LOCUS       NM_001083537            2403 bp    mRNA    linear   PRI 26-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 86 member B1
            (gene/pseudogene) (FAM86B1), transcript variant 1, mRNA.
ACCESSION   NM_001083537
VERSION     NM_001083537.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   Dale,G., Bonham,J.R., Lowdon,P., Wagget,J., Rangecroft,L. and
            Scott,D.J.
  TITLE     Diagnostic value of rectal mucosal acetylcholinesterase levels in
            Hirschsprung's disease
  JOURNAL   Lancet 1 (8112), 347-349 (1979)
   PUBMED   85002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145124.3.
            
            On Dec 30, 2020 this sequence version replaced NM_001083537.3.
            
            Sequence Note:.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support and it is therefore inferred, but it is
            supported by the full-length paralogous transcript AY037162.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448228.7/ ENSP00000407067.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC145124.3         25455-25562         c
            109-171             AC145124.3         23259-23321         c
            172-252             AC145124.3         21288-21368         c
            253-386             AC145124.3         18180-18313         c
            387-652             AC145124.3         17832-18097         c
            653-802             AC145124.3         16856-17005         c
            803-2403            AC145124.3         13586-15186         c
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..2403
                     /gene="FAM86B1"
                     /note="family with sequence similarity 86 member B1
                     (gene/pseudogene)"
                     /db_xref="GeneID:85002"
                     /db_xref="HGNC:HGNC:28268"
                     /db_xref="MIM:616122"
     exon            1..108
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..903
                     /gene="FAM86B1"
                     /note="protein FAM86B1; family with sequence similarity
                     86, member B1"
                     /codon_start=1
                     /product="putative protein N-methyltransferase FAM86B1"
                     /protein_id="NP_001077006.1"
                     /db_xref="CCDS:CCDS59512.1"
                     /db_xref="GeneID:85002"
                     /db_xref="HGNC:HGNC:28268"
                     /db_xref="MIM:616122"
                     /translation="MAPEENAGTELLLQGFERRFLAVRTLRSFPWQSLEAKLRDSSDS
                     ELLRDILQKTVRHPVCVKHPPSVKYAWCFLSELIKKSSGGSVTLSKSTAIISHGTTGL
                     VTWDAALYLAEWAIENPAAFINRTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVL
                     EQLRGNVLLNGLSLEADITGNLDSPRVTVAQLDWDVAMVHQLSAFQPDVVIAADVLYC
                     PEAIVSLVGVLQRLAACREHKRAPEVYVAFTVRNPETCQLFTTELGRDGIRWEAEAHH
                     DQKLFPYGEHLEMAMLNLTL"
     exon            109..171
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..252
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..386
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..652
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..802
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..2403
                     /gene="FAM86B1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM86B1"
                     /note="hexamer: AATAAA"
     polyA_site      2403
                     /gene="FAM86B1"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcccacg ttatggcgcc cgaggagaac gcggggaccg aactcttgct gcagggtttt
       61 gagcgccgct tcctggcggt gcgcacactg cgctccttcc cctggcagag cttagaggca
      121 aagttaagag actcatcaga ttctgagctg ctgcgggata ttttgcagaa gactgtgagg
      181 catcctgtgt gtgtgaagca cccgccgtca gtcaagtatg cctggtgctt tctctcagaa
      241 ctcatcaaaa agtcctcagg aggctcagtc acactctcca agagcacagc catcatctcc
      301 cacggtacca caggcctggt cacatgggat gccgccctct accttgcaga atgggccatc
      361 gagaacccgg cagccttcat taacaggact gtcctagagc ttggcagtgg tgccggcctc
      421 acaggccttg ccatctgcaa gatgtgccgc ccccgggcat acatcttcag cgaccctcac
      481 agccgggtcc tcgagcagct ccgagggaat gtccttctca atggcctctc attagaggca
      541 gacatcactg gcaacttaga cagccccagg gtgacagtgg cccagctgga ctgggacgta
      601 gcaatggtcc atcagctctc tgccttccag ccagatgttg tcattgcagc agacgtgctg
      661 tattgcccag aagccatcgt gtcgctggtc ggggtcctgc agaggctggc tgcctgccgg
      721 gagcacaagc gggctcctga ggtctacgtg gcctttaccg tccgcaaccc agagacgtgc
      781 cagctgttca ccaccgagct aggccgggat gggatcagat gggaagcgga agctcatcat
      841 gaccagaaac tgtttcccta tggagagcac ttggagatgg caatgctgaa cctcacactg
      901 taggactcac acatgactcc aaagggattg tgagaatcaa gtcactctcg tgggaagaat
      961 ttttatatgg gaaagtggat aaaactttca ttggactgga atgtttggag attattaaac
     1021 tccaaatcag gaatcaaaac tgccctctaa taagacatta gctgtctagg cgtgtgggtg
     1081 ccccctttct gccagcagtt ctggttctca agaaaatcat cataaatcag acatgaaaat
     1141 tctagctcca aaaatagcat tttctttctg caaataaaaa cgtgtgtatc aaggatgacg
     1201 ttcccccaac gtggacacac tcggttcctc agaaagccaa gcccgctgca gctgccacat
     1261 ccctggacac actcggttcc tcacaaagcc aagcccgctg cagctgccac atccctggac
     1321 acactcggtt cctcacaaag ccaagcccgc tgcagctgcc acatccctgg acacactcgg
     1381 ttcctcacaa agccaagccc gctgcagctg ccacatccca gggcttatgg tgcagcaggc
     1441 gcttttttca agacaggaat gaaagtgtta ggaacacggc agaaaggtga cacctggaga
     1501 ccaaatgcag gatgaggagt actgcagagg tcacagggaa gtcacagaac agtaatacgc
     1561 tagcaggggc atggggcatg aagaacagaa gacaggaagc atttcagaga ctccaaagaa
     1621 gaaatcaggg ccaaccacag cttcccgggt cattcaccag gtgacaccac tgccgtcatt
     1681 tcagcttctg gccactggga ggcgctgctc gaaaggcttt gccctgagac tccaagaagc
     1741 tgcgggaagg acagcagggg ccctggggtt ttagcctctg gcccaggagt tatgtgtcca
     1801 taaccaaagg gagcacagtc tgcacccagc tctcatccca tcagagctgc tgagactctt
     1861 gcaggttctt ccagaactgg cttagcttgc ctgcaggatc agaaaagttt gagaaaagca
     1921 tctgcaaaat gctaaagagc agagcttaac tcattgcctg tccccacccc atcccaggtc
     1981 accacttgga tgaccccagg tccccgaccc aacaacaacc cctcccaagt ccctaactcc
     2041 ctcacttgga cttgagaccc ttcacaaccc ccctcacttg gacttgagac ccttcacaac
     2101 ccagcagcgc tccacttcca acttgacatc atgctttctg gaaacttccc cgtatgtccc
     2161 actttcccac acttggtgcc ctggagcacc ttccggcctc tacatgctgt acgttcccct
     2221 gtgagcaccc tcctctcggc ctctggccaa cacagtccca cccatctgtg ggtaacaagg
     2281 gggtgtgggt gttcttttca gccttgctaa actgtctgaa tcaaggatca caaactacag
     2341 cctgcaggcc aaatccagcc cacagcctgt gtttgtaaat aaagctttgt tggaacaaag
     2401 cca
//
