LOCUS       NM_178468               3169 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member C (FAM83C),
            mRNA.
ACCESSION   NM_178468
VERSION     NM_178468.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3169)
  AUTHORS   Fulcher,L.J., Bozatzi,P., Tachie-Menson,T., Wu,K.Z.L.,
            Cummins,T.D., Bufton,J.C., Pinkas,D.M., Dunbar,K., Shrestha,S.,
            Wood,N.T., Weidlich,S., Macartney,T.J., Varghese,J., Gourlay,R.,
            Campbell,D.G., Dingwell,K.S., Smith,J.C., Bullock,A.N. and
            Sapkota,G.P.
  TITLE     The DUF1669 domain of FAM83 family proteins anchor casein kinase 1
            isoforms
  JOURNAL   Sci Signal 11 (531) (2018)
   PUBMED   29789297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3169)
  AUTHORS   Cipriano,R., Miskimen,K.L., Bryson,B.L., Foy,C.R., Bartel,C.A. and
            Jackson,M.W.
  TITLE     Conserved oncogenic behavior of the FAM83 family regulates MAPK
            signaling in human cancer
  JOURNAL   Mol Cancer Res 12 (8), 1156-1165 (2014)
   PUBMED   24736947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121753.32, AK091116.1 and
            BC113483.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_178468.5.
            
            Summary: This gene encodes a member of the family with sequence
            similarity 83 protein family. The encoded protein may be involved
            in regulating MAPK signaling in cancer cells. [provided by RefSeq,
            Mar 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374408.4/ ENSP00000363529.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL121753.32        102143-102145       c
            4-24                AK091116.1         1-21
            25-2383             BC113483.1         1-2359
            2384-3169           AL121753.32        95451-96236         c
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..3169
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /note="family with sequence similarity 83 member C"
                     /db_xref="GeneID:128876"
                     /db_xref="HGNC:HGNC:16121"
     exon            1..634
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2365
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /codon_start=1
                     /product="protein FAM83C"
                     /protein_id="NP_848563.1"
                     /db_xref="CCDS:CCDS13251.1"
                     /db_xref="GeneID:128876"
                     /db_xref="HGNC:HGNC:16121"
                     /translation="MFGGPGPGVLGAQGMAGPLRGRVEELKLPWWRESSPLVLRHSEA
                     ARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASGP
                     DRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNIKD
                     LLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYK
                     MDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQ
                     AHTSMVLQLRGRIVEDFDREFRCLYAESQPVEGFCGGEDPLSPRALRPPPVALAFRPD
                     VPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTGVVSSSLGPARREASGQP
                     SLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPLTLAVGSPLLPRSR
                     PLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQL
                     DLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDLLSRALGTGG
                     APELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSSARPARRAPD
                     ERRQTLGHSQLDLITKFGPFRGEGPGPNGLPISSPARTAGAGSGDEKRLTLGHSKLDL
                     ITKYHQLHGARQGTEPGGPKGGHLNGGNSDLVRDEKRLTLGHSKLDLITKYNKSKFKQ
                     LRSRFES"
     exon            635..802
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /inference="alignment:Splign:2.1.0"
     exon            803..927
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /inference="alignment:Splign:2.1.0"
     exon            928..3169
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /note="hexamer: AATAAA"
     polyA_site      3169
                     /gene="FAM83C"
                     /gene_synonym="C20orf128; dJ614O4.7"
                     /note="major polyA site"
ORIGIN      
        1 gccacacaca cagcgagcgg gcgggcagaa ggcggttctg ctggtctcct cttcctgctg
       61 cagccagccc agcgtgcggg ccatgggccc tgccggcggg tgaggcagcc gcgtggcagg
      121 catgttcgga ggcccggggc ctggggtcct gggagcccag ggcatggcgg gacccctgcg
      181 gggccgggtg gaagagctga agctgccgtg gtggcgggag agctcaccgc tggtgctgcg
      241 gcacagcgag gcggctcggc tggcggccga cgccctcctg gagcggggtg aggctgccta
      301 cctgcgggtc atctccgagg agcgggagct gcccttcctg agcgccctgg atgtggacta
      361 catgaccagc catgtgcgcg ggggccctga gctcagcgag gctcaggggc aggaggcctc
      421 cgggccagac cgcctcagcc tgctctctga agtcacctca gggacttact tccccatggc
      481 ctctgacata gaccccccag acctggacct gggctggccc gaggtgccac aggccacagg
      541 cttcagcccc acccaggctg tggtccactt ccagagggac aaggccaaga acatcaagga
      601 cctgctgcgc ttccttttca gccaggccca cacggtggtg gctgtggtga tggacatatt
      661 cactgacatg gagcttctgt gtgacctcat ggaggcctca agccggcgtg gtgtccctgt
      721 gtacctgctc cttgcccagg agcacctgag gcacttcctg gagatgtgct acaagatgga
      781 cctcaatggg gagcacctgc cgaacatgcg tgtgcggagc acgtgtgggg acacatactg
      841 cagcaaggct ggccgccgct tcacggggca ggccctggag aagttcgtcc tcattgactg
      901 tgagcaagtg gtggcgggca gttacagctt cacctggctt tgcagccagg cccacactag
      961 catggtgctg cagctgaggg gccgcatcgt ggaagacttt gaccgggagt tccgctgtct
     1021 gtacgctgag tcgcagcctg tggagggctt ctgtggcggt gaggacccgc tgtctccccg
     1081 ggcactgcgt cctccccctg tggccctagc cttcaggcct gatgtcccaa gccccacgtc
     1141 gtccctgccc tccagcacca gcctcagcag catcaagcag tcaccgctta tgggtcgctc
     1201 ctcctacctc gctctaccag gaggtggtga ttgcagtgat acgggtgtgg tgtcctcgtc
     1261 cctgggtcct gcccgccgtg aggccagtgg ccagccctcc ctacatcgcc aactgtcaga
     1321 ccctaaccac ggctcccctc ctgggctcta tagggccaat ctcggcaagc taggggcata
     1381 cccatggtcc cagtcctccc ctgccctcaa ccataatagt accagcccct taaccttggc
     1441 agtggggtca cctctgcttc ctcgctcccg gcccctcctc cagttccatc ggggtgcccc
     1501 agctctgtcc cggttcccag agaatgggct cccaggaagc caagagccca gccccctgcg
     1561 gggtcgatgg gtacctggca caaccctgga gacagtggag gagaaggaga agaaggcatc
     1621 tccaagtcag agccgtggcc agctggatct ccttgtcccc ttccccagag cccgagaagt
     1681 gggagaccct gactctgggg ttacccccaa ctcaggcccc cttcggcctg gcgagcaggc
     1741 cccagaggac aggaggttgt ccccaagcca ggccgacagc cagctggatc tcctgtcccg
     1801 agccctgggt actgggggtg cccctgagtt gggttccctc agacctggtg atcgggccct
     1861 ggaggacagg aggctgtccc taaaccaaag ccgtggccaa tcagacctcc tgatgcagta
     1921 ccccaaggcc cagggttcca gagtgcccct tgaaaccaac tcctcagcca gacctgccag
     1981 acgggcacca gatgagcggc ggcagaccct ggggcacagc cagctggacc tcatcacaaa
     2041 gttcggccca ttccgtggtg aggggcctgg gcccaatggt ctcccgatat caagccctgc
     2101 tcgcacggct ggagctgggt ctggggatga gaaacggcta accctgggcc acagcaagct
     2161 ggacctcatc accaagtatc atcagttgca cggggccagg cagggaactg agcctggggg
     2221 tcccaagggt ggccatctca atggtggtaa cagtgacctg gtcagggatg agaaacggct
     2281 gaccctgggt cacagcaaac tggacctcat cactaagtac aacaagtcca agttcaagca
     2341 gctccgaagc cgctttgagt cctagccaaa ggactggcat cgggggtgca ctggcaaggg
     2401 caggcccctc ctctgtccac cgagactctg gacttgctca ggtcccagac tggggaaggg
     2461 aggtgtctag aaacccaggt cagacacact ctctgggctc aagattcttg tgtacacaca
     2521 cacacacaca cacacacaca cacaccctaa ctagtatctt cttgaatcta ggctgtgttt
     2581 ccagccctgt gctgggcctg tagagctgac aggtgggtca cactcagacc tggggacaga
     2641 ggtgaaatgc acaagctgct ggagaagggg tcagagccat atcaagttaa aggttaacca
     2701 gttacagagg gtgttagaaa acaaagggca gagagtcctg gagaaggtgg agtagtcaga
     2761 aaactttctt agaggagatg gaggtggcct ttgagccagg ccctgaagga tggggaggtt
     2821 ttggacagag ggaggagaga gttagaaaaa tttttggtag agagaatcag gtgaaagaga
     2881 tgccctaaag aggactgagt gggtctgagg tgaatgagtg aggaagagca gagtatgtgg
     2941 atacccggaa acacacacac acacacatca tcattatcat catcatcatt gtcgtcgtca
     3001 tcatcttgct gagtcatcat catcatcatc atcattgtcg tcgtcatcat cttgctgagt
     3061 gtctcttgaa gtacaggctg tgacaggttg tgggccattt tcctgaactc accacttacc
     3121 cgggatagta aacatgatac acatcaataa aggcagactt tattgtgaa
//
