LOCUS       NP_775882                433 aa            linear   PRI 28-APR-2025
DEFINITION  protein FAM98B [Homo sapiens].
ACCESSION   NP_775882
VERSION     NP_775882.2
DBSOURCE    REFSEQ: accession NM_173611.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Akter,K.A., Mansour,M.A., Hyodo,T. and Senga,T.
  TITLE     FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex
            involved in colorectal cancer progression
  JOURNAL   Int J Biochem Cell Biol 84, 1-13 (2017)
   PUBMED   28040436
  REMARK    GeneRIF: the two structural homologs FAM98A and FAM98B included in
            a novel complex with DDX1 and C14orf166 are required for PRMT1
            expression in colorectal cancer cell lines
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Armstrong,D.L., Zidovetzki,R., Alarcon-Riquelme,M.E., Tsao,B.P.,
            Criswell,L.A., Kimberly,R.P., Harley,J.B., Sivils,K.L., Vyse,T.J.,
            Gaffney,P.M., Langefeld,C.D. and Jacob,C.O.
  TITLE     GWAS identifies novel SLE susceptibility genes and explains the
            association of the HLA region
  JOURNAL   Genes Immun 15 (6), 347-354 (2014)
   PUBMED   24871463
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Popow,J., Jurkin,J., Schleiffer,A. and Martinez,J.
  TITLE     Analysis of orthologous groups reveals archease and DDX1 as tRNA
            splicing factors
  JOURNAL   Nature 511 (7507), 104-107 (2014)
   PUBMED   24870230
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Perez-Gonzalez,A., Pazo,A., Navajas,R., Ciordia,S.,
            Rodriguez-Frandsen,A. and Nieto,A.
  TITLE     hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel
            transcription-dependent shuttling RNA-transporting complex
  JOURNAL   PLoS One 9 (3), e90957 (2014)
   PUBMED   24608264
  REMARK    GeneRIF: hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B
            in a novel transcription-dependent shuttling RNA-transporting
            complex.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Popow,J., Englert,M., Weitzer,S., Schleiffer,A., Mierzwa,B.,
            Mechtler,K., Trowitzsch,S., Will,C.L., Luhrmann,R., Soll,D. and
            Martinez,J.
  TITLE     HSPC117 is the essential subunit of a human tRNA splicing ligase
            complex
  JOURNAL   Science 331 (6018), 760-764 (2011)
   PUBMED   21311021
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Tegha-Dunghu,J., Neumann,B., Reber,S., Krause,R., Erfle,H.,
            Walter,T., Held,M., Rogers,P., Hupfeld,K., Ruppert,T., Ellenberg,J.
            and Gruss,O.J.
  TITLE     EML3 is a nuclear microtubule-binding protein required for the
            correct alignment of chromosomes in metaphase
  JOURNAL   J Cell Sci 121 (Pt 10), 1718-1726 (2008)
   PUBMED   18445686
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP872319.1, BC035600.1, BC045690.1, BU633364.1, DA118586.1,
            BX454964.2, DA520319.1, DB552059.1 and AI638256.1.
            
            On Jun 22, 2006 this sequence version replaced NP_775882.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397609.6/ ENSP00000380734.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     Protein         1..433
                     /product="protein FAM98B"
                     /calculated_mol_wt=45416
     Region          34..330
                     /region_name="DUF2465"
                     /note="Protein of unknown function (DUF2465); pfam10239"
                     /db_xref="CDD:463016"
     Region          303..433
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q52LJ0.2)"
     CDS             1..433
                     /gene="FAM98B"
                     /coded_by="NM_173611.4:36..1337"
                     /db_xref="CCDS:CCDS10047.2"
                     /db_xref="GeneID:283742"
                     /db_xref="HGNC:HGNC:26773"
                     /db_xref="MIM:616142"
ORIGIN      
        1 mrgpepgpqp tmegdvldtl ealgykgpll eeqaltkaae gglsspefse lciwlgsqik
       61 slcnleesit sagrddlesf qleisgflke macpysvlis gdikdrlkkk edclklllfl
      121 stelqasqil qnkkhknsql dknsevyqev qamfdtlgip ksttsdiphm lnqveskvkd
      181 ilskvqknhv gkpllkmdln seqaeqleri ndalsceyec rrrmlmkrld vtvqsfgwsd
      241 rakvktddia riyqpkryal spkttitmah llaaredlsk iirtssgtsr ektacainkv
      301 lmgrvpdrgg rpneiepppp emppwqkrqe ggggrggwgg ggggggrggg gggggrggwg
      361 gggggwgggg gggggwgggg gggrggfqgr gdyggrggyg grggyggrgy gdpygggggg
      421 gggggggggy rry
//
