LOCUS       NM_173611               4388 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 98 member B (FAM98B),
            mRNA.
ACCESSION   NM_173611
VERSION     NM_173611.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Akter,K.A., Mansour,M.A., Hyodo,T. and Senga,T.
  TITLE     FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex
            involved in colorectal cancer progression
  JOURNAL   Int J Biochem Cell Biol 84, 1-13 (2017)
   PUBMED   28040436
  REMARK    GeneRIF: the two structural homologs FAM98A and FAM98B included in
            a novel complex with DDX1 and C14orf166 are required for PRMT1
            expression in colorectal cancer cell lines
REFERENCE   3  (bases 1 to 4388)
  AUTHORS   Armstrong,D.L., Zidovetzki,R., Alarcon-Riquelme,M.E., Tsao,B.P.,
            Criswell,L.A., Kimberly,R.P., Harley,J.B., Sivils,K.L., Vyse,T.J.,
            Gaffney,P.M., Langefeld,C.D. and Jacob,C.O.
  TITLE     GWAS identifies novel SLE susceptibility genes and explains the
            association of the HLA region
  JOURNAL   Genes Immun 15 (6), 347-354 (2014)
   PUBMED   24871463
REFERENCE   4  (bases 1 to 4388)
  AUTHORS   Popow,J., Jurkin,J., Schleiffer,A. and Martinez,J.
  TITLE     Analysis of orthologous groups reveals archease and DDX1 as tRNA
            splicing factors
  JOURNAL   Nature 511 (7507), 104-107 (2014)
   PUBMED   24870230
REFERENCE   5  (bases 1 to 4388)
  AUTHORS   Perez-Gonzalez,A., Pazo,A., Navajas,R., Ciordia,S.,
            Rodriguez-Frandsen,A. and Nieto,A.
  TITLE     hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel
            transcription-dependent shuttling RNA-transporting complex
  JOURNAL   PLoS One 9 (3), e90957 (2014)
   PUBMED   24608264
  REMARK    GeneRIF: hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B
            in a novel transcription-dependent shuttling RNA-transporting
            complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4388)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 4388)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 4388)
  AUTHORS   Popow,J., Englert,M., Weitzer,S., Schleiffer,A., Mierzwa,B.,
            Mechtler,K., Trowitzsch,S., Will,C.L., Luhrmann,R., Soll,D. and
            Martinez,J.
  TITLE     HSPC117 is the essential subunit of a human tRNA splicing ligase
            complex
  JOURNAL   Science 331 (6018), 760-764 (2011)
   PUBMED   21311021
REFERENCE   9  (bases 1 to 4388)
  AUTHORS   Tegha-Dunghu,J., Neumann,B., Reber,S., Krause,R., Erfle,H.,
            Walter,T., Held,M., Rogers,P., Hupfeld,K., Ruppert,T., Ellenberg,J.
            and Gruss,O.J.
  TITLE     EML3 is a nuclear microtubule-binding protein required for the
            correct alignment of chromosomes in metaphase
  JOURNAL   J Cell Sci 121 (Pt 10), 1718-1726 (2008)
   PUBMED   18445686
REFERENCE   10 (bases 1 to 4388)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP872319.1, BC035600.1, BC045690.1, BU633364.1, DA118586.1,
            BX454964.2, DA520319.1, DB552059.1 and AI638256.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173611.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397609.6/ ENSP00000380734.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               BP872319.1         1-152
            153-1540            BC035600.1         11-1398
            1541-2337           BC045690.1         229-1025
            2338-2898           BU633364.1         18-578              c
            2899-3122           DA118586.1         322-545
            3123-3699           BX454964.2         59-635              c
            3700-4085           DA520319.1         1-386               c
            4086-4382           DB552059.1         158-454
            4383-4388           AI638256.1         5-10                c
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..4388
                     /gene="FAM98B"
                     /note="family with sequence similarity 98 member B"
                     /db_xref="GeneID:283742"
                     /db_xref="HGNC:HGNC:26773"
                     /db_xref="MIM:616142"
     exon            1..106
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1337
                     /gene="FAM98B"
                     /codon_start=1
                     /product="protein FAM98B"
                     /protein_id="NP_775882.2"
                     /db_xref="CCDS:CCDS10047.2"
                     /db_xref="GeneID:283742"
                     /db_xref="HGNC:HGNC:26773"
                     /db_xref="MIM:616142"
                     /translation="MRGPEPGPQPTMEGDVLDTLEALGYKGPLLEEQALTKAAEGGLS
                     SPEFSELCIWLGSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGD
                     IKDRLKKKEDCLKLLLFLSTELQASQILQNKKHKNSQLDKNSEVYQEVQAMFDTLGIP
                     KSTTSDIPHMLNQVESKVKDILSKVQKNHVGKPLLKMDLNSEQAEQLERINDALSCEY
                     ECRRRMLMKRLDVTVQSFGWSDRAKVKTDDIARIYQPKRYALSPKTTITMAHLLAARE
                     DLSKIIRTSSGTSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGG
                     RGGWGGGGGGGGRGGGGGGGGRGGWGGGGGGWGGGGGGGGGWGGGGGGGRGGFQGRGD
                     YGGRGGYGGRGGYGGRGYGDPYGGGGGGGGGGGGGGGYRRY"
     exon            107..252
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            253..387
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            388..566
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            567..647
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            648..764
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            765..932
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     exon            933..4388
                     /gene="FAM98B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98B"
                     /note="hexamer: AATATA"
     polyA_site      1762
                     /gene="FAM98B"
                     /note="major polyA site"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98B"
                     /note="hexamer: TATAAA"
     polyA_site      2894
                     /gene="FAM98B"
                     /note="major polyA site"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98B"
                     /note="hexamer: AGTAAA"
     polyA_site      3093
                     /gene="FAM98B"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98B"
                     /note="hexamer: AATATA"
     polyA_site      3763
                     /gene="FAM98B"
     regulatory      4356..4361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98B"
                     /note="hexamer: AATAAA"
     polyA_site      4388
                     /gene="FAM98B"
ORIGIN      
        1 acttagagcg ccgaacagct ctgggccaaa ggaccatgag agggccggag ccgggtcccc
       61 aaccgacgat ggagggagac gtgctggaca cactggaggc gctggggtat aaaggaccat
      121 tgttagaaga gcaagccctt acaaaggcgg cagagggtgg attatcttca cctgaatttt
      181 cagagctctg tatttggtta ggctctcaaa taaaatcatt atgcaacttg gaagaaagta
      241 tcacgtctgc tggaagagat gatctagaga gcttccagct tgagataagt ggctttttaa
      301 aagaaatggc atgtccatat tctgtactca tatcaggaga tattaaagat cgtttaaaaa
      361 agaaggagga ctgtttgaaa cttctattat ttttaagtac agaacttcaa gcttcacaga
      421 tattacagaa caagaaacat aaaaattctc aattagataa aaatagtgaa gtttatcagg
      481 aagttcaagc tatgtttgat acacttggta tacccaagtc aacaacttct gacattccgc
      541 atatgctaaa ccaagtggaa tcaaaggtga aagatattct ctcaaaggtc cagaaaaatc
      601 atgtgggaaa accactgctg aaaatggatt taaattcaga acaggcggaa caactggaaa
      661 gaatcaatga tgctctttcc tgtgaatatg agtgccgccg acgaatgtta atgaaacgat
      721 tagatgtgac tgtacagtcc tttggatggt ctgatagagc aaaggtaaaa acagatgata
      781 tagcaagaat ttatcagcct aagcgttatg ctttgtcacc caagacaacg attacaatgg
      841 cacatctact tgctgctcgt gaagatctat ccaagatcat taggacaagt agtggcacca
      901 gccgggagaa gaccgcatgt gccattaata aggtgctgat gggaagggtg cctgacaggg
      961 gaggccggcc gaatgaaatt gaaccaccac ctccagaaat gcccccttgg caaaagagac
     1021 aagaaggcgg cggtggaagg ggtggttggg gtggtggtgg tggaggtggt ggtagaggag
     1081 gtggtggggg tgggggtggg agaggtggct gggggggtgg aggaggaggt tggggaggtg
     1141 gtgggggagg gggaggaggg tgggggggag gaggaggagg tggtagagga ggtttccaag
     1201 gcaggggaga ttatggtgga agagggggtt atggtggaag agggggctat ggtggaagag
     1261 gctatggaga tccatatgga ggaggtggtg gtggtggtgg tggtggtggt ggaggaggtg
     1321 gatatagaag atactaaaaa ctataaaaat tagatagcag tgcttgcttc tttatagata
     1381 cattagaaat agtgttccaa ataacatact tgaatatcat ctttgaagta aacaccatgt
     1441 tagactccct ggtgatacca ctcttgaatt ggttaatatg taagaacatt gttttttatt
     1501 accagttgat ctctcaaatg aagtgatgac tttttccata ttctgtgtac ccttgagcat
     1561 gttgtgtctt tttaaaaaac aaaaaaaaga acaaaaatta ttttttaaaa tgtaaatatt
     1621 tattaccatc agacttggaa aatggaaagt attttattgt catgattgaa tttagattgt
     1681 tacctgtatt ttgttcaggt ttgagacata taaaagaccc cacctgtaat agaaaggaat
     1741 atagaccctt gcctcacctg tattgctgtg gatgtgtttt gtgggttttt cattcgattt
     1801 tacaaaatag ggaaaggcac ttccagttgt atttagtagg cagttgttgt gaatcatttt
     1861 tttctcttat aggaggagat tcctctctag ccatgtttct gttaaagttt cattaattga
     1921 agcccaagtt tactttttac tgtacatact tattttctaa ttggatttga aatcagcatg
     1981 attttgtttg acaaagcaaa gtttaagatt gaggtcagaa atactttaat ggagcaaaga
     2041 cacataccaa ctttacatga cggtgtgaga aatagtccta taaactggtc tcttcatcat
     2101 ttatgctctc actttagata tccaaatatt aaaaggcagg ctgacctgta tcacacagaa
     2161 ttaaggcagt aattttctgc ttcagtagat caagggtagg gctaaggcat cctgtggtaa
     2221 ttctgattca cagctagatt tgggaaacac aaagttaggg aatggctata tgtgatttgc
     2281 tagttggagc agtcaaagtc ttagctatca agagttgtga atttgaatca tggcactagg
     2341 tcaggggtgc tatggattga aatgacctta gttctcaagg agtgatttgt cctcatttgt
     2401 caaatgagga atgagacact taccatcatc tcaggttgtt tcttaaagac ctaaatacaa
     2461 atacaatttg ttaaaaactt acagagggcc tattttgaat gctttaagat gtaggccaag
     2521 taatgtattt ttctcttagt gtagaaagtt aagagaaaaa gagctggtac cataaatttt
     2581 ttcaatctta gtgtaaaatc tgtatctcat tgtaggcttc tggtcaatac ctatacataa
     2641 caacttaatg tgatctaacc aactcaactg atagaaagct gaattgttcc cagtggacaa
     2701 gtggtatttg atgtttagca ggtttttttg ttgttatttt tttggtaaac tctgtggtaa
     2761 aatctaaaat aatgttaaaa ccctaaaagt aactattgaa tattctgtaa tcttagacat
     2821 gtatttttca agctaaccct ttgaagaaat gtgttcaagg taggaaaata taaaattttt
     2881 tggttatttg taaatttatt ttttgtgtgt ttatatttaa tgaaaagatg taatttcatt
     2941 tgtgatagct gaaaaaaagg ctttccataa ttaagaaaat acctttatca gtagctatga
     3001 actctgaaaa ataattttta aaaactttta agaaaaaaac tacttgagta aaatatttca
     3061 agagttgttt aaaaatcttc tttaaaacct ttacatttct gcctcacttc ttttttggta
     3121 gcattagttg ctgatgaagg agatttacaa ctactttcaa cttttttacc actaaaggtt
     3181 tatggtaaat atggcagaaa caatagttta tcagtttcat tagattttcc ataagatttc
     3241 tttgtacctt tataggagtg ctgcttgggt tattcactac aatcacttat ttcctatcaa
     3301 agtttagcac ttgctcctgg aatcgtgttg gagctgaaac cactcctatg tacacattcc
     3361 tataaacctt aattgaatga aaagctgaat caggtagact cttaatattt tactctttcc
     3421 tgtaaggtgg gattttcctg ataatctttg ttcagtaaaa atttcttttg tagaacagtt
     3481 tgctgagcag tatctggaat agcaggaagg aaatttgggg ccttaatggg aaaggccata
     3541 gtgtgaaaat gttttataaa ttgagtgcaa tacgacatgg agtatgatga atggcactcc
     3601 actgcttcct aaaatccaac actttttttg atacctcctt ttcattcttt tttgcctggt
     3661 tctcaatttc attttttaat tacctcattg tccttcccct tttttcttct ctttttgtcc
     3721 agcctggtac ctaatagcaa atatagacat gatcttactg ggagtttctg cctaaagtag
     3781 tcatctttcc tctcgaccgt ataaagagca tgtattctgt ctataacata atcaccacac
     3841 tattactcat aagcacacat caaaagggaa acaagggttt tctttgaact tacttttgtt
     3901 ttgcagatca gggaaacctt gcctcattaa acagaaaaag gaaaacattt taaataaaaa
     3961 acatcttatt acctgtatct gtgacaagag gaggcatgac aacctaaaaa aaatttgtga
     4021 ccagaaaaat gtcctgagca gtgatactat ctataccttg gaaggagcac aggttagaga
     4081 aatgtgggga tgaaaattgg ggaaggtgag caggcagttt aatcttgcct tcaggatcag
     4141 gctgtcagtg tgactttatt actttgtatg aagtattatg aattgcccaa atgataaata
     4201 cacccccatc taaatgttcc agaatgcatt ccacagagga atttgagtga ctgaaatttt
     4261 tcctctttct tcattggtgt ggttaaacaa aaattagctg gggattaagg gaaaattgtg
     4321 gctatgtctg atcattctaa ataatcatga ccacaaataa attgccctga gtaggtctgt
     4381 aacctgga
//
