LOCUS       NM_138435              15561 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member F (FAM83F),
            mRNA.
ACCESSION   NM_138435
VERSION     NM_138435.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15561)
  AUTHORS   Tai,G., Zhang,M. and Liu,F.
  TITLE     Circ_0000735 enhances the proliferation, metastasis and glycolysis
            of non-small cell lung cancer by regulating the miR-635/FAM83F axis
  JOURNAL   Exp Lung Res 47 (3), 136-148 (2021)
   PUBMED   33560141
  REMARK    GeneRIF: Circ_0000735 enhances the proliferation, metastasis and
            glycolysis of non-small cell lung cancer by regulating the
            miR-635/FAM83F axis.
REFERENCE   2  (bases 1 to 15561)
  AUTHORS   Dunbar,K., Jones,R.A., Dingwell,K., Macartney,T.J., Smith,J.C. and
            Sapkota,G.P.
  TITLE     FAM83F regulates canonical Wnt signalling through an interaction
            with CK1alpha
  JOURNAL   Life Sci Alliance 4 (2), e202000805 (2020)
   PUBMED   33361109
  REMARK    GeneRIF: FAM83F regulates canonical Wnt signalling through an
            interaction with CK1alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15561)
  AUTHORS   Fan,G., Xu,P. and Tu,P.
  TITLE     MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by
            targeting MYC and FAM83F
  JOURNAL   J Cell Biochem 121 (2), 1675-1689 (2020)
   PUBMED   31595558
  REMARK    GeneRIF: MiR-1827 functions as a tumor suppressor in lung
            adenocarcinoma by targeting MYC and FAM83F.
REFERENCE   4  (bases 1 to 15561)
  AUTHORS   Salama,M., Benitez-Riquelme,D., Elabd,S., Munoz,L., Zhang,P.,
            Glanemann,M., Mione,M.C., Goldin,R., Soussi,T., Davidson,G. and
            Blattner,C.
  TITLE     Fam83F induces p53 stabilisation and promotes its activity
  JOURNAL   Cell Death Differ 26 (10), 2125-2138 (2019)
   PUBMED   30692643
  REMARK    GeneRIF: Fam83F induces p53 stabilisation and promotes its
            activity.
REFERENCE   5  (bases 1 to 15561)
  AUTHORS   Fuziwara,C.S., Saito,K.C., Leoni,S.G., Waitzberg,A.F.L. and
            Kimura,E.T.
  TITLE     The Highly Expressed FAM83F Protein in Papillary Thyroid Cancer
            Exerts a Pro-Oncogenic Role in Thyroid Follicular Cells
  JOURNAL   Front Endocrinol (Lausanne) 10, 134 (2019)
   PUBMED   30881348
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15561)
  AUTHORS   Xu,L., Yu,Q.W., Fang,S.Q., Zheng,Y.K. and Qi,J.C.
  TITLE     MiR-650 inhibits the progression of glioma by targeting FAM83F
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (23), 8391-8398 (2018)
   PUBMED   30556880
  REMARK    GeneRIF: Low MiR-650 expression in glioma cells promotes tumor cell
            proliferation by up-regulating the expression of FAM83F.
REFERENCE   7  (bases 1 to 15561)
  AUTHORS   Gu,G.M., Zhan,Y.Y., Abuduwaili,K., Wang,X.L., Li,X.Q., Zhu,H.G. and
            Liu,C.L.
  TITLE     MiR-940 inhibits the progression of NSCLC by targeting FAM83F
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (18), 5964-5971 (2018)
   PUBMED   30280778
  REMARK    GeneRIF: Results show that FAM83F expression was distinctly
            upregulated in non-small cell lung cancer (NSCLC) tissues. MiR-940
            inhibited the proliferation of cancer cells by targeting FAM83F and
            further restrained the progression of NSCLC.
REFERENCE   8  (bases 1 to 15561)
  AUTHORS   Fulcher,L.J., Bozatzi,P., Tachie-Menson,T., Wu,K.Z.L.,
            Cummins,T.D., Bufton,J.C., Pinkas,D.M., Dunbar,K., Shrestha,S.,
            Wood,N.T., Weidlich,S., Macartney,T.J., Varghese,J., Gourlay,R.,
            Campbell,D.G., Dingwell,K.S., Smith,J.C., Bullock,A.N. and
            Sapkota,G.P.
  TITLE     The DUF1669 domain of FAM83 family proteins anchor casein kinase 1
            isoforms
  JOURNAL   Sci Signal 11 (531) (2018)
   PUBMED   29789297
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 15561)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z82206.1, Z83847.1 and KF457465.1.
            
            On May 21, 2019 this sequence version replaced NM_138435.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031099.1, DRR138519.539227.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333407.11/ ENSP00000330432.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-578               Z82206.1           140456-141033
            579-746             Z83847.1           21027-21194
            747-868             Z83847.1           21746-21867
            869-1542            Z83847.1           23149-23822
            1543-3517           Z83847.1           31375-33349
            3518-3830           KF457465.1         1-313
            3831-15561          Z83847.1           33663-45393
FEATURES             Location/Qualifiers
     source          1..15561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..15561
                     /gene="FAM83F"
                     /note="family with sequence similarity 83 member F"
                     /db_xref="GeneID:113828"
                     /db_xref="HGNC:HGNC:25148"
     exon            1..578
                     /gene="FAM83F"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1592
                     /gene="FAM83F"
                     /codon_start=1
                     /product="protein FAM83F"
                     /protein_id="NP_612444.2"
                     /db_xref="CCDS:CCDS14000.2"
                     /db_xref="GeneID:113828"
                     /db_xref="HGNC:HGNC:25148"
                     /translation="MAESQLNCLDEAHVNEKVTEAQAAFYYCERRRAALEALLGGGEQ
                     AYRERLKEEQLRDFLSSPERQALRAAWSPYEDAVPAANARGKSKAKAKAPAPAPAESG
                     ESLAYWPDRSDTEVPPLDLGWTDTGFYRGVSRVTLFTHPPKDEKAPHLKQVVRQMIQQ
                     AQKVIAVVMDLFTDGDIFQDIVDAACKRRVPVYIILDEAGVKYFLEMCQDLQLTDFRI
                     RNIRVRSVTGVGFYMPMGRIKGTLSSRFLMVDGDKVATGSYRFTWSSSHVDRNLLLLL
                     TGQNVEPFDTEFRELYAISEEVDLYRQLSLAGRVGLHYSSTVARKLINPKYALVSGCR
                     HPPGEMMRWAARQQREAGGNPEGQEEGASGGESAWRLESFLKDLVTVEQVLPPVEPIP
                     LGELSQKDGRMVSHMHRDLKPKSREAPSRNGMGEAARGEAAPARRFSSRLFSRRAKRP
                     AAPNGMASSVSTETSEVEFLTGKRPNENSSADISGKTSPSSAKPSNCVIS"
     exon            579..746
                     /gene="FAM83F"
                     /inference="alignment:Splign:2.1.0"
     exon            747..868
                     /gene="FAM83F"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1542
                     /gene="FAM83F"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..15561
                     /gene="FAM83F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8531..8536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83F"
                     /note="hexamer: AATAAA"
     polyA_site      8558
                     /gene="FAM83F"
                     /note="major polyA site"
     regulatory      8579..8584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83F"
                     /note="hexamer: AATAAA"
     polyA_site      8600
                     /gene="FAM83F"
     regulatory      14685..14690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83F"
                     /note="hexamer: AGTAAA"
     polyA_site      14712
                     /gene="FAM83F"
     regulatory      15537..15542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83F"
                     /note="hexamer: AATAAA"
     polyA_site      15561
                     /gene="FAM83F"
ORIGIN      
        1 gccccgcccc tcggcggctc caggtgcggc tgtgggacct cggaccgcgg cggggccggg
       61 gccagggccg gggccggggc cggggcgcca tggccgagtc ccagctgaac tgcctggacg
      121 aggcgcacgt gaacgagaag gtgaccgagg cgcaggccgc cttctactac tgcgagcggc
      181 ggcgggccgc gctggaggcg ctgctgggcg gcggcgagca ggcctaccgc gagcggctca
      241 aggaggagca gctgcgggac ttcctctcca gcccggagcg ccaggccctg cgggccgcct
      301 ggagccccta cgaggacgcc gtccccgccg ccaacgcccg gggcaagagc aaggccaagg
      361 ccaaggcccc cgcgccggcg ccggctgagt ccggcgagtc cctggcctac tggcccgacc
      421 gttccgacac cgaggtgcct cctctggacc tgggctggac ggacactggt ttctaccgcg
      481 gcgtgagccg ggtcacgctc ttcacccacc cgcccaagga cgagaaggcg ccgcacctca
      541 agcaggtggt caggcagatg atccaacagg cccagaaggt cattgctgtg gtcatggacc
      601 tcttcactga tggtgatatc tttcaagaca ttgtggatgc tgcctgtaag cgccgggtcc
      661 cagtgtacat catcctggac gaggcaggag tgaagtattt cctggagatg tgtcaggacc
      721 tgcagctcac tgacttccgg attcggaaca tccgtgtccg ctctgtgaca ggcgtcggct
      781 tctacatgcc catggggagg atcaagggga ccctgtcatc aaggttcctg atggtggacg
      841 gtgacaaagt ggccactgga tcttacaggt tcacctggag ttcctcccat gtggacagaa
      901 acctcctcct gctcctgaca ggacagaacg tagagccctt tgacacggag ttccgggagc
      961 tgtacgccat ctccgaggag gtggacttgt accggcagct gagcctggcg ggcagggttg
     1021 gcctccatta ctcctccact gtggctcgaa agcttatcaa ccccaagtac gccttggtgt
     1081 caggctgccg ccacccgcct ggggagatga tgcgctgggc tgcccggcaa cagcgggagg
     1141 cgggcggcaa cccggagggg caggaggagg gcgccagcgg tggcgagtcg gcctggcgcc
     1201 tggagagctt cctgaaagac ctggttacgg tggagcaggt gctgcccccc gtggagccca
     1261 tccccttggg agagctgagc cagaaggatg gcaggatggt ctctcacatg cacagagacc
     1321 tgaagcccaa atcccgagag gcacccagcc gaaacggcat gggagaagcg gcccgggggg
     1381 aggccgcccc cgccaggcgc ttcagcagca ggctcttcag tcgccgagcc aagaggcctg
     1441 cggcgcccaa tggcatggcc agctctgtct ccaccgagac ctctgaagtg gagtttctga
     1501 cggggaagag gcccaacgag aattccagtg ctgacatctc aggtaaaaca agtcccagtt
     1561 ctgccaagcc tagcaactgt gtgatttcct gagctgcggg atggtggtgg gcaggacgtg
     1621 tggatgcctg cctgccctgc cctgtgctgt ggagagcgca ggtcgcacac tgcaccagtt
     1681 tgcacatcag acgccaactg gccttctgcc ctgcagcctc cgtcctggcc tcagggacgc
     1741 tggatcccaa atgagagggt ccgaagcatc tcagtcacac gcctccaccg gactgtcggt
     1801 ggctgggcag gggtcagtgc cacggcctcc ttgtttacat gaagtggaag cttgaccagt
     1861 gtctgctcgc ctttgtgccc caccccctcc gctgattgcc agatggggtg agggcccatt
     1921 ctttaaacct ttatggggtg gggtgtctgg ggcagctgca gtggcttctc ctttcccagg
     1981 cttcctggtg cttctggttc cccacgccac tccccaccca agagattggt ggaataaaag
     2041 ggaagagggc agggccctga gcctgggatc ccaagttcca gtctttctct agcctctgaa
     2101 ctccagatgt aaggtgcagc tggaactgca ggggcactgg ctgcagtggc cttcctggcc
     2161 ccatccctgc aggctcctga actagacttg aatgagggta agatcctgcg gcctcccgca
     2221 gtgggggcag aatttgacac tgcttttctg agagcgctcg cactgaggtc tctttttccc
     2281 tgcccagtgc cgtcctggca gtctcggcat gggtggttga gacctccttg gctgctgcct
     2341 gctgcgggcc tatgtggggg tccttacagg gcctttacct gggactgctc cttccctcag
     2401 tcagtaaact ttggtttaca gcccaaggca gggagggagc ttggctgaga ggggattggg
     2461 ggtgtgggag gctgggccct gaggacagga gcatttgcct tttctccctc aactctaacg
     2521 gggtcctcgg accccttcac caaccagggc ttccaggtta cactttggcc agactggcct
     2581 ttgcctcctg cgagagtcag gccattttta ggagcctgtg cctcgccaga gcaggtcagc
     2641 ctaatggcca tgaggctgag ctgggaggcc cagtaagcaa ttccattctg ccttccccac
     2701 ttgggtgact ggagagggcc gaggagagtt tgtgaatgga cctgggagaa attgccaaac
     2761 tgcagactct gtgagccggc cctgccggca gggcgatggg ggatccaagc cctgtggaag
     2821 agccatgcag cggactttct tgccctctga cctctgaacc aaactctcat cctctttctt
     2881 tccttctaaa aaaccctagg acactaccag cacctggggg aggggtacag atgtctgcaa
     2941 ggcagctgat gtgagagcaa gaaaaggggc tgctctggct gggctgtggg agccaggcat
     3001 tgcttctgag gaagcaggaa gtggggacca catgtggcgg ccattgagga gatgcaatct
     3061 ctctggcagt ggggagggga agggaaagga agggtgagcc tgtccccagg gtcttctctg
     3121 ttaatcccaa ggctggcttc tagggcgtgt ggagaaggga ctctggccca cctccctgag
     3181 cttttatgaa ggtgaaatgc ttctgggaag tgtttcctta ggcaccaaga ccaggcagtg
     3241 tggcatgagc tcattctgga ggggagggaa gggagagagg ggggaggtgg gatgtggggg
     3301 tgttacacct cagctcgagg cggacacctt gaaggtatgg gacatgaaat gtgtaaactg
     3361 caacgcggca aagagatcac tctctggtgt ggagggtggg tgtctctggg gattagggag
     3421 gcagcctggg gaagggaccg gcctccaagc aagtcagcca agggcatctg tgcctcccct
     3481 gccagaagag caggccctgc tttgtccctt tacctcctct aggcccaaag cacacccagg
     3541 tccctcccct gccctgacat ctaatctggg aggatccctg attggaatct ccaagtcacc
     3601 acagccttga gccaggcctt cctttctgcc tcagtttctc catgtgccaa gatggcgttt
     3661 ttcacacttt cttggtagaa atgatgggga gaccatatgt taggaagcaa gttggcatag
     3721 tgggaagagg gccagccaca aggcaggagt gcccaggcag ggtgcctctc cctgctggcc
     3781 tgtgtcctcg tccttatagc agtgtggaca agatggtgtc ggcacccccc gctccaaaag
     3841 gcttgagaca gaaactgtag tccgagatgg caaggatttt gaactcacaa aatgcagctc
     3901 ttcatgtttg cctgtctgcc taggcaccgg cccactctgt tctgcctctt ggcttctcag
     3961 ctgtgagtac gcctgccctc tgttccagca cttgcacata ctttgtgaag cagtctctta
     4021 ctcatcaaat ctcaagggta catctggccc tcccagttgg atggcaagtt caagggtgga
     4081 tcatgccctt ggtccctgca cagcagcttc tgcaaggctg gttacattgg aagggctcta
     4141 ggaggaacag gataaggcag cactctcggg gctggggtct ggcttcactg cacccccctc
     4201 ccaccccaca ccaccaccaa gctgctgtct ttctgagtca gcttctgtag ggtaagtgtt
     4261 cacagctggt gcagctcttt gggaaaccta acctcccagt gagctgagcc cctggtgcgg
     4321 ccgccacgct tgcttctgcc ccacaagggc agtaagcaca ggacttctgg atggatctgg
     4381 gagcctgccc cttgggattt ggcaaaactt cccatctcct tagctacctg tccttaatct
     4441 tatccctgac ccctcgaggg ctttcaagat agcctctgtt aacatcacta ccctctgcct
     4501 gtgtagaact ttatagaaag gctaggcaaa aaatgagacc cagagatatg gaagaaactg
     4561 gccaaagagg ggaaagtggg ctatttcttt tttttttttc tttttttttt ctgagacaga
     4621 gtctcaccct gttgcccagg ctggagtgca gtgacagcga tcttggctca ctgcaagctc
     4681 cgcctcccgg gttcacgcca ttcttctgcc tcagcctcct gagcagctat gactacaggt
     4741 gcccaccacc atgcctggct aattttttta tatttttatt agagacaggg tttcaccatg
     4801 ttagccaggt tggtcttgat ctcctgacct tgtgatccgc ccgccttggc ctcccaaagt
     4861 gctgggatta caggccaccg tacccggcca ggctattttt ttgttttgtt tttgtttact
     4921 actgtattgc ttttctcttt ttcatattta ttgagcacct actatatgcc agtcaccatg
     4981 ctagatgctt tagtaacatg aaggtttcaa actaagaaaa gctcaacaaa gagcccttta
     5041 gaaaggtaac agttttcctg tgtattgggg gagtgggtct cataaggttg tatgatgaga
     5101 agcgcaagta attgttttgt tttttttttg agacaatgtc ttgctctgtc gatcaggctg
     5161 gagtgcagtg gcgtcatctc agctcgctac aacctccacc tcctgggttt aagtgattct
     5221 ctggcctcag cctcctgagt agctgagatt acaggcacgc gccaccacgc ccggctaatt
     5281 tttgtatttt tagtagagac agggtttcac tatgttggtc aggctgatct tgaactcccg
     5341 gcctcaggtg atctgcctgc cttggcctcc caaactgctg ggattacagg catgagccac
     5401 cacgcccagc ctggctaagg ttcattatcc ccatctttca gatgaggagg cacacaactc
     5461 tccccagatc ccacgtcaca gagaatgcag gtctgagtct gttccttgag ctcagggtct
     5521 tggcaatggt gatgctttgg agctgcagaa tcctctgttg gggatggggc tgccctgtgc
     5581 attatagtac gtttagcaac atccctagct tccacctact aaatgccact agcactcctt
     5641 cagatgagac caccaaaaat gtctccagat gttaccacat gtcccctggg gggtaaaagt
     5701 gcccccgttg agagcactgg ctcttttctt cacagtcctg acctggtggc ctgcacaggc
     5761 cacttctccg aagtgtttca atgcactctc tgccctgggt accttggaca cagcaccctg
     5821 gcccagagag gttggctgac ttgcctgaga cgctgcttcc tgggagacgc agtagcatct
     5881 ttcctttctg ttctggttat ctttcttagt tctttaccac cttatattcc ccatgacagg
     5941 tgtgtttatg tacacacatc tgcctcactc cactcagctc cctgtcaggt ttcctgccag
     6001 tctgtccctc ttccttcagg ctcagctacg tcctgcacag acagtaccac tgcacatacc
     6061 tgtgtgtgcc cagcggtgga cccacctcca aaagcagcca gtgctgacag cagagagcct
     6121 tccacactca agtcaggcca agcaggaatc gctacctgcc tgtcatgacc acattctcag
     6181 tgaacattga caaagccccc ttagcagcta attagccctg ccgtgcgcta gggatgcaat
     6241 ttctcatctg gcagtgcgcc acactcctgc ctccctgccc aaaggacgta gtggctgctg
     6301 ctgatcgtct gcactgctgt tccaggggca ggaggtttgc tgcaaatcag gtacccccag
     6361 ctcagtgagc agaaccagtc caaggttgag tgaggagaag ggcaagaagg gcaggcacag
     6421 ccgtgagtat gttctggggc taagtaacca tgagatcagc ccagagacct tgcacagtta
     6481 ggcaggcctg gacttctcgc ccttcccctt gcagcttctg ctctcccagc tagggactga
     6541 ggaaagccct gcttctagat gccatgtgct gctgcctggc acgataggta cccatctgtc
     6601 cttggggttc ctgagcctgg agagcgggct ttgtgagcac tggtgcctca cctgcctggc
     6661 tcagctctgc agccacaata tatgcttaat acctatttgt taaatgattg aagacttgac
     6721 tgccattcag tacagagaat tagccaggtg aataaacagg atgtgtcata gaggttctag
     6781 aattgatcat gaccctttct gtctcattcc tgacttctaa taccgtatat gccaaatggg
     6841 gttctgctgt gatttaattt cttaaggact gggtttatca aaagtccctc ctgatctaat
     6901 cctttcctct aggaaggctt ctcctttctt catctgtcct aagtgcatgg tcttcatctc
     6961 ctgggtggtc cagactaggt ggcactgggc ctgcaggcct ctagctgctc aaggatggcc
     7021 ctgtctgcat gcttcctttc aaaagctagc atagaaagga gggcccaagg tgaggaaatt
     7081 tgtccaaagt cacccaatga gtcgcaggaa gggctagaat ctggttatct ggaccgtcct
     7141 agagcacttt cacagtgaca gccggctgga atcaagtttt catttagaaa aatggctaga
     7201 agttagggca ttgcctgcag ccactgaaaa gcagctttag gagcagatgt ccacgtaata
     7261 gaaggagatg ggctagggcc tgccacggaa gccagcaagc gcgtgggagc tgggggagga
     7321 aaggagcaaa aggcaagaac aggcagtatg tccgcggtgc ccacagtgct gtgggtacaa
     7381 gcaaggggaa aagagcccat ggtgtgcaga aaaccatgcg tcatgattct tatttcctgc
     7441 tcgcagcttt gactctctgc ctcatctctt cctggaagtg tcttggaagt taggcgactg
     7501 cacagggaaa ggttcgctgc agtgcttgca ggcctgcacc catttattca tccggtggat
     7561 atttgctggg tgcccggcct ggggatccat ggtgagcgag gaaggcatgg tattgaagtg
     7621 gtatgcctgc atgaccttgg cgggggcgca tggcatagag aggacaggct tcagaacagg
     7681 caggcaaggg ctgaaatcct atctctgcca ccgaacagct aatgacccca gcaagcaatt
     7741 tcacatcccc gaactttcct gtttcctcat gtgtcaaatg gggatgatct cgagacgact
     7801 ctccagagta accacgtgaa gcacctagca caggggctga cgcaaacagc tgggcatcgg
     7861 aggagcctcc agggttgtga cctccagtgg cttattttcc ttttgggatc ttctctccta
     7921 gatcctcccc tttaattccc tgtgaaattt accactttca tattgaatcg ttggcacaca
     7981 gggctaactg cttgttcacc tgaaggaagc tacagagttc aggtttcttt tttctttctt
     8041 tctttctttt ttgctttttt aagatgatct tgctccgtca cccaggctgg agtgcagtgg
     8101 cgtaatcatg gcttcctgca gcctcaaact cctgggctca atgagttcct tgagatcttc
     8161 catcctcagc ttcccaagta gctagtagta gtagtggctt gcaccaacgc tcctgcccta
     8221 attttcaata tttttttgta gagataggat ctcactgtgt tacccaagct agacttgaac
     8281 tcctggcctc aagcgatcct tccgccttgg cctcccaaag tgttgggatt acaggcatta
     8341 gctaccacac ctggccaagg cccaggtttc gacagaaagg gagagaaaac ctgccagaga
     8401 tgccatttcg gagccactct gcttggcagg gacctgtgtt cccctcatgc aggttcatcc
     8461 ttagagggct gcggtcttat ctggttgtgc aaaagtccca caacctttct ggattgatag
     8521 tttgtggtga aataaacaat tttagtttgt ttggagaatc ttttgtatac aaaatacaaa
     8581 taaaacctaa atcaaagaaa cagagcatgt ccggagaagt ctgccaaccc ttctccaggc
     8641 catggggctt cccaagccag gcctgtactc ctcatgtaga ttccacaccc cgccttgatg
     8701 tctttggctt tcacactagt gactatagcc tggtgggacg gggtctaggg gccacagtcc
     8761 tggtcctgcg caggtggccc tggagagaag ccttggagaa cttggagaag cccacgcggc
     8821 tggcagcatc atggtgagag gctgacacct tgtggctggc tggcagcata cgtccttcct
     8881 cccctaggtc agctagacgg ccaaagcagg gatctgcaag ctccttctgt ggcgggccaa
     8941 aaagtgaaca ttcagtgtgt ctgttgcagc tactgtcata gcactgaggc acccctagac
     9001 agtacagaaa caagcaggtg tggccatgtt ccagtgaaac cttatgaata ctgaaatctg
     9061 aatccataat tttcatgtat cacaaagtag taatattctt ttaatatgca aaaaccggcc
     9121 aggtgcggtg gctcatgcct gtgacctcag cactttggga ggccgaggtg ggtggatcac
     9181 ctgaggtcag gagttcgaaa ccagcctggc caacgtggtg aaaccctgtc tctattaaaa
     9241 atacaaaaat tagcctggtg tggtggcaca tgcctgtaat cccagctact cgggaggctg
     9301 aggcgtagga attgcttaaa cctgggaggc ggaggttgca gtgagctgag atcatgccac
     9361 tgcacttcag cctgggcaac agagctagac tccatctcaa aaacaaacaa acaaaaaaac
     9421 aaaagcaaaa accagtctta gctcacaggc tgtgccaaaa caggcagtgg gctggatttg
     9481 gtcctcaagc ctgggcttgc tgacctctgg cctaggacac ctctccttta tgcctccgct
     9541 cccaacacgg actctcaact ctcatgttta ccttgtcatt gttctgtcaa gaggaattca
     9601 ctagtctcac tcctccaacc agaccgctgc cactaaggct tcttctgaac agaaattctg
     9661 gatttgttct cacccatttc ataaatgtac ataagcaccc atcaggtgcc aagccctgtg
     9721 ctgagatgcc tgcagagccc agagttttca ccaacttttt ttttaagaga tgggggtctc
     9781 tgttgccagg ttggagtgca atgacataat cataactcac cgcaacctca aactcctagg
     9841 ttcaggtgat cctcccgcct cagcctccca agtagctggg actacaggca tgcaccaccc
     9901 tgcccagcta attaaaaaaa aaactttagg gatggggtct tgctatgttg tctaggctgg
     9961 tctctaactc ctgggctcaa gtgatcctcc cacctcagcc tcccaagtag ctgggcttac
    10021 agatgtgagc cactgcacct gctcaacatt taattttttc attcattcat tcgttcattc
    10081 atttgttcaa acgaacttat tgagaactta ctgtgttcca ggcactgtga taagatagac
    10141 ctggccttta ccttcaaatg ttcagaacat ggttaggaag atggatactg ggaggcaagt
    10201 gttctgatgg gaaagcacag catgtaaaga agcccagagg aggcacttaa cctgggggag
    10261 aagaacaggg taggcttcct ggaggaggag gtaatctctg agccgatacc tgaggagtga
    10321 atggaggagg ggacaatgag gcaaggcatt ccagggaaag gtccagagcc tagacagaac
    10381 tcttttagga gaattatgag aatcacaatt atcgaggaca cagtgaagac tcagataact
    10441 caaatatagg ttttgcccgc aaagccttcc tgtctggtgg gtgagacagt ctacagcaag
    10501 ctgctccaag gatatggaga aaaaagtttt tcctctggcc ttgtaggatt ggttattact
    10561 gagcctggag tacgcaaagg ccagcgagtg ctcctaaggc agggaggggg ctgccttcac
    10621 tatgggtgct caggaaatct gccaggggaa gggagatgtg ggcctgcctc ggctgcagaa
    10681 acccctcaga ggaggaggag gggcttgaac tgagctttga agaaagtgta gacttgggga
    10741 caggcagagg aagagggggc atcataggca gcagaaacca catggacaaa ctctctgccg
    10801 gagaatgggc atggccgggc tgaggggtcc ctggacagga accagccttc cctatgcacc
    10861 tgcacccgtg agtctcacaa cagccccaac aggcaagtgt tattttcctc aattctacca
    10921 attaaaaact gaccttgggc aactgcttaa cctatctctg ccttactttc ttcatctgta
    10981 tctacctcag aaagttacta tgaggactga ataagctcat acatatacaa tgcttggagc
    11041 agaggctggt actagagctg gcttcatggg catgaaacct gtgaacacag aaccccatgc
    11101 tttcattttc cacttagtcc tgcctggcat agtatgcagt ttttttaatt tgagatggag
    11161 tctccctttg ttgcccaggc ttgagtgcag tggcgcgatc tcagctcact gcaacctcca
    11221 cctcccaggt tgaagcagtt ctcctgcctc agcctcctga gtagctggga ttacaggtgc
    11281 gcgccaccat acccagctaa tttttgtatt tttagtagag atgaggtttt gccattttgg
    11341 ccagcctggt cttgaacctc tgacttccat gatccacctg cctctgcctc ccaaagtgct
    11401 gggaggatta caggcatgaa ccactacgcc tggcctggta tgtgggttaa aatgttaggt
    11461 tttatcatta tcttaggtgg agaataacaa atccgattca atatattcat tttagaaacg
    11521 aggaaactga agcttagata gtttgtgtga cttgcaaaaa gtcacgcagc aaacaagctg
    11581 cagaatgaag ggtggagatg gagagataga attctcatct tagaggtgaa agtaggataa
    11641 tgacccagct gagcttgctg agtcctgcga gcgtcgcacg cccccagaga caacataagg
    11701 agagaagtgc agacagattc ctttgaagga gcttagagaa agagatggta gggaaaagag
    11761 catgaacagt tgtagaggta ggaggaaagc tggctatttg gggaagcaaa gaaaagattc
    11821 tcagagtaaa acgtattggt gaagccatgg aaacaaggac tgagaaagtc tcttggatct
    11881 tggccacaaa aaggttatag atgagcttag agaaatgaat ttcagtagag ttagggctag
    11941 aagccaggtt cagagagaga aaacgagaga gcattcctgg tggtggagat ggccgcaggc
    12001 cattatttaa aaagctagga taagaaaata gagaagaaag ggaaggaagc tatttgaagg
    12061 gagtgggaga aaagccagat ctcagttggg acgtggagga aggaccacca gaggcagtaa
    12121 tttagccgga aagaggtgta tttctttcct tgagtttata gggggtaaag aggatggggc
    12181 tgagatacta aagactacga ggacaactgt tcattgaggg ctggtcatct ccccagctgc
    12241 actgtggggt tcccaagtca gacatcccag aggcaatata gcagcgtgga caagagctta
    12301 ctcgttggag tcagaccgcc taggttcaac gatgggttag ttagcccttc agtgcctcca
    12361 ttttcctatc tagaaaatgt ggataacaat ggttgttgtg aagattaaca gccataatcc
    12421 acgtaaagcc ctcagtacag tgtatgacac acagcaagtg tccaccaaag ggtagttatt
    12481 attaaccata atcctggttc tcttgtgagc tgcctcctgt gtgtctagca ttggccagca
    12541 cacatgaggg ggtccagtgt ttgctgctta actaagtagc ttctcaggaa gtgtggtcat
    12601 aaaaaatgat aggtgattta gaaggtgaga cagacacaag ggatgtgttg cacagtaaat
    12661 gctcccagac atgcaataaa tgcttataag catgccctct gtaatcagcc ctctttagag
    12721 agtttccctg cctcattgct cttggtcttt ggcaatggct acacccactg cccaagcaag
    12781 cagtatcagc tgtcagctgt ccccttgtct tttggatcag attcctttac agggatcttc
    12841 ccattgttat aagcttcaag aattggagaa tgcttaatga acacttccaa attcttcata
    12901 gctatgaggg gccagtgcaa agggcggaag gagttcttct gtgtcacaga aattagagct
    12961 ggagcagatc cagcttgcta tccccccttc ccccagcttg tgggttattg cagaattgtt
    13021 cacaaaaatt cccattgcct tggaatttgt ccaagccgag ggcagggatc acaacacaac
    13081 ctctcaaggg aaaaaaggaa ggcctgttgc ttgagatggc tcagagcact tttggtagcc
    13141 agccaaggca gctatcactc atgaaatctg ccttcccctc cagcaaaaag ccaactgtat
    13201 agaacaccac atatagagcg ctaagaatag cacagcgctc caagaacata gtgcacttgg
    13261 cctgcataca agtgtgcagg gcttaacgag tctttttact ctgaaagctg ggtgggttgg
    13321 aacaaacaaa cagaaaaata ttttccccaa gtagcatgca gagaggaaat gagagcaagc
    13381 acaagagagc accctggcat agcattctct gacctgggct gccttttcag ggtatgagtt
    13441 gattccgcag gcaccaaggc atgcctgtaa gccctacagg gcagacgccc tcaccccaat
    13501 cattggctta acattcacac caggctgagt aagccccaaa agtcctgcca ttggctctga
    13561 caggaattga aacccatctt ctccacaata aatatttgat tgacagattg gcttccttcc
    13621 tataagtata gaaagcgagg gcaggttcca tccaaagccg cagttctggg tgatgagagc
    13681 tctgagagcc cagaaaagac cctgaaccac atcccactgt ttgttggaag aagaaactca
    13741 tttgtgggtc tgttcataaa agagtctggg aagatagtct ccttaacagt gtctggatgt
    13801 aacagactat gggcggcttt tactttataa ctttctatat tgtctgaaat acagaatatt
    13861 aaatattgag ttaatattat atttactcaa tgttactttt tttttttttg agacagggtc
    13921 ttgctctatt gcccaggctg gagtgcagtg gtgtggctca ctgcagcctt gaactcccag
    13981 gctcaagcaa tcctcccacc tcagcatccc aagtagctgg gactgtaggc gcaggccacc
    14041 atgcgcaact atttattttc tttctttttg tagaaatggg ctctgcctgt gttgctctag
    14101 ctagtctcaa gctcctggcc tcaagcaatc cttccgcctt ggcctctcaa attgctggga
    14161 ttacaagcat aagccaatgt gcctggcctc aatgttactt ttatgatcag aaaaacggcc
    14221 atcttatttg gaaattattt tcctattctc aagtgggcaa ataggagaag gtttcaggca
    14281 tttgttttgt ctctgggagg gaaggcacaa tgaggtggag tggacaaatt gctgaggcct
    14341 ttatggacaa agattctaag aagaacaggc tttggccatc tctggatatt cccattctgc
    14401 tccctgccac cagagagcaa atgtcgtagg tcaccacaca tcaccagtct cttgcctagc
    14461 taaccgtaac tcattcttta gttctccttg aaggtgtcac ttcttccagg aagccatttc
    14521 tgtccctccc gagatggagt cccatgtccc taccatttgc ttccagggca ccttctcaca
    14581 gcactgcatc atggttatct gcttatctgc tggacacccc tactcgactg aggtccttga
    14641 aggaagagag agtgtatcac tcatctgcat agcctttgta acttagtaaa agtgcctgac
    14701 atgctcacta aacatttact gagtaattat ttatttgggg gccttttacg atcagaacaa
    14761 tgtgaaggac acaaagatga aaaagaaacc atctgcttca aggtacttac aactgaaatg
    14821 tatcaaacaa ttacccagaa agtcaagcac caacttaagt gctaaaatag gggtccaagc
    14881 aaccaacttt gaagattagg aaggttttag attctgaatg tttctcattc attgtgtttt
    14941 tgagttcaga atccccatac tggaaggcta atatggggta tgtgcataca attttaagga
    15001 ctcacgttct tacaacctat attagaattt gacgcacgat ctttcttctg tccttcttgc
    15061 agttgcccta ggaatacatg ccacttactc ttaattgacg tttatgaaat accttggctt
    15121 catttgctga aaggctctaa gtgttgagca ttgttactat gttacaatgg ttgttttatt
    15181 attaaagcag tgccaaggag gttacacaac agcttggatc aggaagtgaa acaagggcgg
    15241 tgatcccact gaagctacag gggatgggga tttgggacgg taaaatgtta attacccaag
    15301 atggaatgtg ggctagagtc cagcgttgtg ctcctggaga tcatttcggt cgcaaaagct
    15361 cactggcaat gggtcctaag cgtcctgccc tcctctggct gaaatgttgg attcacttcg
    15421 atgaatgctg ctatagggaa agaacccagt ggccaccagc caggagcaca cgtcttgctc
    15481 agcatcaact atcctggaag atttccagga gctgaagggc tgttctcttt gcatgcaata
    15541 aattattcat ttctaagacg a
//
