LOCUS       NM_015475               2751 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 98 member A (FAM98A),
            transcript variant 1, mRNA.
ACCESSION   NM_015475 XM_043885
VERSION     NM_015475.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2751)
  AUTHORS   Wang,N., Guo,Y., Song,L., Tong,T. and Fan,X.
  TITLE     Circular RNA intraflagellar transport 80 facilitates endometrial
            cancer progression through modulating miR-545-3p/FAM98A signaling
  JOURNAL   J Gynecol Oncol 33 (1), e2 (2022)
   PUBMED   34783205
  REMARK    GeneRIF: Circular RNA intraflagellar transport 80 facilitates
            endometrial cancer progression through modulating miR-545-3p/FAM98A
            signaling.
REFERENCE   2  (bases 1 to 2751)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2751)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2751)
  AUTHORS   Li,Z., Li,N., Sun,X. and Wang,J.
  TITLE     FAM98A promotes cancer progression in endometrial carcinoma
  JOURNAL   Mol Cell Biochem 459 (1-2), 131-139 (2019)
   PUBMED   31114934
  REMARK    GeneRIF: Mechanistically, it was demonstrated that miR-142-3p
            directly targeted FAM98A, and modulated its expression.
REFERENCE   5  (bases 1 to 2751)
  AUTHORS   Ozeki,K., Sugiyama,M., Akter,K.A., Nishiwaki,K., Asano-Inami,E. and
            Senga,T.
  TITLE     FAM98A is localized to stress granules and associates with multiple
            stress granule-localized proteins
  JOURNAL   Mol Cell Biochem 451 (1-2), 107-115 (2019)
   PUBMED   29992460
REFERENCE   6  (bases 1 to 2751)
  AUTHORS   Schou,K.B., Andersen,J.S. and Pedersen,L.B.
  TITLE     A divergent calponin homology (NN-CH) domain defines a novel
            family: implications for evolution of ciliary IFT complex B
            proteins
  JOURNAL   Bioinformatics 30 (7), 899-902 (2014)
   PUBMED   24257188
REFERENCE   7  (bases 1 to 2751)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 2751)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2751)
  AUTHORS   Popow,J., Englert,M., Weitzer,S., Schleiffer,A., Mierzwa,B.,
            Mechtler,K., Trowitzsch,S., Will,C.L., Luhrmann,R., Soll,D. and
            Martinez,J.
  TITLE     HSPC117 is the essential subunit of a human tRNA splicing ligase
            complex
  JOURNAL   Science 331 (6018), 760-764 (2011)
   PUBMED   21311021
REFERENCE   10 (bases 1 to 2751)
  AUTHORS   Yang,H.C., Liang,Y.J., Wu,Y.L., Chung,C.M., Chiang,K.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chen,C.I., Fann,C.S., Wu,J.Y., Lin,T.N.,
            Lin,S.J., Chen,Y.T., Chen,J.W. and Pan,W.H.
  TITLE     Genome-wide association study of young-onset hypertension in the
            Han Chinese population of Taiwan
  JOURNAL   PLoS One 4 (5), e5459 (2009)
   PUBMED   19421330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA310995.1, BC136768.1, BC060860.1 and AC017050.9.
            
            On Nov 24, 2018 this sequence version replaced NM_015475.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.107418.1,
                                           SRR3476690.402691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238823.13/ ENSP00000238823.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA310995.1         64-96
            34-2715             BC136768.1         1-2682
            2716-2750           BC060860.1         2692-2726
            2751-2751           AC017050.9         17177-17177         c
FEATURES             Location/Qualifiers
     source          1..2751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..2751
                     /gene="FAM98A"
                     /note="family with sequence similarity 98 member A"
                     /db_xref="GeneID:25940"
                     /db_xref="HGNC:HGNC:24520"
                     /db_xref="MIM:620904"
     exon            1..131
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1635
                     /gene="FAM98A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM98A"
                     /codon_start=1
                     /product="protein FAM98A isoform 1"
                     /protein_id="NP_056290.3"
                     /db_xref="CCDS:CCDS33179.1"
                     /db_xref="GeneID:25940"
                     /db_xref="HGNC:HGNC:24520"
                     /db_xref="MIM:620904"
                     /translation="MECDLMETDILESLEDLGYKGPLLEDGALSQAVSAGASSPEFTK
                     LCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRL
                     LIQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPA
                     NITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAIANEYEVR
                     RKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKTTISVAHLLAARQDLS
                     KILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQTG
                     GRGGGRGGYEHSSYGGRGGHEQGGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGG
                     GYQDGGYRDSGFQPGGYHGGHSSGGYQGGGYGGFQTSSSYTGSGYQGGGYQQDNRYQD
                     GGHHGDRGGGRGGRGGRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHS
                     GFGQGRHYTS"
     exon            132..280
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            281..415
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            416..600
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            601..681
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            682..798
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            799..966
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2751
                     /gene="FAM98A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM98A"
                     /note="hexamer: AATAAA"
     polyA_site      2751
                     /gene="FAM98A"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcat gcgcgagtgt acgcgttgcc ggcgaagagg ggagcctgac gactcggaaa
       61 tttgaatacc acagtagcat ggagtgtgac ctcatggaga ctgacatctt ggagtcgttg
      121 gaagatctag gttacaaggg cccattgttg gaagatggag cgctctctca ggcagtctct
      181 gctggagcca gttcccccga gtttaccaaa ctctgtgctt ggctggtgtc tgaattaaga
      241 gtgctctgta aactagagga aaacgtgcaa gcaactaaca gtccgagtga agctgaagaa
      301 ttccagcttg aggtgagtgg gctactaggg gagatgaact gcccgtatct ttcactgaca
      361 tctggggatg tgaccaagcg ccttctcatt cagaagaact gcctcctctt gctcacatac
      421 ctcatctcag aactagaagc tgccagaatg ctctgtgtga atgctcctcc aaaaaaagct
      481 caagaaggag gcggtagtga ggtctttcaa gagttgaaag gcatatgtat tgctctagga
      541 atgtccaaac ctccagccaa tataactatg ttccaattct tcagcgggat tgaaaaaaaa
      601 ttaaaggaaa cattagcaaa agttccacct aatcatgtgg gaaagccttt actgaagaag
      661 ccaatgggac cagcccactg ggaaaagata gaagcaatta accaagccat agccaatgaa
      721 tatgaagtcc ggagaaagct gctaataaaa cgtttggatg tcactgtaca atcctttggc
      781 tggtctgaca gagctaagag ccagacagaa aaattagcca aggtttacca gccgaaacgt
      841 tcagtcttat cccctaaaac tactatttct gttgcccatc ttttggctgc aaggcaggac
      901 ttgtcaaaga ttttaaggac aagcagcggc tctataagag aaaagactgc ctgtgccatc
      961 aataaggtgt tgatgggcag ggtgcctgac agaggtggta gacccaatga aatcgaacct
     1021 ccacccccag agatgccacc gtggcagaag aggcaagatg gcccccagca gcaaacagga
     1081 ggccgaggag gagggagagg tggctatgaa cattcctcat acggaggacg aggaggtcat
     1141 gaacaaggag gcgggagagg tggacgtggt ggctatgacc atggtggccg agggggagga
     1201 agaggaaata agcatcaagg aggctggaca gatggaggga gtggtggagg aggtggctac
     1261 caagatggtg gttatcgaga ttcaggtttc cagccaggtg gctatcatgg tggccacagc
     1321 agtggtggct atcaaggcgg aggttatggt ggcttccaaa catcttcttc atatacagga
     1381 agtggatacc agggtggtgg ctaccagcag gacaatagat accaagatgg cgggcaccat
     1441 ggtgatcgtg gtggtggtcg tggtgggcga ggtggtcgtg gaggccgagg tggtcgtgca
     1501 ggccagggag gaggctgggg aggaagaggg agccagaatt atcaccaagg gggtcaattt
     1561 gaacagcatt tccagcatgg aggttatcag tataatcatt ctggatttgg acagggaaga
     1621 cattacacta gttgaggcta ccgaacctta cattttgcta gagctcaagt aatagaaact
     1681 tagtttcaga atcctgaatt cagcacctat tttgaattaa tgtgagacca caggtggcag
     1741 gcagattcct gcttggcata agcatttgta ggtcttcatt caattctgtt agattttttt
     1801 attggactta cataatgccg tttatttgag aaacacataa catctctcct ttctatgaaa
     1861 aattttttaa aaggtggtta aaattgcctt taattgccca gtagactaat tccacagtca
     1921 gaacatgcaa acttttttga agaaattact tgaataagta gttttcatgt tttcaatatg
     1981 cagttttgaa aatgaggatt cacctagact tttttagatt tactactagg aaaccttcct
     2041 catatgaata accatttata tgtgttttgc ttaaagtatt ccaatgccta ttttccaagc
     2101 acagttctgc cccccggttg acttttatgc cacgtgtgct tcatgatgga acttttaggt
     2161 cagttcctat taaatgagct cttttgcaga tagcacattc agtagcctta ttttgttgat
     2221 ggaatactgt atcatatgct caactctgaa aaccttgaac acggccaaaa tccataaaga
     2281 ttataaaagc aaactaagtt gtgaagctat agtacatgta ggcatttagt taagtatagc
     2341 aattcaaact gacctgcatc catccaaaac aaattcctcc ttcaacctta tttttacttg
     2401 aaatttgcta gaagaaatag caaaccgaaa tttgttttat gcatgagtta ataccactgg
     2461 ctcagcaaat acaagttagt ttgctttaag caggtaactt tttttgtaat ggaagaaatg
     2521 cactacaaag ttaagacaga tttttgctaa gtgcaggagg ccctttatta ttgctgcaga
     2581 aaacaaaagc ctggctgagt tgatgtttta cattctccct tactgaaatc tacatgacat
     2641 gatgcttctt gctgggtttt tgtacatgta aacattgtca agctgtgaaa gaaaatggct
     2701 ggaggtgtgc tttgtgtgaa aggtgagcaa taaagtatct gttaagttct c
//
