPRPPLGEGVVEGAGMVQELDLT
                     LQALGLPRPAPGTPASQLLQELHAKISELQPSLPPGSLQPLLSCSLDAPRWEALESLS
                     QSLRDQYRCRRCLLLKRLDLTTSAFHWSDRAEAQGEAMRAVLIPIREVLTPESDISIA
                     HVLAARADLSCLVPATSVAVRRGTCCAINKVLMGNVPDRGGRPNELEPPMPTWRSRRE
                     DGGPQCWGRKKKKKK"
     exon            127..275
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            276..410
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            411..616
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            617..694
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            695..811
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            812..979
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1313
                     /gene="FAM98C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98C"
                     /note="hexamer: AATAAA"
     polyA_site      1313
                     /gene="FAM98C"
                     /note="major polyA site"
ORIGIN      
        1 cggcgctttt ggggcggagc ctgccaccgg ccgccagggg gcgcgccgag accacacttt
       61 catggaggcg gtgaaggcgg aagcgtggga gggggccgcg gtggcccagg acctgctggc
      121 tctggggtat ggaggtgtcc cgggggcggc gtcgcggggc gcctcatgcc cagacttcag
      181 ggggctgtgc gtgcggctgg cggcggagct ggcgacgctg ggcgccctcg agcagcagcg
      241 agaggcgggc gcggaggtgc tgagcgccgg cgacggccct ggcgcggagg aggactttct
      301 gcggcagctc ggcagcctgc tgcgggagct gcactgcccg gatcgcgcgc tctgcggcgg
      361 ggatggcgcg gctgcgcttc gggaacccgg tgccggactg cgcctgctgc gctttctctg
      421 ctcagagctc caagccaccc gcctcctgtg cctccgctct ctgctggatc cgagtcctag
      481 gccacccctt ggtgaagggg tagtggaggg agccggcatg gtccaagaac tggaccttac
      541 cctccaagcc ctggggctgc ccagacctgc accagggacc cccgccagcc agctgctgca
      601 ggagttgcat gctaagatct cagagctgca gccttctctg cccccagggt ccctgcagcc
      661 cctcctcagc tgctcgctag atgcacccag atgggaagcg ttggagtctc tgtcccaaag
      721 cctcagagat cagtaccgct gccgccgctg cctcctcctc aagcgccttg acctcactac
      781 atctgctttc cactggagtg accgggcaga ggcccaagga gaggccatga gggcagtgct
      841 gatcccaatt cgagaggttc tgaccccaga atcggacatc tccattgcac acgttctggc
      901 tgcccgagcc gacctgtctt gtctcgtccc agccaccagc gtggctgtcc gcagagggac
      961 ctgctgtgcc atcaacaagg tgcttatggg caacgttcca gaccgggggg gccgcccaaa
     1021 tgagctggag cctcccatgc ccacctggag gagccgaaga gaggatggag gcccccagtg
     1081 ttggggtcgc aagaagaaga agaagaagta aagggggact ggtggtcggg ggcggggggt
     1141 cctccatgag atgctaatgc tatcggtaat ctctggggag tccgtttaag gctttccttg
     1201 gtatttggca cccaagcccc ccatctccta ttcctgagtc cccaaatgcc ctgctcccat
     1261 tcacgtcaat accaagaacc atgttctcca gagaataaat ttaatttatg aca
//
