LOCUS       NM_144963               5529 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 91 member A1
            (FAM91A1), transcript variant 1, mRNA.
ACCESSION   NM_144963
VERSION     NM_144963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Zhao,L., Deng,H., Yang,Q., Tang,Y., Zhao,J., Li,P., Zhang,S.,
            Yong,X., Li,T., Billadeau,D.D. and Jia,D.
  TITLE     FAM91A1-TBC1D23 complex structure reveals human genetic variations
            susceptible for PCH
  JOURNAL   Proc Natl Acad Sci U S A 120 (45), e2309910120 (2023)
   PUBMED   37903274
  REMARK    GeneRIF: FAM91A1-TBC1D23 complex structure reveals human genetic
            variations susceptible for PCH.
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Navarro Negredo,P., Edgar,J.R., Manna,P.T., Antrobus,R. and
            Robinson,M.S.
  TITLE     The WDR11 complex facilitates the tethering of AP-1-derived
            vesicles
  JOURNAL   Nat Commun 9 (1), 596 (2018)
   PUBMED   29426865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5529)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7.. PMID: 29311657]
REFERENCE   4  (bases 1 to 5529)
  AUTHORS   Han,M.H., Hu,Z., Chen,C.Y., Chen,Y., Gucek,M., Li,Z. and
            Markey,S.P.
  TITLE     Dysbindin-associated proteome in the p2 synaptosome fraction of
            mouse brain
  JOURNAL   J Proteome Res 13 (11), 4567-4580 (2014)
   PUBMED   25198678
REFERENCE   5  (bases 1 to 5529)
  AUTHORS   Low,S.K., Kuchiba,A., Zembutsu,H., Saito,A., Takahashi,A., Kubo,M.,
            Daigo,Y., Kamatani,N., Chiku,S., Totsuka,H., Ohnami,S., Hirose,H.,
            Shimada,K., Okusaka,T., Yoshida,T., Nakamura,Y. and Sakamoto,H.
  TITLE     Genome-wide association study of pancreatic cancer in Japanese
            population
  JOURNAL   PLoS One 5 (7), e11824 (2010)
   PUBMED   20686608
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5529)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   7  (bases 1 to 5529)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   8  (bases 1 to 5529)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011134.15.
            
            On Nov 23, 2018 this sequence version replaced NM_144963.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.38700.1,
                                           SRR1660803.259490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334705.12/ ENSP00000335082.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC011134.15        86657-86992         c
            337-421             AC011134.15        81267-81351         c
            422-573             AC011134.15        80133-80284         c
            574-631             AC011134.15        78109-78166         c
            632-699             AC011134.15        77339-77406         c
            700-813             AC011134.15        76659-76772         c
            814-904             AC011134.15        75356-75446         c
            905-967             AC011134.15        74889-74951         c
            968-1074            AC011134.15        70855-70961         c
            1075-1113           AC011134.15        70312-70350         c
            1114-1226           AC011134.15        69690-69802         c
            1227-1342           AC011134.15        68821-68936         c
            1343-1455           AC011134.15        68058-68170         c
            1456-1542           AC011134.15        67681-67767         c
            1543-1675           AC011134.15        65686-65818         c
            1676-1824           AC011134.15        57193-57341         c
            1825-1959           AC011134.15        55777-55911         c
            1960-2073           AC011134.15        55546-55659         c
            2074-2146           AC011134.15        50092-50164         c
            2147-2296           AC011134.15        49202-49351         c
            2297-2401           AC011134.15        47055-47159         c
            2402-2525           AC011134.15        46415-46538         c
            2526-2595           AC011134.15        45080-45149         c
            2596-5529           AC011134.15        39979-42912         c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..5529
                     /gene="FAM91A1"
                     /note="family with sequence similarity 91 member A1"
                     /db_xref="GeneID:157769"
                     /db_xref="HGNC:HGNC:26306"
     exon            1..336
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2781
                     /gene="FAM91A1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     skeletal muscle cells re-entry induced; protein FAM91A1"
                     /codon_start=1
                     /product="protein FAM91A1 isoform 1"
                     /protein_id="NP_659400.3"
                     /db_xref="CCDS:CCDS6346.2"
                     /db_xref="GeneID:157769"
                     /db_xref="HGNC:HGNC:26306"
                     /translation="MNIDVEFHIRHNYPWNKLPANVRQSLGNSQREYEKQVVLYSIRN
                     QLRYRNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIM
                     EDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLMNQCRSSKKFFRRKTARDLLPIK
                     PVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNK
                     GFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLE
                     IDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVNRLKSTLDPQKMLLSWD
                     GGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMM
                     GNLSPNLKSHAVTMFEVGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTIL
                     FLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLT
                     NEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQS
                     YDRLLITSWGHDPGVVPTSNVLTMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETE
                     LQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERGEPDL
                     ASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKV
                     CRKIAAHGLCRKESLQNLLHSSRKLSLQVLNFVHSFQEGASILDIHTEPSFSSLLSQS
                     SCADMGVPLPAKNLIFKDGVLSEWSGRSPSSLLIANLHLQ"
     exon            337..421
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..573
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..631
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..699
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..813
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..904
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..967
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1074
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1113
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1226
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1342
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1455
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1542
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1675
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1824
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1959
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2073
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2146
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2296
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2401
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2525
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2595
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..5529
                     /gene="FAM91A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5495..5500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM91A1"
                     /note="hexamer: AATAAA"
     polyA_site      5529
                     /gene="FAM91A1"
                     /note="major polyA site"
ORIGIN      
        1 agagccattt ccggcggccc gaaactagga agaaacttgg agctgttcag gcgatccagc
       61 ctccaatcgc tgctgctctt gtactcggtt ggcccgggcg gcgctgaact gtcgggagcc
      121 taggccatgg ggcagcctgg gccttctgca gtgtgaggcg cggggcctcc cgcgtcgctc
      181 cgctgacagg ctgcgggcgg gcaggcggga ggcgtagtgt gggtcgcggt ggcggccccg
      241 gccgccggcc ctggccgcgg catcatgaac atagacgtgg agttccacat ccggcacaac
      301 tacccctgga acaagttgcc ggccaacgtg agacagagtc ttggaaattc acagagagaa
      361 tatgaaaagc aggttgtcct gtacagtatc cgcaatcagt tacgatatag aaataactta
      421 gttaaacatg tcaagaaaga tgaacgcaga tactatgagg aactgctaaa gtacagccga
      481 gatcatctca tgctgtaccc ttaccatcta tcggatatta tggtgaaagg cttgaggata
      541 acaccatttt catattatac tgggattatg gaggatatta tgaacagtga gaaaagttat
      601 gattcattgc ccaattttac tgctgctgac tgtctaaggc ttcttggcat aggaagaaac
      661 cagtatattg atcttatgaa tcagtgtaga tcatcaaaaa aattcttcag aaggaaaaca
      721 gcccgtgatc ttctaccaat aaagccagtg gaaattgcca tagaggcgtg gtgggtggtg
      781 caggctggct atatcacaga agatgacatc aagatatgca ctttgcctga gaaatgcgct
      841 gttgataaga tcatcgattc aggccctcaa ctctctggat cactagatta caatgtagta
      901 catagtttgt ataacaaagg atttatttat ctggatgtac caatatctga tgacagttgt
      961 atagcagttc cacctcttga aggttttgta atgaatcgag tgcaaggtga ttattttgaa
     1021 actctactct ataagatatt tgtttcaata gatgagcaca caaatgttgc agagcttgca
     1081 aatgtccttg agattgactt atccctggtt aagaatgctg tttcaatgta ttgccgattg
     1141 ggctttgccc ataagaaggg acaagtaatt aatttggatc aacttcattc atcatggaag
     1201 aatgttccat ccgtaaacag attaaagagt accttagatc cacagaagat gctcttgtca
     1261 tgggatggag gggaaagtag gagtcctgta caagaagctt catcggcaac tgacactgat
     1321 acaaatagtc aagaagatcc agctgacaca gccagtgtaa gcagcctgag tctgtctaca
     1381 ggacacacga agcgcatcgc attcctgttt gactccactc ttactgcctt cttaatgatg
     1441 ggaaatcttt caccaaactt gaaaagtcat gcagtcacaa tgtttgaagt aggcaaactc
     1501 tcagatgagt ctctggacag ctttcttata gaactagaaa aggttcagag cactggtgaa
     1561 ggagaagcac agagatattt tgatcatgca cttactctga gaaacacaat actgtttctg
     1621 cgtcataaca aagatctagt tgcgcaaact gcacagccag accaacccaa ttatggtttt
     1681 cctctggatc tcttacgctg tgaaagcctt cttggtttgg accctgcaac ttgcagcaga
     1741 gttctaaaca aaaattacac gctgcttgtt tccatggctc ccctcaccaa tgaaatccgg
     1801 cctgtcagca gctgcacccc tcagcatatt ggaccagcta tcccagaagt cagctctgtc
     1861 tggtttaaac tgtacattta tcatgtcact ggacaaggac caccatccct tttattgtcc
     1921 aaaggtacaa gacttcgaaa actgccagat atatttcaga gttatgatcg attgctaata
     1981 acatcttggg gtcatgatcc tggagtagtt cctacctcaa atgtgctcac gatgttgaat
     2041 gatgctttaa cacattctgc agttttaatt caggggcatg gtctgcatgg gataggagaa
     2101 actgtccatg tcccatttcc atttgatgaa acagaactac aaggagagtt cactcgtgtc
     2161 aatatgggtg ttcataaagc attgcagata ctaaggaaca gagtggactt acagcatctc
     2221 tgtggatatg tcaccatgtt gaatgcttcc agccaacttg cagatagaaa actcagtgat
     2281 gcttctgatg agagaggaga acctgatttg gcttctggct cagatgtaaa tgggagtaca
     2341 gagtcatttg aaatggtcat tgaggaagca actatagatt cagcaacaaa gcaaacctct
     2401 ggtgccacaa cagaagcaga ttgggttcct ctcgagctgt gctttggaat tccactgttc
     2461 agttccgaat taaaccggaa agtttgtagg aaaattgctg cacatggcct ttgcagaaaa
     2521 gagagccttc aaaacctctt acattccagt agaaaactct ctctgcaagt ccttaacttt
     2581 gttcactcat tccaggaagg tgcttcaata ttggatattc acacagagcc cagtttttca
     2641 agtttgcttt cacagtcatc gtgtgctgac atgggtgttc cacttcctgc aaaaaactta
     2701 atatttaaag atggtgtctt atcagaatgg agtggacggt caccttcctc acttcttatt
     2761 gctaatctcc atttgcaata atttggttac accatttgtt gctcacactt tctgcctttt
     2821 ttctttctta acgttagctt tatagtgtca gccactaaaa agcatcctgc tgctgcagtg
     2881 caattcttgc ttaactaata ttaaaagttg gggaacatat tcatgttttc tgaagttttg
     2941 ctcattattg cacatcttat tgcgacaaag tgctttttag cagccagcac tgtatttttt
     3001 accttgagac aatctgcatt tcttttataa aactaagtat atactttata ggctttatga
     3061 tgactgttat gtttataagc agtcactatg aaaattgcaa tggtaatttt atatgttagt
     3121 ttatcaaaca taaatcttgt ttaattttat attttgttac ctatactttg ggggatcaag
     3181 ggaagagatg gaactcttcc tctgaaaagg cttcttggta cttaaagtag taaaactata
     3241 aaacaataaa catccagtat tgagagatga tatgataggg cattatgaat tcctatgggt
     3301 gtctgtaaat tatgtatgtc agttggacat tgtagaaggt atgtaaatca gcatagttgt
     3361 gtataactta accttgattt ataaggtctt aagattatga ctattcattg acatctcatg
     3421 agaagcttta gaagactttc tatttttaaa caccatttat atgtggactt ctgttgtcac
     3481 tgactttggg ctttatattt tcatagagtc tttatggaaa aaatagaatt tattttccac
     3541 tcttgtagct atagctgctg cacactttca ccctgattta tttttttgtt tcttagcttt
     3601 gatgttttca aaccaaggat tgtgatttta ggttagaatt acatattaga agcattaaga
     3661 ctatgtcttt ggatcagaat gctttagtga taaacctact ttgaagacat actcttaagc
     3721 aatctggatc ttaaatttat gtgaatactt ttttagaaaa tgataaagaa aaatggaatt
     3781 acttcaaagt gtttcttgag tcattgattc ttttagcatc tcaaatgtta attagaataa
     3841 ttggaatcac tttttagact tttcaagtta ccttccttgg gaagtttgtg cagtgttata
     3901 gtttagttta gctcctctta cagggtaatg gtttgctagt ttaaaactgt aaccaaacga
     3961 actggtcaga caacatatat ctaaaacact taaaatgtta ggaagtttgg gaatgttata
     4021 acctaaacgt ttttgctggt aactttttgt tatttataga tatttgtgta tttaacatac
     4081 atacttcagg aaatatatgc ctttcctaaa acttaaccat gcattcaata ccatggccta
     4141 tctatagaat tgaatatttt ggaccatgtt atctgtggca cagtcagtgc tgtgtttgag
     4201 gtaaatgcag taacggttag ttttctactt tgtcttatag aaggtagaaa ccatgtgtat
     4261 gttatgtttg tctataaaag aaaaaatact aatattaaat aatttcttac gactctgagt
     4321 cactcactta tttttccaat aattgatatt gtacattcct agtgccatta ggtatgtatg
     4381 tatgtaactt ttacagtttt tcagctgaaa gttgtaagta tttttttttt ttgatcgggg
     4441 ctctttaatc tcattttaat ttcctttgtt tgaactgtag ttattttatt tattcctata
     4501 ttaaccatct aaaccaactg taatgacatg tacactaata cagaattgaa catttgtagt
     4561 tgttggcagt gaacccagtt gttggtgaat ttaaagctta aaatatggga atgatttgct
     4621 gctatatttc ctttgagaga gaaaggagga agaaatagaa cctaatagtg atcatgaatt
     4681 ttagggaaag taccgaagaa ccatggggtc ccctctggtt tcttgtgttg aatgaggcaa
     4741 gggtaatcat ctgattccga gctgaagacc tctggtcctc ttaaggaggg agagtgcatt
     4801 tttagagctt ttagcaaaat gtgaaaagct gatgtttgcg ccttgctttg tgaatttggc
     4861 tttgttttac ttatacatta actcatgtaa tctcttaaat cttacaagca ttgatccatt
     4921 tcaacaaaaa ggtaaattta aaatgcagac tttgttattt gccaaagaag attcatgaaa
     4981 aatttacgtc caattatttt gcaaatagtt aatttcattt ggctttttac catgttcctt
     5041 cctttctttt tcccgcttcc ttaatgtaat ttaaaccctg gcaaacattc tttagaaacc
     5101 aagaggaaag aaagaacaaa tatcaaaaaa gacatagaat ttaatattga tacaatttca
     5161 cctctaaaat ggatttgaag aaatgcaact ttatatcaaa aaatgtcatc tgatttcctt
     5221 tgtttctttt ttaaattatg taatcagatg attttatgtt tttttttcag gggagcggaa
     5281 tattggtttc ttttacttgt tgttttcagt tttctctgcc attcatgttt cttttttgtg
     5341 ttcagtgttt caaatacaat ttgtatttaa ggattttaaa ataccaaact gtaactgagt
     5401 acagtggatc gttttctgtt aggatgttaa tattatacaa tgaaatctat aaagtgttgt
     5461 caatttgatt attgacacat ataacatgtt tacaaataaa ctgtggtatt gatcaagtta
     5521 ctatgaaaa
//
