LOCUS       NM_001137610            2518 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens family with sequence similarity 86 member B2
            (FAM86B2), transcript variant 1, mRNA.
ACCESSION   NM_001137610 XM_003960424 XM_928336
VERSION     NM_001137610.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Alkan,C., Kidd,J.M., Marques-Bonet,T., Aksay,G., Antonacci,F.,
            Hormozdiari,F., Kitzman,J.O., Baker,C., Malig,M., Mutlu,O.,
            Sahinalp,S.C., Gibbs,R.A. and Eichler,E.E.
  TITLE     Personalized copy number and segmental duplication maps using
            next-generation sequencing
  JOURNAL   Nat Genet 41 (10), 1061-1067 (2009)
   PUBMED   19718026
  REMARK    GeneRIF: Identifies FAM86B2 as being one of 30 genes with the most
            variable copy numbers in three human genomes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087203.12.
            
            On Oct 21, 2020 this sequence version replaced NM_001137610.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2941459.1,
                                           SRR14038193.344976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262365.9/ ENSP00000262365.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC087203.12        104771-104923       c
            154-216             AC087203.12        102575-102637       c
            217-297             AC087203.12        100605-100685       c
            298-399             AC087203.12        98873-98974         c
            400-533             AC087203.12        97504-97637         c
            534-799             AC087203.12        97156-97421         c
            800-949             AC087203.12        96180-96329         c
            950-2518            AC087203.12        92944-94512         c
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..2518
                     /gene="FAM86B2"
                     /note="family with sequence similarity 86 member B2"
                     /db_xref="GeneID:653333"
                     /db_xref="HGNC:HGNC:32222"
                     /db_xref="MIM:616123"
     exon            1..153
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1050
                     /gene="FAM86B2"
                     /note="protein FAM86B2"
                     /codon_start=1
                     /product="putative protein N-methyltransferase FAM86B2"
                     /protein_id="NP_001131082.1"
                     /db_xref="CCDS:CCDS59092.1"
                     /db_xref="GeneID:653333"
                     /db_xref="HGNC:HGNC:32222"
                     /db_xref="MIM:616123"
                     /translation="MAPEENAGTELLLQGFERRFLAVRTLRSFPWQSLEAKLRDSSDS
                     ELLRDILQKTVRHPVCVKHPPSVKYAWCFLSELIKKHEAVHTEPLDKLYEVLAETLMA
                     KESTQGHRSYLLSSGGSVTLSKSTAIISHGTTGLVTWDAALYLAEWAIENPAAFINRT
                     VLELGSGAGLTGLAICKMCRPRAYIFSDPHSRILEQLRGNVLLNGLSLEADITGNLDS
                     PRVTVAQLDWDVAMVHQLSAFQPDVVIAADVLYCPEAIVSLVGVLQRLAACREHKRAP
                     EVYVAFTVRNPETCQLFTTELGRDGIRWEAEAHHDQKLFPYGEHLEMAMLNLTL"
     exon            154..216
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..297
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..399
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..533
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..799
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..949
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..2518
                     /gene="FAM86B2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccaggcc cggcttcctc caggtctccc ggcaacggct gcggcctcgc ccacgttatg
       61 gcgcccgagg agaacgcggg gaccgaactc ttgctgcagg gttttgagcg ccgcttcctg
      121 gcggtgcgca cactgcgctc cttcccctgg cagagcttag aggcaaagtt aagagactca
      181 tcagattctg agctgctgcg ggatattttg cagaagactg tgaggcatcc tgtgtgtgtg
      241 aagcacccgc cgtcagtcaa gtatgcctgg tgctttctct cagaactcat caaaaagcac
      301 gaggctgtcc acacggagcc tttggacaaa ctgtacgagg tgctcgcgga gactctgatg
      361 gccaaggagt ccacccaggg ccaccggagc tatttgctgt cctcaggagg ctcagtcaca
      421 ctctccaaga gcacagccat catctcccac ggtaccacag gcctggtcac atgggatgcc
      481 gccctctacc ttgcagaatg ggccatcgag aacccggcag ccttcattaa caggactgtc
      541 ctagagcttg gcagtggtgc cggcctcaca ggccttgcca tctgcaagat gtgccgcccc
      601 cgggcataca tcttcagcga ccctcacagc cggatcctcg agcagctccg agggaatgtc
      661 cttctcaatg gcctctcatt agaggcagac atcactggca acttagacag ccccagggtg
      721 acagtggccc agctggactg ggacgtagca atggtccatc agctctctgc cttccagcca
      781 gatgttgtca ttgcagcaga cgtgctgtat tgcccagaag ccatcgtgtc gctggtcggg
      841 gtcctgcaga ggctggctgc ctgccgggag cacaagcggg ctcctgaggt ctacgtggcc
      901 tttaccgtcc gcaacccaga gacatgccag ctgttcacca ccgagctagg ccgggatggg
      961 atcagatggg aagcggaagc tcatcatgac cagaaactgt ttccctatgg agagcacttg
     1021 gagatggcaa tgctgaacct cacactgtag gactcacaca tgactccaaa gggattgtga
     1081 gaatcaagtc actctcgtgg gaagaatttt tatatgggaa agtggataaa actttcattg
     1141 gactggaatg tttggagatt attaaactcc aaatcaggaa tcaaaactgc cctctaataa
     1201 gacattagct gtctaggcgt gtgggtgccc cctttctgcc agcagttctg gttctcaaga
     1261 aaatcatcat aaatcagaca tgaaaattct agctccaaaa atagcatttt ctttctgcaa
     1321 ataaaaacgt gtgtatcaag gatgacgttc ccccaacgtg gacacactca gttcctcaga
     1381 aagccaagcc cgctgcagct gccacatccc tggacacact cggttcctca caaagccaag
     1441 cccgctgcag ctgccacatc cctggacaca ctcggttcct cacaaagcca agcccgctgc
     1501 agctgccaca tccctggaca cactcggttc ctcacaaagc caagcccgct gcagctgcca
     1561 catcccaggg cttatggtgc agcaggcgct tttttcaaga caggaatgaa agtgttagga
     1621 acacggcaga aaggtgacac ctggagacca aatgcaggat gaggagtact gcagaggtca
     1681 cagggaagtc acagaacagt aatacgctag caggggcatg gggcatgaag aacagaagac
     1741 aggaagcatt tcagagactc caaagaagaa atcagggcca accacagctt cccgggtcat
     1801 tcaccaggtg acaccactgc cgtcatttca gcttctggcc actgggaggc gctgctcgaa
     1861 aggctttgcc ctgagacccc aagaagctgc gggaaggaca gcaggggccc tggggtttta
     1921 gcctctggcc caggagttat gtgtccataa ccaaagggag cacagtctgc acccagctct
     1981 catcccatca gagctgctga gactcttgca ggttcttcca gaactggttt agcttgcctg
     2041 caggatcaga aaagtttgag aaaagcatct gcaaaatgct aaagagcaga gcttaactca
     2101 ttgcctgtcc ccaccccatc ccaggtcacc acttggctga ccccaggtcc ccgacccaac
     2161 aacaacccct cccaagtccc taactccctc acttggactt gagacccttc acaacccagc
     2221 agcgctccac ctccaacttg acatcatgct ttctggaaac ttccccgtat gtcccacttt
     2281 cccacacttg gtgccctgga gcaccttccg gcctctacat gctgtacgtt cccctgtgag
     2341 caccctcctc tcggcctctg gccaacacag tcccacccat ctgtgggtaa caagggggtg
     2401 tgggtgttct tttcagcctt gctaaactgt ctgaatcaag gatcacaaac tacagcctgc
     2461 aggccaaatc cagcccacag cctgtgtttg taaataaagc tttgttggaa caaagcca
//
