LOCUS       NM_017708               4112 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member E (FAM83E),
            mRNA.
ACCESSION   NM_017708
VERSION     NM_017708.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4112)
  AUTHORS   Fulcher,L.J., Bozatzi,P., Tachie-Menson,T., Wu,K.Z.L.,
            Cummins,T.D., Bufton,J.C., Pinkas,D.M., Dunbar,K., Shrestha,S.,
            Wood,N.T., Weidlich,S., Macartney,T.J., Varghese,J., Gourlay,R.,
            Campbell,D.G., Dingwell,K.S., Smith,J.C., Bullock,A.N. and
            Sapkota,G.P.
  TITLE     The DUF1669 domain of FAM83 family proteins anchor casein kinase 1
            isoforms
  JOURNAL   Sci Signal 11 (531) (2018)
   PUBMED   29789297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4112)
  AUTHORS   Cipriano,R., Miskimen,K.L., Bryson,B.L., Foy,C.R., Bartel,C.A. and
            Jackson,M.W.
  TITLE     Conserved oncogenic behavior of the FAM83 family regulates MAPK
            signaling in human cancer
  JOURNAL   Mol Cancer Res 12 (8), 1156-1165 (2014)
   PUBMED   24736947
REFERENCE   3  (bases 1 to 4112)
  AUTHORS   Liang,Y., Tang,W., Huang,T., Gao,Y., Tan,A., Yang,X., Zhang,H.,
            Hu,Y., Qin,X., Li,S., Zhang,S., Mo,L., Liang,Z., Shi,D., Huang,Z.,
            Guan,Y., Zhou,J., Winkler,C., O'Brien,S.J., Xu,J., Mo,Z. and
            Peng,T.
  TITLE     Genetic variations affecting serum carcinoembryonic antigen levels
            and status of regional lymph nodes in patients with sporadic
            colorectal cancer from Southern China
  JOURNAL   PLoS One 9 (6), e97923 (2014)
   PUBMED   24941225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4112)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4112)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 4112)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4112)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022154.4, DB209905.1, DB200401.1, BC111970.1, AC008403.8 and
            CD722642.1.
            
            On Jul 1, 2020 this sequence version replaced NM_017708.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2376543.1,
                                           SRR18074969.2535252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263266.4/ ENSP00000263266.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC022154.4         16381-16520         c
            141-467             DB209905.1         24-350
            468-842             DB200401.1         209-583
            843-1462            AC022154.4         14882-15501         c
            1463-1601           BC111970.1         1-139
            1602-1798           AC022154.4         14546-14742         c
            1799-2393           BC111970.1         337-931
            2394-2394           AC008403.8         187317-187317       c
            2395-3049           BC111970.1         933-1587
            3050-3473           CD722642.1         195-618
            3474-4112           AC008403.8         183475-184113       c
FEATURES             Location/Qualifiers
     source          1..4112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4112
                     /gene="FAM83E"
                     /note="family with sequence similarity 83 member E"
                     /db_xref="GeneID:54854"
                     /db_xref="HGNC:HGNC:25972"
     exon            1..140
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     exon            141..272
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1992
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     CDS             1528..2964
                     /gene="FAM83E"
                     /codon_start=1
                     /product="protein FAM83E"
                     /protein_id="NP_060178.2"
                     /db_xref="CCDS:CCDS42587.1"
                     /db_xref="GeneID:54854"
                     /db_xref="HGNC:HGNC:25972"
                     /translation="MAASQLAALEGVDSGPRVPGASPGFLYSEGQRLALEALLSKGAE
                     AFQTCVQREELWPFLSADEVQGLAAAAEDWTVAKQEPSGMAEGATTTDVDAGSLSYWP
                     GQSEQPAPVLRLGWPVDSAWKGITRAQLYTQPPGEGQPPLKELVRLEIQAAHKLVAVV
                     MDVFTDPDLLLDLVDAATRRWVPVYLLLDRQQLPAFLELAQQLGVNPWNTENVDVRVV
                     RGCSFQSRWRRQVSGTVREKFVLLDGERVISGSYSFTWSDARLHRGLVTLLTGEIVDA
                     FSLEFRTLYAASCPLPPAPPQKPSVIGGLQRGRSPHRVSRRRSVAPASPPPPDGPLAH
                     RLAACRVSPATPGPALSDILRSVQRARTPSGPPARPSRSMWDLSRLSQLSGSSDGDNE
                     LKKSWGSKDTPAKALMRQRGTGGGPWGEVDSRPPWGGALPLPPAHRLRYLSPARRRFG
                     GDATFKLQEPRGVRPSDWAPRAGLGGQP"
     exon            1993..2160
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2285
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2703
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..4112
                     /gene="FAM83E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83E"
                     /note="hexamer: AATAAA"
     polyA_site      4112
                     /gene="FAM83E"
                     /note="major polyA site"
ORIGIN      
        1 gtggaccggg aagtgcaggg tgcaggctgg cagggctgtg gggagggaga gactgcctgg
       61 gaacaggtga ggcaatctca accccccggg gaccgggaag cctgagtcta gaggggcgtt
      121 caccccctgg gagagcacag gtcgaggcct gatgagtgag gccagaagcc gggaagcacc
      181 gcagaagtag aagccgggga gccacagcct acgttctcgg aaaaagcagg cactggaagg
      241 gaggccattg agcccggcac tagccggtgt ggctccctgc tgtggtctgg aggaagcagc
      301 ggcctgggtt ggtgggattg gaatgaaggg cttctggttt gcagggatca agggtccagg
      361 gtccccgagg ttgggtcagg agcctcaagg ggataactga ggcttgggag ggagacaggg
      421 cgagatagag actggcccct gtccgggaag aagcgtccgg gtagctggca ggagatagca
      481 tttaggcaga aaccaggctg ggggcagctt gggtagggct ccccgcagat cagaggacgg
      541 cctggaacag gtcccagggc caggccccag gcaggggcag ccagcctgag gagggtggct
      601 ggttaggtgg cactcacacc tagatgggct gtgaagatca tagacctgtc ccatagtaat
      661 ggagacccct gtagcgcatt tcaccctcca ctgcagcagc tggaaggagt gtgaggaggg
      721 tccagggagc agggtccccc attgacaggg tagggaaggg tttgccaagc cttcggcctt
      781 taaggctgag cgagcaggcc cagtggagag gcatcctggc tggtctgcgg gtgagagctg
      841 atgagcagga gaaactcgtg ggggctgtca gatttggcca gagacagatg ctccaacagg
      901 cagatactgt gactgtcagt cggaagccat tggcgtttgc cagacagtgg aaggagaggg
      961 tcagttcgtc gtgctcttgg ccgggggcag gcaggcaacc tgtcgtgcct ttaaggacct
     1021 ttgggtgatt agagacaggc aggcagcttg ccgcctggaa atgatcaagt ggtcagcctg
     1081 accaaattca ggacagctga agggtctgac tgggcactgt gtgactggtg ggttggaggc
     1141 tgtcgtgtgg ctgagcagag atggccagct gatgggtcac acagttgggg atggtgtcag
     1201 gaggtcaacc tgaccagcag agacggctgg caggaaggtc acggaaggcc agccaggcat
     1261 ggtgccactg ggtgcaggca ggtggcggat ctgagtggcc tgacacattg gatggtcgct
     1321 tatttgggca gcgtgattgt cagaacagtg tggcaggggc tgctgcaggg agccatttgg
     1381 acatctgcag ggccccgccg gaggcctcgg atggccacgt agggtctgcc tatcaggaga
     1441 acccccagat gatcacagtc cccagagaca gccagacccc cggggaccca gcctctcaca
     1501 gtcagtcctc ccacccgagt gaccccgatg gcggcctccc agctggcggc gctggaagga
     1561 gtggactccg gtcccagggt gcccggggcc agccccggct ttctatattc cgagggccag
     1621 cggctggcac tggaggctct gttgagcaag ggcgcggagg cgttccagac ctgcgtgcag
     1681 cgcgaggagc tgtggccctt cctcagtgcg gatgaggttc agggcttggc agcggcagct
     1741 gaagactgga cagtggccaa gcaggagccc agcgggatgg cagagggagc caccaccacc
     1801 gatgtggacg cgggcagcct gagctactgg cctgggcagt cggagcagcc ggcgcccgtc
     1861 ctgcggctgg gctggccagt ggactctgcg tggaaaggca tcacccgggc gcagctgtac
     1921 acccagcctc ctggagaggg tcagccgccc ctcaaggagc tggtgcggct ggagatccag
     1981 gctgcccaca agctggtggc cgtggtcatg gacgtcttca ctgacccaga cctgcttttg
     2041 gacttggtgg atgctgccac gcgccgctgg gtacctgtct acctgctcct ggaccgccag
     2101 cagctgcctg ccttcctgga actggcccag cagctggggg tgaacccctg gaacacggag
     2161 aacgtggatg tccgtgtcgt gcggggctgc agcttccaga gccgctggcg acggcaggtg
     2221 agcggcaccg tgcgggagaa gtttgtgctg ctggacggcg agagggtcat ctcaggatcc
     2281 tacagcttca cgtggagtga cgcacgcctg caccgaggcc tggtgaccct gctgactggt
     2341 gaaattgttg acgccttcag ccttgagttc cggacgctgt acgcggcctc ctgcccgctc
     2401 ccacctgcgc ccccccagaa accctcggtc ataggtggcc tgcagcgggg ccgcagcccg
     2461 caccgcgtgt cccgccgccg ctccgtggcc cccgcgtcgc ctccgccgcc tgacggcccg
     2521 ctggcccacc gcctggccgc ctgccgcgtc tcccctgcta ccccggggcc ggcactcagt
     2581 gacattctaa ggagtgtgca gcgcgcccgg acccccagcg gccccccggc ccggcccagc
     2641 cgctccatgt gggacctaag ccgcctgtcc cagctgtctg gctccagtga tggggacaac
     2701 gagctcaaga aatcctgggg ctccaaggac actccagcca aggctctgat gaggcagcgg
     2761 ggcactggag gaggcccctg gggggaagtg gactcccgac ctccgtgggg cggtgccctg
     2821 cccctgcccc ccgcccaccg cctccgctat ctgtccccag cccgaaggcg gttcggtggg
     2881 gatgctacat tcaaacttca agagcccaga ggcgtcaggc cgtcagactg ggccccccgg
     2941 gcaggacttg gggggcaacc ctgaacagga gcccaagcca aatctgctgg cccacccaag
     3001 gagcagtgcc ggacaactgt cggctcagag ccctctgcct caatgccctg ccttggacaa
     3061 ggcttctggc ctcggcgtct gtcaagcaga agggatgttt gtcacttgtt ctgcaacttg
     3121 ggccgggagt ggtggctcat gcctgtaatc cctgcacttt gggaggctaa ggtgggaggg
     3181 ttgcttaagg ccaggagttg gagaccagcc tgggcaacat agtgagaccc catctctaca
     3241 attaaaaaaa caaattagtt gggtgtggtg gcgcacgcct gtggtcccag ctacgcagga
     3301 ggctgaggtg ggaggatccc ttgagctcag gaggtggagg cagcagtgag ccaagatcat
     3361 gcccttgcac tccagcctgg gcaacacagt gagaggccat ctctttaaaa aaaaaaaaaa
     3421 aagaaaaaag aaaaagaaag gctgatcgag gtggctcact cctgtaatcc cagcactttg
     3481 ggaggctgag gcatgtggat cacctgaggt caggagttca agaccaacct gaccaacatg
     3541 gtgaaacccc atctctacca aatacaaaaa ttagccaggt gtggtggcgg gcgcctgtaa
     3601 tcccagctac ttaggaggct gagacgggag aattgcttga acccgggagg cggaggttgc
     3661 agtgagctga gatcacgcca ctgcactcca gcctgggtga cagagcgaga tttcatctca
     3721 aacaaaaaaa aggacttggg caagcccatt gcctgcacca gacctcagtg tcacaaccca
     3781 gaagatgggc tggcagcgtc cccaggcagc ggatcctaaa gaagacacac acagctcccg
     3841 agggtcaggc cttcctgatg aggggcccgg gtgaggcccc gagctagagc tgctagagct
     3901 gtggagggga agatggggag tcgctgccag gcacactgtg ttcaggagct gtggggaaac
     3961 tgaggcaagg agctgaatac tgagggagtg gaatgtggta cagccacagg ggaacagggt
     4021 gggtggtggg actttctgtg ggcgctgaga gggcgggtct gccggagctc ccgtttacct
     4081 ctgctcggaa taaaaccact ttatgccaaa aa
//
