LOCUS       NM_016255               4726 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 8 member A1 (FAM8A1),
            mRNA.
ACCESSION   NM_016255
VERSION     NM_016255.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4726)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4726)
  AUTHORS   Schulz,J., Avci,D., Queisser,M.A., Gutschmidt,A., Dreher,L.S.,
            Fenech,E.J., Volkmar,N., Hayashi,Y., Hoppe,T. and Christianson,J.C.
  TITLE     Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex
            formation for ER-associated degradation (ERAD)
  JOURNAL   J Cell Sci 130 (19), 3322-3335 (2017)
   PUBMED   28827405
REFERENCE   3  (bases 1 to 4726)
  AUTHORS   Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
            Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
            Harper,J.W. and Kopito,R.R.
  TITLE     Defining human ERAD networks through an integrative mapping
            strategy
  JOURNAL   Nat Cell Biol 14 (1), 93-105 (2011)
   PUBMED   22119785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4726)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   5  (bases 1 to 4726)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 4726)
  AUTHORS   Jamain,S., Girondot,M., Leroy,P., Clergue,M., Quach,H., Fellous,M.
            and Bourgeron,T.
  TITLE     Transduction of the human gene FAM8A1 by endogenous retrovirus
            during primate evolution
  JOURNAL   Genomics 78 (1-2), 38-45 (2001)
   PUBMED   11707071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA333190.1, BC047881.1, AF097027.1, AL138824.19 and BQ015864.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016255.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.187565.1, AF097027.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259963.4/ ENSP00000259963.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DA333190.1         17-77
            62-1575             BC047881.1         1-1514
            1576-2409           AF097027.1         1523-2356
            2410-4402           AL138824.19        78141-80133
            4403-4726           BQ015864.1         22-345              c
FEATURES             Location/Qualifiers
     source          1..4726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..4726
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /note="family with sequence similarity 8 member A1"
                     /db_xref="GeneID:51439"
                     /db_xref="HGNC:HGNC:16372"
                     /db_xref="MIM:618409"
     exon            1..820
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1350
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /note="Autosomal Highly Conserved Protein"
                     /codon_start=1
                     /product="protein FAM8A1"
                     /protein_id="NP_057339.1"
                     /db_xref="CCDS:CCDS4540.1"
                     /db_xref="GeneID:51439"
                     /db_xref="HGNC:HGNC:16372"
                     /db_xref="MIM:618409"
                     /translation="MAEGPEEARGHPPGQDDGGGDHEPVPSLRGPPTTAVPCPRDDPQ
                     AEPQAPGRPTAPGLAAAAAADKLEPPRELRKRGEAASGSGAELQEQAGCEAPEAAAPR
                     ERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAYCSPQPSPQSFPSGGAAVPQ
                     AAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAPVAGLGPRAPHVQASVRATPV
                     TRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSG
                     IKDISKFAMHYIIEEIDEDTSMEDLQKMMVVALIYRLLVCFYEIICIWGAGGATPGKF
                     LLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQ
                     HNRTAYDIVAGTIVVKRNGVR"
     exon            821..941
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1065
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1205
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..4726
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4707..4712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /note="hexamer: AATAAA"
     polyA_site      4726
                     /gene="FAM8A1"
                     /gene_synonym="AHCP"
                     /note="major polyA site"
ORIGIN      
        1 gttgacgcct gcggttgctg cggtggtgac ggggctgttg gggaggggcc attgggggag
       61 ggaaacggag cagtgacagg tatcccagag ggtgctgctg aggcgacgat ggccgagggg
      121 cccgaggaag cccgaggcca ccctcccggg caggacgatg gcggagggga ccacgagccc
      181 gtcccttccc tgagaggccc tcctaccacc gccgtcccat gcccccgcga cgacccccag
      241 gccgaacccc aggccccggg ccggcccaca gccccgggcc tcgcggctgc cgccgcagcc
      301 gacaaattgg agccgccgcg cgagctcagg aagcgcgggg aggcggcctc cggctccggt
      361 gcagagctgc aggagcaggc gggctgcgag gcgcccgaag ccgcggcgcc acgagagaga
      421 ccagctcggc tgagcgcccg cgagtactcc cggcaagtgc acgagtggct gtggcagtcc
      481 tactgcggct acctcacctg gcacagcggc ctggccgcct tcccagccta ctgcagcccc
      541 cagccctccc cgcagagctt cccttcgggc ggcgctgcag tcccccaggc cgcggcgccg
      601 ccgcccccgc agctgggcta ttacaacccc ttctacttcc tgagccccgg ggccgcgggg
      661 cctgacccgc ggacagctgc cggcatcagc acccctgctc cagtcgcggg cctgggaccc
      721 cgggctcctc acgtgcaggc gtcggtccgg gccactccag tgacgagggt aggatccgca
      781 gccccttcgc gaagcccgag cgagaccggg cgacaggcag gcagagaata tgttattcca
      841 tccttggccc acagatttat ggcagagatg gtggatttct ttattctctt ctttataaaa
      901 gcaaccattg tcttaagcat tatgcacctc agtgggataa aggatatctc taagtttgct
      961 atgcattata taatagaaga aatagatgaa gacacatcaa tggaagactt gcagaaaatg
     1021 atggttgtgg cacttatata cagattatta gtttgtttct atgagataat ttgcatttgg
     1081 ggagcaggtg gagctacccc agggaagttc ctgctggggc ttcgagttgt gacatgtgat
     1141 acatcagtgc ttattgcacc aagtcgggtt ttagtgattc cttcctcaaa tgttagcatt
     1201 acaacgtcca ctatccgagc tttgatcaag aatttttcaa ttgcttcttt tttccctgct
     1261 ttcatcacac tgctgttttt tcagcataat cgaacagctt atgacattgt agcaggaacc
     1321 attgtggtaa aaagaaatgg ggtcagatga tgccccccaa aaccctgatt tccacacact
     1381 aagactaaat tatgtatcaa ggccatcagt atccctgggt tacactaatt gatgatttag
     1441 aaattaaagc agtcactcca gtgtgatgca ggtgactact ctgaaagtat tgattatact
     1501 tgaatgccaa agaacttgtc cagaagaaaa acctgttaaa ttcaagtatt aaaattttta
     1561 gatcaaaaag gcaaatgatt ttataaacaa tggacaatat atactttctt aagatctaag
     1621 gtactttctt aagatctaag aatttgctga aagcattttc agctttgaaa tctccaaatg
     1681 aaactttaaa atttattttg gtttatccca aaataatgga aaatgtccag ttgtgttttg
     1741 taaacaccta tgtaactcat cttttagttt acacttcctg gggaaattgt ctttggtgtt
     1801 tagaggaggg aatgagaaca caaattggat aatccactgt ctcccatccc aggaggtggt
     1861 gagttggcta caagagaaag ggacaagtga ggcaggccta gcagttccct tacctgaagt
     1921 tttcaaatcc atactgcagt tccctctcgt aatgatgtaa ctttacaact attcttaatg
     1981 cttgaacatg tatttagggg caagtttctc atgatgatga aaaagtatca agtcatattg
     2041 ctatgttaat tggttttttt ttttaaaagg taagttagtg attactgtta atggtggggg
     2101 agtaagtttt cactgtaaat tgaacttata atttatgtgc aagtgttttc agtgccctga
     2161 atcaaactat aaatgtgggg agaaatcacc tccatcaaac agttgcatat ttactgtaaa
     2221 agtattccca gtatgtgtgc agcatgaaga aagtattagt gcttctcagt gttctcagtg
     2281 taaattctat ttatatacag catattcaca tactactttc cttatatttt atatagttct
     2341 atgactgttg aaacatcaag gagttaaaaa aatcttaata tttcatgatt aactctaagt
     2401 actattaatt aatagcttgc gaaatattag caattttccc attatggact attctctcta
     2461 aagcaagaga gactagcatt cccagacatc attctagggt ctttaagctc attttgggtc
     2521 tgctaaagtt tggggggaaa tgttacgcaa agtgatactg tgtatgttgc cattttgctt
     2581 tattcttctg ttgaagcaaa attgtggggt tttattatgt gtgtgtgctt ttcctagatg
     2641 tcccagttag ctgtgctgag atatacctgt actatttatg gtttaagttt tgattcttag
     2701 gtattttctc cagctctgac attgttttcc aaagacacac taaactgcat tgcacagttc
     2761 aaaatttgat tacttaaggg atcaatctag gtggtgttct tggtcttaaa tttaacagca
     2821 aacacagcac atatctatta tcactatatt aattttcaaa ggtttttctt tgacgtttaa
     2881 aactgtgaca acagatattc acatttgatt atagaaactt aatgtctatt aataatttta
     2941 gtacaaaatt tcataaaccg tgtttttcaa aataagttta tgtcaaatcc agcttcccag
     3001 aaacactaat aattaagtac atcaatgtac taaataaatc attcagttgc acccatgggg
     3061 aagattgtgt tactgccctt cacagtgaaa aaaagaaaaa tctttcattt ttaaaattag
     3121 gagatgttac gtaacttggc actttagtag tgtatacact agcattagtt tatacaccac
     3181 ttttgccgct ggggaattca agttgaaatg tccctcaatc atataggtct ggaatacatc
     3241 tttcattcat aatttctgct cagataattg aatagtttgc catcgagatt attttcattt
     3301 atactataaa acaaaagcaa actagtccag tttaattttt tgtacttaga atattgcaca
     3361 ttttctatat atgagttatt cagattagta tctatgtagg ttcagtcaga tccaaccatg
     3421 gattcgaggt attatactgt ataaccctac aaaatacata gaagtattat ttgccttcat
     3481 aatagaaccc aagagtctgt ttcaatttat gaattcagta tttgcaccga gattttgatt
     3541 cccaaagttt ggaaaaaaat gacaaaacaa cgagggaaga aggaaccaga ccttagtgcc
     3601 acatattttt ctcttggggt tgtaaggtag tctcctgctt tccagaacac tttattatat
     3661 ttcacttata gacctgattt tctgtgtcaa agtataattc tcatgctgaa gctgtagcct
     3721 aaaaagccaa aagaaagttg tcttcattgt acaaacatat tcatcacttt aacaataagg
     3781 gaacaaaatt tagtattcaa gctgagtgag aatactgttt caatgagcat gtccctaaga
     3841 taaaccagaa ttggcagtta atttaggcgt ctagaaaatc tcagttccca ccagtaaaat
     3901 tatcctgagt agctaatgca ccttgagaaa aatctggcat actgaataaa taacattaac
     3961 ttgggagcca agagctgggt aagccttacc tttagactac tctgtgacta cagaaataaa
     4021 gccagcactt ttggaactaa taagccttca cttgtcagta tcataaagag tattgcccaa
     4081 ctgaactttg ctcccactgg tttaatagtt acttatttct gcctaagcac tcaccttccg
     4141 attttaccca agtatatata taggatagaa aaaaatgcat tatatttgag agctacttcg
     4201 cccaaattac aaaatgagtg tttttagatt caagtgacag taaaaggatt tgttcccttc
     4261 agtgacttga gtgttttagt tatgcataag tatttctagc aaaggaaggg tagaaaggaa
     4321 ttgaaaatta atttacacta gttgctactt gggaataaag ggctttttga ggggggtatg
     4381 gatattaaat gttttcgtta tatacttatc cctattaaaa caggcagttg tttctttgaa
     4441 tatgcctaaa taacagtatt cttaaaatct gacagacaag taacatgtca attacttgat
     4501 attccttgtc tccagtacca caggccactc ttgacatccc atgtttgcct ggataaagtt
     4561 cctcatttca aacagtatac atacttcttt gcagttcatt atagtaaggc ttaacctgta
     4621 aacagtatct gatggcccac ctataaataa aattcagcat tctattttta ataatttgta
     4681 tgccaccaat ttgtattatt tgtctcaata aatacttagt catcaa
//
