LOCUS       NM_001098785            1251 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 89 member B (FAM89B),
            transcript variant 1, mRNA.
ACCESSION   NM_001098785
VERSION     NM_001098785.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
  REMARK    GeneRIF: the functional relevance of the LRAP25-MRCK complex in
            LIMK1-cofilin signaling and the importance of LRAP adaptors as key
            determinants of MRCK cellular localization and downstream
            specificities.
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Stewart,A.F.
  TITLE     Identification of human homologues of the mouse mammary tumor virus
            receptor
  JOURNAL   Arch Virol 147 (3), 577-581 (2002)
   PUBMED   11958456
  REMARK    GeneRIF: identified two human genes, Mtvr1 and Mtvr2, encoding
            proteins highly related to the Mouse Mammary Tumor Virus receptor
            [Mtvr1] [Mtvr2]
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Sakuma-Takagi,M., Tohyama,Y., Kasama-Yoshida,H., Sakagami,H.,
            Kondo,H. and Kurihara,T.
  TITLE     Novel related cDNAs (C184L, C184M, and C184S) from developing mouse
            brain encoding two apparently unrelated proteins
  JOURNAL   Biochem Biophys Res Commun 263 (3), 737-742 (1999)
   PUBMED   10512749
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Golovkina,T.V., Dzuris,J., van den Hoogen,B., Jaffe,A.B.,
            Wright,P.C., Cofer,S.M. and Ross,S.R.
  TITLE     A novel membrane protein is a mouse mammary tumor virus receptor
  JOURNAL   J Virol 72 (4), 3066-3071 (1998)
   PUBMED   9525630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032373.1 and BE394215.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098785.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.122499.1,
                                           SRR1163657.432601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530349.2/ ENSP00000431459.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               BC032373.1         201-468
            269-935             BE394215.1         1-667
            936-1251            BC032373.1         1097-1412
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1251
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /note="family with sequence similarity 89 member B"
                     /db_xref="GeneID:23625"
                     /db_xref="HGNC:HGNC:16708"
                     /db_xref="MIM:616128"
     exon            1..423
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..702
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammary tumor virus receptor homolog 1; protein FAM89B;
                     leucine repeat adaptor protein 25; leucine repeat adapter
                     protein 25"
                     /codon_start=1
                     /product="leucine repeat adapter protein 25 isoform 1"
                     /protein_id="NP_001092255.1"
                     /db_xref="CCDS:CCDS53662.1"
                     /db_xref="GeneID:23625"
                     /db_xref="HGNC:HGNC:16708"
                     /db_xref="MIM:616128"
                     /translation="MNGLPSAEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERV
                     YSQRSRIHDELSRAARAPDGPRHAAGAANAGPAAGPRRPVNLDSALAALRKEMVGLRQ
                     LDMSLLCQLWGLYESIQDYKHLCQDLSFCQDLSSSLHSDSSYPPDAGLSDDEEPPDAS
                     LPPDPPPLTVPQTHNARDQWLQDAFHISL"
     exon            424..1251
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /note="hexamer: AATAAA"
     polyA_site      1251
                     /gene="FAM89B"
                     /gene_synonym="LRAP25; MTVR; MTVR1"
                     /note="major polyA site"
ORIGIN      
        1 aaggaacaaa gcgaggcctg cgggcggcgg ctgggctccg gcggggccgc ggggtgcggg
       61 gcctgcgggc ggcggcccgg gcggagcgtt ggagggaagg aggtggcatc gccgtccgcg
      121 ccggccccgg ccatgaacgg gctgccctcg gcagaggcgc cgggcggggc gggctgcgct
      181 ttggccgggc tcccaccgct gccgcgcggc ctcagcggcc tccttaatgc gagcgggggc
      241 tcgtggcggg agctggagcg cgtctacagc cagcgcagcc gcatccacga cgagctgagc
      301 cgcgccgccc gcgccccgga cgggccccgc cacgccgccg gcgccgccaa cgcgggaccc
      361 gcagccggcc cgcgtcgtcc tgtcaacctc gactcagcgc tggccgcgct gcgcaaggag
      421 atggtggggc tgcggcagtt ggacatgtcc ttgttgtgcc agctgtgggg cctgtacgag
      481 tcaatccagg actacaaaca cctgtgccaa gacctgagct tctgccagga cctgtcatcc
      541 tccctccatt cggacagctc ctacccaccg gatgcgggcc tgtctgacga cgaggagcct
      601 cccgatgcca gcctgcctcc tgacccgcca ccccttactg tgccccagac gcacaatgcc
      661 cgtgaccagt ggctgcagga tgccttccac atcagcctct gaagggctgg ggggcagggg
      721 gcatgcaccc atgcaaaagg ctcagaaact ccccctccgg caagccctca gacttcggag
      781 cctgcgcctt cccccctacc gcctcacctc acaggagggc caggcatgta ttcctcagag
      841 gcgaaactgc caaactcttt ctcctgtctt gggttggctg gcactggggc gggcatctag
      901 ggtacagcct ctgctcatgg cactgggcct ccagttcttc cacatgtgtg cacccccagc
      961 ttggccaacc ctcagccttg cggtggggcc cgaagcatct tcccttccgc ttggcgtctc
     1021 tgggattggg atgagtgcct ggctcccatc tcctcctcac cttttgttgc tatcggcagc
     1081 tgctggctca ggggcatccc acctccgggc tctgggttcc tctgccctgg aagggctcca
     1141 ggacccgtcc caataaccac ccacggccag gagggccaag gccccgtgct ggatatttaa
     1201 atttaggggc cggtctccag ggcgcgtaga taaataaata cactcagcgt c
//
