LOCUS       NM_001039999            5226 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member G (FAM83G),
            mRNA.
ACCESSION   NM_001039999 XM_930369
VERSION     NM_001039999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5226)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5226)
  AUTHORS   Liu,C., Huang,X.Y. and Huang,Y.
  TITLE     FAM83G promotes proliferation, invasion, and metastasis by
            regulating PI3K/AKT signaling in hepatocellular carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 567, 63-71 (2021)
   PUBMED   34144502
  REMARK    GeneRIF: FAM83G promotes proliferation, invasion, and metastasis by
            regulating PI3K/AKT signaling in hepatocellular carcinoma cells.
REFERENCE   3  (bases 1 to 5226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5226)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 5226)
  AUTHORS   Okada,J., Sunaga,N., Yamada,E., Saito,T., Ozawa,A., Nakajima,Y.,
            Okada,K., Pessin,J.E., Okada,S. and Yamada,M.
  TITLE     FAM83G Is a Novel Inducer of Apoptosis
  JOURNAL   Molecules 25 (12), 2810 (2020)
   PUBMED   32570757
  REMARK    GeneRIF: FAM83G Is a Novel Inducer of Apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5226)
  AUTHORS   Vogt,J., Dingwell,K.S., Herhaus,L., Gourlay,R., Macartney,T.,
            Campbell,D., Smith,J.C. and Sapkota,G.P.
  TITLE     Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for
            type I bone morphogenetic protein receptors and modulates bone
            morphogenetic protein signalling
  JOURNAL   Open Biol 4 (2), 130210 (2014)
   PUBMED   24554596
  REMARK    GeneRIF: PAWS1 regulates the expression of some SMAD4-independent
            BMP target genes as well as some BMP-independent genes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5226)
  AUTHORS   Radden,L.A. 2nd, Child,K.M., Adkins,E.B., Spacek,D.V.,
            Feliciano,A.M. and King,T.R.
  TITLE     The wooly mutation (wly) on mouse chromosome 11 is associated with
            a genetic defect in Fam83g
  JOURNAL   BMC Res Notes 6, 189 (2013)
   PUBMED   23656696
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5226)
  AUTHORS   Varjosalo,M., Sacco,R., Stukalov,A., van Drogen,A., Planyavsky,M.,
            Hauri,S., Aebersold,R., Bennett,K.L., Colinge,J., Gstaiger,M. and
            Superti-Furga,G.
  TITLE     Interlaboratory reproducibility of large-scale human
            protein-complex analysis by standardized AP-MS
  JOURNAL   Nat Methods 10 (4), 307-314 (2013)
   PUBMED   23455922
REFERENCE   9  (bases 1 to 5226)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 5226)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090286.16, CF138357.1, CN370352.1, DN831927.1, BX365956.2,
            BX402942.2, DY655105.1, CX165458.1 and CR735308.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039999.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388995.11/ ENSP00000373647.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC090286.16        165-181
            18-249              CF138357.1         65-296
            250-890             CN370352.1         1-641
            891-1155            DN831927.1         255-519
            1156-1636           BX365956.2         228-708
            1637-2170           BX402942.2         334-867
            2171-2378           DY655105.1         224-431
            2379-2912           CX165458.1         149-682
            2913-2947           CR735308.1         455-489
            2948-5226           AC090286.16        33862-36140
FEATURES             Location/Qualifiers
     source          1..5226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..5226
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /note="family with sequence similarity 83 member G"
                     /db_xref="GeneID:644815"
                     /db_xref="HGNC:HGNC:32554"
                     /db_xref="MIM:615886"
     exon            1..56
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..706
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2656
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /note="protein associated with SMAD1"
                     /codon_start=1
                     /product="protein FAM83G"
                     /protein_id="NP_001035088.2"
                     /db_xref="CCDS:CCDS42276.1"
                     /db_xref="GeneID:644815"
                     /db_xref="HGNC:HGNC:32554"
                     /db_xref="MIM:615886"
                     /translation="MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRD
                     AFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEAS
                     GADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAH
                     IKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHM
                     CERACMHLGHLKNLRVRSSGGTEFFTRSATKFKGALAQKFMFVDGDRAVCGSYSFTWS
                     AARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGIPMEKEPEPEPIVLPSVVPL
                     VPAGTVAKKLVNPKYALVKAKSVDEIAKISSEKQEAKKPLGLKGPALAEHPGELPELL
                     PPIHPGLLHLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPSQMNRIKIR
                     DTSQASAQHQLWKQSQDSRPRPEPCPPPEPSAPQDGVPAENGLPQGDPEPLPPVPKPR
                     TVPVADVLARDSSDIGWVLELPKEEAPQNGTDHRLPRMAGPGHAPLQRQLSVTQDDPE
                     SLGVGLPNGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVRE
                     HSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKR
                     MQAQRSTDKEAQGQQFHHHRVPASGTRDKDGFPGPPRYRSAADSVQSSTRNAGPAMAG
                     PHHWQAKGGQVPRLLPDPGSPRLAQNARPMTDGRATEEHPSPFGIPYSKLSQSKHLKA
                     RTGGSQWASSDSKRRAQAPRDRKDP"
     exon            707..874
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..999
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..2266
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..5226
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5192..5197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /note="hexamer: AATAAA"
     polyA_site      5226
                     /gene="FAM83G"
                     /gene_synonym="PAWS1"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgccgc cgccgcagcc gccgcgtgtg cgccccgctc cgccagcgcc cgctcgattg
       61 ctcatgggca gagaagcaga ggccgcggag aggcccccga gcgcgcggtg ccccagctgg
      121 gccggagcta ggagctggac cttgcccacc cacccccggc agcagtgccc gggcaggcgg
      181 cgccatggcc ttctctcagg tgcagtgtct ggacgacaac catgtgaact ggcgctccag
      241 cgagtccaag cctgagttct tctacagcga ggagcagcgg ctggcgctgg aggccctggt
      301 ggcccgcggc cgggacgcct tctacgaggt gctcaagcgg gagaacatcc gagacttcct
      361 ctcggagctg gagctcaagc gcatcctgga gaccatcgag gtgtacgacc cgggctctga
      421 ggaccctcgg ggcacgggcc cctctcaggg gcccgaggac aatggggtcg gcgacggcga
      481 ggaagccagc ggggcggatg gggtccccat cgaggccgag ccgctgccct ccctggagta
      541 ctggccccag aagtcggacc gctccatccc gcagctggac ctgggctggc ccgacaccat
      601 cgcctaccgc ggcgtgaccc gggctagcgt ctacatgcag ccccccatag acgggcaggc
      661 ccacatcaaa gaggtggtgc ggaagatgat cagccaggca cagaaggtga tagctgtggt
      721 catggacatg ttcaccgacg tggacatctt caaggacctg ctggacgccg gcttcaagag
      781 gaaagtggcc gtgtacatca tcgtggatga gagtaacgtc aagtacttcc tgcacatgtg
      841 tgagcgggcc tgcatgcacc tggggcacct caagaatctc agagtgcgga gcagcggggg
      901 aactgagttc ttcacgcggt cggcaaccaa gttcaagggt gccctggccc agaagttcat
      961 gtttgtggat ggagaccggg ctgtgtgcgg ctcctacagc ttcacgtggt cggccgcgcg
     1021 gacggaccgg aatgtgatct ctgtgctgtc tggccaggtg gtggagatgt ttgaccggca
     1081 gttccaggag ctgtacctca tgtcacacag tgtgagcctc aagggcatcc ctatggagaa
     1141 ggaaccggag ccggagccta ttgtgctgcc ctctgtggtc cccctggtgc ccgcgggcac
     1201 tgtggccaag aagctcgtca accccaagta cgcacttgtc aaggccaaga gcgtcgacga
     1261 gattgccaag atctcctctg agaagcagga ggccaagaag cccctggggc tgaaaggccc
     1321 agcgctggct gagcatccag gggaactccc cgagctgctg ccacccatcc acccaggact
     1381 gcttcacctg gagagggcca acatgtttga gtacctgccc acgtgggtgg agccagaccc
     1441 ggagcctggc agcgacatcc tgggctacat caatatcatc gaccccaaca tctggaaccc
     1501 ccagcccagc cagatgaacc gcatcaagat ccgtgacacc tcccaggcca gcgcccagca
     1561 ccagctgtgg aagcagagcc aggacagcag gccccgtcca gagccttgcc ctcccccaga
     1621 gcccagtgcc ccccaggacg gtgtcccagc tgagaacggc ctcccccagg gggaccctga
     1681 gccattgccc cccgtgccca agccccggac agtccctgtg gcagatgtac tagcccggga
     1741 cagcagtgat attggctggg tcctggagct ccccaaagag gaagctcccc agaatgggac
     1801 agaccatagg ctacccagga tggcaggccc aggccacgcc ccactccagc ggcagctatc
     1861 tgtgacccag gatgaccccg agagcctcgg ggtggggctc cccaatgggc tggatggggt
     1921 ggaagaagaa gatgatgacg actacgtaac cctcagtgac caggacagcc actcaggcag
     1981 ctccggccgt ggccctggcc cccgacggcc ctcagtggct tcctctgtgt cagaggagta
     2041 cttcgaggtg agagagcact cagtccctct ccggaggcgc cactcagagc aagtggccaa
     2101 cgggccaacc ccaccaccgc gccggcagct gagtgccccc catataaccc gagggacctt
     2161 tgttggaccc cagggtggct ccccatgggc ccagagtcgg ggaagagaag aagcagatgc
     2221 gttgaagagg atgcaggccc agcgctccac agacaaggag gcacagggcc agcagtttca
     2281 tcatcacagg gtccctgcct cagggactag ggataaagac ggcttcccag gaccccctag
     2341 gtaccgctct gctgctgaca gcgtccagag ctctaccaga aacgctggcc cagccatggc
     2401 tggcccccac cactggcagg ccaagggagg tcaggtaccc cgcctgcttc cggatcccgg
     2461 cagcccaaga ctggcccaaa atgcccgccc catgaccgat ggcagggcca ccgaggagca
     2521 tccgagtccc ttcggaatcc catactccaa actgtctcag tcgaagcacc taaaggccag
     2581 gacgggcggt agccagtggg cctcatcgga ttctaaacgg agggctcaag ccccccggga
     2641 ccgcaaagac ccctagcagc atgtcccagc ctggagccac accttctgag gccccagccc
     2701 agactcatga cgcggagggc agacaggccg cctgggccta ccagagccca ctgggacggc
     2761 aggaaggtgg gatgggcggg agacgttggc actcacctgg tcggtgcacc agtaccaggt
     2821 ggccatgatg gtcaggccaa aggtcatccc ggtccacggc aggtcccctg tgtgggggtc
     2881 tcgaaacatg tgcatggcgt ctgtacgtgg caggtggcag gtggtgttgg caatggtcct
     2941 ggagggaatg gcctgggcgt aggctgcctc cagctgcccg taaccaccga tctggtcaaa
     3001 agctggaggg gtcagggtgg aacagggaca gtttggtggt tgcggggccc tgactccctg
     3061 ggctcccccc tgccttcatc tcacaagaaa cttcctgatg catcaaactt gagttttttc
     3121 cacctcatct ttcccagtgt ttggaaaggt gtgagggtag agggttgttt ttttttttaa
     3181 ggtgtatttg aatgactatt ttattcgtat ttaaaataat actattaagt aagcattttg
     3241 cacatgggca ccccagtgtc ccgctggccc agcaggagtc actgttggcc tctggacact
     3301 catcggcctt gggcaagtgg ttctcagcca ggtttccgat tgtcgattca aggaagcaaa
     3361 agtaattttt cttgacattt gaggaccttc ctgaggcttc taaagtgttc atcctgatca
     3421 cctgaagggt gtgattttag cagagctgag agtggctggt ggtgatgtgg ccccaccccc
     3481 tgaggcacag agaagaggga gacaggtcca gagagggatg gggcctccac caagaccata
     3541 tagaccatct ggcgggctca agccggggct ttttcctctc cagtccaaaa cacctcactg
     3601 ttcctgtcta cctcggggtc agggcccggc atggccaagc cctggcccat ctgtgtctgt
     3661 gtcactcccc tcccttccag actgggcctg gctgctggga tccctctcat gcggtgggtc
     3721 ccagggacac tagagcccct ggtctgagag ggagaagcct ggatgtagga aaacccgttt
     3781 ccaccccagg ccctactccc tagccttttc caagtgggac atggaagagg cagcctgctg
     3841 cctggatgct ggtctcccca gcatcactgt tcccatggag ctcaggtcag gctctgtatt
     3901 cagaccgagg gtttgtgtga ggctcagagc aaatgaacaa gtgccattca agggttagaa
     3961 actgctcagc cacagggtcc cagtgtctga gtctggaaga gtctttagag atttgttcac
     4021 tctctgaggg atcctcctgg ctctgcttac atacttccag ggacggtgag ctcacgctct
     4081 ctccgggcag ccctgtgagt ttcctatctg ttccagacta gtatcgccaa tctctcccag
     4141 ctctcttctt tcctccctgg cctttgtcct gcaggaggta gcatcacctc ttggcatttt
     4201 gtacatgctt ttaaacaatt ggaggagctg cccaggcagt tttatggcct cctggttgtg
     4261 tgccttcaca cccgcctaca gccccacctc accatcaagc gctgagccaa tgcgggtgtg
     4321 gctggccctg agttcctgag tcagctcctt gccagggcca gagctggtaa cagcggggca
     4381 gcagggtggg tagcctctac cagccagggc agtccctgag gggccagcag gggggctgac
     4441 tgcctagtgg ctcaacctcc tgaacccacc cactcccagc gatgctaccc agaaccccaa
     4501 cggcatgaat cctgcacagt gccgggcagt gccagactcc aaagggctcg ctgtggggac
     4561 agccccgcca tggccacaga ctctgtcctc acctttgatt gtcaggatga cagcccccac
     4621 caccatgatg agcgtctgca gggcgtccgt gtagattaca gcagccaggc cccctgccag
     4681 tggaagcaag gttgctggag ggggccctgg ccccagggag gagggacacg gggaggaact
     4741 tctggggctc ctgctggggc cacttcctgg gctgctccct cgggcctgta gggggaggtg
     4801 gccttctgac ccctttacac gtcccctggg tggacctccc tgctgcaggc accatacctg
     4861 cgatggtgta cagggctgtg atgccgagcg tgaggatggt ggagaggtag aagttccagc
     4921 ccaggcagat gtgcacaaac agagcccccg cgtacaggtc cagctgcgga gggagagagc
     4981 cttgtgtggg actgttattc ccagggctcc agcaagccac tccctgggtg acctcgggca
     5041 aggccctctc tgggcctcgg tggcctgtgg ataaggaggg gagaccccca ctcgcctgcc
     5101 tgcctgcatc acggggccat tgtgaggttg ggggaagacc tggccgtgga gctacaagct
     5161 tgtgcggatg tcaggggaca ttactgttgc taataaagtc caaagtggcc aatgcctttc
     5221 ccaaaa
//
