LOCUS       NM_018088               2516 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 90 member A1
            (FAM90A1), transcript variant 1, mRNA.
ACCESSION   NM_018088 XM_005253404
VERSION     NM_018088.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2516)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2516)
  AUTHORS   Cheng,S., Li,C., Xie,W., Miao,Y., Guo,J., Wang,J. and Zhang,Y.
  TITLE     Integrated analysis of DNA methylation and mRNA expression profiles
            to identify key genes involved in the regrowth of clinically
            non-functioning pituitary adenoma
  JOURNAL   Aging (Albany NY) 12 (3), 2408-2427 (2020)
   PUBMED   32015217
  REMARK    GeneRIF: Integrated analysis of DNA methylation and mRNA expression
            profiles to identify key genes involved in the regrowth of
            clinically non-functioning pituitary adenoma.
REFERENCE   5  (bases 1 to 2516)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2516)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2516)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2516)
  AUTHORS   Bosch,N., Caceres,M., Cardone,M.F., Carreras,A., Ballana,E.,
            Rocchi,M., Armengol,L. and Estivill,X.
  TITLE     Characterization and evolution of the novel gene family FAM90A in
            primates originated by multiple duplication and rearrangement
            events
  JOURNAL   Hum Mol Genet 16 (21), 2572-2582 (2007)
   PUBMED   17684299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA088850.1, AC092111.9 and BC042608.1.
            
            On or before Aug 31, 2013 this sequence version replaced
            XM_005253404.1, NM_018088.2.
            
            Summary: FAM90A1 belongs to subfamily I of the primate-specific
            FAM90A gene family, which originated from multiple duplications and
            rearrangements (Bosch et al., 2007 [PubMed 17684299]).[supplied by
            OMIM, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151887 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538603.6/ ENSP00000445418.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               DA088850.1         1-215
            216-279             AC092111.9         97914-97977         c
            280-395             BC042608.1         260-375
            396-396             AC092111.9         97518-97518         c
            397-542             BC042608.1         377-522
            543-548             AC092111.9         96419-96424         c
            549-925             BC042608.1         528-904
            926-926             AC092111.9         95089-95089         c
            927-1259            BC042608.1         906-1238
            1260-2516           AC092111.9         92835-94091         c
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2516
                     /gene="FAM90A1"
                     /note="family with sequence similarity 90 member A1"
                     /db_xref="GeneID:55138"
                     /db_xref="HGNC:HGNC:25526"
                     /db_xref="MIM:613041"
     exon            1..139
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..346
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..503
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..682
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..1954
                     /gene="FAM90A1"
                     /codon_start=1
                     /product="protein FAM90A1"
                     /protein_id="NP_060558.3"
                     /db_xref="CCDS:CCDS31738.1"
                     /db_xref="GeneID:55138"
                     /db_xref="HGNC:HGNC:25526"
                     /db_xref="MIM:613041"
                     /translation="MMARRDPKPGAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKC
                     KNCEAFGHTARSTRCPMKCWKAALVPPNFGEKEGKENLKPWKPQVEANPGPLNKDKGE
                     KEERPRPQDPQRKALLHIFSRKPPEKPLPNQKGSTESSDYLRVASGPMPVHTTSKRPR
                     VDPVLSDRSATEMSDRGSVLASLSPLRKASLSSSSSLGPKERQTGAAADIPQTAVRHQ
                     GPEPLLVVKPTHSSPAGGCREVPQAASKTHGLLQAVSPQAQDKRPAVTSQPCPPAATH
                     SLGLGSNLSFGPGAKRSAPAPIQACLNFPKKPRLGPFQIPESAIQGGELGAPENLQPP
                     PAATELGPRTSPQTGTRTPAQVLSGDRQPPHSRPCLPTAQACTMSHHPAASHDGAQPL
                     RVLFRRLENGRWSSSLLTAPSFHSPEKPGAFLAQSPHVSEKSEGPCVRVPPSVLYEDL
                     QVPSSSEDSDSDLE"
     exon            683..882
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..991
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..2516
                     /gene="FAM90A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM90A1"
                     /note="hexamer: AATAAA"
     polyA_site      2516
                     /gene="FAM90A1"
                     /note="major polyA site"
ORIGIN      
        1 agctccagtc aggccccatc cgggcccttc cagaagcaac ccaggagccc cgagacctgc
       61 agggatgtgt gcaccctgac ccctgacgca tagccctgca cctgcagcca gctggcctcg
      121 ggcttgaaaa catggcgggt gcgctccaat tcacggtggt ttccaagcgc attctggagg
      181 agaaaacaca tgagtgtgtg gtcagggttc tctgctgaca gacctaccgt ggggaagaaa
      241 gagaagctct gaagatggat catggccgtg actgcatgtc aaggagaatc tccatgatga
      301 cacggaggcc tacgtcgaga tagagtaaat atggtccaat taaaaggtga ccagaggcag
      361 tataaaaggc agcctggaaa gcagaggtcc ctctctgccc cttcctccgt cttcctggat
      421 gctgcatcgc ttccagcggg gctgctccag cacctgccca tctcagcgcc agccggggaa
      481 agaaagtaga cgtgtaattt caggtgaccc gacaatcaac ccctgaaaaa ggcggtcata
      541 aaacccccag gagacgaaga tgatggcacg tcgtgacccc aaacctgggg caaagagact
      601 ggtgagagcc cagaccctcc agaagcagcg gagggcccca gttgggccaa gggctccccc
      661 gcccgatgaa gaagatccca ggctcaagtg caaaaactgt gaggcctttg gccacacggc
      721 cagaagtacc aggtgcccca tgaagtgctg gaaggcagcc ctggttccac cgaactttgg
      781 ggaaaaggaa gggaaggaaa acctgaaacc atggaagccc caggttgaag cgaaccctgg
      841 gcccttgaac aaggataagg gagagaagga agagagacca aggccacaag acccgcagag
      901 gaaggctctc ctccacatat tttccaggaa acctccagag aagccgctgc caaatcaaaa
      961 aggatccacg gaatcttctg attatctgag ggttgcaagc gggccaatgc cggtccacac
     1021 aaccagtaag aggccgcgtg tggaccctgt cctctctgat cgctcagcta ccgaaatgtc
     1081 tgacaggggc tccgtcttag cttcactgtc tcccctcaga aaagccagtc tgagctcctc
     1141 ctcaagtctt ggaccaaagg aaagacagac aggggctgcg gccgacatcc ctcagactgc
     1201 agtcaggcac cagggccccg agcctctcct cgtggtgaag ccgacacaca gcagccctgc
     1261 gggtggctgt cgagaagttc cccaggctgc ctccaaaacc cacggcctgc tccaggccgt
     1321 cagcccccag gcacaagaca aacgtcctgc ggtgacctca cagccctgcc caccagccgc
     1381 cacacacagc ttgggcctag gctccaatct cagcttcggg ccaggagcca agagatctgc
     1441 cccggctccg attcaggctt gcctgaactt ccccaagaaa ccgagactgg gtcccttcca
     1501 gatccccgaa agcgccatcc agggaggtga gctgggggcc ccggagaatc tccaacctcc
     1561 gccagccgca accgaacttg gaccacgtac gtcaccccag acaggcacga ggacacccgc
     1621 ccaggtgctt agcggcgacc ggcagcctcc gcacagcaga ccttgcctgc ctactgccca
     1681 ggcctgcacc atgtcccatc acccagcggc cagccatgat ggggcccagc ctctcagagt
     1741 gctctttcgg agactggaaa acggacgctg gagctccagc ctgctgacgg ccccctcatt
     1801 tcactctcct gagaagccgg gagccttcct cgctcagagc cctcatgtct cagagaagtc
     1861 tgagggtccc tgtgttcgtg tcccaccaag cgtcctctat gaggaccttc aggttccctc
     1921 ctcctcagag gacagcgatt ctgacctgga gtgagactgc aggtggcagg ggctccttgg
     1981 cctccagctc ccgtgacttg gaggggactg tgggactgag gagcacagag cagagagcag
     2041 actctgtgcg gtgactccga agctccccgg ctgtggccct tctgtggatg tgggagccca
     2101 ggccaggcag ggagcagatg cagggactct gccacgttga attctggtga gggacattgt
     2161 agttcgcatg gttctctgga aacgcgccag gaaaagcttc cgtgccagtg attcgttgcc
     2221 tcagaaactg catgacgcgc aggagtcaga cttccgctgg gacgtcaata ggaaacgggg
     2281 gaattactgt gtatttgctc tctagacgac tgaataaggg aaaagttagg gaaccctgag
     2341 aggtgcagcc cttccgctgt gccccgccct gagagcagtg tttcggacgc tgggaagcgc
     2401 gctgtgcaaa gcgctctcgg ggtctttcct cagcctcgaa aagtgggctc tggaatccct
     2461 ttgtaaatag gtgtgttgaa tttgttttga agtgaataaa attctcaaaa agatga
//
