LOCUS       NM_030919               2370 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member D (FAM83D),
            mRNA.
ACCESSION   NM_030919
VERSION     NM_030919.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Li,J., Tian,J., Ma,M., Qin,Z., Cao,B., Yang,J., Wang,X. and Yang,X.
  TITLE     FAM83D promotes the progression of 4NQO-induced esophageal
            carcinoma via inhibiting FBWX7
  JOURNAL   Exp Cell Res 442 (2), 114252 (2024)
   PUBMED   39260674
  REMARK    GeneRIF: FAM83D promotes the progression of 4NQO-induced esophageal
            carcinoma via inhibiting FBWX7.
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Yu,X., Li,Y., Kong,F. and Xu,Q.
  TITLE     METTL3 regulates FAM83D m6A modification to accelerate
            tumorigenesis of triple-negative breast cancer via the
            Wnt/beta-catenin pathway
  JOURNAL   Toxicol In Vitro 95, 105746 (2024)
   PUBMED   38043628
  REMARK    GeneRIF: METTL3 regulates FAM83D m[6]A modification to accelerate
            tumorigenesis of triple-negative breast cancer via the
            Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Geng,Y., Liu,J., Wang,Z., Liu,T., Peng,X. and Huang,Y.
  TITLE     Systematic analysis of the oncogenic role of FAM83D across cancers
            based on data mining
  JOURNAL   Cell Cycle 22 (8), 1005-1019 (2023)
   PUBMED   36710419
  REMARK    GeneRIF: Systematic analysis of the oncogenic role of FAM83D across
            cancers based on data mining.
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Gao,G., Guo,X., Gu,W., Lu,Y. and Chen,Z.
  TITLE     miRNA-142-3p functions as a potential tumor suppressor directly
            targeting FAM83D in the development of ovarian cancer
  JOURNAL   Aging (Albany NY) 14 (8), 3387-3399 (2022)
   PUBMED   35489022
  REMARK    GeneRIF: miRNA-142-3p functions as a potential tumor suppressor
            directly targeting FAM83D in the development of ovarian cancer.
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Santamaria,A., Nagel,S., Sillje,H.H.W. and Nigg,E.A.
  TITLE     The spindle protein CHICA mediates localization of the
            chromokinesin Kid to the mitotic spindle
  JOURNAL   Curr Biol 18 (10), 723-729 (2008)
   PUBMED   18485706
  REMARK    GeneRIF: interaction partner of the chromokinesin Kid that is
            required for the generation of polar ejection forces and chromosome
            congression
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Tegha-Dunghu,J., Neumann,B., Reber,S., Krause,R., Erfle,H.,
            Walter,T., Held,M., Rogers,P., Hupfeld,K., Ruppert,T., Ellenberg,J.
            and Gruss,O.J.
  TITLE     EML3 is a nuclear microtubule-binding protein required for the
            correct alignment of chromosomes in metaphase
  JOURNAL   J Cell Sci 121 (Pt 10), 1718-1726 (2008)
   PUBMED   18445686
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Sauer,G., Korner,R., Hanisch,A., Ries,A., Nigg,E.A. and Sillje,H.H.
  TITLE     Proteome analysis of the human mitotic spindle
  JOURNAL   Mol Cell Proteomics 4 (1), 35-43 (2005)
   PUBMED   15561729
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055793.1, BC080188.1, BC053683.1 and AL023803.3.
            
            On Nov 24, 2018 this sequence version replaced NM_030919.2.
            
            CCDS Note: The coding region has been updated to shorten the
            N-terminus based on the use of a downstream in-frame start codon,
            which is supported by ribosome profiling and conservation data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.99276.1, AK055793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619850.2/ ENSP00000481465.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK055793.1         108-116
            10-2313             BC080188.1         2-2305
            2314-2324           BC053683.1         2306-2316
            2325-2370           AL023803.3         31459-31504
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2370
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /note="family with sequence similarity 83 member D"
                     /db_xref="GeneID:81610"
                     /db_xref="HGNC:HGNC:16122"
                     /db_xref="MIM:618380"
     exon            1..509
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1784
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /note="spindle protein CHICA"
                     /codon_start=1
                     /product="protein FAM83D"
                     /protein_id="NP_112181.3"
                     /db_xref="CCDS:CCDS42872.2"
                     /db_xref="GeneID:81610"
                     /db_xref="HGNC:HGNC:16122"
                     /db_xref="MIM:618380"
                     /translation="MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGP
                     EAFAAFLRRERLARFLNPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYF
                     PEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAR
                     EVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKL
                     MTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILS
                     GQVVEHFDLEFRILYAQSKPISPKLLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRL
                     ARLSSTPRKADLDPEMPAEGKAERKPHDCESSTVSEEDYFSSHRDELQSRKAIDAATQ
                     TEPGEEMPGLSVSEVGTQTSITTACAGTQTAVITRIASSQTTIWSRSTTTQTDMDENI
                     LFPRGTQSTEGSPVSKMSVSRSSSLKSSSSVSSQGSVASSTGSPASIRTTDFHNPGYP
                     KYLGTPHLELYLSDSLRNLNKERQFHFAGIRSRLNHMLAMLSRRTLFTENHLGLHSGN
                     FSRVNLLAVRDVALYPSYQ"
     exon            510..677
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..802
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..2370
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2293..2298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /note="major polyA site"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="FAM83D"
                     /gene_synonym="C20orf129; CHICA; dJ616B8.3"
ORIGIN      
        1 gagggctgtc gagtccgagc gccgccatgg ctctgctgtc cgagggcctg gacgaggtgc
       61 ccgccgcctg cctgtcgccg tgcgggccgc ccaacccgac cgagctgttc agcgagtcac
      121 ggcgcctggc tctggaggag ctggtggcgg gcggccccga agccttcgcg gccttcctgc
      181 gacgcgagcg cctggctcgt ttcctgaacc ccgatgaggt gcacgccatt ctgcgcgcgg
      241 cggagaggcc gggagaggag ggcgcggcgg cggcggcggc ggccgaggac tcgttcggct
      301 cctcgcacga ctgctcttcg ggcacctact tccccgagca gtcggacctg gagccaccgc
      361 tgttggagct tggctggccc gccttctacc agggcgccta ccgcggcgcc acgcgtgtcg
      421 agacgcactt ccagccccgc ggcgctggcg aaggtggccc ctacggctgc aaggacgctc
      481 tgcgccagca gctccgctcg gcgcgagagg tgattgcagt ggtcatggac gtgttcacag
      541 acatcgacat cttcagagac ctgcaagaaa tatgcaggaa acagggagtt gctgtgtata
      601 tccttctgga ccaggctctc ctctctcaat ttctggatat gtgcatggat ctgaaagttc
      661 atcctgaaca ggaaaagtta atgacagttc ggactatcac aggaaatatc tactatgcaa
      721 ggtcaggaac taagattatt gggaaggttc acgaaaagtt cacgttgatt gatggcatcc
      781 gcgtggcaac aggctcctac agttttacat ggacggatgg caaattaaac agcagtaact
      841 tggtaattct gtctggccaa gtggttgaac actttgatct ggagttccga atcctgtatg
      901 cccagtccaa gcccatcagc cccaaactcc tgtctcactt ccagagcagc aacaagtttg
      961 atcacctcac caaccgaaaa ccacagtcca aggagctcac cctgggcaac ctgctgcgga
     1021 tgcggctggc taggctgtca agtactccca ggaaggcgga cctggaccca gagatgcccg
     1081 cagagggcaa ggcagagcgc aagccccatg actgtgagtc ctctactgtt agtgaggaag
     1141 actacttcag cagccacagg gacgagctcc agagcagaaa ggccattgac gctgccactc
     1201 aaacagagcc aggagaggag atgccagggc tgagtgtgag tgaggtggga acacaaacca
     1261 gcatcaccac agcatgtgct ggtacccaga ctgcagtcat caccaggata gcaagctctc
     1321 aaaccacgat ttggtccaga tcgaccacta ctcagactga catggatgag aacattctct
     1381 ttcctcgagg aactcaatct acagaagggt caccagtctc aaaaatgtct gtatcgagat
     1441 cttccagttt gaagtcttcc tcctctgtgt cttcccaagg ctctgtggca agctccactg
     1501 gttctcccgc ttccatcaga accactgact tccacaatcc tggctatccc aagtacctgg
     1561 gcacccccca cctggaactg tacttgagtg actcacttag aaacttgaac aaagagcggc
     1621 aattccactt cgctggtatc aggtcccggc tcaaccacat gctggctatg ctgtcaagga
     1681 gaacactctt tactgaaaac caccttggcc ttcattctgg caatttcagc agagttaatt
     1741 tgcttgctgt tagagatgta gcactttatc cttcctatca gtaactgctc cgtgttcaga
     1801 ctcctggttt cttccaggct tacagtggac atcatcagct tcctgcttta aaaaatatct
     1861 tatgtcccta attgcctttc ttttacctga ctttgtcacc tttgttgtct ttgaattctt
     1921 taggctgcat attattttac atgctttgtt ttgtcatgta tataccaggt attggtttta
     1981 tggtttaaac actatggata caggggtttg ttttgcacaa ttttaatagt catgcactac
     2041 ataatgatgt tttggtcaat gacagaccac gtatatgttg gcagtctcat aagattataa
     2101 tactgtattt ttactatacc ttttctgtgt ttagatacaa ataccattat gttacagttg
     2161 cctacagtat tcagtgcagt aacatgatgt acaggtttgt agcctgtttt gcatttttct
     2221 taggttgtat gctcttctgt tttaaaggtt tgaatcacca gcatttttgt gatcaaaatc
     2281 ctatttagaa aaaataaaac tactttctgt ttatctcttt agaatatctg tgttcttagc
     2341 attaaataaa tataaacttg tgcttctgta
//
