LOCUS       NP_056290                518 aa            linear   PRI 20-SEP-2024
DEFINITION  protein FAM98A isoform 1 [Homo sapiens].
ACCESSION   NP_056290 XP_043885
VERSION     NP_056290.3
DBSOURCE    REFSEQ: accession NM_015475.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 518)
  AUTHORS   Wang,N., Guo,Y., Song,L., Tong,T. and Fan,X.
  TITLE     Circular RNA intraflagellar transport 80 facilitates endometrial
            cancer progression through modulating miR-545-3p/FAM98A signaling
  JOURNAL   J Gynecol Oncol 33 (1), e2 (2022)
   PUBMED   34783205
  REMARK    GeneRIF: Circular RNA intraflagellar transport 80 facilitates
            endometrial cancer progression through modulating miR-545-3p/FAM98A
            signaling.
REFERENCE   2  (residues 1 to 518)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 518)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 518)
  AUTHORS   Li,Z., Li,N., Sun,X. and Wang,J.
  TITLE     FAM98A promotes cancer progression in endometrial carcinoma
  JOURNAL   Mol Cell Biochem 459 (1-2), 131-139 (2019)
   PUBMED   31114934
  REMARK    GeneRIF: Mechanistically, it was demonstrated that miR-142-3p
            directly targeted FAM98A, and modulated its expression.
REFERENCE   5  (residues 1 to 518)
  AUTHORS   Ozeki,K., Sugiyama,M., Akter,K.A., Nishiwaki,K., Asano-Inami,E. and
            Senga,T.
  TITLE     FAM98A is localized to stress granules and associates with multiple
            stress granule-localized proteins
  JOURNAL   Mol Cell Biochem 451 (1-2), 107-115 (2019)
   PUBMED   29992460
REFERENCE   6  (residues 1 to 518)
  AUTHORS   Schou,K.B., Andersen,J.S. and Pedersen,L.B.
  TITLE     A divergent calponin homology (NN-CH) domain defines a novel
            family: implications for evolution of ciliary IFT complex B
            proteins
  JOURNAL   Bioinformatics 30 (7), 899-902 (2014)
   PUBMED   24257188
REFERENCE   7  (residues 1 to 518)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (residues 1 to 518)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (residues 1 to 518)
  AUTHORS   Popow,J., Englert,M., Weitzer,S., Schleiffer,A., Mierzwa,B.,
            Mechtler,K., Trowitzsch,S., Will,C.L., Luhrmann,R., Soll,D. and
            Martinez,J.
  TITLE     HSPC117 is the essential subunit of a human tRNA splicing ligase
            complex
  JOURNAL   Science 331 (6018), 760-764 (2011)
   PUBMED   21311021
REFERENCE   10 (residues 1 to 518)
  AUTHORS   Yang,H.C., Liang,Y.J., Wu,Y.L., Chung,C.M., Chiang,K.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chen,C.I., Fann,C.S., Wu,J.Y., Lin,T.N.,
            Lin,S.J., Chen,Y.T., Chen,J.W. and Pan,W.H.
  TITLE     Genome-wide association study of young-onset hypertension in the
            Han Chinese population of Taiwan
  JOURNAL   PLoS One 4 (5), e5459 (2009)
   PUBMED   19421330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA310995.1, BC136768.1, BC060860.1 and AC017050.9.
            
            On Dec 17, 2004 this sequence version replaced NP_056290.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.107418.1,
                                           SRR3476690.402691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238823.13/ ENSP00000238823.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     Protein         1..518
                     /product="protein FAM98A isoform 1"
                     /note="protein FAM98A"
                     /calculated_mol_wt=55142
     Region          28..327
                     /region_name="DUF2465"
                     /note="Protein of unknown function (DUF2465); pfam10239"
                     /db_xref="CDD:463016"
     Region          297..415
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NCA5.2)"
     Region          434..518
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NCA5.2)"
     CDS             1..518
                     /gene="FAM98A"
                     /coded_by="NM_015475.5:79..1635"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33179.1"
                     /db_xref="GeneID:25940"
                     /db_xref="HGNC:HGNC:24520"
                     /db_xref="MIM:620904"
ORIGIN      
        1 mecdlmetdi lesledlgyk gplledgals qavsagassp eftklcawlv selrvlckle
       61 envqatnsps eaeefqlevs gllgemncpy lsltsgdvtk rlliqkncll lltylisele
      121 aarmlcvnap pkkaqegggs evfqelkgic ialgmskppa nitmfqffsg iekklketla
      181 kvppnhvgkp llkkpmgpah wekieainqa ianeyevrrk llikrldvtv qsfgwsdrak
      241 sqteklakvy qpkrsvlspk ttisvahlla arqdlskilr tssgsirekt acainkvlmg
      301 rvpdrggrpn eieppppemp pwqkrqdgpq qqtggrgggr ggyehssygg rggheqgggr
      361 ggrggydhgg rgggrgnkhq ggwtdggsgg gggyqdggyr dsgfqpggyh gghssggyqg
      421 ggyggfqtss sytgsgyqgg gyqqdnryqd gghhgdrggg rggrggrggr ggragqgggw
      481 ggrgsqnyhq ggqfeqhfqh ggyqynhsgf gqgrhyts
//
